Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives

The use of autologous platelet concentrates, represent a promising and innovator tools in the medicine and dentistry today. The goal is to accelerate hard and soft tissue healing. Among them, the platelet-rich plasma (PRP) is the main alternative for use in liquid form (injectable). These injectable form ofplatelet concentrates are often used in regenerative procedures and demonstrate good results. The aim of this study is to present an alternative to these platelet concentrates using the platelet-rich fibrin in liquid form (injectable) and its use with particulated bone graft materials in the polymerized form.

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Platelet rich fibrin in dentistry: A review of literature

International Journal of Medicine ◽

10.14419/ijm.v3i2.5079 ◽

2015 ◽

Vol 3 (2) ◽

pp. 72 ◽

Cited By ~ 3

Author(s):

Vishnu Ravi Kumar ◽

Gayathri Gangadharan

Keyword(s):

First Generation ◽

Platelet Rich Plasma ◽

Invasive Procedure ◽

Great Promise ◽

Review Of Literature ◽

Platelet Concentrates ◽

Platelet Rich Fibrin ◽

Patient Morbidity ◽

Affected Tissue ◽

High Doses

<p>The aim of any invasive procedure is the complete eradication and elimination of the infection and associated necrotic tissue followed by repair and regeneration of the affected tissue. In order to achieve this goal various biological products have been introduced, among which are present the platelet concentrates. Platelet concentrates with their higher concentration of platelets has been used in the field of medicine since the 1990s in the form of the first-generation concentrates-Platelet Rich Plasma, and the second generation concentrated -Platelet Rich Fibrin. Choukroun’s Platelet Rich Fibrin is one such material, which is used by itself and also as an adjunct with grafts. It has been successful as it delivers high doses of growth factors and has anti-inflammatory properties. They have been shown to be of great promise in the field of dentistry, ranging from implantology; Sinuses lift procedures, treating of endodontic and periodontal lesions to regeneration of necrotic pulp. This novel technique has the potential to revolutionize the treatment mode in dentistry and help with reducing patient morbidity. We will be further looking into the specification and implications of this material in this review.</p>

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The effectiveness of platelet concentrations in periodontal surgeries

International Journal of Dental Research ◽

10.14419/ijdr.v6i2.12414 ◽

2018 ◽

Vol 6 (2) ◽

pp. 61 ◽

Cited By ~ 1

Author(s):

Ronad Al-Azem ◽

Neveen Ali ◽

Diana Mostafa

Keyword(s):

Case Report ◽

Growth Factors ◽

Bone Graft ◽

Tissue Regeneration ◽

Platelet Rich Plasma ◽

Research Process ◽

Platelet Concentrates ◽

Platelet Rich Fibrin ◽

Barrier Membrane ◽

Concentrated Growth Factors

Platelets release several growth factors which stimulate tissue regeneration. Several techniques for platelet concentrates such as platelet rich plasma (PRP), plasma rich in growth factors (PRGF), platelet rich fibrin (PRF) and concentrated growth factors (CGF) have been introduced in dental surgeries for the prevention of hemorrhage and acceleration of tissue regeneration. However, a fabricating growth factors-enriched bone graft matrix which is called “sticky bone” has been demonstrated to provide stabilization in bony defects. In this article, we presented the method of preparing and utilizing CGF and sticky bone and evaluate the effect of CGF mixed with bone graft and CGF barrier membrane in periodontal surgeries.Methodology: We used websites such as PubMed, Scopus, and ISI Web of knowledge to get related articles about this subject. The research process involved specific key words " concentrated growth factor”- “Platelet rich fibrin”- growth factors-enriched bone graft” - “sticky bone” to find more articles which published from 2007 to March 2018.Results: We reviewed 48 articles, 43 articles were excluded. Only five articles have been conducted. Original human studies and case report were included.Conclusion: We concluded that the use of sticky bone and CGF is effective in bone grafting and implant.

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Do the Fibrin Architecture and Leukocyte Content Influence the Growth Factor Release of Platelet Concentrates? An Evidence-based Answer Comparing a Pure Platelet-Rich Plasma (P-PRP) Gel and a Leukocyte- and Platelet-Rich Fibrin (L-PRF)

Current Pharmaceutical Biotechnology ◽

10.2174/138920112800624382 ◽

2012 ◽

Vol 13 (7) ◽

pp. 1145-1152 ◽

Cited By ~ 156

Author(s):

David M. Dohan Ehrenfest ◽

Tomasz Bielecki ◽

Ryo Jimbo ◽

Giovanni Barbe ◽

Marco Del Corso ◽

...

