scholarly journals OBTAINING A WOUND-HEALING EFFECT WHEN USING PHOTON THERAPY IN THE EXPERIMENT

2021 ◽  
pp. 44-48
Author(s):  
T.M. Kanishyna ◽  
L.I. Shkilniak
Keyword(s):  
Polymorphonuclear Leukocytes ◽  
Inflammatory Cell ◽  
Photon Radiation ◽  
Inflammatory Cell Infiltrate ◽  
Secondary Effects ◽  
Complications Of Diabetes ◽  
Photon Irradiation ◽  
Positive Therapeutic Effect ◽  
Wound Healing Effect ◽  
Morphological Differences

Introduction. The absorption of photon radiation causes biochemical, bioelectrical and bioenergetic effects in the biotissue. These primary effects, which occur directly under the action of photon irradiation, also cause secondary effects. Secondary effects are divided into three groups: analgesic, anti-inflammatory and biostimulating. At the same time, huge resources in the world are spent on the fight against diabetes and its complications. At the heart of the pathogenesis of the most common complications of diabetes are changes in the vessels of the microcirculatory tract that develop during the disease. Therefore, the possibility of using photonic physiotherapeutic effects for the prevention of complications of diabetes is of interest to researchers. The aim. The research method is investigated in experimental efficiency by means of radiation of a red spectrum for prevention of postoperative relations which can develop after publication of teeth against a diabetes mellitus. Materials and methods. Physiotherapeutic effect was performed using a multispectral photon system and morphological study of the features of surgical wound regeneration. Results. Research results. In the course of studying the pathomorphological features of post-extraction wound regeneration, the differences between the 1st and 2nd groups of animals were established. In the second group (photon physiotherapeutic effect was used) there was a less pronounced inflammatory cell infiltrate with fewer polymorphonuclear leukocytes in biopsies, a larger number of fibroblasts on the 3rd and 7th day of observation and faster appearance of fibrous structures in the granules. Epithelialization of the postextraction wound began earlier in group II, and the process of angiogenesis was also more active. Conclusion. The revealed morphological differences between the obtained results of the 1st and 2nd groups of animals testify to the positive therapeutic effect of photonic influence.

Diabetes and Vascular Disease: Is It All About Glycemia?

2019 ◽  
Vol 25 (29) ◽  
pp. 3112-3127 ◽  
Author(s):  
Alessandra Vecchié ◽  
Fabrizio Montecucco ◽  
Federico Carbone ◽  
Franco Dallegri ◽  
Aldo Bonaventura
Keyword(s):  
Vascular Disease ◽  
Inflammatory Cell ◽  
Vascular Dysfunction ◽  
Microvascular Complications ◽  
Coagulation Cascade ◽  
Inflammatory Cell Infiltrate ◽  
Extracellular Traps ◽  
Thrombotic Complications ◽  
Independent Entity ◽  
Complications And Mortality

Background: Diabetes is increasing over time, mainly driven by obesity, aging, and urbanization. Classical macro- and microvascular complications represent the final result of a complex interplay involving atherosclerosis at all stages. Methods: In this review, we aim at focusing on current updates in the pathophysiology of vascular disease in diabetes and discussing how new therapies might influence the management of these patients at high cardiovascular risk. Diabetes shows accelerated atherosclerosis with a larger inflammatory cell infiltrate, thus favoring the development of heart failure. ‘Diabetic cardiomyopathy’ perfectly describes a specific ischemia- and hypertension- independent entity due to diabetes-related metabolic alterations on myocardial function. Moreover, platelets from subjects with diabetes display a typical hyperreactivity explaining the stronger adhesion, activation, and aggregation. Additionally, diabetes provokes an exaggerated stimulation of the endothelium, with an increased release of reactive oxygen species and a reduced release of nitric oxide, both key elements of the endothelial dysfunction. Also, the coagulation cascade and leukocytes activate contributing to this pro-thrombotic environment. Neutrophils have been recently recognized to play a pivotal role by releasing neutrophil extracellular traps. Finally, microparticles from platelets, neutrophils or monocytes are detrimental effectors on the vessel wall and are involved both in vascular dysfunction and in thrombotic complications. Conclusion: In light of these findings, the therapeutic management of diabetes needs to be mostly focused on limiting the progression of complications by targeting precise pathophysiological mechanisms rather than the mere glycemic control, which failed to markedly reduce the risk for macrovascular complications and mortality.

