scholarly journals The modern view of congenital cytomegalovirus infection: clinical observations

2020 ◽  
Vol 19 (4) ◽  
pp. 58-63
Author(s):  
N. V. Kholodnova ◽  
L. N. Mazankova ◽  
A. A. Volter ◽  
I. E. Turina ◽  
A. L. Rossina ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Modern View ◽  
Clinical Observations ◽  
Wide Range ◽  
Newborn Child ◽  
Intrauterine Infections

Тhis work is a continuation of the literature review «The modern view of congenital cytomegalovirus infection» and is devoted to the clinical cases. Particular attention is paid to the severity of congenital cytomegalovirus infection (CCMVI), as well as the its clinical variability, including developmental anomalies. The variety of clinical forms requires a wide range of examinations to identify all this infection manifestations in a newborn child and children in the first months of life, as well as the doctors alertness regarding the timely diagnosis of intrauterine infections based on the existing clinical features. The presented cases demonstrate the CCMVI clinical manifestations: the «classical» generalized manifest form, with a specific clinical, laboratory and instrumental findings, the severe generalized CCMVI with kidney congenital malformation and postnatal development of congenital cataract.

Congenital Cytomegalovirus Infection: A Cause of Renal Dysplasia?

2007 ◽  
Vol 10 (4) ◽  
pp. 300-304 ◽  
Author(s):  
Maren Chan ◽  
Jonathan L. Hecht ◽  
Theonia Boyd ◽  
Seymour Rosen
Keyword(s):  
Viral Infections ◽  
Tissue Injury ◽  
Clinical Manifestations ◽  
Renal Dysplasia ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Wide Range ◽  
The Central Nervous System ◽  
Multicystic Dysplasia

Cytomegalovirus (CMV) infection is one of the most frequently encountered viral infections of the fetus and induces a wide range of histologic and clinical manifestations. Congenital abnormalities are typically restricted to the central nervous system despite evidence of CMV inclusions occurring in most epithelial cells. Although tissue injury and even glomerulonephritis have been observed in congenital CMV infections, renal multicystic dysplasia has not been reported. Herein, we describe a case of unilateral renal dysplasia in a 19-week fetus with concurrent CMV infection. We believe the present case to be the first description of a virus apparently inducing renal multicystic dysplasia.

scholarly journals Research Progresses of Congenital Cytomegalovirus Infection

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Rong Tao ◽  
Shiqiang Shang
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Manifestations ◽  
Screening Methods ◽  
Prevention Strategies ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Congenital Infections ◽  
Narrative Perspective ◽  
Route Of Transmission ◽  
And Control

Congenital cytomegalovirus infection (cCMVi) in the newborn is one of the most common congenital infections. The children who are infected will present different clinical manifestations. The mild symptoms may be asymptomatic. However, severe cases may have permanent sequelae and even endanger their life. This paper would review the research progresses in the following fields including the epidemiology, the route of transmission, clinical manifestation, screening methods , narrative perspective of prevention and control means. Then the prevention strategies would be summarized.

Intellectual Development in School-Aged Children With Asymptomatic Congenital Cytomegalovirus Infection

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 801-806 ◽  
Author(s):  
Thomas J. Conboy ◽  
Robert F. Pass ◽  
Sergio Stagno ◽  
William J. Britt ◽  
Charles A. Alford ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Intellectual Development ◽  
The United States ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
School Aged Children ◽  
Asymptomatic Children ◽  
Increased Risk ◽  
Wide Range ◽  
Intelligence Scores

Congenital cytomegalovirus infection occurs in about 1% of live births. Although symptomatic congenital infection often results in severe developmental deficits and mental retardation, about 90% have asymtomatic infection. Previous studies of the intellectual development in children with asymptomatic congenital cytomegalovirus have resulted in mixed findings. To control for the effects of hearing impairment (which occurs in about 15% of asymptomatic children) on intelligence scores, we tested 18 prospectively followed, normally hearing, school-aged children with asymptomatic congenital cytomegalovirus (15 black, ten male) and 18 controls matched for age, sex, race, school grade, and socioecnomic status. Children were tested via the Wechsler Intelligence Scale for Children-Revised, the Kaufman Assessment Battery for Children, and the Wide Range Achievement Test. Multivariate analysis revealed no differences between groups on intelligence scores or subscales, achievement scores, or incidence of learning disabilities (defined as significant discrepancy between intelligence and achievement), and mean scores for both groups were very close to national norms. It is concluded that the 25,000 children born in the United States each year with asymptomatic congenital cytomegalovirus and normal hearing are not likely to be at increased risk of mental impairment.

Prevalence and Clinical Manifestations of Congenital Cytomegalovirus Infection in a Screening Program in Madrid (PICCSA Study)

2020 ◽  
Vol 39 (11) ◽  
pp. 1050-1056
Author(s):  
Daniel Blázquez-Gamero ◽  
María Soriano-Ramos ◽  
Marta Vicente ◽  
Carmen Rosa Pallás-Alonso ◽  
Alfredo Pérez-Rivilla ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Screening Program ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus

Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infection

1987 ◽  
Vol 111 (3) ◽  
pp. 343-348 ◽  
Author(s):  
Thomas J. Conboy ◽  
Robert F. Pass ◽  
Sergio Stagno ◽  
Charles A. Alford ◽  
Gary J. Myers ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Intellectual Outcome

Differential Clinical Manifestations of Congenital Cytomegalovirus Infection between Dizygotic Twins: A Case Report

2004 ◽  
Vol 21 (7) ◽  
pp. 383-386 ◽  
Author(s):  
Kei Kawana ◽  
Masahiro Nakayama ◽  
Toshiharu Yasugi ◽  
Mizuho Ishiwata ◽  
Genzo Marumo ◽  
...  
Keyword(s):  
Case Report ◽  
Cytomegalovirus Infection ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Dizygotic Twins

scholarly journals Modern diagnostic and treatment approaches of congenital cytomegalovirus infection: a clinical case

