scholarly journals Correlation between Red Cell Distribution Width (RDW) with Kidney Function and Hematologic Parameters in Patients undergo Regular Hemodialysis

2020 ◽  
Vol 2 (4) ◽  
pp. 171-176
Author(s):  
Soraya Mourina Hutasuhut ◽  
Alwi Thamrin Nasution ◽  
M. Feldy Gazaly Nasution
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Hematological Analysis ◽  
Regular Hemodialysis

Background. Red cell distribution width (RDW) is a coefficient of variation in red blood cells that can decrease erythropoesis or increase the destructiveness of red blood cells. The objectives of research  to determine the relationship of RDW as an inflammatory marker with renal function and hematological parameters in patients undergoing regular hemodialysis Method; Cross sectional research on 20 patients undergoing regular hemodialysis > 3 months in RSUP H Adam Malik Medan. Vital sign, antropometry and venous blood retrieval are performed  shortly  before hemodialysis. RDW measurement comes from the red blood cell distribution curve in hematological analysis and is an indicator of variation in red blood cell size. Result: out  of 20 subjek studies,  there were 13 men (65.0%) and 7 (35.0%) women The majority of subjects had comorbid  diabetes mellitus  14 (70.0%), hypertension 4 (20.0%). The average length of time patients underwent  hemodialysis was 24.45 ± 20.98 months. There is a significant correlation between RBW and creatinine, Hb, and neutropil (r: 0.519, p:0,019*; r:  0.497,  p: 0.026*;r: 0.464,  p: 0.039*, respectively) Conclusion: There is a significant relationship between RBW and creatinine, Hb and neutropphils in patients undergoing regular hemodialysis > 3 months.

612: RED CELL DISTRIBUTION WIDTH IS ASSOCIATED WITH NUCLEATED RED BLOOD CELLS IN SURGICAL ICU PATIENTS

2016 ◽  
Vol 44 (12) ◽  
pp. 229-229
Author(s):  
Tiffany Otero ◽  
Andrea Tsai ◽  
Daniel Yeh ◽  
Ruben Azocar ◽  
Donna Belcher ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Icu Patients ◽  
Distribution Width ◽  
Nucleated Red Blood Cells ◽  
Surgical Icu

scholarly journals Red Blood Cell Distribution Width-to-Platelet Ratio Inversely Correlates with Indicators of Disease Activity Status in Rheumatoid Arthritis Patients

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Amela Dervišević ◽  
Amila Muhić ◽  
Asija Začiragić ◽  
Almir Fajkić ◽  
Lejla Dervišević ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Blood Cell ◽  
Disease Activity ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Cell Distribution ◽  
Distribution Width ◽  
Low Disease Activity ◽  
Red Blood Cell Distribution

AbstractIntroduction: Present study was performed to verify red blood cell distribution width-to-platelet ratio (RPR) level in rheumatoid arthritis (RA) patients and to examine its correlation with clinical and biochemical indicators of disease activity status.Methods: In this cross-sectional analytical study, 67 patients with RA and 34 age- and gender-matched healthy control subjects were enrolled. Based on the disease activity score 28-ESR (DAS28-ESR), RA patients were divided into subgroups: low disease activity (n=20), moderate disease activity (n=22) and high disease activity (n=25). Laboratory tests included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) concentration, platelet count (PLT), red blood cells count (RBC), red blood cells distribution width (RDW) and fibrinogen concentration. Statistical analyses were carried out using SPSS 13 software. Statistical significance was set at a p-value less than 0.05.Results: There was statistically significant difference (p=0.006) between RPR in RA patients with different stages of disease activity, with higher values in patients with low disease activity. The RPR showed statistically significant negative correlations with ESR (rho= -0.309; p=0.012), CRP (rho= -0.421; p=0.001), swollen joint count - SJC (rho = -0.368; p=0.002) and tender joint count - TJC (rho= -0.355; p=0.003), DAS28-ESR (rho= -0.409; p=0.001), DAS28-CRP (rho= -0.422; p<0.0005) and Visual analogue scale - VAS (rho= -0.260; p=0.033) in RA patients.Conclusion: The present study provided evidence that the lower RPR values in RA patients are significantly associated with the disease activity indicators.

scholarly journals Evaluation of Red Blood Cell Parameters as a Biomarker for Long-Term Glycemic Control Monitoring Among Type 2 Diabetic Patients in Southwest Ethiopia: A Cross-Sectional Study

2021 ◽  
Author(s):  
Misganaw Asmamaw ◽  
Tariku Sime ◽  
Kumsa Kene ◽  
Minale Fekadie ◽  
Muluken Teshome ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Red Cell Distribution Width ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Cell Distribution ◽  
Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Cell Parameters

