Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive

2015 ◽  
Author(s):  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Home ◽  
Nursing Home Placement ◽  
Cause And Effect ◽  
Home Placement

scholarly journals Short-Term Response to Cholinesterase Inhibitors in Alzheimer’s Disease Delays Time to Nursing Home Placement

2018 ◽  
Vol 15 (10) ◽  
pp. 905-916 ◽  
Author(s):  
Carina Wattmo ◽  
Elisabet Londos ◽  
Lennart Minthon
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Home ◽  
Nursing Home Placement ◽  
Specific Response ◽  
Short Term ◽  
Chei Treatment ◽  
The Individual ◽  
Home Placement ◽  
Term Response

Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer’s disease (AD). Whether the individual-specific response directly affects time to nursing home placement (NHP) was not investigated. Objective: We examined the relationship between the 6-month response to ChEI and institutionalization. Methods: In a prospective, observational, multicenter study, 881 outpatients with a clinical AD diagnosis and a Mini-Mental State Examination score of 10-26 at the start of ChEI therapy (baseline) were included. The participants were evaluated using cognitive, global, and activities of daily living (ADL) scales at baseline and semiannually over 3 years. The date of NHP was recorded. Results: During the study, 213 patients (24%) were admitted to nursing homes. The mean ± standard deviation time from baseline (AD diagnosis) to NHP was 20.8 ± 9.3 months. After 6 months of ChEI treatment, the improved/unchanged individuals had longer time to NHP than those who worsened. The prolonged time to NHP was 3 months for cognitive response (P=0.022), 4 months for global response (P=0.004), 6 months for basic ADL response (P<0.001), and 8 months for response in all three scales (P<0.001). No differences were detected between the improved and unchanged groups in any scales. Conclusion: Patients who exhibit a positive short-term response to ChEI can expect to stay in their own home for 3-8 months longer. These findings underline the importance of a comprehensive clinical examination including various assessment scales to evaluate treatment response and provide a more accurate prognosis.

scholarly journals High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer’s disease

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Malin Degerman Gunnarsson ◽  
Martin Ingelsson ◽  
Kaj Blennow ◽  
Hans Basun ◽  
Lars Lannfelt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Nursing Home ◽  
Nursing Home Placement ◽  
Rapid Progression ◽  
Home Placement

Treatment with galantamine and time to nursing home placement in Alzheimer's disease patients with and without cerebrovascular disease

2009 ◽  
Vol 24 (5) ◽  
pp. 479-488 ◽  
Author(s):  
Howard H. Feldman ◽  
Tuula Pirttila ◽  
Jean François Dartigues ◽  
Brian Everitt ◽  
Bart Van Baelen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Home ◽  
Cerebrovascular Disease ◽  
Nursing Home Placement ◽  
Home Placement

P2-321: Factors that influence nursing home placement in an Alzheimer's disease cohort

2012 ◽  
Vol 8 (4S_Part_10) ◽  
pp. P375-P375
Author(s):  
Susan Rountree ◽  
Wenyaw Chan ◽  
Valory Pavlik ◽  
Rachelle Doody
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Home ◽  
Nursing Home Placement ◽  
Home Placement

Donepezil Is Associated with Delayed Nursing Home Placement in Patients with Alzheimer's Disease

2003 ◽  
Vol 51 (7) ◽  
pp. 937-944 ◽  
Author(s):  
David S. Geldmacher ◽  
George Provenzano ◽  
Thomas McRae ◽  
Vera Mastey ◽  
John R. Ieni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Home ◽  
Nursing Home Placement ◽  
Home Placement

P2-317: Factors influencing time to nursing home placement in persons with probable Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_10) ◽  
pp. P374-P374
Author(s):  
Angeline Nguyen ◽  
Jocelyn McGee ◽  
Wenyaw Chan ◽  
Eveleen Darby ◽  
Valory Pavlik ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Home ◽  
Nursing Home Placement ◽  
Factors Influencing ◽  
Home Placement
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