scholarly journals Pathophysiological characteristics of the development of arterial hypertension in Yorkshire Terriers with alimentary obesity

2021 ◽  
pp. 30-34
Author(s):  
D. A. Korkots ◽  
Yu. A. Vatnikov ◽  
A. A. Rudenko ◽  
P. A. Rudenko
Keyword(s):  
Arterial Hypertension ◽  
Pathological Condition ◽  
Significant Risk ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Concentric Hypertrophy ◽  
Comparative Aspect ◽  
Alimentary Obesity ◽  
Yorkshire Terrier

Relevance. The study of the pathogenesis of obesity in domestic animals is an urgent problem in veterinary medicine, which is associated with the high prevalence of this pathological condition and a significant risk of complications from the cardiovascular system. The aim of the study was to present the pathophysiological characteristics of the development of arterial hypertension syndrome in obesity in Yorkshire Terrier dogs.Methods. In a comparative aspect, clinical, tonometric, electrocardiographic, echocardiographic and biochemical parameters were studied in obese patients (n = 13) and clinically healthy dogs (n = 7).Results. Our study shows the negative role of obesity in the development of arterial hypertension syndrome in Yorkshire Terrier dogs. It was also found that obesity in dogs is accompanied by impaired lipid metabolism, oxidative stress, the development of arterial hypertension and a tendency to the development of concentric hypertrophy of the left ventricular myocardium and hepatopathy.

scholarly journals Diagnostics and treatment of arterial hypertension in children and adolescents, overview of new clinical guidelines of the American Academy of Pediatrics

2019 ◽  
Vol 64 (4) ◽  
pp. 114-127 ◽  
Author(s):  
L. I. Agapitov ◽  
I. V. Cherepnina
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Children And Adolescents ◽  
Clinical Guidelines ◽  
Blood Pressure Monitoring ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
New Guidelines ◽  
Hypertension In Children

The article analyzes clinical guidelines oftheAmericanAcademy ofPediatrics dd 2017 “ClinicalPractice Guideline forScreening andManagement of High Blood Pressure in Children and Adolescents”. This document contains new values of blood pressure in children, replaces the term “prehypertension” with the term “elevated blood pressure”, provides a simplified classification of arterial hypertension in adolescents over 13 years and revisesthe guidelinesfor daily blood pressure monitoring and echocardiography. The documentspecifiesthe criteria for diagnosing increased body weight of the left ventricular myocardium, changesthe target blood pressure levels. This new guidelines helps to optimize the diagnostics and treatment of hypertension in children. At the same time there is need for further comprehensive analysis of clinicalrecommendations and assessment of their practicalsignificance for pediatrics.

scholarly journals INFLUENCE OF COMBINED PHARMACOTHERAPY ON CARDIO-VASCULAR SYSTEM OF ARTERIAL HYPERTENSION (IN EXPERIMENT)

2020 ◽  
Vol 73 (8) ◽  
pp. 1712-1716
Author(s):  
Svetlana N. Chuhray ◽  
Viktoria E. Lavrynenko ◽  
Ruzhena M. Matkivska ◽  
Tetiana V. Lachtadyr ◽  
Valentina M. Hamalii ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Structural Changes ◽  
Vascular System ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Morphometric Study ◽  
Left Ventricular Myocardium ◽  
Electron Microscopic

DOI: 10.36740/ BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE, TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV, KYIV, UKRAINE 3KYIV CITY CLINICAL EMERGENCY HOSPITAL, KYIV, UKRAINE ABSTRACT The aim: Study of the patterns of structural changes in the left ventricular myocardial capillaries of rats with arterial hypertension with combined pharmacotherapy with Bisoprolol and Thiotriazolinum. Materials and methods: Experiments were conducted on 30 line rats with congenital stress-induced arterial hypertension: 10 animals without treatment and 10 animals with treatment. Pharmacological correction of spontaneous arterial hypertension was performed with 20 mg / kg of Bisoprolol and 50 mg / kg of Thiotriazolinum per os once a day. Pharmacotherapy began at 5 months of age, that is, at a time when compensated heart failure was formed in rats with arterial hypertension. Animals were withdrawn from the experiment 100 days after the start of the correction. Control was provided by intact animals (10 rats) of the corresponding age. While extracted from the experiment rats of all experimental groups had their arterial pressure measured using a plethysmograph, electron microscopic examination of the left ventricular myocardium and morphometric study of volumetric and quantitative densities, cross-section area and form factor of micropinocytotic vesicles were conducted. Results: In rats with arterial hypertension after application of Bisoprolol and Thiotriazolinum, arterial pressure significantly decreases in experimental rats compared to animals without correction. The number of capillaries in the myocardium after pharmacotherapy increases up to control values, which shows their reparation. In most endothelial cells, organelles retain their integrity and presence that are characteristic of intact rats. The well-expressed processes of transcytosis are shown by the statistical similarity of the quantitative density and the size of the micropinocytotic vesicles in the endothelial cells of the myocardium capillaries of compared experimental animals. Conclusions: In rats with arterial hypertension, the combination of Bisoprolol and Thiotriazolinum prevents the decrease in the number of capillaries in the myocardium of the left ventricle, promotes the preservation of the ultrastructure of their endothelial cells and maintains the processes of transedothelial transfer of substances at the level of intact animals.

