scholarly journals Association of the Red Cell Distribution Width with Red Blood Cell Deformability

2012 ◽  
pp. 211-216 ◽  
Author(s):  
Kushang V. Patel ◽  
Joy G. Mohanty ◽  
Bindu Kanapuru ◽  
Charles Hesdorffer ◽  
William B. Ershler ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Cell Deformability ◽  
Distribution Width ◽  
Red Blood Cell Deformability

scholarly journals Evaluation of Red Blood Cell Parameters as a Biomarker for Long-Term Glycemic Control Monitoring Among Type 2 Diabetic Patients in Southwest Ethiopia: A Cross-Sectional Study

2021 ◽  
Author(s):  
Misganaw Asmamaw ◽  
Tariku Sime ◽  
Kumsa Kene ◽  
Minale Fekadie ◽  
Muluken Teshome ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Red Cell Distribution Width ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Cell Distribution ◽  
Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Cell Parameters

Abstract Background: Type 2 Diabetes Mellitus (T2 DM) is a common type of DM characterized by hyperglycemia. Glycation of hemoglobin and related proteins in DM can affect the physiological and structural properties of red blood cells. Although glycated hemoglobin (HbA1c) test continues to be the gold standard for the assessment of long-term glycemic control accessibility and affordability of the test in routine diagnosing service are still limited in developing countries. Hence, this study was aimed to assess red blood cell parameters as a biomarker for long-term glycemic monitoring among T2 DM patients.Methods: Facility-based cross-sectional study through a consecutive sampling technique was conducted among 124 T2 DM patients at the chronic illness follow-up clinic of Jimma Medical Center (JMC) from July 27 to August 31, 2020. A structured questionnaire was used to collect socio-demographic and clinical-related data. Five milliliters of the blood specimen was collected from each eligible T2 DM patient. HbA1c and red blood cell parameters were determined by Cobas 6000 and DxH 800 fully automated analyzers respectively. Data were entered into Epi-data software version 3.1 and exported to SPSS 25 version for analysis. Independent t-test and Pearson’s correlation coefficient were used to address the research questions. A P-value < 0.05 was considered statistically significant. Results: The mean age of study participants was 51.84± 11.6 years. 60.5% of T2 DM patients were in poor glycemic control. There was a significant mean difference between good and poor glycemic controlled T2 DM patients in red blood cell count (4.79±0.5 vs 4.38±0.8), hemoglobin (14.13±1.4 vs 13.60±1.6), mean corpuscular volume (89.52±4.7 vs 92.62±7.5), mean corpuscular hemoglobin (29.63±1.6 vs 30.77±2.9), and red cell distribution width (13.68±1.1 vs 14.63±1.2) respectively. Red blood cell count was inversely correlated (r=-0.280, p=0.002) with HbA1c while mean corpuscular volume (r=0.267, p=0.003), mean corpuscular hemoglobin (r=0.231, p=0.010), and red cell distribution width (r= 0.496, p=0.000) were positively correlated with level of HbA1c. Conclusion: Red cell count, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width could be useful indicators to monitor the glycemic status of T2 DM patients instead of HbA1c, though large prospective studies should be considered.

scholarly journals Correlation between Red Cell Distribution Width (RDW) with Kidney Function and Hematologic Parameters in Patients undergo Regular Hemodialysis

2020 ◽  
Vol 2 (4) ◽  
pp. 171-176
Author(s):  
Soraya Mourina Hutasuhut ◽  
Alwi Thamrin Nasution ◽  
M. Feldy Gazaly Nasution
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Hematological Analysis ◽  
Regular Hemodialysis

