scholarly journals A Ten year Clinicopathological Study of Female Genital Tuberculosis and Impact on Fertility

2008 ◽  
Vol 48 (173) ◽  
Author(s):  
Santosh Kumar Mondal ◽  
TK Dutta
Keyword(s):  
Histopathological Examination ◽  
Female Genital Tract ◽  
Diagnostic Procedures ◽  
Genital Tuberculosis ◽  
Secretory Phase ◽  
Tissue Sections ◽  
Female Genital Tuberculosis ◽  
Polymerase Chain ◽  
Age Range ◽  
Female Genital

INTRODUCTION:To determine the histological pattern of involvement, clinical presentation, impact on fertility in women with genital tuberculosis.METHODS:A total number of 68 cases of gynaecological tuberculosis affecting different parts of female genital tract from 56 patients were selected. The age range of the patients was 17-36 years with mean age of 25.6 years. The diagnostic procedures used included endometrial curettage and biopsy, histopathological examination, culture and Mycobacterium Tuberculosis Polymerase Chain Reaction (MTB PCR), laparoscopy, Hysterosalpingography (HSG) and Ultrasonography (USG). Most of the specimens received were biopsies of endometrial curettage for evaluation of infertility. In 7 cases, specimens of total hysterectomy with bilateral salpingo-oophorectomy were submitted with lesions involving multiple sites.RESULTS:Patients presented with infertility (65-70%), pelvic/abdominal pain (50-55%), and menstrual disturbances (20-25%). Tuberculosis involved the endometrium in 55.88%, tubes in 23.53%, ovaries in 14.71% and cervix in 5.88% of the 68 cases. The endometrium(38 cases)was in the proliferative phase in 31 cases (81.57%), secretory phase in 4 cases (10.52%) and it was atrophic in 3 cases (7.89%).Caseation was present in 9 out of 68 cases and Ziehl-Neelsen (ZN) stain revealed Acid Fast Bacilli (AFB) in tissue sections in only 4 cases . After therapy, 9 patients conceived of which 8 suffered spontaneous abortions. Only one patient had a successful pregnancy and the baby was born through caesarean section.CONCLUSIONS:Genital tuberculosis is an important cause of female infertility in developing countries like India, Nepal, Bangladesh and Pakistan. Successful uterine pregnancy is rare after treatment and chances of ectopic pregnancy are high.Keywords: Key Words:female infertility, genital tuberculosis, histology

scholarly journals Prevalence of Male Genital Tuberculosis in Indian Infertile Couples and Its Correlation with Female Genital Tuberculosis

2016 ◽  
Vol 8 (1) ◽  
pp. 13-15
Author(s):  
Manila Kaushal ◽  
Pooja Kadi ◽  
Asha Baxi ◽  
Hansali Neema ◽  
Dawal Baxi
Keyword(s):  
South Asian ◽  
Genital Tuberculosis ◽  
Urogenital Infection ◽  
Observational Series ◽  
Female Genital Tuberculosis ◽  
Polymerase Chain ◽  
Infertile Couples ◽  
Tb Pcr ◽  
Female Genital ◽  
Male Genital

ABSTRACT Objectives To study the prevalence of male and female genital tuberculosis in Indian infertile couples as detected by semen polymerase chain reaction (PCR) and endometrial PCR and to study the correlation of semen TB PCR with endometrial TB PCR of sexual partner. Design Noncomparative retrospective observational series. Patients A total of 100 couples presenting with infertility at clinic were enrolled after obtaining informed consent. Interventions All couples were tested for mycobacterium tuberculosis (MTB) by nested PCR on the semen and the endometrial sample. The results of PCR of sexual partners were mutually correlated. Results Out of 108 couples, 56 males and 52 females had positive PCR in the sample of semen and the endometrium. Also, 30 couples simultaneously had both semen PCR and endometrial PCR positive. Conclusion Addition of PCR tests to the routine clinical and laboratory assessments may add to the detection of subclinical urogenital infection and the timely evaluation of the asymptomatic partner of the infected person can improve the early detection of a silent but potentially devastating infection. How to cite this article Baxi A, Neema H, Kadi P, Baxi D, Kaushal M. Prevalence of Male Genital Tuberculosis in Indian Infertile Couples and Its Correlation with Female Genital Tuberculosis. J South Asian Feder Obst Gynae 2016;8(1):13-15.

