scholarly journals STATUS OF HbA1c;

2012 ◽  
Vol 20 (01) ◽  
pp. 054-059
Author(s):  
NUDRAT ANWAR ZUBERI ◽  
NAVEED AHSAN ◽  
ALIYA JAFRI ◽  
Tehseen Iqbal ◽  
Tahira Parveen
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Iron Status ◽  
Tertiary Care ◽  
Deficiency Anemia ◽  
Diabetic Patients ◽  
Iron Deficient

Background: Glycated hemoglobin [HbA1c] is a marker to identify the average plasma glucose level over past threemonths but it is also influenced by the iron deficiency status of an individual. Objective: Research is designed to assess the relationshipbetween HbA1c concentration and iron status among diabetic and non diabetic subjects. Design: Cross sectional comparative study.Setting: Tertiary Care Unit of Karachi, Pakistan. Period: Dec 2010 till June 2011. Material and methods: A total of 75 subjects of bothsexes were taken and divided into three groups. Fasting and random glucose levels, serum iron and TIBC were performed by enzymaticmethod while HbA1c was estimated by fast iron resin separation method and Complete blood count (CBC ) was done by Coulter.Statistical analysis: The data feeding and analysis was on computer package SPSS (Statistical Packages of Social Sciences) version16.0. the results were given in the mean and Standard Deviation (SD) and correlation ( r ) for quantitative data i.e. age, FBS, RBS, HbA1c,Serum Iron , Hb HCT, and TIBC. Using Analysis of Variance (ANOVA) with tukey test for comparison (Controls, Iron deficiency anemia withand without diabetes mellitus). In all statistical analysis only p < 0.01 will be considered significant. Results: HbA1c is a non-specificmarker of Diabetes mellitus in iron deficieny anemia patients. Thus it is reccomended that iron status of diabetic patients must beconsidered while interpreting results. This study showed significantly raised levels of Fasting blood glucose (FBS), random blood glucose(RBS) and HbA1c in diabetic anemic patients when compared to control and nondiabetic anemic subjects (p < 0.01) while total ironbinding capacity (TIBC) and HbA1c in nondiabetic anemic subjects were also significantly raised when compared to control (p < 0.01).Hemoglobin (Hb) , Hematocrit (HCT) and Serum Iron levels were significantly decreased in diabetic and nondiabetic anemic subjectswhen compared to control (p < 0.01). Conclusions: Our study depicted that while diagnosing Diabetes mellitus in iron deficient patientsone should be carefull as HbA1c is not a very reliable parameter to assess glycemic control in iron deficiency anemia patients.

scholarly journals Effects of Iron Deficiency Anemia and Its Rapid Correction on the Serum Metabolomic Profile of Rhesus Infants

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1070-1070
Author(s):  
Brian Sandri ◽  
Gabriele Lubach ◽  
Eric Lock ◽  
Michael Georgieff ◽  
Pamela Kling ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Acid Production ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Iron Dextran ◽  
Metabolomic Profile ◽  
Intramuscular Injections ◽  
Iron Deficient ◽  
Rapid Correction

Abstract Objectives To determine whether rapid correction of iron deficiency using intramuscular iron dextran normalizes serum metabolomic changes in a nonhuman primate model of iron deficiency anemia (IDA). Methods Blood was collected from naturally iron-sufficient (IS; n = 10) and IDA (n = 12) male and female infant rhesus monkeys (Macaca mulatta) at 6 months of age. IDA infants were treated with intramuscular injections of iron dextran, 10 mg/weekly for 4–8 weeks. Iron status was reevaluated following treatment using hematological measurements and sera were metabolically profiled using HPLC/MS with isobaric standards for identification and quantification. Results Early-life iron deficiency anemia negatively affects many cellular metabolic processes, including energy production, electron transport, and oxidative degradation of toxins. Slow iron repletion with dietary supplementation restores iron deficient monkeys from a hematological perspective, but the serum metabolomic profile remains differed from monkeys that had been iron sufficient their entire life. Whether rapid iron restoration through intramuscular injections of iron dextran normalizes serum metabolomic profile is not known. A total of 654 metabolites were measured with differences in 53 metabolites identified between IS and IDA monkeys at 6 months (P 0.05). Pathway analyses provided evidence of altered liver function, hypometabolic state, differential essential fatty acid production, irregular inosine and guanosine metabolism, and atypical bile acid production in IDA infants. After treatment, iron-related hematological parameters had recovered, but the formerly IDA infants remained metabolically distinct from the IS infants, with 225 metabolites differentially expressed between the groups. Conclusions As with slow iron repletion, rapid iron repletion does not normalize the altered serum metabolomic profile in rhesus infants with IDA, suggesting the need for iron supplementation in the pre-anemic stage. Funding Sources National Institutes of Health.

