scholarly journals The effectiveness of platelet concentrations in periodontal surgeries

2018 ◽  
Vol 6 (2) ◽  
pp. 61 ◽  
Author(s):  
Ronad Al-Azem ◽  
Neveen Ali ◽  
Diana Mostafa
Keyword(s):  
Case Report ◽  
Growth Factors ◽  
Bone Graft ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Research Process ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin ◽  
Barrier Membrane ◽  
Concentrated Growth Factors

Platelets release several growth factors which stimulate tissue regeneration. Several techniques for platelet concentrates such as platelet rich plasma (PRP), plasma rich in growth factors (PRGF), platelet rich fibrin (PRF) and concentrated growth factors (CGF) have been introduced in dental surgeries for the prevention of hemorrhage and acceleration of tissue regeneration. However, a fabricating growth factors-enriched bone graft matrix which is called “sticky bone” has been demonstrated to provide stabilization in bony defects. In this article, we presented the method of preparing and utilizing CGF and sticky bone and evaluate the effect of CGF mixed with bone graft and CGF barrier membrane in periodontal surgeries.Methodology: We used websites such as PubMed, Scopus, and ISI Web of knowledge to get related articles about this subject. The research process involved specific key words " concentrated growth factor”- “Platelet rich fibrin”- growth factors-enriched bone graft” - “sticky bone” to find more articles which published from 2007 to March 2018.Results: We reviewed 48 articles, 43 articles were excluded. Only five articles have been conducted. Original human studies and case report were included.Conclusion: We concluded that the use of sticky bone and CGF is effective in bone grafting and implant.  

scholarly journals From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery

2019 ◽  
Vol 13 (02) ◽  
pp. 280-286 ◽  
Author(s):  
Andrea Caruana ◽  
Daniele Savina ◽  
José Paulo Macedo ◽  
Sandra Clara Soares
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Tissue Regeneration ◽  
Second Generation ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Maxillofacial Surgery ◽  
Cellular Migration ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin

AbstractIn the past 20 years, the platelet concentrates have evolved from first-generation products, i.e., platelet-rich plasma (PRP) and plasma rich in growth factors to the second-generation products such as leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). These autologous products with a higher leukocyte inclusion and flexible fibrin mesh act as a scaffold to increase cellular migration in the angiogenic, osteogenic, and antimicrobial potential of these biomaterials in tissue regeneration. In the second-generation platelet concentrates, the protocols are easier, cheaper, and faster with an entire physiological fibrin matrix, resulting in a tridimensional mesh, not as rigid as one of the first generations. This allows the slow release of molecules over a longer period of time and triggers the healing and regenerative process at the site of injury. The potential of A-PRF to mimic the physiology and immunology of wound healing is also due to the high concentration of growth factors released as follows: vascular endothelial growth factor, platelet-derived growth factor, transforming growth factor-β, and anti-inflammatory cytokines that stimulate tissue cicatrization, vessels formation, and bone cell proliferation and differentiation. Furthermore, the number of neutrophils and monocytes/macrophages is higher releasing important chemotactic molecules such as chemokine ligand-5 and eotaxin. Thus, L-PRF and A-PRF have been used, especially in implantology, periodontology, and maxillofacial surgery. Future clinical applications include tissue regeneration/grafts, ulcers/skin necrosis in the diabetic patient and others, plastic surgery, and even musculoskeletal lesions.

scholarly journals Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: technical note

2015 ◽  
Vol 42 (6) ◽  
pp. 421-423 ◽  
Author(s):  
Carlos Fernando de Almeida Barros Mourão ◽  
Helder Valiense ◽  
Elias Rodrigues Melo ◽  
Natália Belmock Mascarenhas Freitas Mourão ◽  
Mônica Diuana-Calasans Maia
Keyword(s):  
Bone Graft ◽  
Platelet Rich Plasma ◽  
Technical Note ◽  
Platelet Concentrates ◽  
Soft Tissue Healing ◽  
Liquid Form ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Autologous Platelet ◽  
Injectable Form

The use of autologous platelet concentrates, represent a promising and innovator tools in the medicine and dentistry today. The goal is to accelerate hard and soft tissue healing. Among them, the platelet-rich plasma (PRP) is the main alternative for use in liquid form (injectable). These injectable form ofplatelet concentrates are often used in regenerative procedures and demonstrate good results. The aim of this study is to present an alternative to these platelet concentrates using the platelet-rich fibrin in liquid form (injectable) and its use with particulated bone graft materials in the polymerized form.

scholarly journals Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: A Narrative Review

2021 ◽  
Vol 14 (10) ◽  
pp. 1041
Author(s):  
Agata Zoltowska ◽  
Katarzyna Machut ◽  
Elzbieta Pawlowska ◽  
Marcin Derwich
Keyword(s):  
Growth Factors ◽  
Tissue Regeneration ◽  
Adult Patients ◽  
Application Site ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin ◽  
Periapical Lesions ◽  
Pubmed Database ◽  
Proliferation And Differentiation ◽  
Different Types