2020 ◽  
pp. 48-54
Author(s):  
O.H. Shadrin ◽  
◽  
A.P. Volokha ◽  
N.H. Chumachenko ◽  
V.M. Fysun ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Severe Infection ◽  
Organ Damage ◽  
Antiviral Drugs ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Congenital Cmv Infection

Cytomegalovirus infection (CMV) is one of the most common causes of fetal infection. Recently fetal infections cause from 11% to 45% of perinatal losses, according to various authors, and are considered to be one of the most likely causes of congenital malformations, which lead to infants disability and reduce quality of life. CMV-infection clinical picture is very diverse, disguised as other diseases. There may be clinical manifestations of both generalized infection and single organ damage, because the virus has tropism to various organs and tissues. Timely diagnosis and treatment are the key to successful therapy of even severe manifestations of congenital CMV-infection in infants. Antiviral drugs usage can be sufficiently justified in patients with severe infection and can prevent complications. A clinical case of a manifest form of cytomegalovirus infection with severe hepatitis in an infant is presented and the therapeutic efficacy and safety of the ganciclovir and valganciclovir antiviral drugs are shown. The study is performed in accordance with principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the article. Informed consent of parents was obtained for the research. The authors declare no conflict of interest. Key words: infants, congenital cytomegalovirus infection, ganciclovir, valganciclovir, clinical case.

scholarly journals Congenital Cytomegalovirus Infection: Evaluation and Management

2019 ◽  
Vol 9 (2) ◽  
pp. 116-126
Author(s):  
Md Benzamin ◽  
Md Mizanur Rahman ◽  
Md Rukunuzzaman ◽  
ASM Bazlul Karim
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Manifestations ◽  
Congenital Infection ◽  
Asymptomatic Infection ◽  
Reproductive Age ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Life Threatening ◽  
Disseminated Disease

Congenital cytomegalovirus (CMV) infection is the most common congenital infection worldwide and most individuals are eventually exposed to this agent. In developing countries the seroprevalence in women of reproductive age approximates 100%. Cytomegalovirus (CMV) infection has great importance to obstetriciangynecologists and pediatricians. Despite the heavy disease burden, CMV infection is severely under-diagnosed because the majority (approximately 80%) of affected mothers are asymptomatic. The clinical manifestations of congenital CMV infection vary widely, from asymptomatic infection to potentially life-threatening disseminated disease. Prenatal diagnosis of fetal CMV infection can be made by testing amniotic fluid for cytomegalovirus by amniocentesis. Diagnosis of congenital cytomegalovirus infection in neonates should include real-time PCR of saliva, urine, or both, as soon as possible after birth. Antiviral therapy is not routinely recommended for congenital cytomegalovirus infection. Neonates with life-threatening infection and moderately to severely symptomatic congenital cytomegalovirus disease, CNS involvement is considered for immediate treatment that should be initiated within first month of life. J Enam Med Col 2019; 9(2): 116-126

scholarly journals Niemann–Pick disease in a child with congenital cytomegalovirus infection

2020 ◽  
Vol 11 (5) ◽  
pp. 67-72
Author(s):  
Elena V. Bem ◽  
Larisa A. Fedorova ◽  
Maria Yu. Sajkova ◽  
Olga G. Reutskaia
Keyword(s):  
Cytomegalovirus Infection ◽  
Intracellular Transport ◽  
Clinical Manifestations ◽  
Inherited Disease ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Target Organs ◽  
Npc1 Gene ◽  
Lysosomal Accumulation ◽  
Niemann Pick

In this publication, we present own clinical observation demonstrating the early diagnosis of NiemannPick disease, type C (NPС) in a child with congenital cytomegalovirus infection (сCMV). NiemannPick disease is a rare orphan inherited disease with an autosomal recessive type of inheritance that belongs to lysosomal accumulation diseases. There are 4 clinical phenotypes of NiemannPick disease (A, B, C, D), among which types A and B are associated with a mutation of the lysosomal sphingomyelinase (SMPD1) gene, and types C and D are associated with mutations in the NPC1 or NPC2 genes responsible for intracellular transport of cholesterol and lipids. The disease is a form of glycosphingolipidosis, which is accompanied by progressive degenerative processes in the target organs. The incidence of NPС is approximately 1 case per 100,000 live births. During the newborn period, NPС may occur under the guise of the other inherited or acquired diseases, and sometimes be combined with them. In particular, the manifest form of neonatal cytomegalovirus infection has similar target organs for damage to the NPС: the liver, the spleen, and the Central nervous system. The multi-system nature of clinical manifestations requires a differential diagnosis and clarification as early as possible. The polymorphism of clinical manifestations and the lack of diagnostic tests for mass screening make it is difficult to diagnose the disease. In the given clinical case, the diagnosis of NPС in a child with congenital cytomegаlovirus infection was established using DNA diagnostics of NPC1 gene mutation at the age of 2.5 months of life, which allowed determining the long-term management and medical observation.

scholarly journals A case of congenital cytomegalovirus infection

2019 ◽  
pp. 84-88
Author(s):  
Banu Anlar
Keyword(s):  
Hearing Loss ◽  
White Matter ◽  
Cytomegalovirus Infection ◽  
Current Approach ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
White Matter Abnormalities ◽  
Intrauterine Infections

Cytomegalovirus is a virus responsible of the majority of intrauterine infections. It may cause hearing loss, microcephaly, cerebral gyral malformations and white matter abnormalities in the fetus. In this paper, a case with congenital cytomegalovirus infection is presented and the current approach is reviewed.

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