scholarly journals ICD-O Tumor Topography Code

2020 ◽  
Author(s):  
Keyword(s):  
Tumor Topography

Letter to the Editor: Craniopharyngiomas in the elderly: the crucial influence of tumor topography on surgical risk assessment

2021 ◽  
Author(s):  
José M. Pascual ◽  
Ruth Prieto
Keyword(s):  
Risk Assessment ◽  
Elderly Patients ◽  
Tumor Tissue ◽  
Significant Proportion ◽  
Wide Band ◽  
The Elderly ◽  
Surgical Risk ◽  
Definition Of ◽  
Weighted Sequences ◽  
Tumor Topography

Classifying CPs within the overly vague, uninformative category “suprasellar” prevents gaining any true insight regarding the risks associated with the surgical procedure employed. Routine MRI obtained with conventional T1- and T2-weighted sequences along the midsagittal and coronal trans-infundibular planes allow an accurate and reliable preoperative definition of CP topography. CPs developing primarily within the infundibulum and/or tuberal region of the hypothalamus, as well as those wholly located within the 3V, should be distinguished preoperatively from those lesions originally expanding beneath the 3V floor (3VF), the true suprasellar tumors. Among adult patients, about 40% of CPs correspond to infundibulo-tuberal tumors expanding primarily within the 3VF, above an intact pituitary gland and stalk. This subgroup of CPs shows strong adherences to the surrounding hypothalamus, as they are embedded within a wide band of reactive gliotic tissue, usually infiltrated by microscopic finger-like solid cords of tumor tissue. In elderly patients, a significant proportion of CPs correspond to papillary tumors developing above an intact 3VF, usually showing small pedicle-like or sessile-like attachments to the infundibulum. With the current diagnostic MRI workup routinely employed for CPs, it is possible, for the majority of lesions, to preoperatively differentiate these topographical variants and predict the type of CP-hypothalamus relationship that will be found during surgery.

Reply to “Tumor Topography for Diagnosis of Prostate Cancer”

2021 ◽  
pp. W1-W1
Author(s):  
Sung Yoon Park ◽  
Nari Shin
Keyword(s):  
Prostate Cancer ◽  
Tumor Topography

Papillary craniopharyngioma: a type of tumor primarily impairing the hypothalamus. A comprehensive anatomo-clinical characterization of 350 well-described cases

2021 ◽  
Author(s):  
Ruth Prieto ◽  
Laura Barrios ◽  
José M. Pascual
Keyword(s):  
High Risk ◽  
Tumor Recurrence ◽  
Psychiatric Symptoms ◽  
Third Ventricle ◽  
Hypothalamic Syndrome ◽  
Psychiatric Disturbances ◽  
Histological Variant ◽  
Major Predictor ◽  
Papillary Type ◽  
Tumor Topography

Objective: Papillary craniopharyngiomas (PCPs) represent a rare histological variant of craniopharyngiomas (CPs) usually involving the hypothalamus. This study systematically analyzes the clinical-anatomical correlation between tumor topography and symptoms related to hypothalamic dysfunction in the largest series of PCPs ever gathered. Methods: From 5,346 CP reports published from 1856 to 2021, we selected 350 well-described cases of the squamous-papillary type. Clinical presentation, tumor topography, severity of hypothalamic adhesion, patient outcome and tumor recurrence were thoroughly analyzed. Results: PCPs predominantly occur in adult (96.3%), male (61.7%) patients presenting with headache (63.4%), visual alterations (56.2%) and psychiatric disturbances (50.4%). Most PCPs are solid (50%), round (50%) lesions that occupy the third ventricle (3V, 94.8%) and show low-risk severity adhesions to the hypothalamus (66.8%). Two major topographical categories can be found: strictly 3V (57.5%), growing above an intact 3V floor (3VF) and not-strictly or infundibulo-tuberal (32.9%), expanding at the infundibulum and/or tuber cinereum. The hypothalamic syndrome predominated among strictly 3V PCPs (p<0.001). Psychiatric symptoms (p<0.001) and high-risk hypothalamic attachments (p=0.031) related to unfavorable postoperative outcomes among patients treated from 2006 onwards. The not-strictly 3V topography was identified as the major predictor of high-risk hypothalamic attachments (71.2% correctly predicted), which, along with incomplete tumor removal (p=0.018), underlies the higher tumor recurrence of this topography (p=0.001). Conclusions: This systematic review evidences that PCP topography is a major determinant of hypothalamic-related symptoms, type of hypothalamic attachments and tumor recurrence rate. Accurate preoperative definition of PCP-hypothalamus relationships is essential for the judicious, safe management of these complex lesions.