Background. Red cell distribution width (RDW) is a coefficient of variation in red blood cells that can decrease erythropoesis or increase the destructiveness of red blood cells. The objectives of research  to determine the relationship of RDW as an inflammatory marker with renal function and hematological parameters in patients undergoing regular hemodialysis Method; Cross sectional research on 20 patients undergoing regular hemodialysis > 3 months in RSUP H Adam Malik Medan. Vital sign, antropometry and venous blood retrieval are performed  shortly  before hemodialysis. RDW measurement comes from the red blood cell distribution curve in hematological analysis and is an indicator of variation in red blood cell size. Result: out  of 20 subjek studies,  there were 13 men (65.0%) and 7 (35.0%) women The majority of subjects had comorbid  diabetes mellitus  14 (70.0%), hypertension 4 (20.0%). The average length of time patients underwent  hemodialysis was 24.45 ± 20.98 months. There is a significant correlation between RBW and creatinine, Hb, and neutropil (r: 0.519, p:0,019*; r:  0.497,  p: 0.026*;r: 0.464,  p: 0.039*, respectively) Conclusion: There is a significant relationship between RBW and creatinine, Hb and neutropphils in patients undergoing regular hemodialysis > 3 months.

scholarly journals Hematological parameters in apparently Healthy Eritrean blood donors at the National Blood Transfusion Center, Asmara, Eritrea.

2020 ◽  
Author(s):  
Faris Abdon ◽  
Elias Adgoy ◽  
Nahom Berhane ◽  
Senet Ibrahim ◽  
Adil Khalil ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Donors ◽  
Hemoglobin Level ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Mean Cell Hemoglobin ◽  
Apparently Healthy

Introduction: This study was done to measure the Hemoglobin levels, Red Blood Cells count, and Red Blood cell parameters: MCV, MCH, MCHC, RDW, and Hematocrit of the apparently healthy blood donors attending the National Blood Bank of Eritrea. Methods: Blood samples were collected from the peripheral veins into the (EDTA)-tube and examined for Red Blood Cell count (RBC), hemoglobin (Hb), Hematocrit (%), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), and red cell distribution width (RDW), analyzed and measured by automated blood analyzer. Results: The mean Hemoglobin level was 14.428±1.485 g/dl, RBCs count was 4.744±0.482×1012/L, HCT was 41.929 ±3.75%, Red cell distribution width (RDW) mean was 13.571±0.744%, MCV was 88.582± 4.0558 Fimtoliter, MCH was 30.470±2.188 picogram, and MCHC was a mean of 34.393±1.347g/dl. The difference between males and females in MCV and MCHC was significant in favor of female donors. And a weak positive correlation had been found between the weight and age of donors and the Hemoglobin level. All the measured values were found to be within the global referenced ranges. Conclusion: Hemoglobin, RBCs count and RBCs indices of apparently healthy Eritrean blood donors were measured for reference, and all values were found within normal reference ranges.

scholarly journals DIAGNOSTIC EFFICACY OF RED BLOOD CELL INDICES IN DIAGNOSIS OF BETA THALASSEMIA TRAIT TAKING HAEMOGLOBIN ELECTROPHORESIS AS GOLD STANDARD

2021 ◽  
Vol 71 (3) ◽  
pp. 1006-10
Author(s):  
Sahar Rabbani ◽  
Muhammad Farooq ◽  
Samina Naeem ◽  
Nasir Uddin ◽  
Muhammad Abdul Naeem ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Red Cell Distribution Width ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Cell Distribution ◽  
Diagnostic Efficacy ◽  
Mean Cell Volume ◽  
Distribution Width ◽  
Thalassemia Trait

Objective: To determine the diagnostic efficacy of haematological indices for the diagnosis of beta thalassemia trait taking haemoglobin electrophoresis as a gold standard. Study Design: Cross sectional study. Place and Duration of Study: Department of Haematology Combined Military Hospital Lahore, from Aug to Dec 2019. Methodology: Two hundred and six anaemic patients 20-70 years of age of both genders were included in the study. Blood was collected from all the patients and complete blood count were generated through automated haematology analyser Sysmex KX-21. Based on the complete blood count parameters like mean cell volume, red blood cell count, red cell distribution width and mean cell haemoglobinthe haematological indices such as Mentzer, Ricerca, mean density of Hb/litre of blood, mean cell Hb density and red cell distributon width indices were calculated. The haemoglobin A2 band of >3.5% on haemoglobin electrophoresis was taken as cut off for Beta thalassemia trait. Results: Out of the 206 blood samples analysed, 120 (58%) were labelled as Beta thalassemia trait after Hb electrophoresis and 86 cases had anemia due to other causes. Mentzer index established the highest sensitivity of 92.5% whereas RICERCA index established the highest specificity of 94.1%. Mentzer and red cell distribution width indexhad highest diagnostic efficacy value up to 90.3%. Conclusion: We conclude that Mentzer and red cell distribution width index showed the highest diagnostic significance. The Mentzer index has the highest sensitivity whereas Ricerca index has the highest specificity. The red blood cell count, haemoglobin and mean cell volume.............

