scholarly journals Peculiarities of clinical course of osteoarthritis combined with type 2 diabetes mellitus, obesity and hypertension

2018 ◽  
Vol 42 (4) ◽  
pp. 42-46
Author(s):  
Y. I. Serdulets
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Motor Function ◽  
Abdominal Obesity ◽  
Clinical Course ◽  
Pain Syndrome ◽  
Daily Activities ◽  
Clinical Indices

The aim of paper is to study the clinical indices of articular syndrome in patients with osteoarthritis combined with type 2 diabetes mellitus, obesity and hypertension. It has been found out that the combined course of osteoarthritis, abdominal obesity and type 2 diabetes mellitus is accompanied by the intensified pain syndrome in the joints, a disruption of the motor function as well as the daily activities of patients.

scholarly journals Clinical and metabolic aspects of the influence of type 2 diabetes mellitus on the manifestation of articular syndrome in patients with gonarthrosis

2011 ◽  
Vol 57 (4) ◽  
pp. 17-20
Author(s):  
L G Strongin ◽  
K D Klimova ◽  
E A Grunina ◽  
K G Korneva ◽  
E S Trifonova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Clinical Course ◽  
Pain Syndrome ◽  
Functional Changes ◽  
Patients With Diabetes ◽  
Inflammatory Processes

The present work was designed to study the influence of type 2 diabetes mellitus on the clinical course of articular syndrome in patients with combined pathology. A total of 45 patients with diabetes mellitus and gonarthrosis were examined and 45 ones with gonarthrosis without concomitant type 2 diabetes. The patients of both groups were matched for age, sex, duration and stage of gonarthrosis, and body mass index. It was shown that concomitant diabetes mellitus promotes progression of articular syndrome. Decompensation of diabetic state leads to exacerbation of pain syndrome, marked functional changes and increased severity of the inflammatory processes in the joints.

Association of Major Dietary Patterns with General and Abdominal Obesity in Iranian Patients with Type 2 Diabetes Mellitus

2015 ◽  
Vol 85 (3-4) ◽  
pp. 145-155 ◽  
Author(s):  
Marjan Ghane Basiri ◽  
Gity Sotoudeh ◽  
Mahmood Djalali ◽  
Mohammad Reza Eshraghian ◽  
Neda Noorshahi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Abdominal Obesity ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Diabetic Patients ◽  
General Obesity ◽  
Healthy Dietary Pattern

Abstract. Background: The aim of this study was to identify dietary patterns associated with general and abdominal obesity in type 2 diabetic patients. Methods: We included 728 patients (35 - 65 years) with type 2 diabetes mellitus in this cross-sectional study. The usual dietary intake of individuals over 1 year was collected using a validated semi-quantitative food frequency questionnaire. Weight, height, and waist circumference were measured according to standard protocol. Results: The two major dietary patterns identified by factor analysis were healthy and unhealthy dietary patterns. After adjustment for potential confounders, subjects in the highest quintile of the healthy dietary pattern scores had a lower odds ratio for the general obesity when compared to the lowest quintile (OR = 0.45, 95 % CI = 0.26 - 0.79, P for trend = 0.02), while patients in the highest quintile of the unhealthy dietary pattern scores had greater odds for the general obesity (OR = 3.2, 95 % CI = 1.8 - 5.9, P for trend < 0.001). There were no significant associations between major dietary patterns and abdominal obesity, even after adjusting for confounding factors. Conclusion: This study shows that in patients with type 2 diabetes mellitus, a healthy dietary pattern is inversely associated and an unhealthy dietary pattern is directly associated with general obesity.

scholarly journals Hepatic Transcriptome Analysis Revealing the Molecular Pathogenesis of Type 2 Diabetes Mellitus in Zucker Diabetic Fatty Rats

2020 ◽  
Vol 11 ◽  
Author(s):  
Chengdong Xia ◽  
Xiuli Zhang ◽  
Tianshu Cao ◽  
Jiannong Wang ◽  
Cuidan Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Liver Injury ◽  
Er Stress ◽  
Molecular Pathogenesis ◽  
Clinical Indices ◽  
Zdf Rats ◽  
Hepatic Transcriptome

Around 9% of the adult population in the world (463 million) suffer from diabetes mellitus. Most of them (~90%) belong to type 2 diabetes mellitus (T2DM), which is a common chronic metabolic disorder, and the number of cases has been reported to increase each year. Zucker diabetic fatty (ZDF) rat provides a successful animal model to study the pathogenesis of T2DM. Although previous hepatic transcriptome studies revealed some novel genes associated with the occurrence and development of T2DM, there still lacks the comprehensive transcriptomic analysis for the liver tissues of ZDF rats. We performed comparative transcriptome analyses between the liver tissues of ZDF rats and healthy ZCL rats and also evaluated several clinical indices. We could identify 214 and 104 differentially expressed genes (DEGs) and lncRNAs in ZDF rats, respectively. Pathway and biofunction analyses showed a synergistic effect between mRNAs and lncRNAs. By comprehensively analyzing transcriptomic data and clinical indices, we detected some typical features of T2DM in ZDF rats, such as upregulated metabolism (significant increased lipid absorption/transport/utilization, gluconeogenesis, and protein hydrolysis), increased inflammation, liver injury and increased endoplasmic reticulum (ER) stress. In addition, of the 214 DEGs, 114 were known and 100 were putative T2DM-related genes, most of which have been associated with substance metabolism (particularly degradation), inflammation, liver injury and ER stress biofunctions. Our study provides an important reference and improves understanding of molecular pathogenesis of obesity-associated T2DM. Our data can also be used to identify potential diagnostic markers and therapeutic targets, which should strengthen the prevention and treatment of T2DM.

scholarly journals Self-reported type 2 diabetes Mellitus is associated with abdominal obesity and poor perception of health in shift workers

2016 ◽  
Vol 29 (6) ◽  
pp. 775-783
Author(s):  
Carine FRÖHLICH ◽  
Raquel CANUTO ◽  
Anderson da Silva GARCEZ ◽  
Marcos Pascoal PATTUSSI ◽  
Ruth Liane HENN ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Waist Circumference ◽  
Abdominal Obesity ◽  
Family Income ◽  
Leisure Time Physical Activity ◽  
Shift Workers ◽  
Reported Health

ABSTRACT Objective: To investigate factors that are associated with type 2 diabetes Mellitus in shift workers of a slaughterhouse in Southern Brazil. Methods: This cross-sectional study included 1,194 18- to 50-year-old workers of both sexes. The presence of type 2 diabetes Mellitus was self-reported and confirmed by the use of hypoglycemic drugs or insulin. The independent variables were sex, age, skin color, marital status, education level, family income, leisure time physical activity, smoking, and self-reported health and nutritional status (body mass index and waist circumference). Multivariate analysis was performed from an a priori conceptual model. Results: The prevalence of diabetes was 1.3% (95%CI=0.6-1.9). Type 2 diabetes Mellitus was associated with poor or regular self-reported health (OR)=3.72; 95%CI=1.28-10.78) and level II abdominal obesity ³102 for men and ³88 for women (OR=5.76; 95%CI=1.07-29.10). Conclusion: The prevalence of type 2 diabetes Mellitus was low. Moreover, the study evidenced the importance of using waist circumference to surveil and screen for metabolic diseases, such as type 2 diabetes Mellitus, and to monitor the low quality of life in the study individuals given the poor self-perceived health of workers with the said disease.

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