scholarly journals The Lung Adenocarcinoma Microenvironment Mining and Its Prognostic Merit

2020 ◽  
Vol 19 ◽  
pp. 153303382097754
Author(s):  
Rongchang Zhao ◽  
Dan Ding ◽  
Wenyan Yu ◽  
Chunrong Zhu ◽  
Yan Ding
Keyword(s):  
Lung Adenocarcinoma ◽  
Cox Regression ◽  
Clinicopathological Characteristics ◽  
Survival Prognosis ◽  
Kaplan Meier ◽  
Relationship Of ◽  
Immune Score ◽  
The Relationship ◽  
Kaplan Meier Plotter ◽  
Tumor Topography

Background: As a common pathological type of lung cancer, lung adenocarcinoma (LUAD) is mainly treated by surgery, chemotherapy, targeted therapy and radiotherapy. Although a relatively mature treatment system has been established, there are few studies on the microenvironment of LUAD. Material and Methods: The immune and stromal scores of patients from the LUAD cohort in the TCGA database were obtained by using ESTIMATE. The relationship of immune and stromal scores with the clinicopathological characteristics and overall survival of LUAD patients was assessed by R. GO, KEGG and Cox regression analyses were employed to analyze intersecting genes and to identify reliable prognostic markers. The identified genes were also analyzed in the GEPIA database to assess their correlations with survival, and these relationships were verified with the Kaplan-Meier Plotter database. Results: The immune score was related to the survival time and tumor topography of LUAD patients. There was a significant correlation between stromal score and tumor metastasis. Through multivariate analysis, stage (HR = 1.640, 95% CI = 1.019-2.642, P = 0.042) and risk score (HR = 1.036, 95% CI = 1.026-1.046, P < 0.001). The genes (ARHGAP15, BTLA, CASS4, CLECL1, FAM129C, STAP1, TESPA1, and S100P) showed credible prognostic value in LUAD patients in TCGA through GEPIA database online analysis and verification in the Kaplan-Meier plotter database. Conclusions: In the microenvironment of lung adenocarcinoma, the differentially expressed genes screened by immune score and stromal score have certain value in evaluating the survival/prognosis of patients, as well as the invasion and progression of tumors.

scholarly journals Initial Evaluation of Computer-Assisted Radiologic Assessment for Renal Mass Edge Detection as an Indication of Tumor Roughness to Predict Renal Cancer Subtypes

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Rahul Rajendran ◽  
Kevan Iffrig ◽  
Deepak K Pruthi ◽  
Allison Wheeler ◽  
Brian Neuman ◽  
...  
Keyword(s):  
Tumor Size ◽  
Renal Mass ◽  
Linear Regression Analysis ◽  
Benign Tumors ◽  
Computer Assisted ◽  
Renal Masses ◽  
Cancer Subtypes ◽  
Topographic Features ◽  
Develop Software ◽  
Tumor Topography