Platelet concentrates have been widely used in regenerative medicine, including endodontics. The aim of this manuscript was to assess critically the efficacy of PRF in the treatment of endodontic periapical lesions in adult patients on the basis of the literature. The PICO approach was used to properly develop literature search strategies. The PubMed database was analyzed with the keywords: “((PRP) OR (PRF) OR (PRGF) OR (CGF)) AND (endodontic) AND ((treatment) OR (therapy))”. After screening of 155 results, 14 articles were included in this review. Different types of platelet concentrates are able to stimulate the processes of proliferation and differentiation of mesenchymal stem cells. Platelet rich fibrin (PRF) releases growth factors for at least 7 days at the application site. Growth factors and released cytokines stimulate the activity of osteoblasts. Moreover, the release of growth factors accelerates tissue regeneration by increasing the migration of fibroblasts. It was not possible to assess the efficacy of PRF supplementation in the treatment of endodontic periapical lesions in permanent, mature teeth with closed apexes, due to the lack of well-designed scientific research. Further studies are needed to analyze the effect of PRF on the healing processes in the periapical region.

scholarly journals Advanced Platelet- Rich Fibrin (A-PRF): A Gender Based Study on Cell Population

2020 ◽  
pp. 1-7
Author(s):  
Harini Kumaran ◽  
Radhika Arjunkumar ◽  
R. Abilasha
Keyword(s):  
Wound Healing ◽  
Sample Size ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Treatment Strategies ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin ◽  
The Difference ◽  
Exogenous Compounds ◽  
Gender Based

Platelet Rich Fibrin (PRF) is a natural fibrin-based biomaterial prepared from an anticoagulant-free blood harvest without any artificial biochemical modification that allows obtaining fibrin membranes enriched with platelets and growth factors. PRF is superior to other platelet concentrates like Platelet Rich Plasma (PRP) due to its ease and inexpensive method of preparation and also it does not need any addition of exogenous compounds like bovine thrombin and calcium chloride. A blood sample of 10 individuals with healthy periodontium and no systemic diseases was collected and centrifuged to get platelet rich fibrin. Platelet rich fibrin is studied histologically to compare the ability of tissue regeneration and wound healing capacity between males and females. Neutrophils and lymphocytes are increased in A-PRF compared to S-PRF. Neutrophils and lymphocytes are proportionately more in males than females in both A-PRF and S-PRF. Monocytes are similar in A-PRF & S-PRF. Cells are more concentrated in S-PRF. Cells are more widely distributed in A-PRF. Fibrin is more dense in A-PRF compared to S-PRF. Hence A-PRF especially in males could have a greater potential of tissue regeneration and wound healing capacity. Although it is not conclusive due to limited sample size, further increase in sample size can throw more light on the clinical implications. The difference in regenerative potential of platelet concentrates can pave the way for specialised and focussed treatment strategies resulting in more favourable patient outcomes.

The Use of Graft Materials and Platelet Rich Plasma in Oral Surgery

2017 ◽  
Vol 376 ◽  
pp. 39-53 ◽  
Author(s):  
Cena Dimova ◽  
Biljana Evrosimovska ◽  
Mirjana Popovska
Keyword(s):  
Clinical Practice ◽  
Growth Factors ◽  
Oral Surgery ◽  
Platelet Rich Plasma ◽  
Everyday Clinical Practice ◽  
Platelet Rich Fibrin ◽  
Barrier Membrane ◽  
Contemporary Work ◽  
Bone Grafting Materials ◽  
Grafting Materials

The aim of this paper is to highlight the classification and indications of different bone grafting materials and barrier membrane for everyday clinical practice of contemporary work in the field of oral surgery and periodontology. Number of different growth factors are used together with graft materials. Among these are platelet rich plasma (PRP) and platelet-rich fibrin (PRF). With the simplified technique, an autologous fibrin matrix, which contains platelets and leucocyte growth factors, is acquired.

scholarly journals Striking Differences in Platelet Distribution between Advanced-Platelet-Rich Fibrin and Concentrated Growth Factors: Effects of Silica-Containing Plastic Tubes

2019 ◽  
Vol 10 (3) ◽  
pp. 43 ◽  
Author(s):  
Tetsuhiro Tsujino ◽  
Hideo Masuki ◽  
Masayuki Nakamura ◽  
Kazushige Isobe ◽  
Hideo Kawabata ◽  
...  
Keyword(s):  
Growth Factors ◽  
High Speed ◽  
Platelet Rich Plasma ◽  
Health Hazard ◽  
Blood Collection ◽  
Platelet Rich Fibrin ◽  
Low Speed ◽  
Glass Tubes ◽  
Concentrated Growth Factors ◽  
Silica Microparticles

Compared with platelet-rich plasma, the preparation of platelet-rich fibrin (PRF) is simple and has not been overly modified. However, it was recently demonstrated that centrifugation conditions influence the composition of PRF and that silica microparticles from silica-coated plastic tubes can enter the PRF matrix. These factors may also modify platelet distribution. To examine these possibilities, we prepared PRF matrices using various types of blood-collection tubes (plain glass tubes and silica-containing plastic tubes) and different centrifugation speeds. The protocols of concentrated growth factors and advanced-PRF represented high- and low-speed centrifugation, respectively. Platelet distribution in the PRF matrix was examined immunohistochemically. Using low-speed centrifugation, platelets were distributed homogeneously within the PRF matrix regardless of tube types. In high-speed centrifugation, platelets were distributed mainly on one surface region of the PRF matrix in glass tubes, whereas in silica-coated tubes, platelet distribution was commonly more diffusive than in glass tubes. Therefore, both blood-collection tube types and centrifugal conditions appeared to influence platelet distribution in the PRF matrix. Platelets distributed in the deep regions of the PRF matrix may contribute to better growth factor retention and release. However, clinicians should be careful in using silica-coated tubes because their silica microparticles may be a health hazard.

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