Aortic Ascorbic Acid, Trace Elements, and Superoxide Dismutase Activity in Human Aneurysmal and Occlusive Disease

1987 ◽  
Vol 184 (2) ◽  
pp. 138-143 ◽  
Author(s):  
M. A. Dubick ◽  
G. C. Hunter ◽  
S. M. Casey ◽  
C. L. Keen
Keyword(s):  
Ascorbic Acid ◽  
Superoxide Dismutase ◽  
Trace Elements ◽  
Occlusive Disease ◽  
Superoxide Dismutase Activity

Changes of superoxide dismutase activity and ascorbic acid in focal cerebral ischaemia in rats

1992 ◽  
Vol 14 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Kiyoshi Takagi ◽  
Hideaki Kanemitsu ◽  
Noriko Tomukai ◽  
Hidemune Oka ◽  
Akira Tamura ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Superoxide Dismutase ◽  
Cerebral Ischaemia ◽  
Superoxide Dismutase Activity ◽  
Focal Cerebral Ischaemia

scholarly journals Preservative postharvest solutions in two varieties of tuberose (Polianthes tuberosa L.) native to Mexico: ‘Mexicano’ and ‘Perla’

2021 ◽  
Vol 13 (1) ◽  
pp. 3-15
Author(s):  
Sandy Lizbeth Fernando-Santos ◽  
◽  
Gloria Alicia Pérez-Arias ◽  
Irán Alia-Tejacal ◽  
Clara Pelayo-Zaldívar ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Superoxide Dismutase ◽  
Citric Acid ◽  
Shelf Life ◽  
Water Consumption ◽  
Superoxide Dismutase Activity ◽  
Fresh Weight ◽  
Chemical Changes ◽  
Non Destructive ◽  
Preservative Solutions

ntroduction: ‘Perla’ and ‘Mexicano’ are varieties of tuberose grown in Mexico that have potential for commercialization and export; however, no preservative solutions have been evaluated to increase their shelf life. Objective: To determine physical, physiological, and chemical changes that occur in postharvest tuberose when different preservative solutions are applied. Methodology: Tuberose flower spikes of varieties ‘Mexicano’ and Perla, with two open basal flowers, were placed in preservative solutions (Crystal®, sucrose [Sac] + citric acid [CA] + hydroxyquinoline citrate [HQC] and ascorbic acid [AAsc]). A group of tuberose flower spikes was kept as control, and in all cases destructive and non-destructive variables were evaluated during postharvest. Results: Relative fresh weight and water consumption increased with preservative solutions in both varieties. The appearance of the ‘Perla’ variety was excellent for 5 days with Crystal®. The ‘Mexicano’ variety had more open flowers with Crystal® and Sac + AC + HQC, while the ‘Perla’ variety had the same result with AAsc and Crystal®. Respiration in the Mexicano’ variety was high with Sac + AC + HQC, and in the case of ‘Perla’ variety, respiration was low with AAsc. The highest specific superoxide dismutase activity was detected with AAsc and Crystal® for ‘Perla’ variety. Study limitations: The results are valid without previous applications of pulse or hydrating solutions in tuberose varieties evaluated. Originality: This is the first study where the postharvest behavior of two Mexican tuberose varieties is evaluated in preservative solutions. Conclusions: ‘Mexicano’ and ‘Perla’ varieties can use Crystal® and AAsc solutions to maintain the quality for longer time in vase.

Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity

2020 ◽  
Vol 13 (1) ◽  
pp. 76-83
Author(s):  
Aline Maria Brito Lucas ◽  
Joana Varlla de Lacerda Alexandre ◽  
Maria Thalyne Silva Araújo ◽  
Cicera Edna Barbosa David ◽  
Yuana Ivia Ponte Viana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Cardiac Hypertrophy ◽  
Superoxide Dismutase Activity ◽  
Heart Weight ◽  
Pharmacological Intervention ◽  
Wall Thickening ◽  
H2o2 Production ◽  
Mitochondrial Superoxide ◽  
Mitochondrial Superoxide Dismutase

Background: Cardiac hypertrophy involves marked wall thickening or chamber enlargement. If sustained, this condition will lead to dysfunctional mitochondria and oxidative stress. Mitochondria have ATP-sensitive K+ channels (mitoKATP) in the inner membrane that modulate the redox status of the cell. Objective: We investigated the in vivo effects of mitoKATP opening on oxidative stress in isoproterenol- induced cardiac hypertrophy. Methods: Cardiac hypertrophy was induced in Swiss mice treated intraperitoneally with isoproterenol (ISO - 30 mg/kg/day) for 8 days. From day 4, diazoxide (DZX - 5 mg/kg/day) was used in order to open mitoKATP (a clinically relevant therapy scheme) and 5-hydroxydecanoate (5HD - 5 mg/kg/day) or glibenclamide (GLI - 3 mg/kg/day) were used as mitoKATP blockers. Results: Isoproterenol-treated mice had elevated heart weight/tibia length ratios (HW/TL). Additionally, hypertrophic hearts had elevated levels of carbonylated proteins and Thiobarbituric Acid Reactive Substances (TBARS), markers of protein and lipid oxidation. In contrast, mitoKATP opening with DZX avoided ISO effects on gross hypertrophic markers (HW/TL), carbonylated proteins and TBARS, in a manner reversed by 5HD and GLI. Moreover, DZX improved mitochondrial superoxide dismutase activity. This effect was also blocked by 5HD and GLI. Additionally, ex vivo treatment of isoproterenol- induced hypertrophic cardiac tissue with DZX decreased H2O2 production in a manner sensitive to 5HD, indicating that this drug also acutely avoids oxidative stress. Conclusion: Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy. This pharmacological intervention could be a potential therapeutic strategy to prevent oxidative stress associated with cardiac hypertrophy.

scholarly journals Two New Compounds From the Heartwood of Dalbergia melanoxylon and Their Protective Effect on Hypoxia/Reoxygenation Injury in H9c2

2021 ◽  
Vol 16 (1) ◽  
pp. 1934578X2098777
Author(s):  
Yang Liu ◽  
Ni Zhang ◽  
Jun-wei He ◽  
Lan-ying Chen ◽  
Li Yang ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Lactate Dehydrogenase ◽  
Protective Effect ◽  
Superoxide Dismutase Activity ◽  
Spectral Evidence ◽  
Reoxygenation Injury ◽  
Dalbergia Melanoxylon ◽  
New Compounds ◽  
Hypoxia Reoxygenation

A new neoflavonoid, named as (7 R)-(-)-3′,5-dihydroxy-4′,2,4-trimethoxy-dalbergiquinol (1) and a new phenanthrenedione, named as 3′,7-dihydroxy-3,6- dimethoxy-9-phenyl-1,4-phenanthrenedione (2), together with 4 known compounds, 5- O-methyldalbergiphenol (3), 3′,7-dihydroxy-4′,3,6-trimethoxy-9-phenyl-1,4-phenanthrenedione (4), (+)-obtusafuran (5), and melanoxin (6) were isolated from the heartwood of Dalbergia melanoxylon. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Moreover, compound 1 showed a protective effect on hypoxia/reoxygenation injury in H9c2 at 10.0 μM by decreasing lactate dehydrogenase and malondialdehyde activity and enhancing superoxide dismutase activity.

Sign in / Sign up

Export Citation Format

Share Document