scholarly journals EPIDEMIOLOGY, RISK FACTORS AND PATHOMORPHOLOGICAL FEATURES OF MAMMARY TUMORS IN CATS

THE BULLETIN ◽  
2020 ◽  
Vol 6 (388) ◽  
pp. 78-84
Author(s):  
Dyulger Georgy Petrovich, ◽  
◽  
Dyulger Petr Georgiyevich, ◽  
Alikhanov Oralbek, ◽  
Sedletskaya Evgenia Sergeevna, ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Carcinoma In Situ ◽  
Mammary Cancer ◽  
Malignant Tumors ◽  
Mammary Tumors ◽  
Biological Behavior ◽  
Histological Structure ◽  
Ovarian Status

Mammary tumors (MT) are the 3rd most common neoplasm in cats. The incidence rate is significantly influenced by gender, age, breed, ovarian status, and the use of progestin-based contraceptives. MTs are a group of neoplasms that is heterogeneous in terms of tissue belonging, histological structure, and biological behavior. Malignant tumors are most frequent and compile from 80% to 96% of all tumors and tumor-like mammary lesions. Mammary cancer (MC) prevails, accounting for 91.4% of all cases of malignant tumors. Invasive breast cancer is much more common than carcinoma in situ. Among histological types of breast cancer, cribriform, solid, and tubulopapillary carcinomas predominate; mucous, tubular, and papillary carcinomas are less common.

scholarly journals A Statistical Analysis of Risk Factors and Biological Behavior in Canine Mammary Tumors: A Multicenter Study

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1687
Author(s):  
Giovanni P. Burrai ◽  
Andrea Gabrieli ◽  
Valentina Moccia ◽  
Valentina Zappulli ◽  
Ilaria Porcellato ◽  
...  
Keyword(s):  
Machine Learning ◽  
Risk Factors ◽  
Statistical Analysis ◽  
Multicenter Study ◽  
Malignant Tumors ◽  
Mammary Tumors ◽  
Supervised Machine Learning ◽  
Biological Behavior ◽  
Clinical Staging ◽  
Canine Mammary Tumors

Canine mammary tumors (CMTs) represent a serious issue in worldwide veterinary practice and several risk factors are variably implicated in the biology of CMTs. The present study examines the relationship between risk factors and histological diagnosis of a large CMT dataset from three academic institutions by classical statistical analysis and supervised machine learning methods. Epidemiological, clinical, and histopathological data of 1866 CMTs were included. Dogs with malignant tumors were significantly older than dogs with benign tumors (9.6 versus 8.7 years, p < 0.001). Malignant tumors were significantly larger than benign counterparts (2.69 versus 1.7 cm, p < 0.001). Interestingly, 18% of malignant tumors were smaller than 1 cm in diameter, providing compelling evidence that the size of the tumor should be reconsidered during the assessment of the TNM-WHO clinical staging. The application of the logistic regression and the machine learning model identified the age and the tumor’s size as the best predictors with an overall diagnostic accuracy of 0.63, suggesting that these risk factors are sufficient but not exhaustive indicators of the malignancy of CMTs. This multicenter study increases the general knowledge of the main epidemiologica-clinical risk factors involved in the onset of CMTs and paves the way for further investigations of these factors in association with CMTs and in the application of machine learning technology.

scholarly journals R1 resection margin after organ-sparing/oncoplastic surgeries for breast cancer

2021 ◽  
Vol 17 (1) ◽  
pp. 12-19
Author(s):  
E.  A. Rasskazova ◽  
A.  D. Zikiryakhodzhaev ◽  
N.  N. Volchenko ◽  
Sh.  G. Khakimova
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Resection Margin ◽  
Invasive Cancer ◽  
Resection Margins ◽  
Histological Structure ◽  
R1 Resection ◽  
Repeated Surgery ◽  
Organ Sparing