scholarly journals Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells

2021 ◽  
Vol 7 (7) ◽  
pp. 533
Author(s):  
Ailish Williams ◽  
Helen Rogers ◽  
David Williams ◽  
Xiao-Qing Wei ◽  
Damian Farnell ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
Inflammatory Cell ◽  
Candida Infection ◽  
Inflammatory Cell Infiltrate ◽  
T Helper ◽  
Cell Infiltrate ◽  
High Prevalence ◽  
Squamous Cell Papilloma ◽  
Oral Lichen

Previous research into the inflammatory cell infiltrate of chronic hyperplastic candidosis (CHC) determined that the immune response is primarily composed of T cells, the majority of which are T helper (CD4+) cells. This present investigation used immunohistochemistry to further delineate the inflammatory cell infiltrate in CHC. Cells profiled were those expressing IL-17A cytokine, EBI3 and IL-12A subunits of the IL-35 cytokine, and FoxP3+ cells. Squamous cell papilloma (with Candida infection) and oral lichen planus tissues served as comparative controls to understand the local immune responses to Candida infection. The results demonstrated that Candida-induced inflammation and immune regulation co-exist in the oral mucosa of CHC and that high prevalence of cells expressing the EBI3 cytokine subunit may play an important role in this regulation. This balance between inflammation and immune tolerance toward invading Candida in the oral mucosa may be critical in determining progress of infection.

scholarly journals Uterine Perforation with Omental Prolapse in a Case of Unsafe Abortion

2012 ◽  
Vol 2 (3) ◽  
pp. 145-147 ◽  
Author(s):  
Parinitha S Sangam ◽  
Nirmala M Jayakumar ◽  
Laxmi V Yaliwal
Keyword(s):  
Inflammatory Cell ◽  
Past History ◽  
Termination Of Pregnancy ◽  
Inflammatory Cell Infiltrate ◽  
Emergency Laparotomy ◽  
Uterine Perforation ◽  
Medical Sciences ◽  
Medical Termination ◽  
Physician Patient ◽  
Omental Fat

We report a rare case of prolapsed omentum presenting as mass per vagina in a 24 year old unmarried female following dilatation and curettage for termination of pregnancy by unqualified physician. Patient presented to Obstetrics and gynaecology (OBG) outpatient with bleeding per vagina since 15 days. Per speculum examination showed a greyish yellow mass protruding through cervical os into the vagina. Ultrasonography showed defect in the fundus of uterus. Past history revealed, she had undergone medical termination of pregnancy (MTP) outside at 5th month of gestation by nonallopathic doctor. Emergency laparotomy was done. Histopathologic examination of mass showed omental fat arranged in lobules with mixed inflammatory cell infiltrate. Uterine perforation is a well known complication of induced abortion. Although most uterine perforations at the time of curettage during abortion go unrecognized, serious complications do occur. DOI: http://dx.doi.org/10.3126/ajms.v2i3.4264 Asian Journal of Medical Sciences 2 (2011) 145-147   

scholarly journals Therapeutic effects of soluble guanylate cyclase stimulation on pulmonary hemodynamics and emphysema development in guinea pigs chronically exposed to cigarette smoke

2019 ◽  
Vol 317 (2) ◽  
pp. L222-L234 ◽  
Author(s):  
Tanja Paul ◽  
Isabel Blanco ◽  
Daniel Aguilar ◽  
Olga Tura-Ceide ◽  
Cristina Bonjoch ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Guanylate Cyclase ◽  
Guinea Pigs ◽  
Inflammatory Cell ◽  
Soluble Guanylate Cyclase ◽  
Pulmonary Vasculature ◽  
Inflammatory Cell Infiltrate ◽  
Therapeutic Effects ◽  
Pulmonary Hemodynamics ◽  
Vessel Remodeling

