Lung transplantation for silicosis: a case study

2019 ◽  
Vol 28 (Volume 28 Issue 2) ◽  
pp. 13-17
Author(s):  
Kate McEwen ◽  
Lyndell Brodie
Keyword(s):  
Lung Transplantation ◽  
Medication Management ◽  
Social Situation ◽  
Non Invasive ◽  
Transplantation Surgery ◽  
Non Invasive Ventilation ◽  
The Social ◽  
End Stage

Lung transplantation has become a well-established treatment for a variety of end-stage pulmonary diseases. Silicosis is a rare indication for lung transplantation; however, there is currently no other treatment available for the disease in its end stages. This case study presents a 52-year-old man who presented with silicosis for lung transplantation. His in-hospital recovery journey is examined and discussion is provided about his experience of complications, including type 2 respiratory failure and non-compliance with non-invasive ventilation therapy. The patient education and support provided, particularly related to medication management following transplantation surgery, if of key importance during the transplant recipient’s recovery. The social situation and its implications for both the patient and their family should also be considered. Both these aspects are also explored in the context of the case presented.

Lung transplantation for silicosis and recovery: an Australian case study

2021 ◽  
Vol 30 (3) ◽  
pp. 178-183
Author(s):  
Kate McEwen ◽  
Lyndell Brodie
Keyword(s):  
Lung Transplantation ◽  
Medication Management ◽  
Social Situation ◽  
Bilateral Lung Transplantation ◽  
Transplantation Surgery ◽  
Australian Case ◽  
Bilateral Lung ◽  
End Stage

Lung transplantation is a well-established treatment for a variety of end-stage pulmonary diseases. However, the journey of a lung transplant recipient is complex and multifaceted. Silicosis is a rare indication for lung transplantation, but no other treatment is yet available for this disease in its end stages. This Australian case study presents a 52-year-old man with silicosis who received bilateral lung transplantation. The patient was frequently noncompliant with noninvasive ventilation therapy and experienced the complication of type 2 respiratory failure. Patient education and support provided, particularly around medication management following transplantation surgery, are discussed here. The patient's social situation and its implications for both him and his family are also considered.

scholarly journals Persistent type 2 respiratory failure on background of advanced thymoma with lung metastases

2019 ◽  
Vol 12 (11) ◽  
pp. e231690
Author(s):  
Abrar Munir ◽  
Mohsin Ijaz Khan ◽  
Jason Kah Chun Cheong
Keyword(s):  
Respiratory Failure ◽  
Lung Metastases ◽  
Pulmonary Arteries ◽  
High Titre ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
History Of ◽  
Bilateral Lung ◽  
End Stage

We report a patient in her 60s with history of end-stage thymoma with bilateral lung metastases on palliative chemotherapy presented to the hospital with sudden shortness of breath initially treated for probable pulmonary embolism (PE) pending CT of the pulmonary arteries which was subsequently negative for PE. During this admission, she developed transient right-sided facial droop and slurred speech which resolved spontaneously; however, the patient became unresponsive and desaturated with severe decompensated type 2 respiratory failure. Patient was supported with non-invasive ventilation (biphasic positive airway pressure) for few days. Myasthenia gravis was suspected due to clinical features and confirmed by the high titre of acetylcholine receptor antibody titre.

The use of non-invasive ventilation in an exacerbation of chronic obstructive pulmonary disease: a case study

2019 ◽  
Vol 28 (22) ◽  
pp. 1461-1467
Author(s):  
Andrew Ratan
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Medical Setting ◽  
Invasive Ventilation ◽  
Obstructive Pulmonary Disease ◽  
Non Invasive ◽  
Non Invasive Ventilation

This article aims to assist nurses and other health professionals to care for patients who have type 2 respiratory failure as a result of chronic obstructive pulmonary disease, and who require non-invasive ventilation. It outlines findings of a case study that are commonplace in the acute medical setting and aims to highlight important factors that impact on patient care and patient outcome, and to help nursing staff to implement recommended and best practices.

