Dietary Intakes of Vitamin E, Vitamin C, and β-Carotene and Risk of Alzheimer's Disease: A Meta-Analysis

AbstractObjectiveThe present review aimed to quantify the association of dietary intake and circulating concentration of major dietary antioxidants with risk of total CVD mortality.DesignSystematic review and meta-analysis.SettingSystematic search in PubMed and Scopus, up to October 2017.ParticipantsProspective observational studies reporting risk estimates of CVD mortality across three or more categories of dietary intakes and/or circulating concentrations of vitamin C, vitamin E and β-carotene were included. A random-effects meta-analysis was conducted.ResultsA total of fifteen prospective cohort studies and three prospective evaluations within interventional studies (320 548 participants and 16 974 cases) were analysed. The relative risks of CVD mortality for the highest v. the lowest category of antioxidant intakes were as follows: vitamin C, 0·79 (95 % CI 0·68, 0·89; I2=46 %, n 10); vitamin E, 0·91 (95 % CI 0·79, 1·03; I2=51 %, n 8); β-carotene, 0·89 (95 % CI 0·73, 1·05; I2=34 %, n 4). The relative risks for circulating concentrations were: vitamin C, 0·60 (95 % CI 0·42, 0·78; I2=65 %, n 6); α-tocopherol, 0·82 (95 % CI 0·76, 0·88; I2=0 %, n 5); β-carotene, 0·68 (95 % CI 0·52, 0·83; I2=50 %, n 6). Dose–response meta-analyses demonstrated that the circulating biomarkers of antioxidants were more strongly associated with risk of CVD mortality than dietary intakes.ConclusionsThe present meta-analysis demonstrates that higher vitamin C intake and higher circulating concentrations of vitamin C, vitamin E and β-carotene are associated with a lower risk of CVD mortality.

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Dementia and Alzheimer's Disease in Community-Dwelling Elders Taking Vitamin C and/or Vitamin E

Annals of Pharmacotherapy ◽

10.1345/aph.1g280 ◽

2005 ◽

Vol 39 (12) ◽

pp. 2009-2014 ◽

Cited By ~ 65

Author(s):

Gerda G Fillenbaum ◽

Maragatha N Kuchibhatla ◽

Joseph T Hanlon ◽

Margaret B Artz ◽

Carl F Pieper ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Vitamin E ◽

Vitamin C ◽

Community Dwelling

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Vitamin C and Vitamin E for Alzheimer's Disease

Annals of Pharmacotherapy ◽

10.1345/aph.1e495 ◽

2005 ◽

Vol 39 (12) ◽

pp. 2073-2080 ◽

Cited By ~ 95

Author(s):

Lisa A Boothby ◽

Paul L Doering

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Vitamin E ◽

Vitamin C

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[P4-027]: ENHANCING THE POWER OF PHYSICAL AND MENTAL ACTIVITIES VERSUS RISK FACTORS INDUCING PROGRESSION OF ALZHEIMER'S DISEASE IN RATS: IMPACT OF EPIGALLOCATECHIN-3-GALLATE IN COMBINATION WITH VITAMIN E, VITAMIN C AND SELENIUM

Alzheimer s & Dementia ◽

10.1016/j.jalz.2017.06.1891 ◽

2017 ◽

Vol 13 (7S_Part_26) ◽

pp. P1264-P1265

Author(s):

Azza A. Ali ◽

Abeer I. Abd El-Fattah ◽

Hemat A. Elariny ◽

Karema Abu-Elfotuh

Keyword(s):

Risk Factors ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Vitamin E ◽

Vitamin C ◽

Versus Risk

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Dietary vitamin and carotenoid intake and risk of age-related cataract

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy270 ◽

2019 ◽

Vol 109 (1) ◽

pp. 43-54 ◽

Cited By ~ 4

Author(s):

Hong Jiang ◽

Yue Yin ◽

Chang-Rui Wu ◽

Yan Liu ◽

Fang Guo ◽

...

