scholarly journals Apolipoprotein B100 Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Apolipoprotein B100

Lp(a): der akzeptierte unabhängige Risikofaktor

2019 ◽  
Vol 23 (09) ◽  
pp. 388-391
Author(s):  
Volker Schettler
Keyword(s):  
Lipoprotein A ◽  
Apolipoprotein A ◽  
Apolipoprotein B100

Lipoprotein(a) (Lp(a)) besteht aus einem LDL-Partikel, an dem über das Apolipoprotein B100 des Partikels eine Disulfidbrücke zu einem Apolipoprotein(a) besteht ( Abb. 1 ). Obwohl Lp(a) bereits 1963 von Berg et al. erstmals als „lipoprotein associated antigen“ entdeckt 1 und schon früh ein Zusammenhang mit kardiovaskulären Ereignissen diskutiert wurde 2, konnten diese Annahmen der klinischen Eigenschaften erst deutlich später im Rahmen von epidemiologischen Evaluationen bestätigt werden 3, 4. Ab einer Lp(a)-Konzentration von über 30 mg/dl (> 75 nmol/l) besteht ein nahezu linearer Zusammenhang zwischen dem Anstieg der Lp(a)-Konzentration und kardiovaskulären Ereignissen wie Myokardinfarkt und das Risiko für eine Aortenklappenstenose 3, 4.

scholarly journals An expression system for human apolipoprotein B100 in a rat hepatoma cell line.

1990 ◽  
Vol 265 (15) ◽  
pp. 8358-8360 ◽  
Author(s):  
B D Blackhart ◽  
Z M Yao ◽  
B J McCarthy
Keyword(s):  
Cell Line ◽  
Hepatoma Cell ◽  
Expression System ◽  
Hepatoma Cell Line ◽  
Human Apolipoprotein ◽  
Apolipoprotein B100 ◽  
Rat Hepatoma Cell Line ◽  
Rat Hepatoma

scholarly journals Carboxyl-terminal truncation impairs lipid recruitment by apolipoprotein B100 but does not affect secretion of the truncated apolipoprotein B-containing lipoproteins.

1994 ◽  
Vol 269 (4) ◽  
pp. 2852-2862 ◽  
Author(s):  
R.S. McLeod ◽  
Y. Zhao ◽  
S.L. Selby ◽  
J. Westerlund ◽  
Z. Yao
Keyword(s):  
Apolipoprotein B ◽  
Apolipoprotein B100 ◽  
Carboxyl Terminal

Abstract 3481: A Prospective Comparison of NMR-Measured LDL Particle Number, Apolipoprotein B100, and Standard Lipids with Incident CHD in 27,673 Initially Healthy Women

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Samia Mora ◽  
James Otvos ◽  
Julie E Buring ◽  
Nader Rifai ◽  
Paul M Ridker
Keyword(s):  
Prospective Cohort ◽  
Large Scale ◽  
Particle Number ◽  
Proton Nuclear Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
Healthy Women ◽  
Prospective Comparison ◽  
Chd Risk ◽  
Hazard Ratios ◽  
Apolipoprotein B100

Background While ATP-III recommends measurement of total and HDL cholesterol (HDL-C) as part of coronary risk assessment, measurement of LDL particle number (LDL-P) is not currently recommended. Methods and Results In a prospective cohort of 27,673 initially healthy women, baseline LDL-P was measured by proton nuclear magnetic resonance spectroscopy, apolipoprotein B100 (ApoB) was measured using an immunoturbidimetric assay, and standard lipids were directly measured. LDL-P correlated with LDL cholesterol (LDL-C; r=0.62), ApoB (0.84), non HDL-C (0.74), and total:HDL-C ratio (0.80). During a mean follow-up of 11 years, 668 incident coronary heart disease (CHD) events occurred. Using the lowest quintile as the reference, and adjusting for age, smoking, blood pressure, diabetes, menopause, hormone use, and body mass index, the association of LDL-P with CHD was stronger than LDL-C (Table ), and comparable in magnitude to ApoB, non HDL-C and total:HDL-C ratio. In a subgroup analysis of women with LDL-C<100 mg/dL, elevations in LDL-P, ApoB, non HDL-C, or total:HDL-C ratio were all separately associated with higher CHD risk (P<0.001 for all). Both LDL-P and ApoB remained associated with CHD after additionally adjusting for total cholesterol, HDL-C, and triglycerides (hazard ratios for top vs bottom quintile: 2.03 [95% CI 1.27–3.24] for LDL-P, and 3.08 [95% CI 1.92– 4.93] for ApoB) overall, and similarly in women with LDL-C<100 mg/dL (2.77 [95%CI 1.05–7.29] for LDL-P and 2.62 [95%CI 0.97–7.05] for ApoB). Conclusions In this large-scale prospective cohort, elevations in NMR-measured LDL particle number were significantly associated with incident CHD, with a magnitude of risk not substantially different from ApoB, non HDL-C, or total:HDL-C ratio. Among women with LDL-C <100mg/dL, elevations in LDL-P, ApoB, non HDL-C, and total:HDL-C ratio all carried higher CHD risk. Risk Factor-Adjusted Hazard Ratios for Incident CHD

A Prospective Comparison of NMR-Measured LDL Particle Number, Apolipoprotein B100, and Standard Lipids with Incident CHD in 27,673 Initially Healthy Women

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Samia Mora
Keyword(s):  
Particle Number ◽  
Healthy Women ◽  
Prospective Comparison ◽  
Apolipoprotein B100

Abstract 3481 Samia Mora, Brigham And Womens Hosp, Boston, MA; James Otvos, LipoScience, Inc., Raleigh, NC; Julie E Buring, Brigham And Women’s Hospital, Boston, MA; Nader Rifai, Boston Children’s Hosp, Boston, MA; Paul M Ridker, Brigham And Women’s Hospital, Boston, MA Samia Mora, 2007 Finalist and Presenting Author

scholarly journals Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100

2018 ◽  
Vol 122 (4) ◽  
pp. 568-582 ◽  
Author(s):  
Jaume Amengual ◽  
Liang Guo ◽  
Alanna Strong ◽  
Julio Madrigal-Matute ◽  
Haizhen Wang ◽  
...  
Keyword(s):  
Apolipoprotein B100

Effect of Atorvastatin on Apolipoprotein B100 Containing Lipoprotein Metabolism in Type-2 Diabetes

2003 ◽  
Vol 306 (1) ◽  
pp. 332-337 ◽  
Author(s):  
Khadija Ouguerram ◽  
Thierry Magot ◽  
Yassine Zäir ◽  
J. S. Marchini ◽  
Bernard Charbonnel ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipoprotein Metabolism ◽  
Apolipoprotein B100

Differential Effects of Estrogen and Progestin on Apolipoprotein B100 and B48 Kinetics in Postmenopausal Women

Lipids ◽  
2018 ◽  
Vol 53 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Stefania Lamon-Fava ◽  
Margaret R. Diffenderfer ◽  
P. Hugh R. Barrett ◽  
Wing Yee Wan ◽  
Borbala Postfai ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Differential Effects ◽  
Apolipoprotein B100
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