Lecithin–cholesterol acyltransferase (LCAT) activity is lower in patients with type 2 diabetes in the presence of metabolic syndrome

Backgrounds: Metabolic syndrome can facilitate the development of diabetes mellitus and has gained a negative reputation for its adverse effects on the general health of the population and its tendency to increase the risk of cardiovascular diseases. Cardiovascular complications may be mediated by the alteration of certain enzyme activities and pathways. Lecithin-Cholesterol Acyltransferase (LCAT) may have a potential role in the prevention of atherosclerosis as a rate-limiting enzyme in reverse cholesterol transport. In this study, LCAT activity was compared among patients with type 2 diabetes in the presence or absence of metabolic syndrome.Methods: In the present study, 55 patients with type 2 diabetes with metabolic syndrome (DM+MS group), 25 patients with type 2 diabetes without metabolic syndrome (DM-MS group), and a control group of 43 subjects without type 2 diabetes (HC group) were compared based on their anthropometric parameters, lipid profiles, glycemic indices, and LCAT activity.Results: LCAT activity was lower among participants of the DM+MS group (70.22±7.88) in comparison with the both HC group (89.51±3.59) and the DM-MS group (76.73±7.25) (respectively P<0.001, P=0.021). There was no significant difference in the fasting blood glucose levels, as evidenced by the HbA1c and HOMA-IR measurements between the DM+MS group and the DM-MS group. BMI was significantly higher in the DM+MS group compared to the DM-MS group (P=0.031). In patients with type 2 diabetes mellitus and metabolic syndrome, there was a negative correlation between LCAT activity and BMI (r=-0.275, P=0.048). There was also a negative correlation between LCAT activity and HbA1c in the DM-MS group (r=-0.606, P=0.008) and the DM+MS group (r=-0.421, P=0.002).Conclusion: LCAT activity was lower among patients with type 2 diabetes compared to subjects without type 2 diabetes and it had a greater reduction in the presence of metabolic syndrome. LCAT activity also had a negative correlation with BMI in patients with type 2 diabetes mellitus and metabolic syndrome compared to patients with type 2 diabetes that did not have metabolic syndrome.Keywords: Lecithin-Cholesterol Acyltransferase (LCAT), Metabolic syndrome, Diabetes mellitus, type 2, BMI

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Circulating adipokine levels and insulin resistance in type 2 diabetes mellitus and metabolic syndrome

Endocrine Abstracts ◽

10.1530/endoabs.41.ep452 ◽

2016 ◽

Author(s):

Sitwat Zehra ◽

Mozaffer Rahim Hingorjo ◽

Erum Imran ◽

Masood Anwar Qureshi

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Type 2 Diabetes Mellitus

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Study on regulation of adipokines on body fat distribution and its correlation with metabolic syndrome in type 2 diabetes mellitus

Minerva Endocrinologica ◽

10.23736/s0391-1977.17.02773-0 ◽

2019 ◽

Vol 44 (3) ◽

Cited By ~ 4

Author(s):

Xiaoxi Liu ◽

Xiaojuan Li ◽

Changhui Li ◽

Chengjun Gong ◽

Songyan Liu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Type 2 Diabetes Mellitus ◽

Body Fat ◽

Fat Distribution ◽

Body Fat Distribution

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Patogenetic and clinical features of metabolic syndrome complicated by chronic coronary (ischemic) heart disease and type 2 diabetes mellitus

Acta Medica Leopoliensia ◽

10.25040/aml2018.02.010 ◽

2018 ◽

Vol 24 (2) ◽

pp. 10-15

Author(s):

R.Ya. Dutka ◽

◽

Yu.M. Vendzylovych ◽

N.Yu. Chmyr ◽

S.Yu. Sandurska ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Clinical Features ◽

Ischemic Heart

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Effects of cardiac rehabilitation on lipoprotein abnormalities in patients with Type 2 diabetes mellitus and metabolic syndrome

Future Lipidology ◽

10.2217/17460875.1.1.65 ◽

2006 ◽

Vol 1 (1) ◽

pp. 65-73

Author(s):

Teresa Caulin-Glaser ◽

James M Falko

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Type 2 Diabetes Mellitus ◽

Cardiac Rehabilitation

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Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes

Head & Face Medicine ◽

10.1186/s13005-020-00253-z ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Yonghuan Bian ◽

Changhao Liu ◽

Zhaojiang Fu

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Chronic Periodontitis ◽

Root Planing ◽

Tnf Α ◽

Significant Difference ◽

Hs Crp

Abstract Background Our study attempted to observe the value of periodontal curettage combined with root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes. Methods There involved 72 patients with type 2 diabetes mellitus complicated with moderate-to-severe chronic periodontitis who were diagnosed and treated in our hospital from January 2019 to December 2019. The patients enrolled were randomly divided into four groups using a computer-generated table: root planing and periodontal curettage combined group (n = 18), root planning group (n = 18), periodontal curettage group (n = 18) and cleansing group (n = 18). Blood glucose, plaque index (PI), gingival index (GI), probing depth (PD), attachment loss (AL), serum levels of inflammatory factors (Tumor Necrosis Factor Alpha [TNF- α] and hypersensitive C-reactive protein [hs-CRP]) were observed before and after treatment. The collecting dates were analyzed by the chi-square χ 2 test, repeated measurement analysis of variance, or t-test according to different data types and research objectives. Results Before treatment, there was no significant difference in PI, GI, PD and AL among the four groups (P> 0.05), while after 3-month treatment, the levels of PI, GI, PD and AL in the combined group were lower than those in the root planing group, periodontal curettage group and cleansing group, with both root planing group and periodontal curettage group significantly lower than cleansing group (P< 0.05). The fasting blood glucose, 2-h postprandial blood glucose and glycosylated hemoglobin in the combined group, root planing group, periodontal curettage group and cleansing group were significantly lower than those before treatment (P < 0.05). Before treatment, there was no significant difference in TNF- α and hs-CRP among the four groups (P> 0.05), but the levels of TNF- α and hs-CRP in the four groups decreased significantly after 3-month treatment (P< 0.05). The levels of TNF- α and hs-CRP in the combined group were lower than those in the root planing group, periodontal curettage group and cleansing group, and those in the root planing group and periodontal curettage group were significantly lower than those in the cleansing group (P< 0.05). Conclusion The combination therapy of periodontal curettage and root planing exerted beneficial effects on moderate-to-severe chronic periodontitis in patients with type 2 diabetes mellitus, which holds the potential to maintain the level of blood glucose and improve the quality of life of the patients.

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