scholarly journals Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983–2011

2013 ◽  
Vol 19 (6) ◽  
pp. 932-937 ◽  
Author(s):  
Michael G. Bruce ◽  
Tammy Zulz ◽  
Carolynn DeByle ◽  
Ros Singleton ◽  
Debby Hurlburt ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Invasive Disease ◽  
Serotype A

scholarly journals First Complete Genome Sequence of Haemophilus influenzae Serotype a

2017 ◽  
Vol 5 (3) ◽  
Author(s):  
Mariam Iskander ◽  
Kristy Hayden ◽  
Gary Van Domselaar ◽  
Raymond Tsang
Keyword(s):  
Haemophilus Influenzae ◽  
Genome Sequence ◽  
Invasive Disease ◽  
Indigenous Populations ◽  
Whole Genome Sequence ◽  
Whole Genome ◽  
Human Pathogen ◽  
Small Children ◽  
Content Type ◽  
Serotype A

ABSTRACT Haemophilus influenzae is an important human pathogen that primarily infects small children. In recent years, H. influenzae serotype a has emerged as a significant cause of invasive disease among indigenous populations. Here, we present the first complete whole-genome sequence of H. influenzae serotype a.

scholarly journals Pediatric invasive disease due to Haemophilus influenzae serogroup A in Riyadh, Saudi Arabia: case series

2016 ◽  
Vol 10 (05) ◽  
pp. 528-532 ◽  
Author(s):  
Zailaie Roaa ◽  
Alawfi Abdulsalam ◽  
Ghazi Shahid ◽  
Baba Kamaldeen ◽  
Al Fawaz Tariq
Keyword(s):  
Saudi Arabia ◽  
Blood Culture ◽  
Haemophilus Influenzae ◽  
Vaccine Development ◽  
Good Condition ◽  
Case Series ◽  
Invasive Disease ◽  
Medical Illness ◽  
Serotype A ◽  
First Case

We describe the first two cases of invasive disease caused by Haemophilus influenzae serotype A in Saudi Arabia. This is the first known reported invasive Haemophilus influenzae serotype A from Saudi Arabia. Case presentation: A ten-month-old and three-month-old male not known to have any past history of any medical illness and who had received H. influenzae type b (Hib) vaccine presented to our hospital mainly with fever of few days’ duration. A provisional diagnosis of meningitis with sepsis was made and laboratory tests were requested. The chest radiograph was normal. The laboratory results revealed leukocytosis, but leukopenia was noticed in the younger infant. Blood culture and cerebrospinal fluid specimens yielded a pure culture of Haemophilus influenzae and serotyping showed the isolates to be serogroup A. Both patients were started on vancomycin and third-generation cephalosporin. On receiving the blood culture result, vancomycin was stopped. Fever subsided after 48 hours, while in the second case, it continued for 12 days from the admission date. The repeat blood cultures were negative. Antibiotic therapy was given for 10 days for the first case with an unremarkable hospital course, while the second case was complicated by seizure and received a longer duration of antibiotics. Both infants were discharged home in good condition. Conclusions: Invasive non-typeable H. influenzae strains are emerging and there is a need for surveillance of this disease. This has implications in future vaccine development.

scholarly journals Septic arthritis and hemarthroses caused by Haemophilus influenzae serotype A in children

2016 ◽  
Vol 8 (3) ◽  
Author(s):  
Ravi S. Samraj ◽  
Jaime Fergie
Keyword(s):  
Respiratory Tract ◽  
Haemophilus Influenzae ◽  
Septic Arthritis ◽  
Respiratory Tract Infections ◽  
Invasive Disease ◽  
Serotype A ◽  
Clinical Syndromes ◽  
Tract Infections

Invasive disease caused by <em>Haemophilus influenzae</em> serotype A (Hia) is rare in children. Clinical syndromes caused by Hia include meningitis, sepsis and respiratory tract infections. Septic arthritis is rare in children with invasive Hia infection and hemarthrosis has not been described in the published literature. We report a case of septic arthritis and hemarthrosis caused by Hia infection in a 2.5 year-old-boy and review invasive Hia infection in children.

scholarly journals Invasive Disease Caused by Haemophilus Influenzae Serotype a, an Emerging Pathogen in Alaska.

