scholarly journals Research Progresses of Congenital Cytomegalovirus Infection

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Rong Tao ◽  
Shiqiang Shang
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Manifestations ◽  
Screening Methods ◽  
Prevention Strategies ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Congenital Infections ◽  
Narrative Perspective ◽  
Route Of Transmission ◽  
And Control

Congenital cytomegalovirus infection (cCMVi) in the newborn is one of the most common congenital infections. The children who are infected will present different clinical manifestations. The mild symptoms may be asymptomatic. However, severe cases may have permanent sequelae and even endanger their life. This paper would review the research progresses in the following fields including the epidemiology, the route of transmission, clinical manifestation, screening methods , narrative perspective of prevention and control means. Then the prevention strategies would be summarized.

scholarly journals Congenital cytomegalovirus: the invisible problem

2015 ◽  
Vol 36 (4) ◽  
pp. 152
Author(s):  
Bill Rawlinson
Keyword(s):  
Cytomegalovirus Infection ◽  
Congenital Infection ◽  
Mental Disability ◽  
Congenital Cytomegalovirus Infection ◽  
Great Pleasure ◽  
Congenital Cytomegalovirus ◽  
Congenital Infections ◽  
The Subject ◽  
Serious Disease ◽  
Congenital Cmv

It is a great pleasure mixed with some sadness to write this editorial. The entire November issue is around the subject of congenital infection, with the focus on the most common, serious cause of congenital malformation in Australia – congenital cytomegalovirus. Infection with cytomegalovirus (CMV) causes serious disease in children globally, resulting in congenital infections present in ~2000 Australian newborns every year, of whom most are asymptomatic, with ~450 per annum (pa) affected by hearing loss, mental disability and other illnesses. Some of the key clinical features of congenital infection are outlined here in articles by Wendy van Zuylen, Klaus Hamprecht and Robert George, and the pathogenetic features in Lenore Pereira’s paper. Treatment and vaccination are moving ahead (as discussed in papers from some key Italian groups), although not fast enough for many of us – as parents of children with CMV discuss in two papers here. We also include papers on other causes of congenital infection that are much less common than congenital CMV in Australia. Although these are not related to congenital CMV clinically, with very different medical and epidemiological settings, it is important to put congenital CMV in context, as well as to draw attention to other important causes of congenital infection.

Congenital Cytomegalovirus Infection: Diagnostic and Prognostic Significance of the Detection of Specific Immunoglobulin M Antibodies in Cord Serum

PEDIATRICS ◽  
1982 ◽  
Vol 69 (5) ◽  
pp. 544-549
Author(s):  
Paul D. Griffiths ◽  
Sergio Stagno ◽  
Robert F. Pass ◽  
Richard J. Smith ◽  
Charles A. Alford
Keyword(s):  
Cytomegalovirus Infection ◽  
Prognostic Significance ◽  
Immunoglobulin M ◽  
Maternal Infection ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Congenital Infections ◽  
Congenital Cmv Infection ◽  
Specific Immunoglobulin

Specific immunoglobulin M antibodies were detected by radioimmunoassay (RIA-IgM) in cord sera from 83/93 (89%) babies congenitally infected with cytomegalovirus (CMV) but in 0/104 cord sera from uninfected control subjects. The type of maternal infection did not affect the ability of the assay to identify congenital infections, but increased RIA-IgM titers were found more frequently in cord sera from babies infected following primary CMV infections (9/18; 50%) than following recurrent CMV infections (1/12; 8%) (P < .05). The magnitude of the fetal immune response was related to disease inasmuch as 14/40 (35%) babies with increased RIA-IgM titers were symptomatic at birth compared with 1/43 (2%) with lower titers (P < .001). When combined with the results of testing for rheumatoid factor and total IgM, the RIA-IgM assay defined subgroups of babies with generally poor (7/15; 47% symptomatic at any stage) or generally good (0/21 symptomatic) prognoses. Prospective studies currently identifying cases of congenital CMV infection may wish to use these three serologic techniques as the results obtained appear to have prognostic significance for those babies who are initially asymptomatic.