Keyword(s):

Growth Factor ◽

Platelet Rich Plasma ◽

Evidence Based ◽

Platelet Concentrates ◽

Platelet Rich Fibrin ◽

Growth Factor Release ◽

Prp Gel ◽

Factor Release

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Use of Platelet-Rich Plasma and Platelet-Rich Fibrin in Dentistry and Oral Surgery: Introduction and Review of the Literature

Journal of Veterinary Dentistry ◽

10.1177/0898756419876057 ◽

2019 ◽

Vol 36 (2) ◽

pp. 109-123 ◽

Cited By ~ 5

Author(s):

Kristina Feigin ◽

Bonnie Shope

Keyword(s):

Soft Tissues ◽

Oral Surgery ◽

Platelet Rich Plasma ◽

Maxillofacial Surgery ◽

Oral And Maxillofacial Surgery ◽

Platelet Concentrates ◽

Platelet Rich Fibrin ◽

Wide Range ◽

Comprehensive Examination ◽

And Function

Platelet concentrates, mostly represented by platelet-rich plasma and platelet-rich fibrin, have gained significant interest in various medical and oral disciplines because of their potential to stimulate and boost regeneration of hard and soft tissues. Prepared from the patient’s own blood, they have been tested and used in various different surgical fields including oral and maxillofacial surgery. The effects of these biomaterials are described to be a result of the large concentration of platelets which contain a wide range of growth factors. The aim of this article is to introduce the principle and function of these platelet concentrates, to review their preparation, and to provide a comprehensive examination of the published oral and maxillofacial literature on this subject.

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The Clinical Application Of Platelet Concentrates: A Systematic Meta-analysis

International Journal of Prosthodontics and Restorative Dentistry ◽

10.5005/jp-journals-10019-1124 ◽

2015 ◽

Vol 5 (1) ◽

pp. 21-26

Author(s):

Sneha Ketan Gada

Keyword(s):

Clinical Application ◽

Oral Surgery ◽

Therapeutic Potential ◽

Platelet Rich Plasma ◽

Meta Analysis ◽

Pediatric Dentistry ◽

Platelet Concentrates ◽

Bone Contact ◽

Platelet Rich Fibrin ◽

Regenerative Dentistry

ABSTRACT Background Autologous plasma rich in platelets is derived blood product whose uses in dentistry dates back to the 1990s and it has been gaining popularity ever since. Aim A systematic review of the available literature to determine the efficacy, safety and success of platelet concentrates in physiological systems as well as describing its vigilant use. Study design and methods A Medline search with keywords ‘platelet rich plasma dental’ further filtered using Boolean opera- tors (AND, OR, NOT) and combination of specific keywords as follows: ‘platelet rich fibrin’, ‘platelet rich plasma regenerative’, ‘platelet rich plasma periodontal’, ‘platelet rich plasma extraction’ with a custom range of 10 years was performed, which yielded 88 results out of which 32 were selected based on the inclusion criteria. Results Significantly, successful outcomes have been wit- nessed in the field of osteoregeneration though it has been evidenced that adequate platelet rich plasma (PrP) additives are essential to bear a therapeutic potential. Favoring blood cell adhesion on the root surface optimizing periodontal healing, PrP has also shown positive effect on gingival repair; though controversial facts have also been reported. In the scope of implant dentistry, PrP has also reported greater implant-bone contact when used in both gel or liquid form. Emerging as a possible pulp capping agent along with properties of decreased chances root growth, PrP has successfully completed apexo- genesis in cases of pulpotomy. Research has shown that although clinical results from the comparison of PrP alone vs PrP and resorbable membrane or various graft materials has shown a varied results, additional research in the field is needed. Conclusion Platelet rich plasma has shown promising results in the field of regenerative dentistry, with high success rate in implantology, periodontology and oral surgery. Because of conflicting success rates reported in literature further research is warrented. Clinical implication Platelet rich fibrin has displayed various features of rapid clinical healing, excellent bone density, less surgical time, less resorption during healing and decreased postoperative pain, as compared to guided bone regeneration procedures. Platelet rich plasma has also shown a myriad of applications ranging from hard tissue regeneration to soft tissue management, stretching across to the field of pediatric dentistry and endodontics. How to cite this article Gada SK, Gupta P. the Clinical Application of Platelet Concentrates: A Systematic Meta- analysis. Int J Prosthodont restor Dent 2015;5(1):21-26.

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