Side effects of spasmolytic agents in the monkey

1973 ◽  
Vol 39 (5) ◽  
pp. 629-635 ◽  
Author(s):  
Albert N. Martins ◽  
John K. Wiley
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Side Effects ◽  
System Function ◽  
Central Nervous System Function ◽  
Content Type ◽  
Spasmolytic Agents ◽  
Nervous System Function ◽  
Fine Print

✓ The authors report a study of the physiological and morphological responses of the rhesus monkey brain to intracisternal injections of two potentially useful spasmolytic agents, phenoxybenzamine and phentolamine. Central nervous system function remained unaffected by intracisternal injections of either drug in doses that were small but nevertheless sufficient to attain pharmacologically effective concentrations in the cerebrospinal fluid. Larger doses of phenoxybenzamine caused a chemical basilar meningitis. Phentolamine caused arterial hypotension without meningitis. It is concluded that intracisternal spasmolytic therapy deserves further experimental evaluation.

Cerebral function during profound oligemic hypotension in the dog

1971 ◽  
Vol 34 (4) ◽  
pp. 494-499 ◽  
Author(s):  
David Yashon ◽  
George E. Locke ◽  
W. George Bingham ◽  
Wigbert C. Wiederholt ◽  
William E. Hunt
Keyword(s):  
Central Nervous System ◽  
Blood Flow ◽  
Nervous System ◽  
System Function ◽  
Cerebral Function ◽  
Central Nervous System Function ◽  
Content Type ◽  
Carotid Blood Flow ◽  
Nervous System Function ◽  
Fine Print

✓ Electrocortigraphic activity and common carotid blood flow were studied in 12 dogs during and following profound oligemic hypotension. Five animals survived but seven died within 75 min of hypotension. Although an 80% to 90% reduction in both mean arterial pressure and common carotid blood flow was observed, only a 20% diminution of intracranial pressure occurred and there was little change in electrocorticographic function. The preservation of cerebral function in the presence of profound systemic hypotension was demonstrated. When death occurred during shock, no prior change in central nervous system function was noted. With reinfusion, no change in parameters was noted, but common carotid blood flow was depressed to 35% to 50% of control levels for up to 2½ hrs of observation.

Central Nervous System Function in Dialysis Patients: A Practical Approach

2007 ◽  
Vol 4 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Allen R. Nissenson ◽  
James T. Marsh ◽  
Warren S. Brown ◽  
Deane L. Wolcott
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Practical Approach ◽  
System Function ◽  
Dialysis Patients ◽  
Central Nervous System Function ◽  
Nervous System Function

Central nervous system function after cardiopulmonary bypass

1993 ◽  
Vol 14 (7) ◽  
pp. 885-890 ◽  
Author(s):  
J. ZEITLHOFER ◽  
S. ASENBAUM ◽  
C. SPISS ◽  
A. WIMMER ◽  
N. MAYR ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cardiopulmonary Bypass ◽  
System Function ◽  
Central Nervous System Function ◽  
Nervous System Function
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