Achieving successful pulpal anesthesia during endodontic treatment of mandibular molars: A systematic review and meta-analysis

Background: Ketorolac has advantages over other analgesics as a pre-anaesthetic medication. Considering this in mind, the present meta-analysis aims to identify the effect of oral ketorolac premedication on the anaesthetic efficacy of Inferior Alveolar Nerve Block (IANB) in patients with irreversible pulpitis. Methods: Full-texts of eligible studies were obtained from electronic databases. The extracted data was analysed using non-Cochrane mode in RevMan 5.0 software. Relative risk [95% CI] was calculated for the success of IANB. Results: Four studies were included for the final review. The success rate of IANB on 221 patients with relative risk of 1.87 [1.36, 2.56] was statistically significant favouring ketorolac. The mean difference for VAS in 171 patients was not statistically significant {-13.55 [-33.91, 6.82]}. Conclusion: Oral ketorolac can be successfully administered as a premedication before conventional inferior alveolar nerve block for endodontic treatment for irreversible pulpitis.

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Effectiveness of single- versus multiple-visit endodontic treatment of teeth with apical periodontitis: a systematic review and meta-analysis

International Endodontic Journal ◽

10.1111/j.1365-2591.2005.00955.x ◽

2005 ◽

Vol 38 (6) ◽

pp. 347-355 ◽

Cited By ~ 89

Author(s):

C. Sathorn ◽

P. Parashos ◽

H. H. Messer

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Apical Periodontitis ◽

Endodontic Treatment ◽

Multiple Visit ◽

Single Versus

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Influence of occlusal reduction on pain after endodontic treatment: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-021-93119-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Nayane Chagas Carvalho Alves ◽

Sirley Raiane Mamede Veloso ◽

Silmara de Andrade Silva ◽

Andressa Cartaxo de Almeida ◽

Christianne Tavares Velozo Telles ◽

...

Keyword(s):

Systematic Review ◽

Postoperative Pain ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Research Question ◽

Endodontic Treatment ◽

Cochrane Library ◽

Endodontically Treated Teeth ◽

Dichotomous Outcome ◽

Significant Difference

AbstractThe purpose of this systematic review was to analyze the influence of occlusal reduction on the postoperative pain levels after endodontic treatment (instrumentation and obturation of the root canal system). This review followed the PRISMA statement and was registered at PROSPERO (CRD42018107918). Two independent reviewers searched the Lilacs, Cochrane Library, PubMed (Medline), Web of Science, Scopus, Scielo, and ScienceDirect for articles published until April 2021. The research question was, "Does occlusal reduction decrease postoperative pain in endodontically treated teeth?". Only randomized clinical trials were included. The RevMan 5 program was used for meta-analysis, calculating the relative risk (RR) and 95% confidence interval (CI) of the dichotomous outcome (presence or absence of pain). The search strategies retrieved 4114 studies. Twelve studies were included for qualitative analysis and nine for quantitative analysis. The meta-analysis results did not reveal a significant difference in the reduction of postoperative pain levels for endodontic instrumentation at 6, 12, 24, 48 h and for endodontic obturation at 6 or 12 h after occlusal reduction. According to the GRADE tool, the analyzed outcome was classified as having a moderate level of certainty. It is concluded that occlusal reduction does not interfere with postoperative pain levels after endodontic treatment.

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