Keyword(s):

Vitamin E ◽

Vitamin A ◽

Vitamin C ◽

Cohort Studies ◽

Dose Response ◽

Meta Analysis ◽

Dietary Vitamin ◽

Age Related ◽

Β Carotene ◽

Reduced Risk

ABSTRACT Background Existing studies suggest that dietary vitamins and carotenoids might be associated with a reduced risk of age-related cataract (ARC), although a quantitative summary of these associations is lacking. Objectives The aim of this study was to conduct a meta-analysis of randomized controlled trials (RCTs) and cohort studies of dietary vitamin and carotenoid intake and ARC risk. Methods The MEDLINE, EMBASE, ISI Web of Science, and Cochrane Library databases were searched from inception to June 2018. The adjusted RRs and corresponding 95% CIs for the associations of interest in each study were extracted to calculate pooled estimates. Dose-response relations were assessed with the use of generalized least-squares trend estimation. Results We included 8 RCTs and 12 cohort studies in the meta-analysis. Most vitamins and carotenoids were significantly associated with reduced risk of ARC in the cohort studies, including vitamin A (RR: 0.81; 95% CI: 0.71, 0.92; P = 0.001), vitamin C (RR: 0.80; 95% CI: 0.72, 0.88; P < 0.001), vitamin E (RR: 0.90; 95% CI: 0.80, 1.00; P = 0.049), β-carotene (RR: 0.90; 95% CI: 0.83, 0.99; P = 0.023), and lutein or zeaxanthin (RR: 0.81; 95% CI: 0.75, 0.89; P < 0.001). In RCTs, vitamin E (RR: 0.97; 95% CI: 0.91, 1.03; P = 0.262) or β-carotene (RR: 0.99; 95% CI: 0.92, 1.07; P = 0.820) intervention did not reduce the risk of ARC significantly compared with the placebo group. Further dose-response analysis indicated that in cohort studies the risk of ARC significantly decreased by 26% for every 10-mg/d increase in lutein or zeaxanthin intake (RR: 0.74; 95% CI: 0.67, 0.80; P < 0.001), by 18% for each 500-mg/d increase in vitamin C intake (RR: 0.82; 95% CI: 0.74, 0.91; P < 0.001), by 8% for each 5-mg/d increase in β-carotene intake (RR: 0.92; 95% CI: 0.88, 0.96; P < 0.001), and by 6% for every 5 mg/d increase in vitamin A intake (RR: 0.94; 95% CI: 0.90, 0.98; P < 0.001). Conclusions Higher consumption of certain vitamins and carotenoids was associated with a significant decreased risk of ARC in cohort studies, but evidence from RCTs is less clear.

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Trends in dietary intakes of vitamins A, C and E among Japanese men and women from 1974 to 2001

Public Health Nutrition ◽

10.1017/s1368980008003960 ◽

2009 ◽

Vol 12 (9) ◽

pp. 1343-1350 ◽

Cited By ~ 5

Author(s):

Yoshimi Kato ◽

Satoyo Ikehara ◽

Koutatsu Maruyama ◽

Mieko Inagawa ◽

Miyuki Oshima ◽

...

Keyword(s):

Vitamin E ◽

Vitamin A ◽

Vitamin C ◽

Dairy Products ◽

Public Health Issue ◽

Dietary Intakes ◽

Adequate Intake ◽

Japanese Men ◽

Men And Women ◽

Β Carotene

AbstractObjectiveTo investigate long-term trends in dietary intakes of vitamins A, C and E in Japanese adults.DesignTime series by community-based nutrition survey.SettingTwo rural communities (Ikawa and Kyowa) between 1974 and 2001 in Japan.SubjectsA total of 3713 men and 3726 women aged 40–69 years.MethodsDietary intake data were collected by the 24 h dietary recall.ResultsIn Ikawa, mean intake of vitamin A (β-carotene and retinol) increased by 13–40 %; vitamins C and E increased by approximately 23–33 % among men and women from 1974–1977 to 1998–2000. In Kyowa, mean intake of vitamin A, primarily retinol, increased by 13–21 % among men and women; vitamin C from fruits decreased by 16 % among men; and vitamin E increased by 29 % among women from 1982–1986 to 1998–2001. Mean intake of vitamin E in the latest survey period was lower than the Adequate Intake among men and women in both communities. Generally, there were increased intakes of β-carotene and vitamin C from green/yellow and other vegetables; increased retinol intake from fish/shellfish, eggs, milk/dairy products and fats/oils; and increased vitamin E intake from green/yellow and other vegetables, fish/shellfish, eggs, milk/dairy products and fats/oils.ConclusionsMean intakes of the antioxidant vitamins A, C and E increased among middle-aged Japanese men and women between the 1970s and the 1990s except for decreased vitamin C among Kyowa men. The lower mean intake of vitamin E than the Adequate Intake should be considered a potential public health issue for the prevention of CVD.

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