scholarly journals “THE HEART KNOWS ALL ABOUT US”: AN ASSESSMENT OF THE FUNCTIONAL STATE OF PATIENTS BY THE INDICATORS OF A SHORT RECORDING OF THE HEART RATE VARIABILITY

Author(s):  
A.S. Korpan

This article highlights the issues of using a hardware technique for assessing the functional state of patients by indicators of a short recording of heart rate variability. The aim of the study is to assess the clinical and diagnostic capabilities of a short recording of heart rate variability in displaying systemic informational energy processes of the human body to increase the effectiveness of measures for the prevention and treatment of non-communicable diseases in Ukraine by introducing the latest science-based technologies into medical practice. An open-label, nonrandomized controlled trial was performed. We studied the wave characteristics of the heart rate in functionally healthy individuals (group 1, n=104) and patients with coronary heart disease including exertional angina, myocardial infarction (in the subacute period) and comorbid pathology (group 2, n=66) by the method of short recording of heart rate variability using spectral analysis and variational pulsometry. The study has demonstrated coronary heart disease is accompanied by a decrease in the overall activity of regulatory systems, inhibition of the energy level of the heart (TP=931.8±710.4 at a rate of 3466±1018 ms²), a low level of hormonal modulation of regulatory mechanisms (VLF=527.3±502.1 ms², which is <700 ms²), depletion of energy resources, a low level of recoverable (HF=205.7±261.8 ms², which is <300 ms²) and mobilization (LF=198.9±191.7 ms², which is <300 ms2) potentials, an imbalance of the mechanisms of neuro-humoral regulation of cardiac activity, a decrease in the resources of cardiac activity VLF=56% when normal values are within 30-50%; VLF>HF+LF), in a state of pronounced distress (SI=256.7±264.7; SI=325.2±297.7; PAPR=71.76±30.3). Using the method of short recording of heart rate variability can allow doctors to determine the current state of physiological circulatory mechanisms, adaptive responses, diagnose maladaptive disorders, stress, monitor the effectiveness of prevention of noncommunicable diseases in respondents.

2014 ◽  
Vol 44 (14) ◽  
pp. 2975-2984 ◽  
Author(s):  
F. Zimmermann-Viehoff ◽  
L. K. Kuehl ◽  
H. Danker-Hopfe ◽  
M. A. Whooley ◽  
C. Otte

BackgroundAntidepressants reduce depressive symptoms in patients with coronary heart disease, but they may be associated with increased mortality. This study aimed to examine whether the use of tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRI) is associated with mortality in patients with coronary heart disease, and to determine whether this association is mediated by autonomic function.MethodA total of 956 patients with coronary heart disease were followed for a mean duration of 7.2 years. Autonomic function was assessed as heart rate variability, and plasma and 24-h urinary norepinephrine.ResultsOf 956 patients, 44 (4.6%) used TCA, 89 (9.3%) used SSRI, and 823 (86.1%) did not use antidepressants. At baseline, TCA users exhibited lower heart rate variability and higher norepinephrine levels compared with SSRI users and antidepressant non-users. At the end of the observational period, 52.3% of the TCA users had died compared with 38.2% in the SSRI group and 37.3% in the control group. The adjusted hazard ratio (HR) for TCA use compared with non-use was 1.74 [95% confidence interval (CI) 1.12–2.69, p = 0.01]. Further adjustment for measures of autonomic function reduced the association between TCA use and mortality (HR = 1.27, 95% CI 0.67–2.43, p = 0.47). SSRI use was not associated with mortality (HR = 1.15, 95% CI 0.81–1.64, p = 0.44).ConclusionsThe use of TCA was associated with increased mortality. This association was at least partially mediated by differences in autonomic function. Our findings suggest that TCA should be avoided in patients with coronary heart disease.


Author(s):  
G. Krstacic ◽  
A. Krstacic ◽  
M. Martinis ◽  
E. Vargovic ◽  
A. Knezevic ◽  
...  

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