2015 ◽  
Vol 44 (suppl_1) ◽  
pp. i195-i195
Author(s):  
M. G. Bruce ◽  
T. Zulz ◽  
C. Debyle ◽  
R. Singleton ◽  
D. Hurlburt ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Invasive Disease ◽  
Emerging Pathogen ◽  
Serotype A

scholarly journals Presence of Antibodies Against Haemophilus influenzae Serotype a in Alaska Before and After the Emergence of Invasive Infections

2020 ◽  
Author(s):  
Max McClure ◽  
Karen Miernyk ◽  
Dana Bruden ◽  
Karen Rudolph ◽  
Thomas W Hennessy ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Alaska Native ◽  
Serum Antibody ◽  
Invasive Disease ◽  
Antibody Concentration ◽  
Serum Samples ◽  
Serotype A ◽  
First Case ◽  
Rural And Urban ◽  
Before And After

Abstract Background Haemophilus influenzae bacteria can cause asymptomatic carriage and invasive disease. Haemophilus influenzae serotype a (Hia) is an emerging cause of invasive disease in Alaska, with greatest burden occurring among rural Alaska Native (AN) children. The first case of invasive Hia (iHia) in Alaska was reported in 2002; however, it is unclear how long the pathogen has been in Alaska. Methods We quantified immunoglobulin G antibodies against Hia (anti-Hia) in 839 banked serum samples from Alaska residents, comparing antibody concentrations in samples drawn in the decades before (1980s and 1990s) and after (2000s) the emergence of iHia. We also assessed serum antibody concentration by age group, region of residence, and race. Results The anti-Hia was &gt;0.1 µg/mL in 88.1% (348 of 395) and 91.0% (404 of 444) of samples from the decades prior and after the emergence of Hia, respectively (P = .17). No significant differences in antibody levels were detected between people from rural and urban regions (1.55 vs 2.08 µg/mL, P = .91 for age ≥5) or between AN and non-AN people (2.50 vs 2.60 µg/mL, P = .26). Conclusions Our results are consistent with widespread Hia exposure in Alaska predating the first iHia case. No difference in Hia antibody prevalence was detected between populations with differing levels of invasive disease.

scholarly journals Epidemiology of Invasive Haemophilus influenzae Serotype a Disease—United States, 2008–2017

2020 ◽  
Author(s):  
Heidi M Soeters ◽  
Sara E Oliver ◽  
Ian D Plumb ◽  
Amy E Blain ◽  
Tammy Zulz ◽  
...  
Keyword(s):  
United States ◽  
Haemophilus Influenzae ◽  
Alaska Native ◽  
Disease Surveillance ◽  
Vaccine Development ◽  
Case Fatality ◽  
The United States ◽  
Invasive Disease ◽  
Bacterial Disease ◽  
Serotype A

Abstract Background Haemophilus influenzae serotype a (Hia) can cause invasive disease similar to serotype b; no Hia vaccine is available. We describe the epidemiology of invasive Hia disease in the United States overall and specifically in Alaska during 2008–2017. Methods Active population- and laboratory-based surveillance for invasive Hia disease was conducted through Active Bacterial Core surveillance sites and from Alaska statewide invasive bacterial disease surveillance. Sterile-site isolates were serotyped via slide agglutination or real-time polymerase chain reaction. Incidences in cases per 100 000 were calculated. Results From 2008 to 2017, an estimated average of 306 invasive Hia disease cases occurred annually in the United States (estimated annual incidence: 0.10); incidence increased by an average of 11.1% annually. Overall, 42.7% of cases were in children aged &lt;5 years (incidence: 0.64), with highest incidence among children aged &lt;1 year (1.60). Case fatality was 7.8% overall and was highest among adults aged ≥65 years (15.1%). Among children aged &lt;5 years, the incidence was 17 times higher among American Indian and Alaska Native (AI/AN) children (8.29) than among children of all other races combined (0.49). In Alaska, incidences among all ages (0.68) and among children aged &lt;1 year (24.73) were nearly 6 and 14 times higher, respectively, than corresponding US incidences. Case fatality in Alaska was 10.2%, and the vast majority (93.9%) of cases occurred among AI/AN. Conclusions Incidence of invasive Hia disease has increased since 2008, with the highest burden among AI/AN children. These data can inform prevention strategies, including Hia vaccine development.

scholarly journals Impact of Haemophilus influenzae type b conjugate vaccination on hospitalization for invasive disease in children fifteen years after its introduction in Italy

Vaccine ◽  
2017 ◽  
Vol 35 (46) ◽  
pp. 6297-6301 ◽  
Author(s):  
Domenico Martinelli ◽  
Chiara Azzari ◽  
Paolo Bonanni ◽  
Susanna Esposito ◽  
Elisabetta Franco ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Invasive Disease ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Conjugate Vaccination

scholarly journals Draft Genome Sequences of Six NontypeableHaemophilus influenzaeStrains That Establish Bacteremia in the Infant Rat Model of Invasive Disease: TABLE 1 

2015 ◽  
Vol 3 (5) ◽  
Author(s):  
Timothy M. VanWagoner ◽  
Daniel J. Morton ◽  
Thomas W. Seale ◽  
Huda J. Mussa ◽  
Brett K. Cole ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Rat Model ◽  
Draft Genome ◽  
Invasive Disease ◽  
Genome Sequences ◽  
Infant Rat

Haemophilus influenzaeis an important cause of invasive disease. The infant rat is the accepted model of invasiveH. influenzaedisease. Here, we report the genome sequences of six nontypeableH. influenzaestrains that establish bacteremia in the infant rat.

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