scholarly journals Editorial. Trauma in patients with spinal ankylosing disorders is often underestimated and frequently overlooked despite the high likelihood of complications

2021 ◽  
Vol 51 (4) ◽  
pp. E3
Author(s):  
Peter Grunert ◽  
Doniel Drazin
Keyword(s):  
2012 ◽  
Vol 2012 ◽  
pp. 1-12
Author(s):  
Han Wang ◽  
Pornpimol Tipthara ◽  
Lei Zhu ◽  
Suk Yean Poon ◽  
Kai Tang ◽  
...  

Chromatin-associated nonhistone proteins (CHRAPs) are readily collected from the DNaseI digested crude chromatin preparation. In this study, we show that the absolute abundance-based label-free quantitative proteomic analysis fail to identify potential CHRAPs from the CHRAP-prep. This is because that the most-highly abundant cytoplasmic proteins such as ribosomal proteins are not effectively depleted in the CHRAP-prep. Ribosomal proteins remain the top-ranked abundant proteins in the CHRAP-prep. On the other hand, we show that relative abundance-based SILAC-mediated quantitative proteomic analysis is capable of discovering the potential CHRAPs in the CHRAP-prep when compared to the whole-cell-extract. Ribosomal proteins are depleted from the top SILAC ratio-ranked proteins. In contrast, nucleus-localized proteins or potential CHRAPs are enriched in the top SILAC-ranked proteins. Consistent with this, gene-ontology analysis indicates that CHRAP-associated functions such as transcription, regulation of chromatin structures, and DNA replication and repair are significantly overrepresented in the top SILAC-ranked proteins. Some of the novel CHRAPs are confirmed using the traditional method. Notably, phenotypic assessment reveals that the top SILAC-ranked proteins exhibit the high likelihood of requirement for growth fitness under DNA damage stress. Taken together, our results indicate that the SILAC-mediated proteomic approach is capable of determining CHRAPs without prior knowledge.


2003 ◽  
Vol 18 (4) ◽  
pp. 291-299 ◽  
Author(s):  
Ernest Sternberg

AbstractThis article seeks to clarify the terminology and methods of planning to avert hospital internal disaster. It differentiates “crisis” from “disaster” in the in-hospital setting. Preparedness, as contrasted with mitigation, is meant to reduce the likelihood that a crisis will turn into a disaster. Though there are some recurring features of crises, allowing for preparedness through the identification of a few high-likelihood contingencies, crises are subject to numerous, overwhelming uncertainties. These include hazard uncertainty, incident uncertainty, sequential uncertainty, informational uncertainty, consequential uncertainty, cascade uncertainty, organizational uncertainty, and background uncertainty. In view of the uncertainties, the primary aim of planners should not be to try to create plans for ever more contingencies, since contingencies are far too numerous and perhapsapproach infinity, but rather to create capabilities (through proper preparedness) for resilience during crisis. Resilience can be cultivated through improvements in information acquisition and dissemination, communication systems, resource management, mobility management, design for resilience, incident command, and staff versatility.


2013 ◽  
Vol 79 (2) ◽  
pp. 294-295 ◽  
Author(s):  
Furrukh Jamil ◽  
Richard J. Q. McNally ◽  
David Richardson ◽  
Steve Ball ◽  
Tim Cheetham

Author(s):  
James Peng ◽  
Carina Marquez ◽  
Luis Rubio ◽  
Gabriel Chamie ◽  
Diane Jones ◽  
...  

Abstract Of 4,133 persons surveyed at a low-barrier COVID-19 test site with high positivity in an urban Latinx community in January 2021, 86% indicated they would accept a COVID-19 vaccination. Top reasons for vaccine hesitancy included concerns around side effects and safety and distrust of healthcare systems.


Autism ◽  
2021 ◽  
pp. 136236132110504
Author(s):  
Lauren H Hampton ◽  
Elizabeth M Rodriguez

Understanding the impact of preemptive interventions on development for those with a high likelihood for autism is a critical step in building a transdiagnostic model of optimized intervention. The purpose of this systematic review and meta-analysis is to examine the impact of preemptive autism interventions on parent outcomes and child developmental outcomes. A total of 345 unique records were assessed for eligibility yielding 13 unique studies with 715 total infant/toddlers with a high likelihood for autism. There was a significant association between the early interventions on parent implementation of intervention strategies immediately following the intervention. However, there was no significant association between the early interventions and child developmental outcomes. The studies reporting moderator and/or mediator analyses suggest a meaningful association between parent implementation and long-term child social communication outcomes. Taken together, these findings suggest that parent-mediated interventions are associated with improved parent use of strategies, and although these results do not translate into immediate or short-term child developmental outcomes, there is evidence that parents with the greatest implementation facilitate later improved communication outcomes for their children. There is an urgent need to develop a nuanced intervention approach during a time of ever-changing concern about child development. Lay abstract Interventions to address core symptoms for young children on the autism spectrum have a strong and growing evidence base. Adapting and delivering evidence-based interventions to infants and toddlers with a high likelihood for autism is a logical next step. This systematic review and meta-analysis summarize the association between infant and toddler interventions and developmental and family outcomes. Results indicate that these early interventions are effective for improving parent implementation of core strategies, yet the effects do not readily translate to child outcomes. However, key studies demonstrate conditional results that indicate that parent implementation is associated with child outcome. Implications for research and practice toward building adaptive interventions that respond to parent implementation and changing child characteristics are discussed.


Author(s):  
Evangeline Bonisiwe Zungu

The recent COVID-19 pandemic took the world by storm. The rate of infection and prevalence of death struck fear in the hearts of many across the globe. The high likelihood of infection required continual testing whilst the trauma of bereavement left many distraught. For traditionalists, a principal concern was whether they would be permitted to exhaustively practise their burial rites in the course of mourning their loved ones. The importance of the custom, as it is believed, is to prevent unsettled feelings in family members. This article is aimed at stimulating consideration, reflection and understanding of the concerns experienced by traditional societies surrounding COVID-19 regulations and the non-performance of important burial rites. Surviving family members experience troubled thoughts as a result of the fear of repercussions, which may include the living-dead withholding their protection of the family which consequently will cause ailments and accidents. This article will utilise inductive thematic analysis to interpret the data collected .


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