scholarly journals Evaluation of skeletal metastatic pattern by 99m Tc- Methylene diphosphonate in prostatic carcinoma patients

2016 ◽  
Vol 17 (2) ◽  
pp. 130-133
Author(s):  
Nasreen Sultana ◽  
Zeenat Jabin ◽  
Rahima Parveen ◽  
Shamim MF Begum ◽  
Rokeya Begum
Keyword(s):  
Nuclear Medicine ◽  
Retrospective Study ◽  
Prostatic Carcinoma ◽  
Cervical Vertebrae ◽  
Lumbar Vertebrae ◽  
Skeletal Metastasis ◽  
Whole Body ◽  
Methylene Diphosphonate ◽  
Group B ◽  
Age Range

Objective: The objective of this study was to find out the pattern of skeletal metastasis in-patient with prostatic carcinoma by using 99mTechnetium-Methylene diphosphonate (99mTc MDP).Methods: This retrospective study was carried out at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS) from January 2014 to December 2014. The study included 65 histologically proven prostatic carcinoma patients. They were divided into three groups according to their age. Whole body bone scintigraphy was performed with 99mTc MDP and was interpreted by expert nuclear medicine physicians as negative or positive for skeletal metastases.Results: Bone scan was done on 65 prostate cancer patients. They were divided into three groups according to their age. In this series, the lowest age of patients were 50 years and highest 85 years with a mean ± SD was 65.80 ± 10.11 years. Group A comprised of 14 subjects age ranged 50 to 59 years. Out of them 8 (57%) were positive for skeletal metastasis. Group B comprised of 25 subjects and age range from 60 to 69 years. Out of them 18(72%) were positive for skeletal metastasis. Third group C comprised of 26 subjects and age ranged from 70-80+ years of age. Out of 26 subjects 22(84%) were positive for skeletal metastasis. The most common site involved was dorsal vertebrae in which 60% secondaries were isolated. Sacroiliac joint 39% and ribs 33% were the second and third most common affected areas respectively. Other involved sites were skull, sacrum, lumbar vertebrae, ileum, mandible, femur, sternum, cervical vertebrae, iliac crest, scapula, hip joint, tibia and pelvis.Conclusion: This retrospective study focused on the pattern of skeletal metastasis in various bony sites due to prostate carcinoma, which might be helpful for the oncologist and clinician in further treatment planning.Bangladesh J. Nuclear Med. 17(2): 130-133, July 2014

Skeletal metastases in advanced pancreatic ductal adenocarcinoma (PDAC): A retrospective analysis.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 245-245
Author(s):  
Akshjot Puri ◽  
John Chang ◽  
Tomislav Dragovich ◽  
Patricia Lucente ◽  
Madappa N. Kundranda
Keyword(s):  
Retrospective Analysis ◽  
Cervical Vertebrae ◽  
Lumbar Vertebrae ◽  
Skeletal Metastasis ◽  
Ductal Adenocarcinoma ◽  
Skeletal Metastases ◽  
Initial Symptom ◽  
Intractable Pain ◽  
Thoracic Vertebrae ◽  
Pathological Fractures

245 Background: Skeletal metastasis (SM) in advanced PDAC is an infrequent occurrence and has been previously reported to be < 2.5%. However; pathological fractures in these patients can result in intractable pain, immobilization and a significant deterioration in quality of life. Methods: A retrospective analysis was conducted of patients (pts) with advanced PDAC receiving palliative chemotherapy. Data collection included age, gender, ECOG, sites of disease, and overall survival (OS). Statistical analysis included Kaplan Meier survival analysis. Results: The 135 pts included had a median age of 65.8 years (range: 53.7–91.3); 5 (31.2%) were women and 11 (68.7%) had an ECOG performance status of 0 or 1. A majority of patients received combination therapy that was either gemcitabine or 5-flurouracil based. Sixteen pts (11.8%) had skeletal metastasis with the primary tumor located in the pancreatic body/tail (11 pts - 68.7%).The sites of SM included thoracic vertebrae (8), lumbar vertebrae (5), pelvis (5), ribs (4), sacrum (4), scapula (3), acetabulum (2), cervical vertebrae (2), femoral head (2), sternum (1) and humerus head (1). A majority of the lesions were osteolytic (62.5%) with a median time of diagnosis of SM from initial diagnosis being 1.25 months (range 0-33). Bone pain was observed as the initial symptom in 5 pts (32%), 1 pt (6.2%) had a pathological fracture. The mOS for patients with SM was 6.5 months (range 0-38) when compared to 8 months (range 0-147) without SM.The mOS for pts treated with gemcitabine based regimen was 5.75 months (range 2.5-14), and patients who received multiple lines of therapy including gemcitabine and 5-FU based regimens was 15 months (range 5-38). Survival from onset of skeletal metastases ranged from 0-14 months (mOS: 4 months). Conclusions: More effective systemic therapies which improve mOS are likely to result in increased incidence of SM. The most common sites observed were the thoracic and lumbar vertebrae and pathological fractures in these sites can be catastrophic. Therefore careful evaluation of skeletal signs and symptoms, early detection and intervention will be important to prevent morbidity and mortality from pathological fractures.