Prevalence and Clinical Manifestations of Congenital Cytomegalovirus Infection in a Screening Program in Madrid (PICCSA Study)

2020 ◽  
Vol 39 (11) ◽  
pp. 1050-1056
Author(s):  
Daniel Blázquez-Gamero ◽  
María Soriano-Ramos ◽  
Marta Vicente ◽  
Carmen Rosa Pallás-Alonso ◽  
Alfredo Pérez-Rivilla ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Screening Program ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus

Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infection

1987 ◽  
Vol 111 (3) ◽  
pp. 343-348 ◽  
Author(s):  
Thomas J. Conboy ◽  
Robert F. Pass ◽  
Sergio Stagno ◽  
Charles A. Alford ◽  
Gary J. Myers ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Intellectual Outcome

Differential Clinical Manifestations of Congenital Cytomegalovirus Infection between Dizygotic Twins: A Case Report

2004 ◽  
Vol 21 (7) ◽  
pp. 383-386 ◽  
Author(s):  
Kei Kawana ◽  
Masahiro Nakayama ◽  
Toshiharu Yasugi ◽  
Mizuho Ishiwata ◽  
Genzo Marumo ◽  
...  
Keyword(s):  
Case Report ◽  
Cytomegalovirus Infection ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Dizygotic Twins

scholarly journals Modern diagnostic and treatment approaches of congenital cytomegalovirus infection: a clinical case

2020 ◽  
pp. 48-54
Author(s):  
O.H. Shadrin ◽  
◽  
A.P. Volokha ◽  
N.H. Chumachenko ◽  
V.M. Fysun ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Severe Infection ◽  
Organ Damage ◽  
Antiviral Drugs ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Congenital Cmv Infection

Cytomegalovirus infection (CMV) is one of the most common causes of fetal infection. Recently fetal infections cause from 11% to 45% of perinatal losses, according to various authors, and are considered to be one of the most likely causes of congenital malformations, which lead to infants disability and reduce quality of life. CMV-infection clinical picture is very diverse, disguised as other diseases. There may be clinical manifestations of both generalized infection and single organ damage, because the virus has tropism to various organs and tissues. Timely diagnosis and treatment are the key to successful therapy of even severe manifestations of congenital CMV-infection in infants. Antiviral drugs usage can be sufficiently justified in patients with severe infection and can prevent complications. A clinical case of a manifest form of cytomegalovirus infection with severe hepatitis in an infant is presented and the therapeutic efficacy and safety of the ganciclovir and valganciclovir antiviral drugs are shown. The study is performed in accordance with principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the article. Informed consent of parents was obtained for the research. The authors declare no conflict of interest. Key words: infants, congenital cytomegalovirus infection, ganciclovir, valganciclovir, clinical case.

scholarly journals The modern view of congenital cytomegalovirus infection: clinical observations

2020 ◽  
Vol 19 (4) ◽  
pp. 58-63
Author(s):  
N. V. Kholodnova ◽  
L. N. Mazankova ◽  
A. A. Volter ◽  
I. E. Turina ◽  
A. L. Rossina ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Modern View ◽  
Clinical Observations ◽  
Wide Range ◽  
Newborn Child ◽  
Intrauterine Infections

Тhis work is a continuation of the literature review «The modern view of congenital cytomegalovirus infection» and is devoted to the clinical cases. Particular attention is paid to the severity of congenital cytomegalovirus infection (CCMVI), as well as the its clinical variability, including developmental anomalies. The variety of clinical forms requires a wide range of examinations to identify all this infection manifestations in a newborn child and children in the first months of life, as well as the doctors alertness regarding the timely diagnosis of intrauterine infections based on the existing clinical features. The presented cases demonstrate the CCMVI clinical manifestations: the «classical» generalized manifest form, with a specific clinical, laboratory and instrumental findings, the severe generalized CCMVI with kidney congenital malformation and postnatal development of congenital cataract.

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