scholarly journals THE EFFECT OF IRON DEFICIENCY ANEMIA ON GLYCATED HEMOGLOBIN (HBA1C) IN NON DIABETIC ADULTS

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Dr. Suman Choudhary ◽  
Dr. Sukh Dev Choudhary ◽  
Dr. Himanshi Choudhary ◽  
Dr. Ronak Gandhi
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Uncontrolled Diabetes ◽  
Iron Deficient ◽  
Healthy Control ◽  
Sugar Levels ◽  
Hba1c Levels

Background: Iron deficiency anemia is the most common form of anemia in India. Hemoglobin A1c (HbA1c) is used in diabetic patients as an index of glycemic control reflecting glucose levels of the previous 3 months. Like blood sugar levels, HbA1c levels are also affected by the presence of variant hemoglobins, hemolytic anemias, nutritional anemias, uremia, pregnancy, and acute blood loss. Previous studies suggest that iron deficiency anemia (IDA) affects the levels of HbA1c. Methods: A prospective observational study on 50 iron deficiency patient cases and 50 healthy control. Exclusion and inclusion criteria were used to recruit cases from the wards and OPDs of the hospital. Appropriate descriptive statistics was used to analyse the data. Results: The HbA1C was significantly higher in the iron deficiency patients as compare to the control (5.88 ± 0.41 vs 5.03 ± 0.17, respectively, P < .05). Conclusion: Our results showed that iron deficiency was associated with higher proportions of HbA1c, which could cause problems in the diagnosis of uncontrolled diabetes mellitus in iron-deficient patients. Keywords: Non-Diabetic Patient, Glycosylated Haemoglobin, Iron Deficiency Anaemia.

scholarly journals Effect of Iron Deficiency Anemia on HbA1c in Non-Diabetics

2020 ◽  
Vol 4 (1) ◽  
pp. 10-16
Author(s):  
R.K. Bansal ◽  
Y.R. Yadav ◽  
H.S. Kulkarni ◽  
Sonam ◽  
S. Garg ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Hba1c Level ◽  
Deficiency Anemia ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Diabetic Patients ◽  
Iron Deficient ◽  
Hba1c Levels

Background: Glycated hemoglobin A1c is a well-known indicator of glycemic control in diabetes patients. It comprises of 5% of total hemoglobin in non-diabetic patients as well. Iron Deficiency Anemia is most common cause of anemia, especially in this part of the world. So, we study the effects of Iron deficiency Anemia on HbA1c levels in non-diabetic adults to determine whether the HbA1c levels increase if any. Methods: A 100 non-diabetic adult patients with Iron Deficiency anemia admitted in various medicine wards and attending OPDs of J.L.N. Medical College and 100 healthy controls were enrolled after fulfilled inclusion and exclusion criteria. Detailed history of clinical examination and biochemical examination was performed including HbA1c. Results: Mean HbA1c level is more in iron deficient Anemic non-diabetic patients in comparison to non-Anemic non-diabetic patients. Mean HbA1c is 5.01 ± 0.41 in control group. While mean HbA1c level in case group is 6.11 ± 0.42. The difference is statistically significant (p value <.001). Conclusion: Iron deficiency Anemia is independent factor affecting HbA1c level in non diabetic patients & it should be interpreted carefully in all iron deficient anemic patients.  

scholarly journals Association between iron deficiency anemia and HBA1C level in diabetic patients with controlled plasma glucose levels.

2020 ◽  
Vol 27 (09) ◽  
pp. 1849-1854
Author(s):  
Muhammad Danish Qureshi ◽  
Saman Waqar ◽  
Muhammad Ihtesham Khan ◽  
Lubna Naseem
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Plasma Glucose ◽  
Hba1c Level ◽  
Deficiency Anemia ◽  
Diabetic Patients ◽  
Care Providers ◽  
Female Ratio ◽  
Iron Deficient ◽  
Study Population