Predictors of success and failure of non-invasive ventilation use in type-2 respiratory failure

2020 ◽  
Author(s):  
Rakesh K. Chawla ◽  
Vinita Yadav ◽  
Sumi Banerjee ◽  
Gaurav Chaudhary ◽  
Aditya Chawla
Keyword(s):  
Respiratory Failure ◽  
Predictors Of Success ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation

scholarly journals Respiratory trajectories in type 2 and non-ambulant 3 Spinal muscular atrophy in the iSMAC cohort study

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011051
Author(s):  
Federica Trucco ◽  
Deborah Ridout ◽  
Mariacristina Scoto ◽  
Giorgia Coratti ◽  
Marion L Main ◽  
...  
Keyword(s):  
Spinal Muscular Atrophy ◽  
Motor Function ◽  
Muscular Atrophy ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Paediatric Cohort ◽  
New Treatments ◽  
Type 3

Objective.To describe the respiratory trajectories and their correlation with motor function in an international paediatric cohort of patients with type 2 and non-ambulant type 3 spinal muscular atrophy (SMA).Methods.Eight-year retrospective observational study of patients in the iSMAc natural history study. We retrieved anthropometrics, forced vital capacity (FVC) absolute, FVC% predicted (FVC%P.), Non-Invasive ventilation (NIV) requirement. Hammersmith functional motor scale (HFMS) and Revised performance of upper limb (RULM) were correlated with respiratory function. We excluded patients in interventional clinical trials and on Nusinersen commercial therapy.Results.There were 437 patients with SMA: 348 type 2, 89 non-ambulant type 3. Mean age at first visit was 6.9(±4.4) and 11.1(±4) years. In SMA type 2 FVC%P declined by 4.2%/year from 5 to 13 years, followed by a slower decline (1.0%/year). In type 3 FVC%P declined by 6.3%/year between 8 and 13 years, followed by a slower decline (0.9%/year). 39% SMA type 2 and 9% type 3 required NIV at median age 5.0(1.8-16.6) and 15.1(13.8-16.3) years. 84% SMA type 2 and 80% type 3 had scoliosis, 54% and 46% required surgery, which did not significantly affect respiratory decline. FVC%P positively correlated with HFMS and RULM in both subtypes.Conclusions.In SMA type 2 and non-ambulant type 3 lung function declines differently, with a common levelling after age 13 years. Lung and motor function correlated in both subtypes. Our data further defines the milder SMA phenotypes and provides novel information to benchmark the long-term efficacy of new treatments for SMA.

scholarly journals Physiotherapy approach after lung transplantation in a critically ill COVID-19 patient: a case report

2021 ◽  
Author(s):  
Veronica Rossi ◽  
Serena Tammaro ◽  
Martina Santambrogio ◽  
Mariangela Retucci ◽  
Francesca Gallo ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Lung Transplantation ◽  
Early Mobilization ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Bilateral Lung Transplantation ◽  
Non Invasive Ventilation ◽  
Respiratory Parameters ◽  
Bilateral Lung

This study describes the case of an 18-years-old male affected by severe COVID-19, who was receiving bilateral lung transplantation (LT), after 71 days of mechanical ventilation and 55 days of veno-venous extracorporeal membrane oxygenation. From post-operative day 2, early mobilization and physiotherapy treatments were performed. Weaning from mechanical ventilation, the use of non-invasive ventilation and tracheostomy management were included in the treatment. Forty-five days after LT the patient was discharged at home, showing improvements in terms of functional and respiratory parameters, quality of life and mood. While evidences about physiotherapy treatments in lung transplantation post severe COVID-19 remain limited, early approach and a multidisciplinary team may be considered key elements for functional recovery of these subjects.

scholarly journals Non-invasive ventilation in acute exacerbation of COPD with mild to moderate type 2 respiratory failure