scholarly journals Nuclear medicine staff exposure to ionising radiation in 18F-FDG PET/CT practice: a preliminary retrospective study

2021 ◽  
Vol 72 (3) ◽  
pp. 216-224
Author(s):  
Bojan Pavičar ◽  
Jasna Davidović ◽  
Biljana Petrović ◽  
Goran Vuleta ◽  
Saša Trivić ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Retrospective Study ◽  
Exposure Dose ◽  
Whole Body ◽  
Annual Number ◽  
Dominant Hand ◽  
Exposure Limits ◽  
Dose Monitoring ◽  
Positron Emission ◽  
Pet Ct

Abstract This retrospective study provides an insight into the levels of radiation exposure of six nuclear medicine (NM) staff (four technologists and two nurses) performing routine diagnostic 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET/CT) at the University Clinical Centre of the Republic of Srpska, Department of Nuclear Medicine and Thyroid Disorders, Banja Luka, Bosnia and Herzegovina. Data analysis included monthly staff exposure measured with personal thermoluminescent dosimeters (TLD) between June and December 2018, quantified in terms of normalised dose for the whole body [Hp(10)] and dominant hand [Hp(0.07)] and their comparison between each staff member and between the two groups (technologists and nurses). The study goal was to establish how our Department compared with reports from other PET/CT centres worldwide in terms of annual number of procedures and exposure limits and whether there could be room for further improvements in radiation protection. The number of procedures rose considerably from 208 in 2016 to 876 in 2019 and was 423 in the observed seven-month period. Mean individual whole-body exposure dose per GBq of injected 18F-FDG activity, [Hp(10)/A] was 18.55 μSv/GBq for the four technologists and 15.61 μSv/GBq for the two nurses. Mean dominant-hand exposure dose per GBq of injected 18F-FDG activity [Hp(0.07)/A] was 16.99 μSv/GBq and 25.44 μSv/GBq for the two groups, respectively. The average annual cumulative dose for all staff was (1.06±0.29) mSv for Hp(10) and (1.15±0.32) mSv for Hp(0.07). These results are comparable with those of similar studies. Staff doses were well below the annual limits. Nurses received slightly higher extremity doses than technologists. In view of the increasing trends in the number of PET/CT procedures, dose monitoring should be continued to identify exposure hotspots and maintain doses as low as possible.

scholarly journals Frequency Distribution of Bone metastasis in Breast cancer: A retrospective study in Khartoum Oncology Hospital 2019

2020 ◽  
Vol 3 (3) ◽  
Keyword(s):  
Breast Cancer ◽  
Retrospective Study ◽  
Bone Metastasis ◽  
Bone Metastases ◽  
Cervical Vertebrae ◽  
Lumbar Vertebrae ◽  
Clinical Information ◽  
Thoracic Vertebrae ◽  
Common Site ◽  
Duration Of Treatment

Background: Breast cancer (BC) is a common cancer in women worldwide and leading cause of bone metastasis (BM). This study reveals the incidence of bone metastases and the most frequent BM sites secondary to BC in Khartoum Oncology Hospital. Materials and method: Retrospective study in Khartoum oncology hospital of medical record from January 2019 to September 2019. Demographic and clinical information extracted from the medical records of eligible patients in the last 5 years 2015-2019 included age, sex, social habits, duration of breast cancer, duration of treatment and location of bone metastasis. Statistical analyses were performed using SPSS, Version 22.0. (IBM, USA). Results: From all patients diagnosed with BC, 3.03% had developed BM out of whom 50% of patients developed bone metastases in 2-5 years of diagnosis of BC and 39.7% in less than 2 year of diagnosis. The median age was 54 years (range 28-78). The most common site is lumbar vertebrae (48.8%), followed by thoracic vertebrae (32.9%), pelvis 34 (32.9%), sternum (27.1%), ribs (25.7%), femur (15.7%), skull (15.7%), clavicle (14.3%), sacral vertebrae (14.3%), cervical vertebrae (12.8%), hummers (11.4%), and tibia (4.3%). Right side BC contribute to 57.1% of BM whereas left side BC to 40%. The duration of BC significantly correlates to number of distant bone metastases (P = 0.006). Conclusion: The most common site of BM in BC patients is lumbar vertebrae, the duration of BC affects development of BM, Exploring the knowledge of patient populations prone to develop bone metastasis helps in further intervention and management.

