scholarly journals Patterns of Sonographically Detectable Echogenic Foci in Pediatric Thyroid Carcinoma with Corresponding Histopathology: An Observational Study

2017 ◽  
Vol 39 (1) ◽  
pp. 156-161 ◽  
Author(s):  
I. Erdem Toslak ◽  
B. Martin ◽  
G.A. Barkan ◽  
A.I. Kılıç ◽  
J.E. Lim-Dunham
Keyword(s):  
Observational Study ◽  
Thyroid Carcinoma ◽  
Echogenic Foci

Differences in the Recurrence and Survival of Patients with Symptomatic and Asymptomatic Papillary Thyroid Carcinoma: An Observational Study of 11,265 Person-Years of Follow-Up

Thyroid ◽  
2016 ◽  
Vol 26 (10) ◽  
pp. 1472-1479 ◽  
Author(s):  
Sung Hee Kim ◽  
Jong-Lyel Roh ◽  
Gyungyup Gong ◽  
Kyung-Ja Cho ◽  
Seung-Ho Choi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Observational Study ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid

Similar stage-dependent survival and outcome in sporadic and hereditary medullary thyroid carcinoma

2021 ◽  
Author(s):  
Friedhelm Raue ◽  
Thomas Bruckner ◽  
Karin Frank-Raue
Keyword(s):  
Observational Study ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Residual Disease ◽  
Disease Specific Survival ◽  
Medullary Thyroid ◽  
Hereditary Medullary Thyroid Carcinoma ◽  
Similar Stage ◽  
Disease Specific

Abstract Context Long-term data are scarce on large cohorts with sporadic (sMTC) and hereditary medullary thyroid carcinoma (hMTC). Objectives To compare long-term disease-specific survival (DSS) and outcomes between sMTC and hMTC groups. Design Retrospective analysis Setting German tertiary referral center Patients 673 patients with MTC that underwent surgery from January 1974 to July 2019 Intervention None (observational study) Main Outcome Measure Differences between sMTC and hMTC in long-term, stage-dependent survival and outcomes Results Surgery was performed at median ages of 49 years for sMTC (n=477, 44% male) and 29 years for hMTC (n=196, 43% male; p<0.0001). The mean follow-up times were 9.2±8.0 (sMTC) and 14.6±10.3 years (hMTC). Age and tumor stage at diagnosis were significantly different between the two groups (p<0.0001). The sMTC and hMTC groups had different overall DSS (log rank, p=0.0183), but similar stage-dependent DSS (log rank, p=0.1242 to 0.8981). In a multivariate analysis, sMTC and hMTC did not differ in DSS (HR=1.56, 95%CI=0.94-2.57), but in both groups, a worse DSS was significantly associated with age at diagnosis (HR=1.04, 95%CI=1.02-1.05), male sex (HR=0.49, 95%CI=0.32-0.76), and stages III and IV at diagnosis (HR=20.00, 95%CI=2.74-145.91 and HR=97.47, 95%CI=13.07-726.67, respectively). The groups had significantly different (p<0.0001) outcomes (i.e., cured, minimal residual disease, structural detectable disease, and death), but similar stage-dependent outcomes (p=0.9449 to 0.0511), except for stage III (p=0.0489). Conclusion Patients with sMTC and hMTC had different ages of onset, but similar stagedependent DSS and outcomes after the MTC diagnosis. This finding suggested that tumor behavior was similar in sMTC and hMTC. Précis This observational study of 673 patients with sporadic (n=477) and hereditary MTC (n=196) revealed similar disease-specific survival rates and outcomes, which suggested similar tumor behavior.

scholarly journals Association of Sonographic Features of Unifocal Papillary Thyroid Carcinoma With Cervical Lymph Node Metastasis

2021 ◽  
Author(s):  
Liuhua Zhou ◽  
Qiaodan Zhu ◽  
Jincao Yao ◽  
Chen Yang ◽  
Dong Xu
Keyword(s):  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Cervical Lymph Node ◽  
Univariate Analysis ◽  
Cervical Lymph Node Metastasis ◽  
Tumour Volume ◽  
Maximum Diameter ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Echogenic Foci

Abstract Background Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid carcinoma. We aim to evaluate the association of sonographic features of PTC and cervical lymph node metastasis (CLNM) at the initial surgery. Methods Clinical information, ultrasonographic measurements and features for 1335 patients were acquired in data collection. Univariate analysis was performed to test CLNM by 7 independent variables. Receiver operating characteristic (ROC) curve was created to evaluate the diagnostic performance. Results Univariate analysis showed that gland, location, aspect ratio, margin and echogenic foci were independently associated with CLNM metastatic status (P<0.05). Binary linear regression analysis showed that sex, age, tumour maximum diameter and volume, location, margin and echogenic foci were independent correlative factors. The ROC curves were established based on the relevant factors, the AUC of tumour maximum diameter, tumour volume and margin were 0.74, 0.73, and 0.71, respectively. The multiple-variable linear regression model was constructed with AUC of 0.81, specificity of 72.8%, and sensitivity of 75.0%. ANOVA variance analysis for sub-positive groups, tumour maximum diameter, tumour volume, margin and echogenic foci had statistical significance (P<0.05).Conclusion Younger age, male, larger tumour, margin, and echogenic foci were high risk factors for CLNM in PTC. Cross-sectional aspect ratio with value≥1 had higher predictive value for CLNM in patients with larger thyroid tumors.

scholarly journals Adverse events in thyroid surgery: observational study in three surgical units with high volume/year