We have analyzed the effect of the soluble guanylate cyclase (sGC) stimulator BAY 41-2272 in a therapeutic intervention in guinea pigs chronically exposed to cigarette smoke (CS). The effects of sGC stimulation on respiratory function, pulmonary hemodynamics, airspace size, vessel remodeling, and inflammatory cell recruitment to the lungs were evaluated in animals that had been exposed to CS for 3 mo. CS exposure was continued for an additional 3 mo in half of the animals and withdrawn in the other half. Animals that stopped CS exposure had slightly lower pulmonary artery pressure (PAP) and right ventricle (RV) hypertrophy than those who continued CS exposure, but they did not recover from the emphysema and the inflammatory cell infiltrate. Conversely, oral BAY 41-2272 administration stopped progression or even reversed the CS-induced emphysema in both current and former smokers, respectively. Furthermore, BAY 41-2272 produced a reduction in the RV hypertrophy, which correlated with a decrease in the PAP values. By contrast, the degree of vessel remodeling induced by CS remained unchanged in the treated animals. Functional network analysis suggested perforin/granzyme pathway downregulation as an action mechanism capable of stopping the progression of emphysema after sGC stimulation. The pathway analysis also showed normalization of the expression of cGMP-dependent serine/kinases. In conclusion, in guinea pigs chronically exposed to CS, sGC stimulation exerts beneficial effects on the lung parenchyma and the pulmonary vasculature, suggesting that sGC stimulators might be a potential alternative for chronic obstructive pulmonary disease treatment that deserves further evaluation.

scholarly journals DNA Vaccines: MHC II-Targeted Vaccine Protein Produced by Transfected Muscle Fibres Induces a Local Inflammatory Cell Infiltrate in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e108069 ◽  
Author(s):  
Tom-Ole Løvås ◽  
Jo C. Bruusgaard ◽  
Inger Øynebråten ◽  
Kristian Gundersen ◽  
Bjarne Bogen
Keyword(s):  
Inflammatory Cell ◽  
Dna Vaccines ◽  
Inflammatory Cell Infiltrate ◽  
Muscle Fibres ◽  
Cell Infiltrate ◽  
Mhc Ii

Immunohistochemical characterization of seminoma and its inflammatory cell infiltrate

1987 ◽  
Vol 18 (5) ◽  
pp. 511-520 ◽  
Author(s):  
Debra A. Bell ◽  
Thomas J. Flotie ◽  
Atul K. Bhan
Keyword(s):  
Inflammatory Cell ◽  
Inflammatory Cell Infiltrate ◽  
Cell Infiltrate

scholarly journals Dynamic Leukocyte Populations Are Associated With Early- and Late-stage Lesions in Hidradenitis Suppurativa

2020 ◽  
pp. 002215542097853
Author(s):  
Savanna R. Altman ◽  
Sheila L. Criswell
Keyword(s):  
Late Stage ◽  
Hidradenitis Suppurativa ◽  
Inflammatory Cell ◽  
Plasma Cells ◽  
Early Stage ◽  
Skin Condition ◽  
The Body ◽  
Inflammatory Cell Infiltrate ◽  
Cell Counts ◽  
Cell Fractions

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition typically targeting the axillary and anogenital regions of the body. The massive inflammatory cell infiltrate produced in this cryptogenic condition has led investigators in the attempt to link particular inflammatory cell fractions and cytokines to disease development, and ultimately to disease treatment. This study qualitatively and quantitatively analyzes the white blood cell fractions of macrophages, B-lymphocytes, T-lymphocytes, plasma cells, and granulocytes in 104 HS lesions on formalin-fixed paraffin-embedded tissues using immunohistochemistry (IHC). Four dermis-associated epithelial categories were investigated from persons with HS: 15 unaffected HS skin (US), 19 distended but unruptured follicle epithelium (UF), 62 migrating stratified squamous epithelium (MSSE) from ruptured follicles, and 35 degraded migrating epithelial sheets (DMES). In addition, 27 control skin (CS) from persons without HS were evaluated. Analysis of cell counts indicated that non-migratory dermal epithelium (CS, US, and UF) stimulated very little inflammatory response. However, contrary to previous studies which indicated macrophages to be the chief inflammatory cell in HS, this study showed that plasma cells were the primary cell type present in early-stage HS lesions (MSSE), whereas granulocytes were the major cell population seen in late-stage HS lesions (DMES):

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