scholarly journals Dietary vitamin and carotenoid intake and risk of age-related cataract

2019 ◽  
Vol 109 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Hong Jiang ◽  
Yue Yin ◽  
Chang-Rui Wu ◽  
Yan Liu ◽  
Fang Guo ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Vitamin C ◽  
Cohort Studies ◽  
Dose Response ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Age Related ◽  
Β Carotene ◽  
Reduced Risk

ABSTRACT Background Existing studies suggest that dietary vitamins and carotenoids might be associated with a reduced risk of age-related cataract (ARC), although a quantitative summary of these associations is lacking. Objectives The aim of this study was to conduct a meta-analysis of randomized controlled trials (RCTs) and cohort studies of dietary vitamin and carotenoid intake and ARC risk. Methods The MEDLINE, EMBASE, ISI Web of Science, and Cochrane Library databases were searched from inception to June 2018. The adjusted RRs and corresponding 95% CIs for the associations of interest in each study were extracted to calculate pooled estimates. Dose-response relations were assessed with the use of generalized least-squares trend estimation. Results We included 8 RCTs and 12 cohort studies in the meta-analysis. Most vitamins and carotenoids were significantly associated with reduced risk of ARC in the cohort studies, including vitamin A (RR: 0.81; 95% CI: 0.71, 0.92; P = 0.001), vitamin C (RR: 0.80; 95% CI: 0.72, 0.88; P < 0.001), vitamin E (RR: 0.90; 95% CI: 0.80, 1.00; P = 0.049), β-carotene (RR: 0.90; 95% CI: 0.83, 0.99; P = 0.023), and lutein or zeaxanthin (RR: 0.81; 95% CI: 0.75, 0.89; P < 0.001). In RCTs, vitamin E (RR: 0.97; 95% CI: 0.91, 1.03; P = 0.262) or β-carotene (RR: 0.99; 95% CI: 0.92, 1.07; P = 0.820) intervention did not reduce the risk of ARC significantly compared with the placebo group. Further dose-response analysis indicated that in cohort studies the risk of ARC significantly decreased by 26% for every 10-mg/d increase in lutein or zeaxanthin intake (RR: 0.74; 95% CI: 0.67, 0.80; P < 0.001), by 18% for each 500-mg/d increase in vitamin C intake (RR: 0.82; 95% CI: 0.74, 0.91; P < 0.001), by 8% for each 5-mg/d increase in β-carotene intake (RR: 0.92; 95% CI: 0.88, 0.96; P < 0.001), and by 6% for every 5 mg/d increase in vitamin A intake (RR: 0.94; 95% CI: 0.90, 0.98; P < 0.001). Conclusions Higher consumption of certain vitamins and carotenoids was associated with a significant decreased risk of ARC in cohort studies, but evidence from RCTs is less clear.

scholarly journals Dietary and circulating vitamin C, vitamin E, β-carotene and risk of total cardiovascular mortality: a systematic review and dose–response meta-analysis of prospective observational studies

2019 ◽  
Vol 22 (10) ◽  
pp. 1872-1887 ◽  
Author(s):  
Ahmad Jayedi ◽  
Ali Rashidy-Pour ◽  
Mohammad Parohan ◽  
Mahdieh Sadat Zargar ◽  
Sakineh Shab-Bidar
Keyword(s):  
Systematic Review ◽  
Vitamin E ◽  
Vitamin C ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Dietary Intakes ◽  
Relative Risks ◽  
Β Carotene ◽  
Cvd Mortality

AbstractObjectiveThe present review aimed to quantify the association of dietary intake and circulating concentration of major dietary antioxidants with risk of total CVD mortality.DesignSystematic review and meta-analysis.SettingSystematic search in PubMed and Scopus, up to October 2017.ParticipantsProspective observational studies reporting risk estimates of CVD mortality across three or more categories of dietary intakes and/or circulating concentrations of vitamin C, vitamin E and β-carotene were included. A random-effects meta-analysis was conducted.ResultsA total of fifteen prospective cohort studies and three prospective evaluations within interventional studies (320 548 participants and 16 974 cases) were analysed. The relative risks of CVD mortality for the highest v. the lowest category of antioxidant intakes were as follows: vitamin C, 0·79 (95 % CI 0·68, 0·89; I2=46 %, n 10); vitamin E, 0·91 (95 % CI 0·79, 1·03; I2=51 %, n 8); β-carotene, 0·89 (95 % CI 0·73, 1·05; I2=34 %, n 4). The relative risks for circulating concentrations were: vitamin C, 0·60 (95 % CI 0·42, 0·78; I2=65 %, n 6); α-tocopherol, 0·82 (95 % CI 0·76, 0·88; I2=0 %, n 5); β-carotene, 0·68 (95 % CI 0·52, 0·83; I2=50 %, n 6). Dose–response meta-analyses demonstrated that the circulating biomarkers of antioxidants were more strongly associated with risk of CVD mortality than dietary intakes.ConclusionsThe present meta-analysis demonstrates that higher vitamin C intake and higher circulating concentrations of vitamin C, vitamin E and β-carotene are associated with a lower risk of CVD mortality.