Abstract Background: Type 2 Diabetes Mellitus (T2 DM) is a common type of DM characterized by hyperglycemia. Glycation of hemoglobin and related proteins in DM can affect the physiological and structural properties of red blood cells. Although glycated hemoglobin (HbA1c) test continues to be the gold standard for the assessment of long-term glycemic control accessibility and affordability of the test in routine diagnosing service are still limited in developing countries. Hence, this study was aimed to assess red blood cell parameters as a biomarker for long-term glycemic monitoring among T2 DM patients.Methods: Facility-based cross-sectional study through a consecutive sampling technique was conducted among 124 T2 DM patients at the chronic illness follow-up clinic of Jimma Medical Center (JMC) from July 27 to August 31, 2020. A structured questionnaire was used to collect socio-demographic and clinical-related data. Five milliliters of the blood specimen was collected from each eligible T2 DM patient. HbA1c and red blood cell parameters were determined by Cobas 6000 and DxH 800 fully automated analyzers respectively. Data were entered into Epi-data software version 3.1 and exported to SPSS 25 version for analysis. Independent t-test and Pearson’s correlation coefficient were used to address the research questions. A P-value < 0.05 was considered statistically significant. Results: The mean age of study participants was 51.84± 11.6 years. 60.5% of T2 DM patients were in poor glycemic control. There was a significant mean difference between good and poor glycemic controlled T2 DM patients in red blood cell count (4.79±0.5 vs 4.38±0.8), hemoglobin (14.13±1.4 vs 13.60±1.6), mean corpuscular volume (89.52±4.7 vs 92.62±7.5), mean corpuscular hemoglobin (29.63±1.6 vs 30.77±2.9), and red cell distribution width (13.68±1.1 vs 14.63±1.2) respectively. Red blood cell count was inversely correlated (r=-0.280, p=0.002) with HbA1c while mean corpuscular volume (r=0.267, p=0.003), mean corpuscular hemoglobin (r=0.231, p=0.010), and red cell distribution width (r= 0.496, p=0.000) were positively correlated with level of HbA1c. Conclusion: Red cell count, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width could be useful indicators to monitor the glycemic status of T2 DM patients instead of HbA1c, though large prospective studies should be considered.

scholarly journals Hematological parameters in apparently Healthy Eritrean blood donors at the National Blood Transfusion Center, Asmara, Eritrea.

2020 ◽  
Author(s):  
Faris Abdon ◽  
Elias Adgoy ◽  
Nahom Berhane ◽  
Senet Ibrahim ◽  
Adil Khalil ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Donors ◽  
Hemoglobin Level ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Mean Cell Hemoglobin ◽  
Apparently Healthy

Introduction: This study was done to measure the Hemoglobin levels, Red Blood Cells count, and Red Blood cell parameters: MCV, MCH, MCHC, RDW, and Hematocrit of the apparently healthy blood donors attending the National Blood Bank of Eritrea. Methods: Blood samples were collected from the peripheral veins into the (EDTA)-tube and examined for Red Blood Cell count (RBC), hemoglobin (Hb), Hematocrit (%), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), and red cell distribution width (RDW), analyzed and measured by automated blood analyzer. Results: The mean Hemoglobin level was 14.428±1.485 g/dl, RBCs count was 4.744±0.482×1012/L, HCT was 41.929 ±3.75%, Red cell distribution width (RDW) mean was 13.571±0.744%, MCV was 88.582± 4.0558 Fimtoliter, MCH was 30.470±2.188 picogram, and MCHC was a mean of 34.393±1.347g/dl. The difference between males and females in MCV and MCHC was significant in favor of female donors. And a weak positive correlation had been found between the weight and age of donors and the Hemoglobin level. All the measured values were found to be within the global referenced ranges. Conclusion: Hemoglobin, RBCs count and RBCs indices of apparently healthy Eritrean blood donors were measured for reference, and all values were found within normal reference ranges.

scholarly journals DIAGNOSTIC EFFICACY OF RED BLOOD CELL INDICES IN DIAGNOSIS OF BETA THALASSEMIA TRAIT TAKING HAEMOGLOBIN ELECTROPHORESIS AS GOLD STANDARD

2021 ◽  
Vol 71 (3) ◽  
pp. 1006-10
Author(s):  
Sahar Rabbani ◽  
Muhammad Farooq ◽  
Samina Naeem ◽  
Nasir Uddin ◽  
Muhammad Abdul Naeem ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Red Cell Distribution Width ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Cell Distribution ◽  
Diagnostic Efficacy ◽  
Mean Cell Volume ◽  
Distribution Width ◽  
Thalassemia Trait

