New bioactive glass-ceramic: Synthesis and application in PMMA bone cement composites

2011 ◽  
Vol 21 (4) ◽  
pp. 247-258 ◽  
Author(s):  
Hamizah Abd Samad ◽  
Mariatti Jaafar ◽  
Radzali Othman ◽  
Masakazu Kawashita ◽  
Noor Hayati Abdul Razak
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Glass Ceramic ◽  
Cement Composites ◽  
Ceramic Synthesis ◽  
Pmma Bone Cement

scholarly journals Antibiotic Elution and Mechanical Strength of PMMA Bone Cement Loaded With Borate Bioactive Glass

2018 ◽  
Vol 3 (4) ◽  
pp. 187-196 ◽  
Author(s):  
Grahmm A. Funk ◽  
Jonathan C. Burkes ◽  
Kimberly A. Cole ◽  
Mohamed N. Rahaman ◽  
Terence E. McIff
Keyword(s):  
Mechanical Strength ◽  
Bioactive Glass ◽  
Bone Cement ◽  
Weight Bearing ◽  
Cement Composites ◽  
Delivery Vehicle ◽  
Glass Composites ◽  
Pmma Bone Cement ◽  
Borate Bioactive Glass ◽  
Do So

Abstract. Introduction: Local delivery of antibiotics using bone cement as the delivery vehicle is an established method of managing implant-associated orthopedic infections. Various fillers have been added to cement to increase antibiotic elution, but they often do so at the expense of strength. This study evaluated the effect of adding a borate bioactive glass, previously shown to promote bone formation, on vancomycin elution from PMMA bone cement.Methods: Five cement composites were made: three loaded with borate bioactive glass along with 0, 1, and 5 grams of vancomycin and two without any glass but with 1 and 5 grams vancomycin to serve as controls. The specimens were soaked in PBS. Eluate of vancomycin was collected every 24 hours and analyzed by HPLC. Orthopedic-relevant mechanical properties of each composite were tested over time.Results: The addition of borate bioactive glass provided an increase in vancomycin release at Day 1 and an increase in sustained vancomycin release throughout the treatment period. An 87.6% and 21.1% increase in cumulative vancomycin release was seen for both 1g and 5g loading groups, respectively. Compressive strength of all composites remained above the weight-bearing threshold of 70 MPa throughout the duration of the study with the glass-containing composites showing comparable strength to their respective controls.Conclusion: The incorporation of borate bioactive glass into commercial PMMA bone cement can significantly increase the elution of vancomycin. The mechanical strength of the cement-glass composites remained above 70 MPa even after soaking for 8 weeks, suggesting their suitability for orthopedic weight-bearing applications.

Novel doped calcium phosphate-PMMA bone cement composites as levofloxacin delivery systems

2015 ◽  
Vol 490 (1-2) ◽  
pp. 200-208 ◽  
Author(s):  
Ana C. Matos ◽  
Catarina F. Marques ◽  
Rosana V. Pinto ◽  
Isabel A.C. Ribeiro ◽  
Lídia M. Gonçalves ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Delivery Systems ◽  
Cement Composites ◽  
Pmma Bone Cement

scholarly journals Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass

2017 ◽  
Vol 14 (131) ◽  
pp. 20161057 ◽  
Author(s):  
Xu Cui ◽  
Chengcheng Huang ◽  
Meng Zhang ◽  
Changshun Ruan ◽  
Songlin Peng ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Setting Time ◽  
Composite Cement ◽  
Collagen Secretion ◽  
Pmma Bone Cement ◽  
Borate Bioactive Glass ◽  
Composite Cements ◽  
Pmma Cement

Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength. The bioactivity of SrBG/PMMA composite cements was confirmed in vitro , evidenced by ion release (Ca, P, B and Sr) from SrBG particles. The cellular responses of MC3T3-E1 cells in vitro demonstrated that SrBG incorporation could promote adhesion, migration, proliferation and collagen secretion of cells. Furthermore, our in vivo investigation revealed that SrBG/PMMA composite cements presented better osseointegration than PMMA bone cement. SrBG in the composite cement could stimulate new-bone formation around the interface between the composite cement and host bone at eight and 12 weeks post-implantation, whereas PMMA bone cement only stimulated development of an intervening connective tissue layer. Consequently, the SrBG/PMMA composite cement may be a better alternative to PMMA cement in clinical applications and has promising orthopaedic applications by minimal invasive surgery.