scholarly journals Vitamin E and risk of age-related cataract: a meta-analysis

2015 ◽  
Vol 18 (15) ◽  
pp. 2804-2814 ◽  
Author(s):  
Yufei Zhang ◽  
Wenjie Jiang ◽  
Zhutian Xie ◽  
Wenlong Wu ◽  
Dongfeng Zhang
Keyword(s):  
Vitamin E ◽  
Relative Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Dietary Vitamin ◽  
Cochrane Library ◽  
Response Analysis ◽  
Age Related ◽  
Supplemental Vitamin

AbstractObjectiveWe conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC).DesignThe fixed- or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg’s test. The dose–response relationship was assessed by a restricted cubic spline model.SettingRelevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions.SubjectsStudies involved samples of people of all ages.ResultsDietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95 % CI 0·58, 0·92), 0·86 (95 % CI 0·75, 0·99) and 0·77 (95 % CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0·92; 95 % CI 0·78, 1·07). The findings from dose–response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk=0·94; 95 % CI 0·90, 0·97).ConclusionsThe findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.

scholarly journals Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Fuqiang Chen ◽  
Qingshu Li ◽  
Yang Yu ◽  
Wenrong Yang ◽  
Fei Shi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bladder Cancer ◽  
Vitamin E ◽  
Vitamin C ◽  
Dose Response ◽  
Meta Analysis

scholarly journals The association and dose–response relationship between dietary intake of α-linolenic acid and risk of CHD: a systematic review and meta-analysis of cohort studies

2018 ◽  
Vol 119 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Jingkai Wei ◽  
Ruixue Hou ◽  
Yuzhi Xi ◽  
Alysse Kowalski ◽  
Tiansheng Wang ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Linolenic Acid ◽  
Random Effects ◽  
Dose Response ◽  
Meta Analysis ◽  
Geographic Region ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Chd Risk ◽  
Reduced Risk

AbstractPrevious studies show inconsistent associations between α-linolenic acid (ALA) and risk of CHD. We aimed to examine an aggregate association between ALA intake and risk of CHD, and assess for any dose–response relationship. We searched the PubMed, EMBASE and Web of Science databases for prospective cohort studies examining associations between ALA intake and CHD, including composite CHD and fatal CHD. Data were pooled using random-effects meta-analysis models, comparing the highest category of ALA intake with the lowest across studies. Subgroup analysis was conducted based on study design, geographic region, age and sex. For dose–response analyses, we used two-stage random-effects dose–response models. In all, fourteen studies of thirteen cohorts were identified and included in the meta-analysis. The pooled results showed that higher ALA intake was associated with modest reduced risk of composite CHD (risk ratios (RR)=0·91; 95 % CI 0·85, 0·97) and fatal CHD (RR=0·85; 95 % CI 0·75, 0·96). The analysis showed a J-shaped relationship between ALA intake and relative risk of composite CHD (χ2=21·95, P<0·001). Compared with people without ALA intake, only people with ALA intake <1·4 g/d showed reduced risk of composite CHD. ALA intake was linearly associated with fatal CHD – every 1 g/d increase in ALA intake was associated with a 12 % decrease in fatal CHD risk (95 % CI −0·21, −0·04). Though a higher dietary ALA intake was associated with reduced risk of composite and fatal CHD, the excess composite CHD risk at higher ALA intakes warrants further investigation, especially through randomised controlled trials.

scholarly journals Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications

Nutrients ◽  
2015 ◽  
Vol 7 (11) ◽  
pp. 9309-9324 ◽  
Author(s):  
Na Yu ◽  
Xinming Su ◽  
Zanfeng Wang ◽  
Bing Dai ◽  
Jian Kang
Keyword(s):  
Lung Cancer ◽  
Vitamin A ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Β Carotene

Dietary Vitamin E and β-Carotene Sources Influence Vitamin A and E Storage in Young Rats Fed Marginal and Adequate Vitamin E

1999 ◽  
Vol 34 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Mamie Y. Jenkins ◽  
Geraldine V. Mitchell ◽  
Erich Grundel
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Dietary Vitamin ◽  
Young Rats ◽  
Β Carotene

scholarly journals Trends in dietary intakes of vitamins A, C and E among Japanese men and women from 1974 to 2001

