Bio-Distribution and Dosimetry of a Renal Agent in Normal Bangladeshi Subjects

2013 ◽  
Vol 4 (1) ◽  
pp. 21-26
Author(s):  
MN Islam ◽  
F Alam ◽  
MF Kabir ◽  
AS Mollah ◽  
MA Zaman
Keyword(s):  
Effective Dose ◽  
Large Intestine ◽  
Medical Physics ◽  
Absorbed Dose ◽  
Region Of Interest ◽  
The Body ◽  
Published Data ◽  
Residence Times ◽  
Time Activity ◽  
Blood Plasma Sample

Radiation absorbed dose estimation was performed on eleven normal patients who were in a process of routine diagnostic investigation of the renal function. Bio-kinetics and bio-distribution of 99mTc-DTPA in patients was evaluated by dual-head gamma camera imaging and blood-plasma sample counting method. Radiation dose estimations were performed using standard MIRD techniques and biodistribution of different organ was estimated by drawing region of interest (ROI) according to MIRD phantom model [1]. From the time-activity curves, cumulative activities and residence times of 99mTc- DTPA in the kidneys, brain, upper large intestine (ULI), small intestine (SI), lower large intestine (LLI), stomach, heart, liver, lung and remainder of the body was calculated. Using the information of residence times of the total body and urinary bladder voiding at 2.4 hours on MIRD 12 absorbed dose for the 99mTc-DTPA in different target organs of the body was measured [2]. The estimated average absorbed dose to the kidneys as a target organ in normal Bangladeshis are 5.71E-03 mGy/MBq of 99mTc-DTPA which is closer to the ICRP 53 and other recent published data. The calculated effective dose equivalent and effective dose was found 5.72E-03 mSv/MBq and 4.89E-03 mSv/MBq respectively. DOI: http://dx.doi.org/10.3329/bjmp.v4i1.14674 Bangladesh Journal of Medical Physics Vol.4 No.1 2011 21-26

scholarly journals Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software

2019 ◽  
Author(s):  
K Ebrahimnejad Gorji ◽  
R Abedi Firouzjah ◽  
F Khanzadeh ◽  
N Abdi-Goushbolagh ◽  
A Banaei ◽  
...  
Keyword(s):  
Effective Dose ◽  
Bladder Wall ◽  
Absorbed Dose ◽  
Region Of Interest ◽  
Time Activity ◽  
Significant Difference ◽  
Urinary Bladder Wall ◽  
The Mean ◽  
Absorbed Radiation Dose ◽  
Renal Agent

Introduction: In this study, organ radiation doses were calculated for the renal agent 99mTc-DTPA in children. Bio-kinetic energy of 99mTc-DTPA was evaluated by scintigraphy and estimates for absorbed radiation dose were provided using standard medical internal radiation dosimetry (MIRD) techniques.Materials and Methods: In this applied research, fourteen children patients (6 males and 8 females) were imaged using a series of planar and SPECT images after injecting with technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA). A hybrid planar/SPECT method was used to plot time-activity curves to obtain the residence time of the source organs and also MIRDOSE software was used to calculate the absorbed dose of every organ. P-values were calculated using t-tests in order to make a comparison between the adsorbed doses of male and female groups.Results: Mean absorbed doses (µGy/MBq) for urinary bladder wall, kidneys, gonads, liver and adrenals were 213.5±47.8, 12.97±6.23, 12.0±2.5, 4.29±1.47, and 3.31±0.96, respectively. Furthermore, the mean effective dose was 17.5±3.7 µSv/MBq. There was not any significant difference in the mean absorbed dose of the two groups.Conclusion: Bladder cumulated activity was the most contribution in the effective dose of patients scanned with 99mTc-DTPA. Using a hybrid planar/SPECT method can cause an increase in accumulated activity accuracy for the region of interest. Moreover, patient-specified internal dosimetry is recommended.

scholarly journals Radiation Absorbed Dose to the Basal Ganglia from Dopamine Transporter Radioligand18F-FPCIT

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
William Robeson ◽  
Vijay Dhawan ◽  
Yilong Ma ◽  
David Bjelke ◽  
Claude Margouleff ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Dopamine Transporter ◽  
Absorbed Dose ◽  
Normal Subjects ◽  
Residence Times ◽  
Time Activity ◽  
High Affinity ◽  
Critical Organ ◽  
Left And Right ◽  
Critical Structure

