Work disability and rheumatoid arthritis: Predictive factors

Work ◽  
2021 ◽  
pp. 1-12
Author(s):  
Doxa Papakonstantinou
Keyword(s):  
Rheumatoid Arthritis ◽  
Predictive Factors ◽  
Work Disability ◽  
Journal Articles ◽  
Field Methods ◽  
Medical Progress ◽  
Societal Factors ◽  
Therapy Interventions ◽  
Holistic Research ◽  
Positive Effect

BACKGROUND: Rheumatoid arthritis is often associated with work disability, a term used to describe the inability to be or to remain employed. Work disability is a common implication of rheumatoid arthritis. OBJECTIVE: This review aims to identify and analyze the predictive factors of work disability among patients with rheumatoid arthritis, as well as to group these factors into broader categories, based on the most current studies in this field. METHODS: An electronic search was conducted using Google Scholar, MEDLINE and PsycINFO databases. Eighty-six international journal articles were finally selected. RESULTS: The results suggest that occupational, personal, medical and societal factors are the main predictive categories of work disability for people with rheumatoid arthritis. CONCLUSIONS: Medical progress has had a positive effect on the development and the rates of work disability among patients with RA. Work disability is, however, not only defined by medical factors. Occupational, personal and societal factors interact with each other and affect the development of work disability in RA. The results of this review emphasize the need for medical and vocational therapy interventions, social support and state policies that target the work status of patients with RA. Future holistic research approaches to the field are required for a complete picture and concrete solutions with the aim of keeping patients with RA employed.

scholarly journals AB0144 PREDICTIVE FACTORS OF SUSTAINED CLINICAL REMISSION IN RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1099.2-1099
Author(s):  
R. Fakhfakh ◽  
N. El Amri ◽  
K. Baccouche ◽  
H. Zeglaoui ◽  
E. Bouajina
Keyword(s):  
Rheumatoid Arthritis ◽  
Predictive Factors ◽  
Clinical Remission ◽  
Power Doppler ◽  
Health Assessment ◽  
Sustained Remission ◽  
Sharp Score ◽  
Remission Criteria ◽  
Ultrasound Parameters

Background:Sustained remission (SR) is an ultimate treatment goal in the management of patients with rheumatoid arthritis (RA) (1) and is associated with better RA prognosis, reflected by the quality of life, physical function and radiographic progression (2).Objectives:To investigate the prevalence and predictors of SR in RA patients.Methods:A longitudinal prospective study of patients with RA. At the inclusion, the patients were in remission DAS28 ESR≤ 2.6 for at least 6 months. A B-mode and power doppler (PD) ultrasound of 42 joints and 20 tendons was performed. Synovial hypertrophy (SH) and tenosynovitis in B-mode and PD were defined and scored from 0 to 3 using the OMERACT. The CDAI, SDAI, Boolean remission criteria, the health assessment questionnaire (HAQ) and the radiological Sharp score were calculated. Then, the DAS28 erythrocyte sedimentation rate (ESR) was evaluated at 6 and 12 months. SR was defined as the persistence of a DAS28 ESR≤2.6 at 6 or 12 months without any change in RA therapy during the follow-up. Unstable remission (UR) was defined either as DAS28 ESR > 2.6 at 6 or 12 months or an increase in RA therapy because of a relapse during the follow-up.Results:At baseline, thirty-seven patients were included. At 6 and 12 months, 28 and 24 patients completed follow-up, respectively. In decreasing order, Boolean remission (92.2%), DAS28ESRremission (85.7%), SDAI remission (85%) and CDAI remission (83.3%) achieved SR at 6 months. At 12 months, SR was found in 100% in Boolean remission, 87.5% in SDAI remission, 86.7% in CDAI remission and in 79.7% in DAS28 ESR remission. At 6 months, only the ESR (17mm/1h in SR versus 32 mm/1h in UR, p=0.04) was associated with SR. The disease duration, remission duration, swollen and tender joints, DAS28ESR, HAQ, rheumatoid factor, radiological Sharp score and ultrasound parameters weren’t associated with SR. At 12 months, the squeeze test (15% in SR vs 80% in UR, P=0.01), the ESR (15 mm/1h in SR versus 30 mm/1h in UR, p=0.03), the Boolean remission (61.1% in SR versus 0% in UR, p=0.04) and the DAS28ESR (mean: 1.8 in SR versus 2.5 in UR, P=0.01) were associated with SR. However, no association was found with radiological Sharp score and ultrasound parameters. On multivariate analysis, the ESR (OR=1.13, CI95%=1.01-1.2, p=0.03) and the Squeeze test (OR=21.3, CI95%=1.7-263, p=0.01) were predictors of SR, at 12 months.Conclusion:At 6 and 12 months, 79.7%-85.7% of patients in DAS28 ESR remission achieved sustained remission, respectively. Boolean and DAS28 ESR remission were associated with SR. Unlike DAS28 ESR, Boolean remission seems to reflect more the SR. The squeeze test and the ESR were predictors’ factor. However, the radiological and the ultrasound parameters didn’t show any association.References:[1]Ajeganova S, Huizinga T. Sustained remission in rheumatoid arthritis: latest evidence and clinical considerations. Ther Adv Musculoskelet Dis. 2017;9(10):249-62.[2]Xie W, Li J, Zhang X, Sun X, Zhang Z. Sustained clinical remission of rheumatoid arthritis and its predictive factors in an unselected adult Chinese population from 2009 to 2018. Int J Rheum Dis. 2019;22(9):1670-8.Disclosure of Interests:None declared