Objective: To determine the diagnostic efficacy of haematological indices for the diagnosis of beta thalassemia trait taking haemoglobin electrophoresis as a gold standard. Study Design: Cross sectional study. Place and Duration of Study: Department of Haematology Combined Military Hospital Lahore, from Aug to Dec 2019. Methodology: Two hundred and six anaemic patients 20-70 years of age of both genders were included in the study. Blood was collected from all the patients and complete blood count were generated through automated haematology analyser Sysmex KX-21. Based on the complete blood count parameters like mean cell volume, red blood cell count, red cell distribution width and mean cell haemoglobinthe haematological indices such as Mentzer, Ricerca, mean density of Hb/litre of blood, mean cell Hb density and red cell distributon width indices were calculated. The haemoglobin A2 band of >3.5% on haemoglobin electrophoresis was taken as cut off for Beta thalassemia trait. Results: Out of the 206 blood samples analysed, 120 (58%) were labelled as Beta thalassemia trait after Hb electrophoresis and 86 cases had anemia due to other causes. Mentzer index established the highest sensitivity of 92.5% whereas RICERCA index established the highest specificity of 94.1%. Mentzer and red cell distribution width indexhad highest diagnostic efficacy value up to 90.3%. Conclusion: We conclude that Mentzer and red cell distribution width index showed the highest diagnostic significance. The Mentzer index has the highest sensitivity whereas Ricerca index has the highest specificity. The red blood cell count, haemoglobin and mean cell volume.............

scholarly journals Correlation of Red Cell Distribution Width Value with Force Expiration Volume One Second in Patients with Stable Chronic Obstructive Lung Disease

2021 ◽  
Vol 9 (T3) ◽  
pp. 48-51
Author(s):  
Martunis Martunis ◽  
Amira Permatasari Tarigan ◽  
Muntasir Muntasir ◽  
Putri Chairani Eyanoer
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Airflow Obstruction ◽  
Red Cell Distribution Width ◽  
Chronic Obstructive ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Copd Patients ◽  
Case Series Study

BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients experience an increase in the number of red blood cells and hemoglobin levels due to body compensation in line with the increased secretion of the hormone erythropoietin which stimulates the production of red blood cells. Studies report that red cell distribution width (RDW) increases with the severity of COPD which raises the opinion that RDW can be used as a biomarker in the evaluation of disease severity in patients with COPD. AIM: This study aims to determine the correlation between the value of RDW and forced expiratory volume in one second (FEV1) in patients with stable COPD. METHODS: This study was a case series study conducted from April to August 2019 at the Department of Pulmonology and Respiratory Medicine, USU Medical Faculty. The research subjects were all COPD patients who visited the Lung Clinic RSUP H Adam Malik, Medan, who were selected by consecutive sampling. Data analysis was performed using the Spearman correlation test. RESULTS: A total of 30 people with COPD who met the criteria were included in this study who were dominated by men (93.3%), aged 50–59 years (46.7%), smokers or former smokers (86.7%), with a body mass index of normoweight (50%), and the degree of airflow obstruction is severe (FEV1 < 30% predicts 50%). There was a weak negative correlation between the RDW value and the FEV1 value in the stable COPD patients who were the study subjects, and the correlation was not statistically significant (p > 0.05). CONCLUSION: There is no significant relationship between RDW and FEV1 values in stable COPD patients.

scholarly journals MO450ANEMIC PATIENTS WITH ELEVATED RED CELL DISTRIBUTION WIDTH (RDW) ARE LIKELY TO HAVE FASTER FUTURE CKD PROGRESSION

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Hiroshi Tanaka
Keyword(s):  
Blood Cells ◽  
Laboratory Data ◽  
Red Cell Distribution Width ◽  
First Year ◽  
Red Cell ◽  
Cell Distribution ◽  
Ckd Progression ◽  
Distribution Width ◽  
Annual Decline ◽  
Egfr Decline

Abstract Background and Aims Elevation in red cell distribution width (RDW), a marker of size variance in red blood cells, recently has been reported to predict future cardiovascular event. RDW elevation has also been reported to be associated with faster CKD progression. It is not known whether the elevation of RDW is merely a sequela of, or truly a predictor of, the decline in kidney function. Method A hospital-wide study with all the laboratory data for a period of 4 years and 2 months was conducted. All the adult patients in whom an eGFR slope was obtained over 731 days or more with haemoglobin (Hb) measurements of at least twice over 731 days or more were included. Hb and RDW values were classified according to the timing of measurement: first-year measurements during the period vs last-year values. The effects of Hb and RDW on the annual decline in eGFR (mL/min/1.73m2/year) were analyzed. Statistical analysis was performed with R 3.6.0 on Ubuntu. Results A total of 4,611 patients (M:F = 2124:2487, age 18-105 (median 68) years) were included. The first-month Hb and RDW were 7.5 − 20.2 (median 13.6) g/dL and 10.5 − 34.6 (median 12.6). eGFR was 3.4 − 195 (median 69.3) mL/min/1.73m2. Patients with the highest tertile in the first-year RDW had significantly faster decline in eGFR than the rest (-1.74 vs -1.51, P=0.04), while patients with the highest tertile in the last-year RDW had virtually identical eGFR decline compared with the rest. Patients with higher RDW (&gt;=median) and lower Hb (&lt; median) had significantly faster decline in eGFR than the rest (-1.84±4.11 vs -1.47±2.95, P =0.002). Conclusion Anemic patients with elevated RDW are likely to have faster CKD progression in the future.

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