Overexpression of MRPS18-2 in Cancer Cell Lines Results in Appearance of Multinucleated Cells
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Human mitochondrial ribosomal protein MRPS18-2 (S18-2) is encoded by a cellular gene that is located on the human chromosome 6p21.3. We discovered that overexpression of the S18-2 protein led to immortalization and de-differentiation of primary rat embryonic fibroblasts. Cells showed anchorage-independent growth pattern. Moreover, pathways characteristic for rapidly proliferating cells were upregulated then. It is possible that the S18-2 overexpression induced disturbance in cell cycle regulation. We found that overexpression of S18-2 protein in human cancer cell lines led to an appearance of multinucleated cells in the selected clones.
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2019 ◽
Vol 76
(4)
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pp. 701-706
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2015 ◽
Vol 17
(10)
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pp. 1005-1017
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2016 ◽
Vol 17
(1)
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pp. 137-142
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2020 ◽
Vol 20
(10)
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pp. 1241-1249
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