2021 ◽  
Vol 6 (3) ◽  
pp. 143-151
Author(s):  
Suprova Chakraborty ◽  
Jaykumari Choudhary ◽  
Ganesh Patel
Keyword(s):  
Respiratory Failure ◽  
Acute Exacerbation ◽  
Chronic Obstructive ◽  
Study Group ◽  
Invasive Ventilation ◽  
Obstructive Pulmonary Disease ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Exacerbation Of Copd

Chronic obstructive pulmonary disease is a syndrome of progressive airflow limitation caused by abnormal inflammatory reaction of airway and lung parenchyma. Risk factor for development of COPD is a complex interaction of genetic factors and many environmental exposures, with the cigarette smoking being the most common etiological agent.It is a prospective observational comparative study conducted among patient with mild to moderate type 2 respiratory failure, secondary to acute exacerbation of Chronic Obstructive Pulmonary Disease admitted in chest ward department of Respiratory medicine, Late Shri Lakhi Ram Agrawal Memorial Medical College, Raigarh, Chhattisgarh, India for a period of one year from April 2020- April 2021.A total 60 patients were studied. Out of which, 30 patients in study group for whom non-invasive ventilation support along with conventional treatment was given and remaining 30 patients in comparison group, same treatment was given without non-invasive ventilation support. Both groups had similar demographic, clinical, biochemical profile at the time of admission. Distribution of comorbidities, smoking history were similar as shown below in tables. After application of Non-invasive ventilation along with conventional treatment in study group, the result showed that mean hours of NIV use in study group was 27 hours and mean hours of Oxygen use in comparison group was 98 hours.Use of non-invasive ventilation in acute exacerbation of COPD, with mild to moderate type 2 respiratory failure, reduced tachypnoea, tachycardia, after 4 hours. There were improvement in oxygen saturation after 4 hours, improvement in PH also occurred after 4 hours by 0.04. Non-invasive ventilation gives rest to fatigued inspiratory muscle so work of breathing is reduced. It also restores functional and biochemical changes associated with fatigued muscle so all complication were reduced with use of non- invasive ventilation.

scholarly journals Effectiveness of non-invasive ventilation in patients with type 2 respiratory failure

2021 ◽  
Vol 9 (3) ◽  
pp. 794
Author(s):  
Shahid M. Patel ◽  
Girija P. Nair ◽  
Balaji G. Tuppekar ◽  
Abhay G. Uppe
Keyword(s):  
Respiratory Failure ◽  
Type Ii ◽  
Invasive Ventilation ◽  
Emergency Visits ◽  
Non Invasive ◽  
First Line Therapy ◽  
Non Invasive Ventilation ◽  
Hospitalised Patients ◽  
Complete History

Background: Assess the use of non-invasive ventilation as an alternative way for ventilation in acute respiratory failure, determine factors that can predict the successful use of NIV, evaluate factors hindering success of NIV.Methods: Thirty hospitalised patients fulfilling inclusion criteria, diagnosed with Type II Respiratory Failure on ABG were recruited after obtaining an informed written consent. Complete history and detailed physical examination were followed by routine investigations.Results: Comparison of the pH on admission with the pH after 1st hour of NIV, the latter showed statistically significant improvement. Drop in PaCo2 and rise in PaO2 on ABG from admission and after stopping NIV was statistically significant. Patients with lower MMRC grade and severe cough showed significant improvement in pH, however patient with higher emergency visits and past hospitalisation showed less improvement in pH, after 1 hour of NIV therapy. A total 4 patients were intubated, with mean pH of 7.22, 3 out of them had higher emergency visits, 2 out of them had ICU admission.Conclusions: NIV treatment for COPD with type II respiratory failure avoids intubation, reduces complications and should be considered as first line therapy instead of ET intubation. Lower mMRC grade, lesser hospitalizations, lesser emergency visits, higher BMI, symptoms like cough, can have a positive predictive value for the outcome of NIV.

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