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Paolo Del Rio ◽  
Paolo Carcoforo ◽  
Fabio Medas ◽  
Elena Bonati ◽  
Tommaso Loderer ◽  
...  
Keyword(s):  
Observational Study ◽  
Thyroid Carcinoma ◽  
Thyroid Surgery ◽  
Postoperative Bleeding ◽  
High Volume ◽  
Differentiated Thyroid Carcinoma ◽  
University Hospital ◽  
Multicenter Observational Study ◽  
Benign Pathology

Abstract Background Thyroid surgery, performed for benign or malignant pathologies, is one of the most frequently performed procedures and its frequency has even been increasing in recent years. Postoperative bleeding, recurrent laryngeal nerve (RLN) palsy, associated to dysphonia, dysphagia, dyspnea, and hypoparathyroidism represent the most fearful and common complications. We conducted a multicenter, observational study of retrospectively collected data in three high-volume referral centers, enrolling all patients undergone to thyroid surgery between January 2016 and December 2017 in Parma University Hospital, Cagliari University Hospital and Ferrara University Hospital. Materials Patients were divided into five groups, differentiated thyroid carcinoma, medullary thyroid carcinoma, non-toxic benign pathology, hyperfunctioning benign pathology and NIFTP (Non-invasive Follicular Thyroid neoplasm with Papillary-like nuclear features). A follow up at 7 and 30 days was executed, evaluating the onset of paresthesia, dysphonia and dysphagia. A 6-month follow-up was conducted in cases of early complications. Results Totally, 1252 patients were eligible for the study: 907 female and 345 male, with a female to male ratio of 2.6:1 and an average age of 53.428. Total thyroidectomy was performed in 1022 cases, lobectomy in 230. After 6 months we recorded paresthesia in 0.5%, dysphonia in 1.8% and dysphagia in 0.5%. Conclusion Our study confirms once again that a share of morbidity escapes the possibilities of prediction and control by the operator, depending on patient anamnestic, pathological or anatomical factors.

scholarly journals Adverse Events in Thyroid Surgery. Observational Study in Three Surgical Units With High Volume/Year.

2020 ◽  
Author(s):  
Paolo Del Rio ◽  
Paolo Carcoforo ◽  
Fabio Medas ◽  
Elena Bonati ◽  
Tommaso Loderer ◽  
...  
Keyword(s):  
Observational Study ◽  
Thyroid Carcinoma ◽  
Thyroid Surgery ◽  
Postoperative Bleeding ◽  
High Volume ◽  
Differentiated Thyroid Carcinoma ◽  
University Hospital ◽  
Multicenter Observational Study ◽  
Benign Pathology

Abstract Background Thyroid surgery, performed for benign or malignant pathologies, is one of the most frequently performed procedures and its frequency has even been increasing in recent years. Postoperative bleeding, recurrent laryngeal nerve (RLN) palsy, associated to dysphonia, dysphagia, dyspnea, and hypoparathyroidism represent the most fearful and common complications. We conducted a multicenter, observational study of retrospectively collected data in three high-volume referral centers, enrolling all patients undergone to thyroid surgery between January 2016 and December 2017 in Parma University Hospital, Cagliari University Hospital and Ferrara University Hospital.Materials Patients were divided into 5 groups, differentiated thyroid carcinoma, medullary thyroid carcinoma, non-toxic benign pathology, hyperfunctioning benign pathology and NIFTP (Non-invasive Follicular Thyroid neoplasm with Papillary-like nuclear features). A follow up at 7 and 30 days was executed, evaluating the onset of paresthesia, dysphonia and dysphagia. A six-month follow-up was conducted in cases of early complications.Results Totally, 1252 patients were eligible for the study: 907 female and 345 male, with a female to male ratio of 2.6:1 and an average age of 53.428. Total thyroidectomy was performed in 1022 cases, lobectomy in 230.After 6 months we recorded paresthesia in 0.5%, dysphonia in 1.8% and dysphagia in 0.5%.Conclusion Our study confirms once again that a share of morbidity escapes the possibilities of prediction and control by the operator, depending on patient anamnestic, pathological or anatomical factors.

scholarly journals Association of Sonographic Features of Unifocal Papillary Thyroid Carcinoma With Cervical Lymph Node Metastasis

2021 ◽  
Author(s):  
Liuhua Zhou ◽  
Qiaodan Zhu ◽  
Jincao Yao ◽  
Chen Yang ◽  
Dong Xu
Keyword(s):  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Cervical Lymph Node ◽  
Univariate Analysis ◽  
Cervical Lymph Node Metastasis ◽  
Tumour Volume ◽  
Maximum Diameter ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Echogenic Foci

Abstract Background Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid carcinoma. We aim to evaluate the association of sonographic features of PTC and cervical lymph node metastasis (CLNM) at the initial surgery.Methods Clinical information, ultrasonographic measurements and features for 1335 patients were acquired in data collection. Univariate analysis was performed to test CLNM by 7 independent variables. Receiver operating characteristic (ROC) curve was created to evaluate the diagnostic performance.Results Univariate analysis showed that gland, location, aspect ratio, margin and echogenic foci were independently associated with CLNM metastatic status (P < 0.05). Binary linear regression analysis showed that sex, age, tumour maximum diameter and volume, location, margin and echogenic foci were independent correlative factors. The ROC curves were established based on the relevant factors, the AUC of tumour maximum diameter, tumour volume and margin were 0.74, 0.73, and 0.71, respectively. The multiple-variable linear regression model was constructed with AUC of 0.81, specificity of 72.8%, and sensitivity of 75.0%. ANOVA variance analysis for sub-positive groups, tumour maximum diameter, tumour volume, margin and echogenic foci had statistical significance (P < 0.05).Conclusion Younger age, male, larger tumour, margin, and echogenic foci were high risk factors for CLNM in PTC. Cross-sectional aspect ratio with value ≥ 1 had higher predictive value for CLNM in PTC patients excluding papillary thyroid microcarcinoma (PTMC).

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