scholarly journals Prevalence and predictive factors of difficult-to-treat rheumatoid arthritis: the KURAMA cohort

2021 ◽  
pp. 1-10
Author(s):  
Ryu Watanabe ◽  
Motomu Hashimoto ◽  
Koichi Murata ◽  
Kosaku Murakami ◽  
Masao Tanaka ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Predictive Factors

The effectiveness of constraints-led training on skill development in interceptive sports: A systematic review

2018 ◽  
Vol 14 (2) ◽  
pp. 229-240 ◽  
Author(s):  
Matthew E Clark ◽  
Kayla McEwan ◽  
Candice J Christie
Keyword(s):  
Systematic Review ◽  
Skill Acquisition ◽  
Reporting Quality ◽  
Poor Quality ◽  
Journal Articles ◽  
Quality Assessments ◽  
Positive Effect ◽  
Sporting Performance ◽  
Training Protocol

There has been a recent increase in constraints-led training to assist the development of technical and cognitive skill in sports. While the benefits of constraints-led training appear obvious, the evidence for this type of training is not clear. Therefore, a systematic review of the literature was conducted to establish the effectiveness of this approach to training within interceptive sports. Four databases (Google Scholar, JURN, Mendeley and Science Direct) were searched for journal articles focused on skill acquisition within interceptive sports. A methodological and reporting quality assessment was done to determine the quality of each article. Eighteen articles were selected for review. The results of these two quality assessments revealed poor quality scores for the majority of the studies. However, 77.7% of the studies found a positive effect in skill acquisition following manipulation in training protocol; therefore, the implementation of the constraints-led approach within interceptive sport can be advocated. Key methodological structures were identified as well as aspects of methodology that should be avoided to ensure reliable results for future studies. Further research is required to determine the effectiveness of constraints-led training on interceptive sporting performance.

scholarly journals A 16-week multicenter observational study of the efficiency and safety of rheumatoid arthritis therapy with methotrexate

2018 ◽  
Vol 12 (4) ◽  
pp. 106-111
Author(s):  
R. M. Balabanova
Keyword(s):  
Rheumatoid Arthritis ◽  
Combination Therapy ◽  
Fasting Glucose ◽  
Morning Stiffness ◽  
Hypolipidemic Effect ◽  
Multicenter Observational Study ◽  
High Doses ◽  
Positive Effect ◽  
Good Agreement

Objective: to evaluate the efficiency of combination therapy with methotrexate (MTX) and hydroxychloroquine (HC) in rheumatoid arthritis (RA) in real clinical practice.Patients and methods. The investigation enrolled 430 patients with documented RA who had been followed up for 16 weeks by rheumatologists in different regions of the country. Individual schedules were filled out for the patients, by adding demographic, clinical, and laboratory parameters that made it possible to assess the activity of the disease and to estimate the level of glucose, cholesterol, and low-density lipoproteins (LDL). The results of the investigation were evaluated at the inclusion of patients in it and then at 8 and 16 weeks. Taking into account the insufficient previous effect of MTX, the treatment was enhanced by HC.Results and discussion. By the end of the investigation, the combination therapy with MTX + HC led to significant decreases in the number of swollen and tender joints, the duration of morning stiffness, the severity of pain, and the integrated DAS28 index. The therapy showed a positive effect on the levels of fasting glucose, cholesterol, and LDL. The quality of life improved in patients by Visit 3. The results obtained are in good agreement with the data by foreign and Russian investigators on the greater efficiency of combination therapy with MTX + HC than that of MTX monotherapy and on the pleiotropic (hypolipidemic and hypolipidemic) effect of HC.Conclusion. It is concluded that in Russian practice when monotherapy with MTX shows an insufficient effect or its high doses cannot be administered to enhance the efficacy of RA therapy, it is possible to use a combination of MTX + HC, especially in older patients with comorbidity (hyperglycemia and hypercholesterolemia).

Sign in / Sign up

Export Citation Format

Share Document