Our previous dosimetry studies have demonstrated that for dopaminergic radiotracers,18F-FDOPA and18F-FPCIT, the urinary bladder is the critical organ. As these tracers accumulate in the basal ganglia (BG) with high affinity and long residence times, radiation dose to the BG may become significant, especially in normal control subjects. We have performed dynamic PET measurements using18F-FPCIT in 16 normal adult subjects to determine if in fact the BG, although not a whole organ, but a well-defined substructure, receives the highest dose. Regions of interest were drawn over left and right BG structures. Resultant time-activity curves were generated and used to determine residence times for dosimetry calculations.S-factors were computed using the MIRDOSE3 nodule model for each caudate and putamen. For18F-FPCIT, BG dose ranged from 0.029 to 0.069 mGy/MBq. In half of all subjects, BG dose exceeded 85% of the published critical organ (bladder) dose, and in three of those, the BG dose exceeded that for the bladder. The BG can become the dose-limiting organ in studies using dopamine transporter ligands. For some normal subjects studied with F-18 or long half-life radionuclide, the BG may exceed bladder dose and become the critical structure.

Proton Dose Conversion Coefficients Based on Chinese Reference Adult Woman Voxel Phantom

2013 ◽  
Author(s):  
Fangfang Liu ◽  
Mingqi Shen ◽  
Taosheng Li ◽  
Chunyu Liu
Keyword(s):  
Effective Dose ◽  
Reference Data ◽  
Absorbed Dose ◽  
The Body ◽  
Adult Woman ◽  
Voxel Model ◽  
Conversion Coefficients ◽  
Computational Phantoms ◽  
Posterior Anterior ◽  
Anterior Posterior

In order to calculate the dose conversion coefficients for proton, the voxel model of Chinese Reference Adult Woman (CRAW) was established by the Monte Carlo transport code FLUKA according to the Chinese reference data and the Asian reference data. Compared with the reference data, the deviations of the mass for organs or tissues of CRAW is less than ±5%. Calculations have been performed for 14 incident monoenergetic protons energies from 0.02GeV to 10TeV at the irradiation incident of anterior-posterior (AP) and posterior-anterior (PA). The results of fluence-to-effective dose conversion coefficients are compared with data from the different models such as an anthropomorphic mathematical model, ICRP reference adult voxel model, the voxel-based visible Chinese human (VCH). Anatomical differences among various computational phantoms and the spatial geometric positions of the organs or tissues lead to the discrepancies of the effective dose conversion coefficients in the ranging from a negligible level to 107% at proton energies below 0.2GeV. The deviations of the coefficients, above 0.2GeV, are mostly within 10%. The results of fluence-to-organ absorbed dose conversion coefficients are compared with the data of VCH. The deviations of the coefficients, below and above 0.2GeV, are within 150% and 20%, respectively. The primary factors of the deviations for the coefficients should be due to the differences of the organ mass and the size of the body shape.

scholarly journals Anniversary of Edith Hinkley Quimby

2021 ◽  
Vol 17 (4) ◽  
pp. 26-29
Author(s):  
A. P. Lushchikova ◽  
A. I. Chemshit
Keyword(s):  
Effective Dose ◽  
20Th Century ◽  
Medical Physics ◽  
Absorbed Dose ◽  
Minimum Effective Dose ◽  
Medical Physicists ◽  
History Of ◽  
American Society ◽  
Iconic Figure ◽  
Acceptance Speech

At the beginning of the 20th century, the whole world was searching for radioactive substances application, in particular radium. Radium can be used to treat oncology, but no one knew the verge of overdosing and underdosing. The founder of radiobiology can be considered Lewis Gray, who introduced unit for absorbed dose of radiation [1]. It was Edith Quimby who started looking for that therapeutically effective absorbed dose. It’s to calculate the minimum effective dose of activity for each patient. She has written 75 articles, published books that have become used concepts in biophysics, and handbooks of modern editions of radiologists. She became the first woman and the first physicist to become president of the American Radium Society, an organization dedicated to the study and treatment of cancer. At one time, Arthur Compton spoke about the need to introduce and apply physics in medicine, and Quimby, in her acceptance speech, outlined the need for an organization of medical physicists, and in 1958, owing to her, the American Society of Medical Physicists was created. Edith Quimby was and remains an iconic figure in the history of the development of medical physics.