Dynamics of Structural – Functional State of the Left Ventricle in Patients with Hypertension and Chronic Ischemic Heart Disease on the Background of Gastroesophageal Reflux Disease Under the Influence of Antihypertensive and Antireflux Therapy

2016 ◽  
pp. 102-107
Author(s):  
Diana Moreva
Keyword(s):  
Heart Disease ◽  
Left Ventricle ◽  
Ischemic Heart Disease ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Left Ventricular Myocardium ◽  
Chronic Ischemic Heart Disease ◽  
Concentric Hypertrophy ◽  
Antireflux Therapy

Diseases of the circulatory system are the most common pathology in Ukraine and cover 26,2 mln. Population 12,3 mln ukrainians suffer from hypertension (AH). Gastroesophageal reflux disease (GERD) is recognized by the World Organization of Gastroenterology disease of the XXI century. Given the common risk factors for hypertension coronary heart disease (CHD) and the question of GERD studies of the combined flow of these diseases and to optimize the treatment of these patients. The objective: to determine the characteristics of intracardiac hemodynamics in patients with hypertension combined with chronic ischemic heart disease on the background of GERD and the determination of the combined effects of antihypertensive and antireflux therapy on the structural-functional state of the left ventricular myocardium. Patients and methods. We examined 107 patients aged 44 to 78 years, with an established diagnosis of hypertension stage I and II in combination with chronic ischemic heart disease. Research methods included anthropometric studies, biochemical blood analysis, ambulatory blood pressure monitoring, the daily ECG monitoring, esophagogas-troduodenoscopy (EGD), echocardiography (echocardiography), testing. Results. Comorbidity for hypertension, chronic ischemic heart disease and GERD is associated with a higher frequency of abdominal type of obesity and the metabolic syndrome according to IDF criteria, significantly higher percentage of patients with grade II and III obesity. That in turn is reflected in the features of the structural1functional state of the left ventricle (LV), which manifests an increase in the number of patients with more severe degrees of left ventricular hypertrophy. Related GERD is associated with a large percentage of cases of concentric hypertrophy of the left ventricle, and a greater prevalence of diastolic dysfunction. The combination of antihypertensive and antireflux therapy for 12 weeks of treatment was reflected in the significant decrease in the weight of the index parameters of left ventricular myocardium (LVMI) and relative wall thickness index and reliable positive dynamics of indicators of left ventricular diastolic function. Conclusion. Patients with hypertension combined with chronic ischemic heart disease with comorbidity with GERD have a higher prevalence of factors of cardiovascular risk. Related GERD is associated with a more severe degree of left ventricular hypertrophy, with a large percentage of cases of concentric hypertrophy of the left ventricle, and a greater prevalence of diastolic dysfunction. A combination of antihypertensive and antireflux therapy for 12 weeks of treatment promoted significant reduction in myocardial mass index indicators LV (LVMI) and relative wall thickness index and had a significant impact on the normalization of LV diastolic function.

scholarly journals Structural and functional state of left ventricular myocardium in patients with stage II hypertension depending on galectin-3 and aldosterone levels

2019 ◽  
Vol 23 (3) ◽  
pp. 425-433
Author(s):  
V.P. Ivanov ◽  
T.P. Onyshchuk
Keyword(s):  
Left Atrium ◽  
Functional State ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Aldosterone Level ◽  
Concentric Hypertrophy ◽  
Galectin 3 ◽  
Echocardiographic Parameters