scholarly journals Effect of Maternal Iron Deficiency Anemia on the Iron Store of Newborns in Ethiopia

Anemia ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Betelihem Terefe ◽  
Asaye Birhanu ◽  
Paulos Nigussie ◽  
Aster Tsegaye
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Complete Blood Count ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Iron Store ◽  
Cross Sectional ◽  
Iron Deficient

Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants. Maternal median hemoglobin and serum ferritin levels were 12.2 g/dL and 47.0 ng/mL, respectively. The median hemoglobin and serum ferritin levels for the newborns were 16.2 g/dL and 187.6 ng/mL, respectively. The mothers were classified into two groups based on hemoglobin and serum ferritin levels as iron deficient anemic (IDA) and nonanemic (NA) and newborns of IDA mothers had significantly lower levels of serum ferritin (P=0.017) and hemoglobin concentration (P=0.024). Besides, newborns’ ferritin and hemoglobin levels showed significant correlation with maternal hemoglobin (P=0.018;P=0.039) and ferritin (P=0.000;P=0.008) levels. We concluded that maternal IDA may have an effect on the iron stores of newborns.

scholarly journals Hematologic Effects of Levothyroxine in Iron-Deficient Subclinical Hypothyroid Patients: A Randomized, Double-Blind, Controlled Study

2009 ◽  
Vol 94 (1) ◽  
pp. 151-156 ◽  
Author(s):  
Hakan Cinemre ◽  
Cemil Bilir ◽  
Feyzi Gokosmanoglu ◽  
Talat Bahcebasi
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Subclinical Hypothyroidism ◽  
Serum Iron ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Controlled Study ◽  
Iron Group ◽  
Iron Deficient

Abstract Context: In patients with coexisting iron-deficiency anemia and subclinical hypothyroidism, anemia does not adequately respond to oral iron therapy. Objective: We studied whether iron-deficiency anemia might indicate treatment of subclinical hypothyroidism. Design: Patients were assigned to a control or experimental group: 240 mg/d oral iron alone (iron group) or 240 mg/d oral iron plus 75 μg/d levothyroxine (iron/levothyroxine group). Levels of hemoglobin, hematocrit, red blood cell count, serum iron levels, ferritin, total iron-binding capacity, TSH, and free T4 were measured before and after treatment. Setting: The study was conducted at a university hospital outpatient clinic. Patients: Fifty-one patients with coexisting iron-deficiency anemia and subclinical hypothyroidism participated in the study. Intervention: Patients were treated as described above in either the iron group or the iron/levothyroxine group. Main Outcome Measure: A clinically satisfactory increase in hemoglobin was regarded as successful. Results: Mean hemoglobin levels increased by 0.4 g/dl in the iron group [95% confidence interval (CI) 0.2–0.7, P = 0.001], whereas it increased by a mean of 1.9 g/dl in the iron/levothyroxine group (95% CI 1.5–2.3, P &lt; 0.0001). The increase in serum iron was greater in the iron/levothyroxine group by a mean of 47.6 μg/dl (95% CI 34.5–60.6, P &lt; 0.0001). Increases in hemoglobin, red blood cells, hematocrit, and serum ferritin levels after treatment were statistically significantly greater in the iron/levothyroxine group (P &lt; 0.0001). Starting hemoglobin and increase in hemoglobin were negatively correlated in the iron/levothyroxine group (r = −0.531, P = 0.006). Conclusions: Subclinical hypothyroidism should be treated in iron-deficiency anemia patients when both conditions coexist. This would provide a desired therapeutic response to oral iron replacement and prevent ineffective iron therapy.

