scholarly journals Chronic Myelocytic Leukemia Developing as a Second Cancer in a Patient with Chronic Lymphocytic Leukemia

1981 ◽  
Vol 31 (3) ◽  
pp. 172-176 ◽  
Author(s):  
A. Khojasteh ◽  
M. C. Perry ◽  
H. M. Taylor
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Chronic Myelocytic Leukemia ◽  
Second Cancer ◽  
Myelocytic Leukemia

scholarly journals The Granulocyte Response to Endotoxin in Patients with Hematologic Disorders

Blood ◽  
1964 ◽  
Vol 23 (5) ◽  
pp. 581-599 ◽  
Author(s):  
JOHN C. MARSH ◽  
SEYMOUR PERRY
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Bacterial Endotoxin ◽  
Chronic Myelocytic Leukemia ◽  
Hematologic Disorders ◽  
Recent Onset ◽  
Myelocytic Leukemia ◽  
Normal Individuals

Abstract Sixty patients with disorders involving the bone marrow were tested with a purified bacterial endotoxin given intravenously. Their leukocyte and granulocyte responses were evaluated based on criteria established in normal individuals and in patients with leukocytosis. Results in patients with chronic myelocytic leukemia, untreated or in relapse, suggest that adequate granulocyte mobilization may still occur if the disease has been of recent onset or if the count has recently started to rise in spite of therapy. Patients in remission demonstrated adequate granulocyte reserves. Most patients with chronic lymphocytic leukemia in this study responded well with an increase in the number of granulocytes. Patients with multiple myeloma as a group showed inadequate granulocyte mobilization. This study demonstrates that endotoxin testing is useful for the evaluation of bone marrow granulocyte reserves in patients with hematologic disorders.

scholarly journals Plasma Lactic Dehydrogenase and Phosphohexose Isomerase in Leukemia

Blood ◽  
1958 ◽  
Vol 13 (3) ◽  
pp. 245-257 ◽  
Author(s):  
M. C. BLANCHAER ◽  
P. T. GREEN ◽  
J. P. MACLEAN ◽  
M. J. HOLLENBERG
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Cell Count ◽  
White Cell Count ◽  
Lactic Dehydrogenase ◽  
High Plasma ◽  
Lymphocytic Leukemia ◽  
Chronic Myelocytic Leukemia ◽  
Phosphohexose Isomerase ◽  
Myelocytic Leukemia ◽  
Plasma Enzymes

Abstract Two enzymes, lactic dehydrogenase (LD) and phosphohexose isomerase (PHI), were measured in the plasma of 30 patients with leukemia and compared with the findings in 66 control subjects. Abnormally elevated PHI levels were found in both acute and chronic myelocytic leukemia, but not in lymphocytic leukemia. The plasma LD was increased above normal in acute and chronic myelocytic leukemia, in acute lymphocytic, but not in chronic lymphocytic leukemia. Both enzymes were normal or only slightly raised in three patients with the aleukemic type of the disease. Hemolytic anemia in seven leukemic patients was associated with high plasma LD values in the presence of relatively low PHI levels. Results of serial enzyme studies from the time of diagnosis until death indicated that both plasma enzymes, but especially the LD, usually reflected changes in the course of the disease-falling during remissions and rising during relapses. In most cases this enzyme paralleled the leukocyte level but occasionally indicated the onset of a relapse or remission before the white cell count had begun to change.

scholarly journals Variation in the Duration of Survival of Patients with the Chronic Leukemias

Blood ◽  
1960 ◽  
Vol 15 (3) ◽  
pp. 332-349 ◽  
Author(s):  
MANNING FEINLEIB ◽  
BRIAN MACMAHON
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Median Duration ◽  
Total Sample ◽  
Lymphocytic Leukemia ◽  
Blood Type ◽  
Chronic Myelocytic Leukemia ◽  
Jewish Women ◽  
Duration Of Symptoms ◽  
Myelocytic Leukemia ◽  
Log Normal