Objective. To develop software to assess the potential aggressiveness of an incidentally detected renal mass using images. Methods. Thirty randomly selected patients who underwent nephrectomy for renal cell carcinoma (RCC) had their images independently reviewed by engineers. Tumor “Roughness” was based on image algorithm of tumor topographic features visualized on computed tomography (CT) scans. Univariant and multivariant statistical analyses are utilized for analysis. Results. We investigated 30 subjects that underwent partial or radical nephrectomy. After excluding poor image-rendered images, 27 patients remained (benign cyst = 1, oncocytoma = 2, clear cell RCC = 15, papillary RCC = 7, and chromophobe RCC = 2). The mean roughness score for each mass is 1.18, 1.16, 1.27, 1.52, and 1.56 units, respectively (p<0.004). Renal masses were correlated with tumor roughness (Pearson’s, p=0.02). However, tumor size itself was larger in benign tumors (p=0.1). Linear regression analysis noted that the roughness score is the most influential on the model with all other demographics being equal including tumor size (p=0.003). Conclusion. Using basic CT imaging software, tumor topography (“roughness”) can be quantified and correlated with histologies such as RCC subtype and could lead to determining aggressiveness of small renal masses.

scholarly journals Craniopharyngioma recurrence: the impact of tumor topography

2016 ◽  
Vol 125 (4) ◽  
pp. 1043-1049 ◽  
Author(s):  
Ruth Prieto ◽  
Inés Castro-Dufourny ◽  
Rodrigo Carrasco ◽  
Laura Barrios ◽  
José María Pascual
Keyword(s):  
The Impact ◽  
Tumor Topography

Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol

2009 ◽  
Vol 27 (6) ◽  
pp. 557-564 ◽  
Author(s):  
Clovis O. Da Fonseca ◽  
Julio Thome Silva ◽  
Igor Rodrigo Lins ◽  
Marcela Simão ◽  
Adriano Arnobio ◽  
...  
Keyword(s):  
Intranasal Administration ◽  
Therapeutic Response ◽  
Malignant Gliomas ◽  
Perillyl Alcohol ◽  
Peritumoral Edema ◽  
Tumor Topography

scholarly journals Identification of the Extradural and Intradural Extension of Pituitary Adenomas to the Suprasellar Region: Classification, Surgical Strategies, and Outcomes

2021 ◽  
Vol 11 ◽  
Author(s):  
YouQing Yang ◽  
YouYuan Bao ◽  
ShenHao Xie ◽  
Bin Tang ◽  
Xiao Wu ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Cerebrospinal Fluid Leakage ◽  
Bilayer Structure ◽  
Total Removal ◽  
Surgical Strategies ◽  
Suprasellar Region ◽  
Different Types ◽  
Neurovascular Structures ◽  
Tumor Topography ◽  
Suprasellar Extension

ObjectiveSuprasellar pituitary adenomas (PAs) can be located in either extradural or intradural spaces, which impacts surgical strategies and outcomes. This study determined how to distinguish these two different types of PAs and analyzed their corresponding surgical strategies and outcomes.MethodsWe retrospectively analyzed 389 patients who underwent surgery for PAs with suprasellar extension between 2016 to 2020 at our center. PAs were classified into two main grades according to tumor topography and their relationships to the diaphragm sellae (DS) and DS-attached residual pituitary gland (PG). Grade 1 tumors were located extradurally and further divided into grades 1a and 1b, while grade 2 tumors were located intradurally.ResultsOf 389 PAs, 292 (75.1%) were surrounded by a bilayer structure formed by the DS and the residual PG and classified as grade 1a, 63 (16.2%) had lobulated or daughter tumors resulting from the thinning or absence of the residual PG and subsequently rendering the bilayer weaker were classified as Grade 1b, and the remaining 34 (8.7%) PAs that broke through the DS or traversed the diaphragmic opening and encased suprasellar neurovascular structures were classified as Grade 2. We found that the gross total removal of the suprasellar part of grade 1a, 1b, and 2 PAs decreased with grading (88.4%, 71.4%, and 61.8%, respectively). The rate of major operative complications, including cerebrospinal fluid leakage, hemorrhage, and death, increased with grading.ConclusionsIt is essential to identify whether PAs with suprasellar extension are located extradurally or intradurally, which depends on whether the bilayer structure is intact. PAs with an intact bilayer structure were classified as grade 1. These were extradural and usually had good surgical outcomes and lower complications. PAs with no bilayer structure surrounding them were classified as grade 2. These were intradural, connected to the cranial cavity, and had increased surgical complications and a lower rate of gross total removal. Different surgical strategies should be adopted for extradural and intradural PAs.

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