The Influence of Prolactin on the Immune Response to Parasitic Diseases

2018 ◽  
Vol 7 (2) ◽  
pp. 107-114
Author(s):  
Martha Legorreta-Herrera
Author(s):  
Mosab Nouraldein Mohammed Hamad ◽  
Sufian Khalid M. Noor ◽  
Awadalla H. Kashif ◽  
Mohammed Medani Eltayeb ◽  
Bader Saud Alotaibi ◽  
...  

Both malaria and leishmania  are most widespread protozoon parasitic diseases, certainly in tropical countries of the world. Malaria leishmania coinfection is common in leishmaniasis endemic areas which is mostly endemic to malaria too. Researchers notice that in cases of malaria leishmania coinfection , leishmania species find the some extent the outcome of malaria infection , but also behavior of malaria parasite species play a significant role to figure the consequences of it. While L. donovani protect from severe malaria complications by suppression of major histocompatibility class Ⅱ , so it diminish the clinical severity of malaria but not malaria parasite density due to dysfunction of major histocompatibility class I, which controlled by suppressed one, In another side L. mexicana tends to sequester in macrophages and lead to severe clinical outcomes when it coexisted with malaria parasite at same host. Experimental studies required to know more information about coinfection of different malaria and leishmania species to establish clinical research. Leishmania infection excluded when studies aim to assess the immune response to only malaria parasite, experimental studies required involving different species of malaria and leishmania.


The Eye ◽  
2020 ◽  
Vol 22 (3(131)) ◽  
pp. 23-25
Author(s):  
T. A. Sharova

Parasitic diseases of the eye are a widespread and poorly studied problem. This article is intended to systematize the possible mechanisms of infection and to determine the features of the clinical course and treatment of an ocular dirofilariasis. For this purpose, case reports and research data from medical professionals from Europe and Asia are presented. Conclusions were drawn regarding the dependence of the clinical course on the host  – parasite interaction and immune response and that the only applicable method of treatment in all the cases considered was surgical intervention.


2020 ◽  
Vol 7 (1A) ◽  
pp. 298-303
Author(s):  
Reqgi First Trasia

LATAR BELAKANG: Kondisi pandemi, kasus Covid-19 semakin meningkat, manifestasi klinis seperti demam, batuk, diare, muntah, sakit kepala, mialgia dan kelelahan, mungkin sulit untuk membedakan COVID-19 dari spektrum penyakit dengan manifestasi serupa, seperti malaria dan cacingan, terutama di daerah endemik. Di Indonesia belum ada artikel yang membahas Covid-19 dengan koinfeksi malaria dan cacing. TUJUAN: Tujuan penulisan ini adalah menelaah dampak klinis infeksi Covid-19 dengan komorbid infeksi parasit yaitu malaria dan kecacingan. METODE: Penelusuran kepustakaan 154 jurnal, terdapat 4 jurnal yang relevan. DISKUSI: Manifestasi klinis malaria yang parah terjadi karena respon proinflamasi yang meningkat, hal yang sama terjadi dalam banyak kasus COVID-19. Koinfeksi Malaria dan COVID-19 dapat menyebabkan respons pro-inflamasi yang berlebihan, manifestasi klinis lebih parah dan prognosis buruk. Berdasarkan imunopatogenitas dari infeksi cacing di daerah endemis, dikhawatirkan hal tersebut akan meningkatkan keparahan gejala Covid-19 pada pasien dengan koinfeksi cacing. KESIMPULAN: Pada kasus Covid-19 yang diikuti dengan koinfeksi malaria menunjukkan keparahan manifestasi klinis akibat peningkatan respon inflamasi. Diduga bahwa respon imun hospes terhadap cacing akan memberikan dampak klinis yang lebih berat pada kasus Covid-19. Kata kunci: Covid-19, koinfeksi, malaria, cacingan, penyakit parasit   BACKGROUND: The condition of the Covid-19 pandemic where the number of cases is increasing. Clinical manifestations such as fever, cough, diarrhea, vomiting, headache, myalgia and fatigue, it may be difficult to distinguish COVID-19 from the spectrum of diseases with similar manifestations, such as malaria and intestinal worms, especially in endemic areas. Indonesia there are no articles discussing Covid-19 with malaria and worm coinfection. OBJECTIVE: The purpose this article is to review the clinical impact of Covid-19 infection with comorbid parasitic infections, in this case malaria and worms. METHOD: Search the literature of 154 journals, there are 4 journals that are relevant DISCUSSION: The severe manifestations of malaria occur because of an increased proinflammatory response, the same thing happens in many cases of COVID-19. Malaria coinfection and COVID-19 can then cause excessive pro-inflammatory responses, severe manifestations and a poor prognosis. In addition, based on immunopathogenicity from worm infections in endemic areas, it is feared that this will increase the severity of Covid-19 symptoms in patients with worm co-infection. CONCLUSION: In the case of Covid-19 followed by co-infection with malaria, it shows the severity of clinical manifestations due to increased inflammatory response. Tobe assumed that the host's immune response to worms will have a more severe clinical impact in the Covid-19 case. Keywords: Covid-19, coinfection, malaria, intestinal worms, parasitic diseases


1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  

2015 ◽  
Vol 21 ◽  
pp. 93
Author(s):  
Merrell Magelli ◽  
Ronald Swerdloff ◽  
John Amory ◽  
Gregory Flippo ◽  
Wael Salameh ◽  
...  

Author(s):  
Barbara Kronsteiner ◽  
Panjaporn Chaichana ◽  
Manutsanun Sumonwiriya ◽  
Kemajitra Jenjaroen ◽  
Fazle Rabbi Chowdhury ◽  
...  

2004 ◽  
Vol 146 (4) ◽  
pp. 159-172 ◽  
Author(s):  
D. Müller-Doblies ◽  
S. Baumann ◽  
P. Grob ◽  
A. Hülsmeier ◽  
U. Müller-Doblies ◽  
...  

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.


2013 ◽  
Author(s):  
Christopher Gelety ◽  
Lauren Johnson ◽  
Melissa Birkett

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