Objectives: To determine association of iron deficiency anemia on hba1c level in diabetic patients. Study Design: Cross Sectional Analytical study. Setting: Department of Pathology PIMS Hospital. Period: From June 2018 to December 2018 (6 months duration). Material & Methods: A total of 117 diagnosed cases of diabetes mellitus were included in the study. Pregnant women, patients with end-stage renal disease, hypothyroidism, +hemoglobinopathies, hemolytic anemia, chronic liver disease and malignancy, participants with poorly controlled diabetes, and patient from the northern areas were excluded from the study. Patients were divided according to their fasting plasma glucose (FPG) level. FPG of 126mg/dl was used as a cut-off point for dividing the study population into two groups, i.e controlled sugar level (FPG between 100 and 126 mg/d L) and well controlled sugar level (FPG less than 100 mg/d L). Variables such as Hemoglobin, serum ferritin, serum Hba1c level etc. Results: Mean age of study population in the present study was 56.97±7.29 years. Out of 117 cases, about 45(38.5%) cases were female and 72 (38.5%) were male. Male to female ratio was 1: 1.6.Mean FPG level was 103.3±7.6 in our study population. The mean hba1c levels in the sample was 6.42±0.70 %. Mean Hb levels were recorded as 11.5±2.7 and 10.9±3.03 g/dl, respectively in female and male. From a total of 117 cases, only 66 were identified as having iron deficiency anemia. Only 54 patients had plasma glucose greater than 100 mg/dl. Odds ratio for hba1c>6.5% in iron deficient was 3.90(p=0.001). Conclusion: Iron deficiency can cause elevated serum hba1c level. Health care providers, including physicians, must consider the iron status before prescribing diabetics treatment on the basis of serum hba1c level.

scholarly journals STATUS OF HbA1c;

2012 ◽  
Vol 20 (01) ◽  
pp. 054-059
Author(s):  
NUDRAT ANWAR ZUBERI ◽  
NAVEED AHSAN ◽  
ALIYA JAFRI ◽  
Tehseen Iqbal ◽  
Tahira Parveen
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Iron Status ◽  
Tertiary Care ◽  
Deficiency Anemia ◽  
Diabetic Patients ◽  
Iron Deficient

Background: Glycated hemoglobin [HbA1c] is a marker to identify the average plasma glucose level over past threemonths but it is also influenced by the iron deficiency status of an individual. Objective: Research is designed to assess the relationshipbetween HbA1c concentration and iron status among diabetic and non diabetic subjects. Design: Cross sectional comparative study.Setting: Tertiary Care Unit of Karachi, Pakistan. Period: Dec 2010 till June 2011. Material and methods: A total of 75 subjects of bothsexes were taken and divided into three groups. Fasting and random glucose levels, serum iron and TIBC were performed by enzymaticmethod while HbA1c was estimated by fast iron resin separation method and Complete blood count (CBC ) was done by Coulter.Statistical analysis: The data feeding and analysis was on computer package SPSS (Statistical Packages of Social Sciences) version16.0. the results were given in the mean and Standard Deviation (SD) and correlation ( r ) for quantitative data i.e. age, FBS, RBS, HbA1c,Serum Iron , Hb HCT, and TIBC. Using Analysis of Variance (ANOVA) with tukey test for comparison (Controls, Iron deficiency anemia withand without diabetes mellitus). In all statistical analysis only p < 0.01 will be considered significant. Results: HbA1c is a non-specificmarker of Diabetes mellitus in iron deficieny anemia patients. Thus it is reccomended that iron status of diabetic patients must beconsidered while interpreting results. This study showed significantly raised levels of Fasting blood glucose (FBS), random blood glucose(RBS) and HbA1c in diabetic anemic patients when compared to control and nondiabetic anemic subjects (p < 0.01) while total ironbinding capacity (TIBC) and HbA1c in nondiabetic anemic subjects were also significantly raised when compared to control (p < 0.01).Hemoglobin (Hb) , Hematocrit (HCT) and Serum Iron levels were significantly decreased in diabetic and nondiabetic anemic subjectswhen compared to control (p < 0.01). Conclusions: Our study depicted that while diagnosing Diabetes mellitus in iron deficient patientsone should be carefull as HbA1c is not a very reliable parameter to assess glycemic control in iron deficiency anemia patients.

scholarly journals Iron supplementation in goitrous, iron-deficient children improves their response to oral iodized oil

2000 ◽  
pp. 217-223 ◽  
Author(s):  
M Zimmermann ◽  
P Adou ◽  
T Torresani ◽  
C Zeder ◽  
R Hurrell
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Thyroid Volume ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Urinary Iodine Concentration ◽  
Iodized Oil ◽  
Iron Deficient ◽  
Group 2