The recurrence rate after organ-sparing surgeries for breast cancer depends on the resection margins: R1 status is associated with a higher risk of recurrence than R0.We analyzed a group of breast cancer patients with an R1 resection margin who underwent organ-sparing/oncoplastic surgeries. The R1 resection margin was detected in 62 out of 1279 patients who had organ-sparing/oncoplastic surgeries (4.9 % ± 0.6 %). In the group with invasive cancer and R1 resection margin, 80 % of patients were diagnosed with lobular carcinoma, whereas 14.8 % of patients had invasive cancer with no specific signs.We divided the group of repeated surgeries according to their histological structure at the resection margin: 28 patients were found to have carcinoma in situ, while 13 patients had invasive cancer.Among patients with carcinoma in situ, the resection margin after repeated surgery had no signs of malignancy in 14 women (50 %), while 10 (35.7 %) and 4 (14.3 %) women were diagnosed with carcinoma in situ and invasive cancer, respectively.In case of invasive cancer, 4 patients (30.8 %) had no signs of malignancy in their resection margins, while 1 (7.7 %) and 8 (61.5 %) patients were found to have carcinoma in situ and invasive cancer, respectivelyFollow-up of patients with an R1 resection margin after repeated surgery or radiotherapy revealed no cases of local recurrence between 3 and 65 months.

scholarly journals Comparison of Risk Factors for Ductal Carcinoma In Situ and Invasive Breast Cancer

1997 ◽  
Vol 89 (1) ◽  
pp. 76-82 ◽  
Author(s):  
J. Barclay ◽  
V. Ernster ◽  
K. Kerlikowske ◽  
D. Grady ◽  
E. A. Sickles
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Ductal Carcinoma In Situ ◽  
Invasive Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma

scholarly journals Clinicopathological Risk Factors for an Invasive Breast Cancer Recurrence after Ductal Carcinoma In Situ—A Nested Case–Control Study

2018 ◽  
Vol 24 (15) ◽  
pp. 3593-3601 ◽  
Author(s):  
Lindy L. Visser ◽  
Lotte E. Elshof ◽  
Michael Schaapveld ◽  
Koen van de Vijver ◽  
Emma J. Groen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Carcinoma In Situ ◽  
Case Control Study ◽  
Ductal Carcinoma ◽  
Cancer Recurrence ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Risk factors for Luminal A ductal carcinoma in situ (DCIS) and invasive breast cancer in the Carolina Breast Cancer Study

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0211488 ◽  
Author(s):  
Lindsay A. Williams ◽  
Patricia Casbas-Hernandez ◽  
Hazel B. Nichols ◽  
Chiu Kit Tse ◽  
Emma H. Allott ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Ductal Carcinoma In Situ ◽  
Invasive Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Luminal A ◽  
Breast Cancer Study ◽  
Carolina Breast Cancer Study

Ductal Carcinoma In Situ, and the Influence of the Mode of Detection, Population Characteristics, and Other Risk Factors

2012 ◽  
pp. 45-48 ◽  
Author(s):  
Beth A. Virnig ◽  
Shi-Yi Wang ◽  
Todd M. Tuttle
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Ductal Carcinoma In Situ ◽  
Invasive Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
The United States ◽  
Population Characteristics ◽  
Breast Irradiation

Overview: Approximately 25% of breast cancers in the United States are diagnosed as ductal carcinoma in situ (DCIS). Rates of DCIS have risen from 5.8 per 100,000 women in the 1970s to 32.5 per 100,000 in 2004. This pattern is generally attributed to increased use of screening mammography. DCIS is a major risk factor for invasive breast cancer, and considerable controversy remains about whether DCIS should be considered a direct precursor of invasive breast cancer. There is, however, a general consensus that DCIS represents an intermediate step between normal breast tissue and invasive breast cancer. Although the majority of major risk factors are similar for DCIS and invasive breast cancer, prognostic factors including estrogen and progesterone receptor status and HER2 positivity are less well studied but look to have similar value in both cases. The use of postdiagnostic MRI, sentinel lymph node biopsy, surgery, radiation, and endocrine therapy are all evolving as evidence from randomized and observational studies continues to accumulate. Treatment of DCIS requires a balance between risk of overtreatment and undertreatment. Ongoing studies are focusing on whether partial-breast irradiation is as effective as whole-breast irradiation and whether treatment with endocrine therapies can reduce the likelihood of either invasive breast cancer or DCIS recurrence. In general, treatment decisions should take into account the likelihood that an apparent case of DCIS could harbor foci of invasive disease.

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