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

2017 ◽  
Vol 106 (3) ◽  
pp. 1245-1257 ◽  
Author(s):  
I. Goñi ◽  
R. Rodríguez ◽  
I. García‐Arnáez ◽  
J. Parra ◽  
M. Gurruchaga
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Cement Composites

Preparation and characterisation of an innovative injectable calcium sulphate based bone cement for vertebroplasty application

2017 ◽  
Vol 5 (1) ◽  
pp. 102-115 ◽  
Author(s):  
Mehran Dadkhah ◽  
Lucia Pontiroli ◽  
Sonia Fiorilli ◽  
Antonio Manca ◽  
Francesca Tallia ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Glass Ceramic ◽  
Calcium Sulphate ◽  
Ceramic Phase ◽  
Mesoporous Bioactive Glass

Spine-Ghost: a novel injectable resorbable cement containing mesoporous bioactive glass and a radiopaque glass-ceramic phase in a calcium sulphate matrix.

Bone-Bonding Strength of Two Kinds of Polymethylmethacrylate-Based Bioactive Bone Cement Containing Bioactive Glass Beads or Glass-Ceramic Powder

2001 ◽  
Vol 218-220 ◽  
pp. 369-374 ◽  
Author(s):  
M. Kamimura ◽  
Jiro Tamura ◽  
S. Shinzato ◽  
Keiichi Kawanabe ◽  
Masashi Neo ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Glass Ceramic ◽  
Bonding Strength ◽  
Ceramic Powder ◽  
Glass Beads

Incorporation of MWCNTs to PMMA Bone Cements: Effects on Fatigue Properties

2014 ◽  
Vol 971-973 ◽  
pp. 1013-1016 ◽  
Author(s):  
Yan Lin ◽  
Yong Zhi Xu
Keyword(s):  
Crack Propagation ◽  
Bone Cement ◽  
Chemical Vapor ◽  
Fatigue Properties ◽  
Cement Composites ◽  
Pmma Bone Cement ◽  
The Matrix ◽  
Multi Walled Carbon Nanotubes ◽  
Number Of Cycles ◽  
Walled Carbon Nanotubes

All the commercially available plain acrylic bone cement brands, which are used incemented arthroplasties, are based on poly (methyl methacrylate). With a few exceptions, have the same constituents. It is well known that these brands are beset with many drawbacks, such as high maximum exotherm temperature, lack of bioactivity, and volumetric shrinkage upon curing. The aim of this study was to investigate the fatigue properties of MWCNTs-PMMA bone cement composites. Multi-walled carbon nanotubes (unfunctionalised and carboxyl functionalised), which was synthesized by infusion chemical vapor deposition, and PMMA bone cement were used to produce pastes. The mixing amount of MWCNTs ranged from 0.1 wt.% to 1wt.%. The fatigue properties of the MWCNTs-PMMA bone cement was characterised with the type and wt.% loading of MWCNTs used having a significant influence on the number of cycles to failure. The condition and degree of dispersion of the MWCNTs in the matrix at different length scales were studied using field emission scanning electron microscopy. Improvements of the fatigue properties were attributed to the MWCNTs arresting or retarding crack propagation through the cement by a bridging effect and hindering crack propagation. MWCNTs agglomerates were evident in the cement microstructure and the degree of agglomeration depended on the level of the mixing amount and the ability of the MWCNTs.

Sign in / Sign up

Export Citation Format

Share Document