Image Processing of Conventional Computer Tomography Images for Segmentation of the Human Cochlea

Against the background of increasing numbers of indications for Cochlea implants (CIs), there is an increasing need for a CI outcome prediction tool to assist the process of deciding on the best possible treatment solution for each individual patient prior to intervention. The hearing outcome depends on several features in cochlear structure, the influence of which is not entirely known as yet. In preparation for surgical planning a preoperative CT scan is recorded. The overall goal is the feature extraction and prediction of the hearing outcome only based on this conventional CT data. Therefore, the aim of our research work for this paper is the preprocessing of the conventional CT data and a following segmentation of the human cochlea. The great challenge is the very small size of the cochlea in combination with a fairly bad resolution. For a better distinction between cochlea and surrounding tissue, the data has to be rotated in a way the typical cochlea shape is observable. Afterwards, a segmentation can be performed which enables a feature detection. We can show the effectiveness of our method compared to results in literature which were based on CT data with a much higher resolution. A further study with a much larger amount of data is planned.

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Impact of 4D CT for treatment planning of moving targets: a computer-based biological evaluation

Current Directions in Biomedical Engineering ◽

10.1515/cdbme-2017-0140 ◽

2017 ◽

Vol 3 (2) ◽

pp. 665-668

Author(s):

Eike Helf ◽

Oliver Waletzko ◽

Christian Mehrens ◽

Ralf Rohn ◽

Andreas Block

Keyword(s):

Treatment Plan ◽

Tumour Volume ◽

Target Volume ◽

Biological Evaluation ◽

Internal Target Volume ◽

4D Ct ◽

Tumour Control ◽

Ct Data ◽

Conventional Ct ◽

The Impact

AbstractThis study deals with comparison of conventional and 4D CT (GE Lightspeed) planning on the tumour control probability (TCP), using the TCP model of the AAPM-Report Task Group 166. In the first step a VMAT treatment plan was calculated (Varian Eclipse 13.7) on basis of conventional CT data. This treatment plan was transferred to the complete 4D CT, which represents the tumour volume in motion. Due to the increased volume and the resulting decrease of tumour coverage the TCP went down from 97,6% to 91,2%. After adding an internal target volume (ITV, ICRU 62) to the conventional CT according to our clinical protocols (1,0 cm cc and 0,3 cm axial plane) the TCP increased to 98,0% when applying the conventional plan to the 4D CT. This finding demonstrates the need of 4D CT for moving tumours in chest and abdomen region.Average IPs with increasing width have been created to evaluate the impact on the TCP and the non-malignant tissue. Our observations had shown that heart, lung and spinal cord radiation exposure did not correlate to chosen respiration segment. This could be explained by the extremely slight ratio of the planning target volume and the irradiated normal tissue.This procedure enables us to evaluate the efficacy of treatment plans. Furthermore, optimizing trials like the influence of respiration-gated RT, setting individual margins and fitting planning objectives and parameters are still under investigation.

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Aortic Aneurysm Morphology for Planning Endovascular Aortic Grafts: Limitations of Conventional Imaging Methods

Journal of Endovascular Therapy ◽

10.1177/152660289500200204 ◽

1995 ◽

Vol 2 (2) ◽

pp. 139-148 ◽

Cited By ~ 13

Author(s):

Hugh G. Beebe ◽

Tonya Jackson ◽

John P. Pigott

Keyword(s):