scholarly journals THE EFFECT OF IRON DEFICIENCY ANEMIA ON GLYCATED HEMOGLOBIN (HBA1C) IN NON DIABETIC ADULTS

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Dr. Suman Choudhary ◽  
Dr. Sukh Dev Choudhary ◽  
Dr. Himanshi Choudhary ◽  
Dr. Ronak Gandhi
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Uncontrolled Diabetes ◽  
Iron Deficient ◽  
Healthy Control ◽  
Sugar Levels ◽  
Hba1c Levels

Background: Iron deficiency anemia is the most common form of anemia in India. Hemoglobin A1c (HbA1c) is used in diabetic patients as an index of glycemic control reflecting glucose levels of the previous 3 months. Like blood sugar levels, HbA1c levels are also affected by the presence of variant hemoglobins, hemolytic anemias, nutritional anemias, uremia, pregnancy, and acute blood loss. Previous studies suggest that iron deficiency anemia (IDA) affects the levels of HbA1c. Methods: A prospective observational study on 50 iron deficiency patient cases and 50 healthy control. Exclusion and inclusion criteria were used to recruit cases from the wards and OPDs of the hospital. Appropriate descriptive statistics was used to analyse the data. Results: The HbA1C was significantly higher in the iron deficiency patients as compare to the control (5.88 ± 0.41 vs 5.03 ± 0.17, respectively, P < .05). Conclusion: Our results showed that iron deficiency was associated with higher proportions of HbA1c, which could cause problems in the diagnosis of uncontrolled diabetes mellitus in iron-deficient patients. Keywords: Non-Diabetic Patient, Glycosylated Haemoglobin, Iron Deficiency Anaemia.

Iron Status and Infant Feeding Practices in an Urban Ambulatory Center

PEDIATRICS ◽  
1983 ◽  
Vol 72 (1) ◽  
pp. 33-36
Author(s):  
P. David Sadowitz ◽  
Frank A. Oski
Keyword(s):  
Iron Deficiency ◽  
Infant Feeding ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Feeding Practices ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Infant Feeding Practices ◽  
Cow's Milk ◽  
Iron Deficient

The relationship of infant feeding practices to iron status was examined in a group of 280 infants, 9 to 12 months of age, attending a "well-baby" clinic. Of this group, 7.6% were found to be iron depleted, 19.7% were iron deficient without anemia, and 8.2% were iron deficient with anemia. The incidence of iron-deficiency anemia was significantly greater in the black infants than the white infants (14.3% v 2.7%). The introduction of whole cow's milk into the diet had occurred prior to 6 months of age in 29.2% of the infants, and 62.1% of these infants had laboratory evidence of nutritional iron inadequacy, as contrasted with only 21.8% of those with iron deficiencies fed cow's milk after 6 months of age. Of the 21 infants with iron-deficiency anemia, 19 (90.5%) had been fed whole cow's milk prior to 6 months of age. Iron deficiency remains a nutritional problem for infants in an urban setting and is largely a result of the early introduction of whole cow's milk into the diet.

scholarly journals Effect of Iron Deficiency Anemia on HbA1c in Non-Diabetics

2020 ◽  
Vol 4 (1) ◽  
pp. 10-16
Author(s):  
R.K. Bansal ◽  
Y.R. Yadav ◽  
H.S. Kulkarni ◽  
Sonam ◽  
S. Garg ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Hba1c Level ◽  
Deficiency Anemia ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Diabetic Patients ◽  
Iron Deficient ◽  
Hba1c Levels

Background: Glycated hemoglobin A1c is a well-known indicator of glycemic control in diabetes patients. It comprises of 5% of total hemoglobin in non-diabetic patients as well. Iron Deficiency Anemia is most common cause of anemia, especially in this part of the world. So, we study the effects of Iron deficiency Anemia on HbA1c levels in non-diabetic adults to determine whether the HbA1c levels increase if any. Methods: A 100 non-diabetic adult patients with Iron Deficiency anemia admitted in various medicine wards and attending OPDs of J.L.N. Medical College and 100 healthy controls were enrolled after fulfilled inclusion and exclusion criteria. Detailed history of clinical examination and biochemical examination was performed including HbA1c. Results: Mean HbA1c level is more in iron deficient Anemic non-diabetic patients in comparison to non-Anemic non-diabetic patients. Mean HbA1c is 5.01 ± 0.41 in control group. While mean HbA1c level in case group is 6.11 ± 0.42. The difference is statistically significant (p value <.001). Conclusion: Iron deficiency Anemia is independent factor affecting HbA1c level in non diabetic patients & it should be interpreted carefully in all iron deficient anemic patients.  

scholarly journals Association between iron deficiency anemia and HBA1C level in diabetic patients with controlled plasma glucose levels.