scholarly journals The incidence detection of tuberculosis in patients with infertility and abnormal uterine bleed: a study in North Indian population

2019 ◽  
Vol 8 (8) ◽  
pp. 3041
Author(s):  
Simmanjit Kaur ◽  
Unmesh Santpur ◽  
Sunita Mor
Keyword(s):  
Female Genital Tract ◽  
Uttar Pradesh ◽  
Reproductive Age ◽  
Genital Tuberculosis ◽  
Immunodeficiency Virus ◽  
Female Genital Tuberculosis ◽  
Acute Form ◽  
Reproductive Age Group ◽  
Hiv Negative ◽  
Female Genital

Background: Tuberculosis (TB) remains a major global health problem, responsible for ill health among millions of people each year. TB ranks as the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus (HIV). The latest estimates included in this report are that there were 9.0 million new TB cases in 2013 and 1.5 million TB deaths (1.1 million among HIV-negative people and 0.4 million among HIV-positive people). In India the incidence of genital tuberculosis is nearly about 18%. And in female genital tract it is estimated that 18% in India suffer from genital TB.Methods: The study was carried-out during November 2014 to March 2016 at Maharishi Markandeshwar deemed to be University, MMIMSR Mullana (Ambala).  A total of 100 females of reproductive age attending the Gynaecology Outpatient were finally recruited on the basis of inclusion and exclusion criteria.Results: In our study majority i.e. 39 (39.0%) patient were found in the group of 20-29 years of age followed by 38 (38.0%) patients in the group of 30-39 years of age. Only 23 (23.0%) were found in the group of 40-49 years of age. In our study majority i.e. 54 (54.0%) patients were from Haryana followed by 44 (44.0%) patients were from Uttar Pradesh and only 2 (2.0%) patients were from Punjab. Out of 100 patients majority i.e. 76 (76.0%) patients had negative TB with either of investigation and only 24 (24.0%) patients had positive TB with either of investigation.Conclusions: Female genital tuberculosis affects the females of reproductive age group. The disease manifests itself as pelvic inflammatory disease in its acute form with menstrual irregularities and later infertility, and is almost always secondary to a primary lesion elsewhere.

comparison of laparoscopic findings with tuberculosis polymerase chain reaction in diagnosis of genital tuberculosis amongst sub fertile women:RCT (Preprint)

2019 ◽  
Author(s):  
JAYA JAIN ◽  
Deepti Shrivastava
Keyword(s):  
Polymerase Chain Reaction ◽  
Predictive Value ◽  
Diagnostic Laparoscopy ◽  
Inclusion Criteria ◽  
Chain Reaction ◽  
Genital Tuberculosis ◽  
Female Genital Tuberculosis ◽  
Polymerase Chain ◽  
Tb Pcr ◽  
Female Genital