Aortic Aneurysms ◽

Neck Length ◽

Detailed Measurement ◽

Abdominal Aortic ◽

Computed Tomography Scanning ◽

Dimensional Measurements ◽

Aneurysm Morphology ◽

Ct Data ◽

Conventional Ct ◽

Adequate Data

Purpose: To test whether conventional computed tomography scanning (CT) and contrast aortography (CA) provide adequate data for planning endovascular aortic grafting by measuring 33 parameters in patients having both imaging examinations for evaluation of abdominal aortic aneurysms (AAA). Methods: Fifty consecutive patients with AAA (41 men, 9 women; average age 65 years) had CT and CA (mean 26 days between exams). The data collected and analyzed included: 8 sites of diameter, 4 lengths, 6 angles, and 15 other dimensional measurements. Results: Conflicts between CA and CT data were common. Eighteen patients appeared to have a distal cuff by CA but not by CT. Proximal neck length could not be assessed by CT in 5 and had a difference between CA and CT > 1 cm in 25 patients. CA overestimated neck length in 11 patients. Common iliac artery angulation > 60° occurred unilaterally in 27 patients and bilaterally in 5. Seven patients had both iliac aneurysm and > 60° iliac angulation. Thirteen patients had one or more iliac aneurysms (> 2 cm) shown by CT but not by CA. Conclusions: For endovascular graft planning: (1) more detailed measurement is required than for traditional surgery; and (2) conventional CT and CA are complementary imaging studies, but each has important limitations.

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The subtalar and talonavicular joints: a way to access the long-term load intake using conventional CT-data

Surgical and Radiologic Anatomy ◽

10.1007/s00276-013-1205-2 ◽

2013 ◽

Vol 36 (5) ◽

pp. 463-472 ◽

Cited By ~ 4

Author(s):

Fabian Mueller ◽

Sebastian Hoechel ◽

Joerg Klaws ◽

Dieter Wirz ◽

Magdalena Müller-Gerbl

Keyword(s):

Ct Data ◽

Conventional Ct

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Computer-assisted fracture reduction of proximal femur using preoperative CT data and intraoperative fluoroscopic images

International Congress Series ◽

10.1016/j.ics.2004.03.335 ◽

2004 ◽

Vol 1268 ◽

pp. 620-625 ◽

Cited By ~ 8

Author(s):

Y Nakajima ◽

T Tashiro ◽

T Okada ◽

Y Sato ◽

N Sugano ◽

...

Keyword(s):

Proximal Femur ◽

Fracture Reduction ◽

Computer Assisted ◽

Preoperative Ct ◽

Ct Data ◽

Assisted Fracture

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Computed tomography is not necessary to assess rotation of the femoral component in navigation-assisted total knee replacement

Journal of International Medical Research ◽

10.1177/0300060516665258 ◽

2016 ◽

Vol 44 (6) ◽

pp. 1314-1322 ◽

Cited By ~ 1

Author(s):

Daniel Hernández-Vaquero ◽

Alfonso Noriega-Fernandez ◽

Ivan Perez-Coto ◽

Manuel A. Sandoval García ◽

Andres A. Sierra-Pereira ◽

...

Keyword(s):

Computed Tomography ◽

Total Knee Replacement ◽

Femoral Component ◽

Knee Replacement ◽

Transepicondylar Axis ◽

Component Rotation ◽

Preoperative Ct ◽

Total Knee ◽

The Mean ◽

Ct Data

Objective To demonstrate that postoperative computed tomography (CT) is not needed if navigation is used to determine the rotational position of the femoral component during total knee replacement (TKR). Methods Preoperative CT, navigational, and postoperative CT data of 70 TKR procedures were analysed. The correlation between the rotational angulation of the femur measured by CT and that measured by perioperative navigation was examined. The correlation between the femoral component rotation determined by navigation and that determined by CT was also assessed. Results The mean femoral rotation determined by navigation was 2.64° ± 4.34°, while that shown by CT was 6.43° ± 1.65°. Postoperative rotation of the femoral component shown by CT was 3.09° ± 2.71°, which was closely correlated with the angle obtained through the intraoperative transepicondylar axis by navigation (Pearson’s R = 0.930). Conclusions Navigation can be used to collect the preoperative, intraoperative, and postoperative data and final position of the TKR. The rotation of the femoral component can be determined using navigation without the need for CT.