2020 ◽  
Vol 27 (09) ◽  
pp. 1849-1854
Author(s):  
Muhammad Danish Qureshi ◽  
Saman Waqar ◽  
Muhammad Ihtesham Khan ◽  
Lubna Naseem
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Plasma Glucose ◽  
Hba1c Level ◽  
Deficiency Anemia ◽  
Diabetic Patients ◽  
Care Providers ◽  
Female Ratio ◽  
Iron Deficient ◽  
Study Population

Objectives: To determine association of iron deficiency anemia on hba1c level in diabetic patients. Study Design: Cross Sectional Analytical study. Setting: Department of Pathology PIMS Hospital. Period: From June 2018 to December 2018 (6 months duration). Material & Methods: A total of 117 diagnosed cases of diabetes mellitus were included in the study. Pregnant women, patients with end-stage renal disease, hypothyroidism, +hemoglobinopathies, hemolytic anemia, chronic liver disease and malignancy, participants with poorly controlled diabetes, and patient from the northern areas were excluded from the study. Patients were divided according to their fasting plasma glucose (FPG) level. FPG of 126mg/dl was used as a cut-off point for dividing the study population into two groups, i.e controlled sugar level (FPG between 100 and 126 mg/d L) and well controlled sugar level (FPG less than 100 mg/d L). Variables such as Hemoglobin, serum ferritin, serum Hba1c level etc. Results: Mean age of study population in the present study was 56.97±7.29 years. Out of 117 cases, about 45(38.5%) cases were female and 72 (38.5%) were male. Male to female ratio was 1: 1.6.Mean FPG level was 103.3±7.6 in our study population. The mean hba1c levels in the sample was 6.42±0.70 %. Mean Hb levels were recorded as 11.5±2.7 and 10.9±3.03 g/dl, respectively in female and male. From a total of 117 cases, only 66 were identified as having iron deficiency anemia. Only 54 patients had plasma glucose greater than 100 mg/dl. Odds ratio for hba1c>6.5% in iron deficient was 3.90(p=0.001). Conclusion: Iron deficiency can cause elevated serum hba1c level. Health care providers, including physicians, must consider the iron status before prescribing diabetics treatment on the basis of serum hba1c level.

Iron Deficiency Anemia: Adverse Effects on Infant Psychomotor Development

PEDIATRICS ◽  
1989 ◽  
Vol 84 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Tomas Walter ◽  
Isidora De Andraca ◽  
Patricia Chadud ◽  
Carmen G. Perales
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Oral Iron ◽  
Iron Therapy ◽  
Psychomotor Development ◽  
Deficiency Anemia ◽  
Placebo Control ◽  
Double Blind ◽  
Iron Deficient

In a double-blind, placebo-control prospective cohort study of 196 infants from birth to 15 months of age, assessment was made at 12 months of age of the relationship between iron status and psychomotor development, the effect of a short-term (10-day) trial of oral iron vs placebo, and the effect of long-term (3 months) oral iron therapy. Development was assessed with the mental and psychomotor indices and the infant behavior record of the Bayley Scales of Infant Development in 39 anemic, 30 control, and 127 nonanemic iron-deficient children. Anemic infants had significantly lower Mental and Psychomotor Developmental Index scores than control infants or nonanemic iron-deficient infants (one-way analysis of variance, P &lt; .0001). Control infants and nonanemic iron-deficient infants performed comparably. No difference was noted between the effect of oral administration of iron or placebo after 10 days or after 3 months of iron therapy. Among anemic infants a hemoglobin concentration &lt; 10.5 g/dL and duration of anemia of &gt; 3 months were correlated with significantly lower motor and mental scores (P &lt; .05). Anemic infants failed specifically in language capabilities and body balance-coordination skills when compared with controls. These results, in a design in which intervening variables were closely controlled, suggest that when iron deficiency progrsses to anemia, but not before, adverse influences in the performance of developmental tests appear and persist for at least 3 months despite correction of anemia with iron therapy. If these impairments prove to be long standing, prevention of iron deficiency anemia in early infancy becomes the only way to avoid them.