scholarly journals The dose of gamma radiation from building materials and soil

Nukleonika ◽  
2015 ◽  
Vol 60 (4) ◽  
pp. 951-958 ◽  
Author(s):  
Goran Manić ◽  
Vesna Manić ◽  
Dragoslav Nikezić ◽  
Dragana Krstić
Keyword(s):  
Gamma Radiation ◽  
Effective Dose ◽  
Building Materials ◽  
Absorbed Dose ◽  
Published Data ◽  
Dose Rates ◽  
Construction Products ◽  
Conversion Coefficients ◽  
Hpge Gamma Spectrometry ◽  
Buildup Factors

Abstract The radioactivity of some structural building materials, rows, binders, and final construction products, originating from Serbia or imported from other countries, was investigated in the current study by using the standard HPGe gamma spectrometry. The absorbed dose in the air was computed by the method of buildup factors for models of the room with the walls of concrete, gas-concrete, brick and stone. Using the conversion coefficients obtained by interpolation of the International Commission on Radiobiological Protection (ICRP) equivalent doses for isotropic irradiation, the corresponding average indoor effective dose from the radiation of building materials of 0.24 mSv·y−1 was determined. The outdoor dose of 0.047 mSv·y−1 was estimated on the basis of values of the specific absorbed dose rates calculated for the radiation of the series of 238U, 232Th and 40K from the ground and covering materials. The literature values of the effective dose conversion coefficients for ground geometry were applied as well as the published data for content of the radionuclides in the soil.

Para-[123I]iodo-L-phenylalanine in patients with pancreatic adenocarcinoma

2008 ◽  
Vol 47 (05) ◽  
pp. 220-224 ◽  
Author(s):  
E. Gouverneur ◽  
A. Schaefer ◽  
J. Raedle ◽  
M. Menges ◽  
C.-M. Kirsch ◽  
...  
Keyword(s):  
Effective Dose ◽  
Brain Tumour ◽  
Pancreatic Adenocarcinoma ◽  
Bladder Wall ◽  
Whole Body ◽  
Residence Times ◽  
Tumour Imaging ◽  
Time Activity ◽  
Tumour Uptake ◽  
Absorbed Doses

SummaryRecently, p-[123I]iodo-L-phenylalanine (IPA) was clinically validated for brain tumour imaging. Preclinical studies demonstrated uptake of IPA into pancreatic adenocarcinoma suggesting its diagnostic application in patients with pancreatic tumours. The aim was to study the tumour uptake of IPA in patients with pancreatic adenocarcinoma and to analyse its biodistribution and dosimetry to assess the radiation dose resulting from its diagnostic use. Patients, methods: Seven patients with pancreatic adenocarcinoma underwent whole-body scintigraphies and SPECT up to 24 h after administration of 250 MBq of IPA. Tumour uptake of IPA was assessed visually. Time activity curves and the corresponding residence times were determined for whole-body, kidneys, liver, spleen, lung, heart content, brain, and testes. Mean absorbed doses for various organs and the effective dose were assessed based on the MIRD formalism using OLINDA/EXM. Results: IPA exhibited no accumulation in proven manifestations of pancreatic adenocarcinomas. IPA was exclusively eliminated by the urine and showed a delayed clearance from blood. Residence times were 0.26 ± 0.09 h for kidneys, 0.38 ± 0.19 h for liver, 0.15 ± 0.07 h for spleen, 0.51 ± 0.20 h for lungs, 0.22 ± 0.07 h for heart content, 0.11 ± 0.05 h for brain, 0.014 ± 0.005 h for testes and 6.4 ± 2.2 h for the remainder. The highest absorbed doses were determined in the urinary bladder wall and in the kidneys. According to the ICRP 60 the effective dose resulting from 250 MBq IPA was 3.6 ± 0.7 mSv. Conclusion: Para-[123I]iodo-L-phenylalanine can be used in diagnostic nuclear medicine with acceptable radiation doses. Besides its proven validity for brain tumour imaging, IPA does not appear to be suitable as tracer for pancreatic cancer.