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Robot Guided Sheaths (RoGS) for Percutaneous Access to the Pediatric Kidney: Patient-Specific Design and Preliminary Results

Volume 1: Aerial Vehicles; Aerospace Control; Alternative Energy; Automotive Control Systems; Battery Systems; Beams and Flexible Structures; Biologically-Inspired Control and its Applications; Bio-Medical and Bio-Mechanical Systems; Biomedical Robots and Rehab; Bipeds and Locomotion; Control Design Methods for Adv. Powertrain Systems and Components; Control of Adv. Combustion Engines, Building Energy Systems, Mechanical Systems; Control, Monitoring, and Energy Harvesting of Vibratory Systems ◽

10.1115/dscc2013-3917 ◽

2013 ◽

Cited By ~ 3

Author(s):

Tania K. Morimoto ◽

Michael H. Hsieh ◽

Allison M. Okamura

Keyword(s):

Three Dimensional ◽

The Body ◽

Surrounding Tissue ◽

Patient Specific ◽

Three Dimensional Model ◽

Specific Design ◽

Surgical Access ◽

Minimally Invasive Surgical ◽

Area Of Interest ◽

Ct Data

Robot-guided sheaths consisting of pre-curved tubes and steerable needles are proposed to provide surgical access to locations deep within the body. In comparison to current minimally invasive surgical robotic instruments, these sheaths are thinner, can move along more highly curved paths, and are potentially less expensive. This paper presents the patient-specific design of the pre-curved tube portion of a robot-guided sheath for access to a kidney stone; such a device could be used for delivery of an endoscope to fragment and remove the stone in a pediatric patient. First, feasible two-dimensional paths were determined considering workspace limitations, including avoidance of the ribs and lung, and minimizing collateral damage to surrounding tissue by leveraging the curvatures of the sheaths. Second, building on prior work in concentric-tube robot mechanics, the mechanical interaction of a two-element sheath was modeled and the resulting kinematics was demonstrated to achieve a feasible path in simulation. In addition, as a first step toward three-dimensional planning, patient-specific CT data was used to reconstruct a three-dimensional model of the area of interest.

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Correlation between the extent of pneumatization of Agger agger Nasi nasi cells and the anterior-to-posterior length of the frontal recess: A a computer-assisted anatomical study.

Otolaryngologia Polska ◽

10.5604/01.3001.0010.0132 ◽

2017 ◽

Vol 71 (3) ◽

pp. 43-55

Author(s):

Ahmet Altıntaş ◽

Mustafa Çelik ◽

Yakup Yegin ◽

Sinan Canpolat ◽

Burak Olgun ◽

...

Keyword(s):

Cell Volume ◽

Anatomical Study ◽

Ct Imaging ◽

Sinus Surgery ◽

Computer Assisted ◽

Frontal Recess ◽

Preoperative Ct ◽

The Mean ◽

Ct Data ◽

The Right

Objectives: To explore the correlation between the volume of the aAgger nNasi (AN) cell bulge and the A-P length of the frontal recess (FR). Subjects and methods: In total, 120 patients, who underwent septoplasty, were included. All patients underwent preoperative paranasal sinus computed tomography of the paranasal sinuses (PNS CT) imaging. In total, CT data on of all 120 PNSs patients were analyzed in terms of thewith respect to the extent of pneumatization of the AN cell bulge and the A-P dimensions of the FR. Each side was analyzed separately. Results: We included 120 patients,: 78 (65.0%) females and 42 (35.0 %) males. Their average age was 33.7 ± 11.6 years (range: 18–65 years). The mean volume of the AN cell bulge was 0.26 ± 0.4 mm3 on both the right and left sides. The A-P length of the FR was 7.7 ± 2.2 mm. No significant between-side difference in the mean volume of the AN cell bulge was apparent observed (p=0.906). This volume did not differ significantly by age or sex (p=0.844 and p=0.971, respectively). We found no correlation between the volume of the AN cell bulge and the A-P length of the FR (r = 0.098, p=0.192). Conclusion: In the present study, no correlation between AN cell volume and the A-P length of the FR was found. When studying the anatomical complexity of the FR, it is essential to consider the AN cell volume. We suggest that preoperative CT imaging is critical when endoscopic sinus surgery is planned. However, further studies with larger numbers of patients are needed to explore the relationship between AN cell pneumatization and the anatomy of the FR.