scholarly journals Iron deficiency anaemia and its association with febrile seizures

2018 ◽  
Vol 5 (3) ◽  
pp. 1120
Author(s):  
Ramesh M. Nigade ◽  
Dhairyashil V. Khambalkar
Keyword(s):  
Iron Deficiency ◽  
Observational Study ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Research Centre ◽  
Age Group ◽  
Iron Deficient ◽  
Low Serum

Background: As reported by World Health Organization of total world’s population about 500 million to 2 billion people are deficient in iron. Iron deficiency is the most common hematological disease found in age group 6 months to 5 years. This age group generally coincides with the age group of occurrences of febrile seizures. Aim of this study was to study the role of iron deficiency in febrile seizures.Methods: This cross sectional, observational study done in the Pediatrics department of D. Y. Patil Hospital and Research Centre. 170 children of age group between 6months to 5 years will be included in the study over a period of 24 months from May 2015 to May 2017, Presenting with simple and complex febrile seizures to the emergency department and Pediatrics ward of hospital.Results: In the study the mean age of onset of febrile seizures is 21 months. Severity of anemia doesn’t have any correlation with occurrence of febrile seizures. Iron deficient in terms of low HB, low MCH, low MCV, high RDW, low serum Iron, high TIBC and low serum iron and TIBC ratio.Conclusions: From the current hospital based observational study we have concluded that, iron deficiency anemia was more frequent among children with febrile seizures. The result suggests that iron deficiency anemia may be a risk factor for febrile seizures screening for IDA should be considered in children with febrile seizures. All the investigations (Sr Iron, TIBC) carried out to evaluate iron deficiency anemia were significantly lower. This suggests that iron deficient children are more prone for febrile seizures.

scholarly journals Prevalence of Iron Deficiency Anemia in Biochemically Defined Moderate to Severely Anemic patients in a Tertiary Care Centre

2019 ◽  
Vol 57 (219) ◽  
Author(s):  
Niharika Shah ◽  
Sairil Pokharel ◽  
Deebya Raj Mishra ◽  
Purbesh Adhikari
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Tertiary Care ◽  
Deficiency Anemia ◽  
Iron Store ◽  
Ferritin Concentration ◽  
Functional Iron Deficiency ◽  
Iron Stores

Introduction: Anemia due to iron deficiency and chronic diseases is common occurrence in developing country like Nepal, the latter seen in patients with various inflammatory, autoimmune, and malignant disorders . The Intensive method of marrow iron examination, which this study has employed, provides clinically useful iron status classification in cases of functional iron deficiency. The aim of the study is to find out the prevalence of iron deficiency anemia in biochemically defined moderate to severe anemic patients in tertiary care center. Methods: A descriptive cross-sectional study was done in 43 patients who underwent bone marrow aspiration for evaluation of any cause and had moderate to severe anemia at the same time over a period of one year from Nov 2015 to 2016. Ethical clearance was obtained from Institutional Review Committee. The bone marrow iron stores were assessed by“intensive method” apart from the routinely used Gale’s method. Data was collected and entry were done in Statistical Package for Social Sciences version 24. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: The intensive grading system demonstrated normal marrow iron store in 13 (30.2%), depleted iron stores in 3 (7%), functional iron deficiency in 14 (32.6%), and combined deficiency in 13 (30.2%) patients. Mean log ferritin concentration was lower in patients with depleted iron stores (2.2μg/l) than in those with normal (2.7μg/l), and functional iron deficiency (2.4μg/l). The mean log ferritin in combined deficiency was lower than the mean log ferritin concentration in iron store deficiency (1.9μg/l). Conclusions: The prevalence of functional iron deficiency anemia was greatest when the intensive method for assessment of bone marrow iron was used, thus differentiating four different iron status categories, including functional iron deficiency, from actual iron store deficiency, avoiding unnecessary iron supplementation in the former group.

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