Faulty RNA Metabolism May Explain Cytoskeleton Abnormalities In Neuronal Diseases

2018 ◽  
Author(s):  
Carlos Suñé
Keyword(s):  
Rna Metabolism

scholarly journals Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2143
Author(s):  
Maria Hernandez-Valladares ◽  
Rebecca Wangen ◽  
Elise Aasebø ◽  
Håkon Reikvam ◽  
Frode S. Berven ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Acute Myeloid Leukemia ◽  
Retinoic Acid ◽  
Protein Kinase ◽  
Myeloid Leukemia ◽  
Rna Metabolism ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Acute Myeloid

All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and improve normal peripheral blood cell counts. In this context, we used a proteomic/phosphoproteomic strategy to investigate the in vivo effects of ATRA/VP on human AML cells. Before starting the combined treatment, AML responders showed increased levels of several proteins, especially those involved in neutrophil degranulation/differentiation, M phase regulation and the interconversion of nucleotide di- and triphosphates (i.e., DNA synthesis and binding). Several among the differentially regulated phosphorylation sites reflected differences in the regulation of RNA metabolism and apoptotic events at the same time point. These effects were mainly caused by increased cyclin dependent kinase 1 and 2 (CDK1/2), LIM domain kinase 1 and 2 (LIMK1/2), mitogen-activated protein kinase 7 (MAPK7) and protein kinase C delta (PRKCD) activity in responder cells. An extensive effect of in vivo treatment with ATRA/VP was the altered level and phosphorylation of proteins involved in the regulation of transcription/translation/RNA metabolism, especially in non-responders, but the regulation of cell metabolism, immune system and cytoskeletal functions were also affected. Our analysis of serial samples during the first week of treatment suggest that proteomic and phosphoproteomic profiling can be used for the early identification of responders to ATRA/VP-based treatment.

scholarly journals The Distinct Roles of Zinc Finger CCHC-type (ZCCHC) Superfamily Proteins in the Regulation of RNA Metabolism

RNA Biology ◽  
2021 ◽  
Author(s):  
Yishu Wang ◽  
Yu Yu ◽  
Yidan Pang ◽  
Haojun Yu ◽  
Wenqi Zhang ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Rna Metabolism

Interplay within tumor microenvironment orchestrates neoplastic RNA metabolism and transcriptome diversity

2021 ◽  
Author(s):  
Subhashis Natua ◽  
Shruti Ganesh Dhamdhere ◽  
Srinivas Abhishek Mutnuru ◽  
Sanjeev Shukla
Keyword(s):  
Tumor Microenvironment ◽  
Rna Metabolism ◽  
Transcriptome Diversity

RNA metabolism of B. subtilis

1963 ◽  
Vol 76 ◽  
pp. 68-79 ◽  
Author(s):  
G. Acs ◽  
E. Reich ◽  
S. Valanju
Keyword(s):  
Rna Metabolism

scholarly journals RNA metabolism is the primary target of formamide in vivo

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Rafael Hoyos-Manchado ◽  
Félix Reyes-Martín ◽  
Charalampos Rallis ◽  
Enrique Gamero-Estévez ◽  
Pablo Rodríguez-Gómez ◽  
...  
Keyword(s):  
Rna Metabolism ◽  
Primary Target
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