BACKGROUND INTRODUCTION •There exists a lot of diagnostic dilemma for genital tuberculosis in the available literature No single test is found confirmatory except for wet culture and histopathological positivity which may become paucibacillary extrapulmonary sites and time consuming too. •Polymerase Chain Reaction is a rapid molecular method for the identification of nucleic acid sequences specific to M. tuberculosis and other mycobacteria in tissue samples of patients with genital TB. PCR assays can detect <10 bacilli/ml including dead bacilli and has a testing time of 8-12 h. •The sensitivity of PCR is higher than culture and histopathology and specificity may be as high as 100 percent in detecting, but also it gives false-positive result hence cannot be used alone •Hence in the present study, we would like to correlate the findings of diagnostic laparoscopy and tuberculosis polymerase chain reaction in diagnosing genital tuberculosis amongst subfertile women. OBJECTIVE AIM This study aimed to find out the comparison between laparoscopic findings and tuberculosis polymerase chain reaction in the diagnosis of genital tuberculosis. OBJECTIVES 1. To take a detailed history, conduct a clinical examination and basic investigations to rule out tuberculosis amongst subfertile women attending infertility OPD of AVBRH 2. To perform diagnostic hysterolaparoscopy of recruited women for any findings of genital tuberculosis and at the same time, collecting endometrial sampling for tuberculosis polymerase chain reaction 3. To correlate the positivity of tuberculosis polymerase chain reaction with laparoscopic findings suggestive of genital TB. METHODS MATERIALS AND METHODS • Study design - Randomized Comparative Interventional Study • Sample size - 50 • Inclusion criteria - All participants will be women with complaints of infertility from whom female genital tuberculosis (FGTB) may be suspected as a cause of infertility. • Exclusion criteria – • Women who have other explained causes of infertility such as anatomical. • Acute PID • Place of study –AVBRH Sawangi (Meghe) Wardha • Methodology- • After selecting the patient according to inclusion criteria women will be posted for a diagnostic laparoscopy and endometrial aspirate will be sent for TB PCR • After due collection of samples and obtaining of results, the results will be comprehensively gathered and data analyzed, the diagnostic tests such as pelvic USG , HPE and also laparoscopy and PCR of endometrial aspirate for patient who are affording ; after which these modalities will be correlated for accurately diagnosing female genital tuberculosis, by calculating sensitivity, specificity, positive predictive value and negative predictive value of the same SAMPLE SIZE CALCULATION n= Za/2 x Px(1-P) / d2 Where Za/2 is the level of significance at 5% i.e. 95% confidence interval = 1.96 P = prevalence of genital TB = 3% = 0.07 d= desired error of margin = 7% = 0.07 n = 1.96x 1.96 x 0.07 x (1-0.07)/ 0.07 x 0.07 = 52 50 patients needed in the study RESULTS EXPECTED OUTCOME We would like to correlate the findings of diagnostic laparoscopy and tuberculosis polymerase chain reaction in diagnosing genital tuberculosis amongst subfertile women This would help to detect infertility cases earlier CONCLUSIONS We would like to correlate the findings of diagnostic laparoscopy and tuberculosis polymerase chain reaction in diagnosing genital tuberculosis amongst subfertile women This would help to detect infertility cases earlier

scholarly journals Emerging progress on diagnosis and treatment of female genital tuberculosis

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110149
Author(s):  
Ying Wang ◽  
Ruifeng Shao ◽  
Chihua He ◽  
Ligang Chen
Keyword(s):  
Blood Circulation ◽  
Histopathological Examination ◽  
Epidemiological Data ◽  
Endometrial Biopsy ◽  
Effective Management ◽  
Menstrual Disorders ◽  
Genital Tuberculosis ◽  
Infertile Women ◽  
Female Genital Tuberculosis ◽  
Female Genital

Female genital tuberculosis (FGTB) is an infection caused by Mycobacterium tuberculosis and usually occurs secondary to pulmonary tuberculosis (TB) through the blood circulation, lymph circulation, or direct spreading from abdominal TB. FGTB is an uncommon type of TB that can destroy genital organs, and lead to menstrual disorders and infertility. The diagnosis of FGTB is often made by detection of acid-fast bacilli under microscopy, culture with endometrial biopsy, or histopathological examination of epithelioid granuloma on a biopsy. A multidrug anti-TB regimen is the major management of FGTB, including rifampicin, isoniazid, pyrazinamide, and ethambutol, while surgery is proposed in more deteriorated cases. However, the conception rate in infertile women with FGTB is still low, even after multidrug anti-TB therapy. Additionally, the risk of complications, such as ectopic pregnancy or miscarriage, remains high. In this review, we summarize the characteristics of FGTB, present current epidemiological data, and focus on its early diagnosis and effective management.

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