The analysis of structural and functional state of the left ventricular myocardium was conducted in the article, which concerned the determination of the general morphological and functional echocardiographic parameters of the heart according to the existing recommendations of the American Echocardiographic Society and the European Society of Cardiovascular Imaging; assessment of the relative dimensions/volumes of the LA (left atrium); determination of the structural-geometric remodeling variant of the left ventricular (LV) according to Ganau (1992) also determining the functions of the heart valves in patients with stage II 1-3 degrees hypertension, of different age and gender depending on plasma levels of galectin-3 and aldosterone. Determined the end-systolic (mm) and end-diastolic dimensions of the LV (mm), the thickness of the interventricular septum (mm) and the posterior wall of the LV (mm) in diastole, aortic diameter (AD, mm), size right atrium (RA, mm) and right ventricle (RV, mm), anterior-posterior size of the left atrium (LA, mm) and its index (ILA, mm/m2), LA volume (LPV, ml) and ejection fraction left ventricle (FV globe, %) by the modified Simpson method. LV mass (LVM, g) was estimated by the Penn Convention formula, and LVM index (LVM, g / m2) as the ratio of LVM to body surface area using the Du Bois nomogram (m2). The EchoCG in color Doppler mode measured the early (Ve) and late transmittal (Va) (m\s), their ratio (Ve\Va), the early LF filling time (DT), and the isovolumic LF relaxation time (IVRT) (ms). Statistical processing of the study results was performed using standard methods using the StatSoft Statistica v application package. 12.0 as recommended. In the case of quantitative values, the results were presented as medians and interquartile ranges (25 and 75 percentiles), in the case of relative values, as percentages (%). Comparison of the quantitative values in the groups was performed using the U-Mann-Whitney and Kruskal-Wallis ANOVA test, the relative values by the criterion χ2. A difference of p<0.05 was considered plausible. The obtained data demonstrate that relatively high levels (RH) of both galectin-3 (>2.4 pg/ml) and aldosterone (>325 pg/ml) are identified with significant morphological and functional changes in heart parameters, namely: worse structural-geometric remodeling of LV (increase in cases of concentric hypertrophy (CH) and decrease in cases with normal geometry (NG) of LV). In order to exclude the fact of cross-influence of neurohormones on echocardiographic parameters of the heart, the alignment of the groups in terms of aldosterone and galectin-3 levels was conducted. The analysis turned to be optimal in groups with galectin-3 level of ->2.0 and ≤2.0 pg/ml and aldosterone level of - >290 and ≤290 pg/ml. As a result, it was detected that galectin-3 has a greater pathophysiological effect than aldosterone on such indices as: an increase in aortic diameter; increase in right and left heart chambers dimensions; LVMMI (left ventricular myocardial mass index) value and increase in systolic, diastolic myocardial stress, increase in the number of cases with CH (concentric hypertrophy) and decrease in cases with normal geometry (NG) of LV. Aldosterone level is associated with an increase in dimension/volume indices of LA, calculated per patient’s body area.

scholarly journals Structural and functional features and indices of left ventricular deformation in coal industry workers depending on the presence of arterial hypertension

2020 ◽  
Vol 99 (7) ◽  
pp. 693-698
Author(s):  
Olga Yu. Korotenko ◽  
Egor S. Filimonov ◽  
Nikolay I. Panev ◽  
Olga N. Blazhina
Keyword(s):  
Left Ventricle ◽  
Arterial Hypertension ◽  
Coal Mine ◽  
Longitudinal Strain ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Coal Industry ◽  
Open Pit ◽  
Left Ventricular Myocardium ◽  
Mine Workers

Introduction. The coal industry occupies an important place in the Kuzbass industry, which involves a significant part of the employable-age population. Early detection of reduced myocardial contractility among coal industry workers, which develops as a result of arterial hypertension, will prevent the development of cardiovascular complications that can lead to disability or lethal outcome.The objective of the study was to evaluate the structural and functional parameters of the left ventricle in workers with and without arterial hypertension employed in coal industry enterprises with different methods of coal mining.Material and methods. The study included 178 coal mine workers and 112 open-pit coal mine workers aged from 40 to 55 years. All subjects underwent echocardiography to determine the geometric and functional parameters of the left ventricle and to assess its global longitudinal deformation.Results. Concentric remodeling of the left ventricle was revealed in open-pit coal mine workers with arterial hypertension. Its ejection fraction in all groups was within normal values but was lower in open pit coal mine workers with arterial hypertension (p=0.012). The global longitudinal strain of the left ventricle was significantly less in individuals with arterial hypertension (p&lt;0.0001). In groups with normal blood pressure, it was significantly lower among miners than in open-pit coal mine workers (p=0.020).Conclusion. Concentric remodeling of the left ventricular myocardium was detected only in the workers of coal mines with arterial hypertension. Among the miners and open-pit coal mine workers with arterial hypertension with a normal left ventricular ejection fraction, a decrease in the longitudinal deformation of the left ventricular myocardium was recorded. Among the workers of the coal industry without arterial hypertension, a decrease in the longitudinal strain of the left ventricle was observed only in miners, which may be due to the influence of a complex of harmful factors of working in underground conditions.

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