Abstract Data on 649 white residents of Brooklyn first diagnosed as having chronic leukemia during the period 1943 to 1952 were obtained from hospital records. Diagnosis was based on marrow biopsy or autopsy in 65 per cent. Follow-up to January 1, 1958 was complete for 90.0 per cent (584) of the patients. The life table method and the method of maximum likelihood applied to the three parameter log-normal distribution were used to analyze survival trends of these patients. The median duration of survival after diagnosis for the total sample was 11.65 months. Sixteen per cent of the patients survived longer than 43 months after diagnosis, and 9 per cent survived for five years. The mean duration of symptoms prior to diagnosis was 5.1 months. Median durations were somewhat longer for females than for males and for patients with chronic lymphocytic leukemia than for those with chronic myelocytic leukemia. However, neither of these differences was statistically significant. The duration of survival after diagnosis was significantly shorter for males and females with chronic myelocytic leukemia who were over 60 years of age than for any other age or diagnosis group. For patients with chronic lymphocytic leukemia, duration of survival was independent of age. Duration of survival after diagnosis was independent of the duration of symptoms prior to diagnosis. The median duration of survival for a group of patients in whom the diagnosis was made during examination for symptoms referable to some other condition was similar to that of those presenting with symptoms clearly referable to leukemia. Two groups by religion and ABO blood type showed significantly longer median durations of survival after diagnosis than comparable groups. Jewish women with chronic lymphocytic leukemia showed a median duration of survival of 21.1 months compared with 6.4 months for the non-Jewish women. Women with chronic myelocytic leukemia of type B or AB blood had median survivals after diagnosis of about 24 months, compared with about 10 months for the same groups with type A or O blood.

Cytofluorometric detection of chronic myelocytic leukemia supervening in a patient with chronic lymphocytic leukemia

1986 ◽  
Vol 80 (2) ◽  
pp. 269-275 ◽  
Author(s):  
Labib Hashimi ◽  
Ayad Al-Katib ◽  
Roland Mertelsmann ◽  
Anwar N. Mohamed ◽  
Benjamin Koziner
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Chronic Myelocytic Leukemia ◽  
Myelocytic Leukemia

CLL-069: Incidence of Second Cancer in Patients with Chronic Lymphocytic Leukemia: The Indian Scenario

2021 ◽  
Vol 21 ◽  
pp. S316-S317
Author(s):  
Ajay Gogia ◽  
Lalit Kumar ◽  
Atul Sharma ◽  
Saumyaranjan Mallick ◽  
Ritu Gupta ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Second Cancer ◽  
Indian Scenario

scholarly journals Gambaran Laboratorium Leukemia Kronik di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang

2013 ◽  
Vol 2 (3) ◽  
pp. 141
Author(s):  
Muthia Rendra ◽  
Rismawati Yaswir ◽  
Akmal M Hanif
Keyword(s):  
Internal Medicine ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Lymphocytic Leukemia ◽  
Chronic Myelocytic Leukemia ◽  
Laboratory Findings ◽  
Medicine Department ◽  
Chronic Leukemia ◽  
Myelocytic Leukemia ◽  
Moderate Anemia