OBJECTIVE: In developing countries, many children are at high risk for both goiter and iron-deficiency anemia. Because iron deficiency may impair thyroid metabolism, the aim of this study was to determine if iron supplementation improves the response to oral iodine in goitrous, iron-deficient anemic children. DESIGN: A trial of oral iodized oil followed by oral iron supplementation in an area of endemic goiter in the western Ivory Coast. METHODS: Goitrous, iodine-deficient children (aged 6-12 years; n=109) were divided into two groups: Group 1 consisted of goitrous children who were not anemic; Group 2 consisted of goitrous children who were iron-deficient anemic. Both groups were given 200mg oral iodine as iodized oil. Thyroid gland volume using ultrasound, urinary iodine concentration (UI), serum thyroxine (T(4)) and whole blood TSH were measured at baseline, and at 1, 5, 10, 15 and 30 weeks post intervention. Beginning at 30 weeks, the anemic group was given 60mg oral iron as ferrous sulfate four times/week for 12 weeks. At 50 and 65 weeks after oral iodine (8 and 23 weeks after completing iron supplementation), UI, TSH, T(4) and thyroid volume were remeasured. RESULTS: The prevalence of goiter at 30 weeks after oral iodine in Groups 1 and 2 was 12% and 64% respectively. Mean percent change in thyroid volume compared with baseline at 30 weeks in Groups 1 and 2 was -45.1% and -21.8% respectively (P<0.001 between groups). After iron supplementation in Group 2, there was a further decrease in mean thyroid volume from baseline in the anemic children (-34.8% and -38.4% at 50 and 65 weeks) and goiter prevalence fell to 31% and 20% at 50 and 65 weeks. CONCLUSION: Iron supplementation may improve the efficacy of oral iodized oil in goitrous children with iron-deficiency anemia.

scholarly journals Effects of Iron Deficiency Anemia and Its Rapid Correction on the Serum Metabolomic Profile of Rhesus Infants

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1070-1070
Author(s):  
Brian Sandri ◽  
Gabriele Lubach ◽  
Eric Lock ◽  
Michael Georgieff ◽  
Pamela Kling ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Acid Production ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Iron Dextran ◽  
Metabolomic Profile ◽  
Intramuscular Injections ◽  
Iron Deficient ◽  
Rapid Correction

Abstract Objectives To determine whether rapid correction of iron deficiency using intramuscular iron dextran normalizes serum metabolomic changes in a nonhuman primate model of iron deficiency anemia (IDA). Methods Blood was collected from naturally iron-sufficient (IS; n = 10) and IDA (n = 12) male and female infant rhesus monkeys (Macaca mulatta) at 6 months of age. IDA infants were treated with intramuscular injections of iron dextran, 10 mg/weekly for 4–8 weeks. Iron status was reevaluated following treatment using hematological measurements and sera were metabolically profiled using HPLC/MS with isobaric standards for identification and quantification. Results Early-life iron deficiency anemia negatively affects many cellular metabolic processes, including energy production, electron transport, and oxidative degradation of toxins. Slow iron repletion with dietary supplementation restores iron deficient monkeys from a hematological perspective, but the serum metabolomic profile remains differed from monkeys that had been iron sufficient their entire life. Whether rapid iron restoration through intramuscular injections of iron dextran normalizes serum metabolomic profile is not known. A total of 654 metabolites were measured with differences in 53 metabolites identified between IS and IDA monkeys at 6 months (P 0.05). Pathway analyses provided evidence of altered liver function, hypometabolic state, differential essential fatty acid production, irregular inosine and guanosine metabolism, and atypical bile acid production in IDA infants. After treatment, iron-related hematological parameters had recovered, but the formerly IDA infants remained metabolically distinct from the IS infants, with 225 metabolites differentially expressed between the groups. Conclusions As with slow iron repletion, rapid iron repletion does not normalize the altered serum metabolomic profile in rhesus infants with IDA, suggesting the need for iron supplementation in the pre-anemic stage. Funding Sources National Institutes of Health.

scholarly journals Eye-Blinking Rates Are Slower in Infants with Iron-Deficiency Anemia than in Nonanemic Iron-Deficient or Iron-Sufficient Infants

2010 ◽  
Vol 140 (5) ◽  
pp. 1057-1061 ◽  
Author(s):  
Betsy Lozoff ◽  
Rinat Armony-Sivan ◽  
Niko Kaciroti ◽  
Yuezhou Jing ◽  
Mari Golub ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Iron Deficient
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