2009 ◽  
Vol 12 (9) ◽  
pp. 1343-1350 ◽  
Author(s):  
Yoshimi Kato ◽  
Satoyo Ikehara ◽  
Koutatsu Maruyama ◽  
Mieko Inagawa ◽  
Miyuki Oshima ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Vitamin C ◽  
Dairy Products ◽  
Public Health Issue ◽  
Dietary Intakes ◽  
Adequate Intake ◽  
Japanese Men ◽  
Men And Women ◽  
Β Carotene

AbstractObjectiveTo investigate long-term trends in dietary intakes of vitamins A, C and E in Japanese adults.DesignTime series by community-based nutrition survey.SettingTwo rural communities (Ikawa and Kyowa) between 1974 and 2001 in Japan.SubjectsA total of 3713 men and 3726 women aged 40–69 years.MethodsDietary intake data were collected by the 24 h dietary recall.ResultsIn Ikawa, mean intake of vitamin A (β-carotene and retinol) increased by 13–40 %; vitamins C and E increased by approximately 23–33 % among men and women from 1974–1977 to 1998–2000. In Kyowa, mean intake of vitamin A, primarily retinol, increased by 13–21 % among men and women; vitamin C from fruits decreased by 16 % among men; and vitamin E increased by 29 % among women from 1982–1986 to 1998–2001. Mean intake of vitamin E in the latest survey period was lower than the Adequate Intake among men and women in both communities. Generally, there were increased intakes of β-carotene and vitamin C from green/yellow and other vegetables; increased retinol intake from fish/shellfish, eggs, milk/dairy products and fats/oils; and increased vitamin E intake from green/yellow and other vegetables, fish/shellfish, eggs, milk/dairy products and fats/oils.ConclusionsMean intakes of the antioxidant vitamins A, C and E increased among middle-aged Japanese men and women between the 1970s and the 1990s except for decreased vitamin C among Kyowa men. The lower mean intake of vitamin E than the Adequate Intake should be considered a potential public health issue for the prevention of CVD.

Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis

2017 ◽  
Vol 29 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Y. Sun ◽  
C. Liu ◽  
Y. Bo ◽  
J. You ◽  
Y. Zhu ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Vitamin C ◽  
Dose Response ◽  
Meta Analysis ◽  
Dietary Vitamin

scholarly journals Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women

2015 ◽  
Vol 102 (5) ◽  
pp. 1167-1175 ◽  
Author(s):  
Sharon G Curhan ◽  
Konstantina M Stankovic ◽  
Roland D Eavey ◽  
Molin Wang ◽  
Meir J Stampfer ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Vitamin E ◽  
Vitamin A ◽  
Vitamin C ◽  
Lower Risk ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Folate Intake ◽  
Health Study ◽  
Β Carotene

ABSTRACT Background: Higher intake of certain vitamins may protect against cochlear damage from vascular compromise and oxidative stress, thereby reducing risk of acquired hearing loss, but data are limited. Objective: We prospectively examined the relation between carotenoids, vitamin A, vitamin C, vitamin E, and folate intake and risk of self-reported hearing loss in women. Design: This prospective cohort study followed 65,521 women in the Nurses’ Health Study II from 1991 to 2009. Baseline and updated information obtained from validated biennial questionnaires was used in Cox proportional hazards regression models to examine independent associations between nutrient intake and self-reported hearing loss. Results: After 1,084,598 person-years of follow-up, 12,789 cases of incident hearing loss were reported. After multivariable adjustment, we observed modest but statistically significant inverse associations between higher intake of β-carotene and β-cryptoxanthin and risk of hearing loss. In comparison with women in the lowest quintile of intake, the multivariable-adjusted RR of hearing loss among women in the highest quintile was 0.88 (95% CI: 0.81, 0.94; P-trend < 0.001) for β-carotene and 0.90 (95% CI: 0.84, 0.96; P-trend < 0.001) for β-cryptoxanthin. In comparison with women with folate intake 200–399 μg/d, very low folate intake (<200 μg/d) was associated with higher risk (RR: 1.19; 95% CI: 1.01, 1.41), and higher intake tended to be associated with lower risk (P-trend = 0.04). No significant associations were observed for intakes of other carotenoids or vitamin A. Higher vitamin C intake was associated with higher risk; in comparison with women with intake <75 mg/d, the RR among women with vitamin C intake ≥1000 mg/d (mainly supplemental) was 1.22 (95% CI: 1.06, 1.42; P-trend = 0.02). There was no significant trend between intake of vitamin E intake and risk. Conclusion: Higher intakes of β-carotene, β-cryptoxanthin, and folate, whether total or from diet, are associated with lower risk of hearing loss, whereas higher vitamin C intake is associated with higher risk.

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