One-pot and Three-Component Synthesis of α-Benzylamino Pyrones
2017 ◽
Vol 41
(1)
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pp. 42-44
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Keyword(s):
One Pot
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The synthesis of α-benzylamino pyrones is described involving the reaction of 4-hydroxy-6-methyl-2 H-pyran-2-one with aromatic aldehydes and secondary amines in the presence of oxalic acid and in aqueous media. The salient features of this protocol are aerobic conditions, short reaction times, milder reaction conditions without additives and high yields.