scholarly journals Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 672
Author(s):  
Yung-Chun Su ◽  
Sheng-Chen Wen ◽  
Ching-Chia Li ◽  
Hsiao-Chun Su ◽  
Hung-Lung Ke ◽  
...  
Keyword(s):  
Blood Cell ◽  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Red Cell Distribution Width ◽  
Width Ratio ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Cell Markers ◽  
Upper Tract

The importance of blood cell markers in patients with malignant tumors has been studied, but there are few studies on the prognostic value of hemoglobin-to-red cell distribution width ratio (HRR) in cancer. This is the first study to investigate the effect of preoperative HRR on patients with upper tract urothelial carcinoma (UTUC). Our retrospective cohort study included 730 UTUC patients who underwent nephroureterectomy from 2000 to 2019. Clinicopathological parameters were compared according to HRR levels, and the relationship between blood cell markers (HRR, white blood cell [WBC] count, platelet count) and prognosis was evaluated using Kaplan–Meier method and Cox regression model. We found that patients with HRR ≤ 1.05 tended to have worse renal function, higher pathological stages, and more high-grade tumors. In univariate analysis, HRR ≤ 1.05, WBC > 8.65 × 103 cells/μL and platelets >309 × 103 cells/μL were associated with poor progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). Multivariate analysis demonstrated that HRR ≤ 1.05 and WBC > 8.65 × 103 cells/μL were independent prognostic factors for predicting deterioration of PFS, CSS, and OS. In conclusion, HRR and WBC are easy to obtain in clinical practice and are useful indicators to provide prognostic information before surgery for UTUC.

scholarly journals Red cell distribution width is associated with future risk of incident stroke

2016 ◽  
Vol 115 (01) ◽  
pp. 126-134 ◽  
Author(s):  
Trygve S. Ellingsen ◽  
Tove Skjelbakken ◽  
Ellisiv B. Mathiesen ◽  
Inger Njølstad ◽  
Tom Wilsgaard ◽  
...  
Keyword(s):  
General Population ◽  
Blood Cell ◽  
Cell Count ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Blood Cell Count ◽  
Distribution Width ◽  
Risk Of Death

SummaryRed cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth survey of the Tromsø Study, conducted in 1994/95. Incident stroke was registered from inclusion until December 31, 2010. Cox regression models were used to calculate hazard ratios (HR) with 95 % confidence intervals (95 % CI) for stroke, adjusted for age, sex, body mass index, smoking, haemoglobin level, white blood cell count, thrombocyte count, hypertension, total cholesterol, triglycerides, self-reported diabetes, and red blood cell count. During a median follow-up of 15.8 years, 1152 participants experienced a first-ever stroke. A 1 % increment in RDW yielded a 13 % higher risk of stroke (multivariable HR: 1.13, 95 % CI: 1.07–1.20). Subjects with RDW in the highest quintile compared to the lowest had a 37 % higher risk of stroke in multivariable analysis (HR: 1.37, 95 % CI: 1.11–1.69). Subjects with RDW above the 95-percentile had 55 % higher risk of stroke compared to those in the lowest quintile (HR: 1.55, 95 % CI: 1.16–2.06). All risk estimates remained unchanged after exclusion of subjects with anaemia (n=1102). RDW was not associated with increased risk of death within one year or during the entire follow-up after an incident stroke. RDW is associated with incident stroke in a general population, independent of anaemia and traditional atherosclerotic risk factors.

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