AbstrakLeukemia merupakan penyakit keganasan sel darah yang berasal dari sumsum tulang ditandai oleh proliferasi sel-sel darah putih, dengan manifestasi adanya sel-sel abnormal dalam darah tepi. Pada tahun 2006, leukemia berada pada urutan ke-5 dari keseluruhan penderita kanker di Indonesia. Leukemia kronik merupakan leukemia yang paling sering terjadi pada dewasa dan lanjut usia. Secara umum leukemia kronik diklasifikasikan atas Leukemia Granulositik Kronik (LGK) dan Leukemia Limfositik Kronik (LLK). Leukemia kronik yang perjalanannya lambat dan diiringi oleh gejala yang tidak khas, maka penelitian ini bertujuan untuk mengetahui gambaran laboratorium leukemia kronik di bagian Peyakit Dalam RSUP DR. M. Djamil Padang. Jenis penelitian ini adalah deskriptif retrospektif. Instrumen yang digunakan pada penelitian ini adalah data sekunder yang diperoleh dari Instalasi Rekam Medik RSUP Dr. M. Djamil Padang berupa data pasien leukemia kronik yang dirawat di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang sejak 1 Januari 2010 – 31 Desember 2012. Hasil penelitian ini menunjukkan bahwa dari 16 kasus leukemia granulositik kronik terdapat 37,5% pasien mengalami anemia sedang, 100% leukositosis, jumlah trombosit dapat menurun, normal, dan meningkat dengan presentase masing-masing 25%, 25%, dan 50%. Gambaran eritrosit sebagian besar normositik anisositosis. Separuh pemeriksaan darah tepi menunjukkan peningkatan persentasi mielosit, 31,25% menunjukkan peningkatan persentasi metamielosit dan eosinofil, serta sebagian besar menunjukkan presentasi blast. Sedangkan gambaran sumsum tulang hiperseluler, penekanan eritropoetik, mielopoetik hiperaktif, dan trombopoetik dalam batas normal. Leukemia limfositik kronik yang terdiri dari 1 kasus menunjukkan gambaran laboratorium berupa anemia sedang, leukositosis, trombositopenia, gambaran eritrosit nomokrom anisositosis, peningkatan jumlah leukosit, peningkatan jumlah limfosit, presentasi smudge cell, dan ditemukan presentasi blast pada darah tepi, tetapi selularitas tidak dapat dinilai.Kata kunci: leukemia kronik, darah tepi, BMPAbstractLeukemia is a malignant disease of blood cells derived from the bone marrow characterized by the proliferation of white blood cells, with the manifestation of the abnormal cells in the peripheral blood. In 2006, leukemia was ranked 5th of all cancer patients in Indonesia. Chronic leukemia is the most common leukemia in adult and the elderly. In general, chronic leukemia classified on chronic myelocytic leukemia (CML) and chronic lymphocytic leukemia (CLL). The onset of chronic leukemia is insidious and accompanied by symptoms that are not typical, this research aims to describe the laboratory findings of chronic leukemia patients treated at Internal Medicine Department of Dr. M. Djamil Hospital Padang.This research is a retrospective descriptive research. The instruments used in this research are the secondary data derived from the Medical Record Departement Dr. M. Djamil Hospital Padang in the form of leukemia chronic patients’ data who were treated in Internal Medicine Department of Dr. M. Djamil Hospital Padang since January 1st 2010 – December 31st 2012. The results of this research showed that of 16 cases of chronic myelocytic leukemia contained 37.5% of the patients had moderate anemia, leukocytosis 100%, platelet count can be decreased, normal, and increased the percentage of each 25%, 25%, and 50%. The morphology of erythrocytes mostly normocytic anisocytosis. Half of peripheral blood examination showed an increase in the percentage of myelocyte, 31.25% showed an increase in the percentage metamyelocyte and eosinophils, as well as most of the shows presentation blast. The bone marrow are hypercellular, compressing erythropoietic, myelopoietic hyperactivity and thrombopoietic mostly normal in number. Chronic lymphocytic leukemia consisting of 1 case shows the laboratory findings are moderate anemia, leukocytosis, thrombocytopenia, the morphology of erythrocyte is normochromic anisocytosis, leukocytes increase in number, increase in the number of lymphocytes, presentations smudge cells, and blast presentation is found in the peripheral blood, but the cellularity not be assessed.Keywords: chronic leukemia, peripheral blood, BMP

scholarly journals Risk of second cancer after chronic lymphocytic leukemia

2007 ◽  
Vol 121 (1) ◽  
pp. 151-156 ◽  
Author(s):  
Claudia Schöllkopf ◽  
Ditte Rosendahl ◽  
Klaus Rostgaard ◽  
Christian Pipper ◽  
Henrik Hjalgrim
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Second Cancer
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