scholarly journals Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Christopher Cawthorne ◽  
Paul Maguire ◽  
Joel Mercier ◽  
David Sciberras ◽  
Kim Serdons ◽  
...  
Keyword(s):  
Effective Dose ◽  
Phase 1 ◽  
Bladder Wall ◽  
Absorbed Dose ◽  
Whole Body ◽  
Time Activity ◽  
Urinary Bladder Wall ◽  
Dose Coefficients ◽  
Pet Scans

Abstract Rationale [11C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two versions of the OLINDA dosimetry program. Methods Sequential whole-body PET scans were performed in 3 healthy subjects for 2 h after injection of 254 ± 77 MBq [11C]-UCB-J. Volumes of interest were drawn over relevant source organs to generate time-activity curves and calculate time-integrated activity coefficients, with effective dose coefficients calculated using OLINDA 2.1 and compared to values derived from OLINDA 1.1 and those recently reported in the literature. Results [11C]-UCB-J administration was safe and showed mixed renal and hepatobiliary clearance, with largest organ absorbed dose coefficients for the urinary bladder wall and small intestine (21.7 and 23.5 μGy/MBq, respectively). The average (±SD) effective dose coefficient was 5.4 ± 0.7 and 5.1 ± 0.8 μSv/MBq for OLINDA versions 1.1 and 2.1 respectively. Doses were lower than previously reported in the literature using either software version. Conclusions A single IV administration of 370 MBq [11C]-UCB-J corresponds to an effective dose of less than 2.0 mSv, enabling multiple PET examinations to be carried out in the same subject. Trial registration EudraCT number: 2016-001190-32. Registered 16 March 2016, no URL available for phase 1 trials.

Dosimetry with 188Re-labelled monoclonal anti-CD66 antibodies

2006 ◽  
Vol 45 (03) ◽  
pp. 134-138 ◽  
Author(s):  
T. Kull ◽  
N. M. Blumstein ◽  
D. Bunjes ◽  
B. Neumaier ◽  
A. K. Buck ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bone Marrow ◽  
Gamma Camera ◽  
Absorbed Dose ◽  
Correlation Coefficients ◽  
Residence Times ◽  
Reliable Prediction ◽  
Red Bone Marrow ◽  
Antibody Preparation ◽  
Simplified Method

SummaryAim: For the therapeutic application of radiopharmaceuticals the activity is determined on an individual basis. Here we investigated the accuracy for a simplified assessment of the residence times for a 188Re-labelled anti-CD66 monoclonal antibody. Patients, methods: For 49 patients with high risk leukaemia (24 men, 25 women, age: 44 ± 12 years) the residence times were determined for the injected 188Re-labelled anti-CD66 antibodies (1.3 ± 0.4 GBq, 5–7 GBq/mg protein, >95% 188Re bound to the antibody) based on 5 measurements (1.5, 3, 20, 26, and 44 h p.i.) using planar conjugate view gamma camera images (complete method). In a simplified method the residence times were calculated based on a single measurement 3 h p.i. Results: The residence times for kidneys, liver, red bone marrow, spleen and remainder of body for the complete method were 0.4 ± 0.2 h, 1.9 ± 0.8 h, 7.8 ± 2.1 h, 0.6 ± 0.3 h and 8.6 ± 2.1 h, respectively. For all organs a linear correlation exists between the residence times of the complete method and the simplified method with the slopes (correlation coefficients R > 0.89) of 0.89, 0.99, 1.23, 1.13 and 1.09 for kidneys, liver, red bone marrow, spleen and remainder of body, respectively. Conclusion: The proposed approach allows reliable prediction of biokinetics of 188Re-labelled anti-CD66 monoclonal antibody biodistribution with a single study. Efficient pretherapeutic estimation of organ absorbed dose may be possible, provided that a more stable anti-CD66 antibody preparation is available.