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Synthesis, Spectral and Molecular Characterization of Some Novel 2, 5-Disubstituted-1, 3, 4–Oxadiazole Derivatives and Evaluation of in vivo Antitumour Activity against HT 29 Cell Line

International Journal of Pharmaceutical Sciences and Drug Research ◽

10.25004/ijpsdr.2018.100602 ◽

2018 ◽

Vol 10 (6) ◽

Author(s):

Asish Bhaumik ◽

M. Chinna Eswaraiah ◽

Raja Chakraborty

Keyword(s):

Overall Survival ◽

Cell Line ◽

Antitumour Activity ◽

Research Work ◽

Surrounding Tissue ◽

Control Group ◽

Standard Drug ◽

Oxadiazole Derivatives ◽

Ht 29

Neoplasia is a type of abnormal and excessive growth of tissue. The growth of a neoplasia is uncoordinated with that of the normal surrounding tissue, and it persists growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass. The main objective of the present research work was the synthesis, characterization and evaluation of in vivo antitumour activity of some novel 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives. The in vivo antitumour activity of synthesized compounds was evaluated by HT 29 cell line induced malignant ascites on mouse model. The apoptosis of HT 29 cells was evaluated by using Gimsa and H33342 stain and the apoptosis ratios were analysed by FCM using AnnexinV-FITC/PI staining. The present experimental data displayed that the mortality was less in all groups except in tumour control group and all the synthesized compounds AB1-AB8 (100 mg/kg) significantly increased the PILS. While 5-FU increased the life span of 97.72%, and the PILS of synthesized compounds were found to be 45.45%, 59.09%, 68.18%, 56.81%, 38.63%, 84.09%, 77.27% and 90.90%. So the Synthesized compounds AB1-AB8 at the dose of 100 mg/kg significantly improved the overall survival of all treated animals and 5-FU was not significantly differed from each other in improving the overall survival of HT-29 cells. The apoptosis ratios of synthesized compounds were found as followed: AB1=26%; AB2=37.6%; AB3=43%; AB4=29%; AB5=24.1%; AB6=59.2%; AB7=48.2%; and AB8=63% respectively, while that of the Group-II (T. control) was 6.1%. When compared with standard drug 5-FU: 66.2%, it was indicated that compound AB8>AB6>AB7>AB3 were able to significantly induce HT-29 cells apoptosis.

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COMPUTER-TOMOGRAPHIC TECHNOLOGIES IN THE SURGERY OF ADRENAL GLANDS

Grekov s Bulletin of Surgery ◽

10.24884/0042-4625-2016-175-1-30-36 ◽

2016 ◽

Vol 175 (1) ◽

pp. 30-36 ◽

Cited By ~ 1

Author(s):

N. A. Maistrenko ◽

I. S. Zheleznyak ◽

P. N. Romashchenko ◽

S. G. Blyumina

Keyword(s):

Method Development ◽

Clinical Laboratory ◽

Laboratory Data ◽

Differential Diagnostics ◽

Adrenal Tumors ◽

Adrenocortical Cancer ◽

Tumor Diagnostics ◽

Preoperative Ct ◽

Ct Data ◽

Made In

The reasonability of application computed tomography (CT) in differential diagnostics of adrenal tumors and navigation of rational surgical approach for adrenalectomy was specified by possibilities of method development. The special research of CT possibilities in adrenal tumor diagnostics and substantiation of choice of surgical interference were made in 188 patients. An analysis of clinical-laboratory and instrumental data allowed diagnostics of aldosteroma in 26% patients, corticosteroma in 33,0%, chromaffinoma in 24,5%, adrenocortical cancer in 8,5%, hormonally inactive tumor in 8,0%. Results of morphological investigations of removed adrenal tumors were matched with the preoperative CT data. There was revealed a certain density of tumors. On the basis of this density and clinical-laboratory data, the authors could reliably make a diagnosis the disease before the operation, which is very important in asymptomatic illness course and subclinical manifestations.

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