Measurement of Renal Parenchymal Transit Time of 99mTc-MAG3 Using Factor Analysis

1990 ◽  
Vol 29 (04) ◽  
pp. 170-176 ◽  
Author(s):  
M. V. Yester ◽  
Eva Dubovsky ◽  
C. D. Russell
Keyword(s):  
Factor Analysis ◽  
Transit Time ◽  
Region Of Interest ◽  
Initial Slope ◽  
Cortical Region ◽  
Time Activity ◽  
Appearance Time ◽  
Activity Curve ◽  
System Factor ◽  
Collecting System

Renal parenchymal transit time of the recently introduced radiopharmaceutical 99mTc-MAG3 (mercaptoacetylglycylglylcylglycinel) was measured in 37 kidneys, using factor analysis to separate parenchymal activity from that in the collecting system. A new factor algorithm was employed, based on prior interpolative background subtraction and use of the fact that the initial slope of the collecting system factor time-activity curve must be zero. The only operator intervention required was selection of a rectangular region enclosing the kidney (by identifying two points at opposite corners). Transit time was calculated from the factor time-activity curves both by deconvolution of the parenchymal factor curve and also by measuring the appearance time for collecting system activity from the collecting system factor curve. There was substantial agreement between the two methods. Factor analysis led to a narrower range of normal values than a conventional cortical region-of-interest method, presumably by decreasing crosstalk from the collecting system. In preliminary trials, the parenchymal transit time did not well separate four obstructed from seventeen unobstructed kidneys, but it successfully (p <0.05) separated six transplanted kidneys with acute rejection or acute tubular necrosis from 10 normal transplants.

scholarly journals Internal dosimetry in F-18 FDG PET examinations based on long-time-measured organ activities using total-body PET/CT: does it make any difference from a short-time measurement?

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Pengcheng Hu ◽  
Xin Lin ◽  
Weihai Zhuo ◽  
Hui Tan ◽  
Tianwu Xie ◽  
...  
Keyword(s):  
Effective Dose ◽  
Dynamic Model ◽  
Bladder Wall ◽  
Time Measurement ◽  
Post Injection ◽  
Time Activity ◽  
Pet Ct ◽  
Long Time ◽  
Total Body ◽  
Short Time

Abstract Purpose A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide total-body coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-activity curve (TAC) measurement of all investigated organs simultaneously with high temporal resolution. This study aims at quantifying the cumulated activity and patient dose of 2-[F-18]fluoro-2-deoxy-D-glucose (F-18 FDG ) imaging by using delayed time-activity curves (TACs), measured out to 8-h post-injection, for different organs so that the comparison between quantifying approaches using short-time method (up to 75 min post-injection) or long-time method (up to 8 h post-injection) could be performed. Methods Organ TACs of 10 healthy volunteers were collected using total-body PET/CT in 4 periods after the intravenous injection of F-18 FDG. The 8-h post-injection TACs of 6 source organs were fitted using a spline method (based on Origin (version 8.1)). To compare with cumulated activity estimated from spline-fitted curves, the cumulated activity estimated from multi-exponential curve was also calculated. Exponential curve was fitted with shorter series of data consistent with clinical procedure and previous dosimetry works. An 8-h dynamic bladder wall dose model considering 2 voiding were employed to illustrate the differences in bladder wall dose caused by the different measurement durations. Organ absorbed doses were further estimated using Medical Internal Radiation Dose (MIRD) method and voxel phantoms. Results A short-time measurement could lead to significant bias in estimated cumulated activity for liver compared with long-time-measured spline fitted method, and the differences of cumulated activity were 18.38% on average. For the myocardium, the estimated cumulated activity difference was not statistically significant due to large variation in metabolism among individuals. The average residence time differences of brain, heart, kidney, liver, and lungs were 8.38%, 15.13%, 25.02%, 23.94%, and 16.50% between short-time and long-time methods. Regarding effective dose, the maximum differences of residence time between long-time-measured spline fitted curve and short-time-measured multi-exponential fitted curve was 9.93%. When using spline method, the bladder revealed the most difference in the effective dose among all the investigated organs with a bias up to 21.18%. The bladder wall dose calculated using a long-time dynamic model was 13.79% larger than the two-voiding dynamic model, and at least 50.17% lower than previous studies based on fixed bladder content volume. Conclusions Long-time measurement of multi-organ TACs with high temporal resolution enabled by a total-body PET/CT demonstrated that the clinical procedure with 20 min PET scan at 1 h after injection could be used for retrospective dosimetry analysis in most organs. As the bladder content contributed the most to the effective dose, a long-time dynamic model was recommended for the bladder wall dose estimation.

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