Quantitative Bone Scintigraphy and 24-Hour Whole-Body Counting of 99mTc-Methylene Diphosphonate in Patients with Prostatic Carcinoma

1992 ◽  
Vol 31 (05) ◽  
pp. 178-181
Author(s):  
L. Ahlgren ◽  
B. Lilja ◽  
S. Mattsson ◽  
Gunilla Sundkvist
Keyword(s):  
Bone Scintigraphy ◽  
Prostatic Carcinoma ◽  
Whole Body ◽  
Methylene Diphosphonate ◽  
Body Counting ◽  
Whole Body Counting

Zusammenfassung34 Patienten mit Prostata-Karzinom wurden vor bzw. zwei Wochen und zwei Monate nach einer Orchiektomie mit der quantifizierenden Skelettszintigraphie und der Bestimmung der Ganzkörper-Retention (GKR) eine und 24 h nach der Injektion von 99mTc-MDP untersucht. 13 Patienten waren bei allen drei Untersuchungen unauffällig; 21 Patienten mit Skelettmetastasen hatten bei den Verlaufsuntersuchungen sowohl höhere lokale Uptake-Werte (Gammakamera) als auch GKR-Werte. Letztere zeigten das »Aufflacker-Phänomen«, wobei ein Anstieg der regionalen Zählrate zwei Wochen nach der Orchiektomie erfolgte, der sich zwei Monate später wieder zurückbildete. Dieser Befund, interpretiert als Antwort auf die Therapie, war allerdings nur mittels der quantifizierenden Skelettszintigraphie, nicht jedoch mit der Ganzkörpermessung faßbar. Trotzdem erwies sich die Ganzkörpermessung als wertvolle Methode zur Erfassung der Gesamtausdehnung der Skelettmetastasen. In der Interpretation individueller Skelettmetastasen war die quantifizierende Skelettszintigraphie präziser.

scholarly journals Role of Whole-Body Tc 99m MDP Bone Scintigraphy for Evaluating Skeletal Metastasis in Patients with Lung Cancer

2017 ◽  
Vol 42 (3) ◽  
pp. 132-136
Author(s):  
Rawnak Afrin ◽  
Fatema Sultana Haque ◽  
Shankar Kumar Biswas ◽  
Sanowar Hossain ◽  
Mahmood Uz Jahan
Keyword(s):  
Lung Cancer ◽  
Cell Carcinoma ◽  
Bone Scintigraphy ◽  
Bone Scan ◽  
Metastatic Cancer ◽  
Lumbar Vertebrae ◽  
Cost Effective ◽  
Skeletal Metastasis ◽  
Whole Body ◽  
Thoracic Vertebrae

Lung cancer is the third most common site of origin of metastatic cancer deposits in bone, after breast and prostate. It’s metastasis to bone is one of the most aggressive tumors and has a very unfavorable prognosis.  This retrospective descriptive study was designed to detect the skeletal metastasis of   carcinoma (Ca) lung patient by Tc 99m MDP bone scan. The medical records of all patients attended between January 2015 and July 2015 with a diagnosis of lung cancer were reviewed. Lung cancer in all patients was confirmed pathologically, and patients underwent whole-body bone scan for evaluating skeletal metastasis.  Patient with clinical and laboratory evidence of infection, trauma, metabolic disease or arthropathy were not included in the study. Bone scan was done after three hours of   intravenous administration of 20mci Tc 99m MDP   (methylene diphosphonate) and images were obtained on a gamma camera.  The mean age of the patients was Mean ± SD was 55.5 ± 12.5   with range from 31 to 90 years.  Out of 47 cases, 36 (76.59%) were diagnosed as positive for skeletal metastasis by bone scan and 11 (23.41%) were negative for bony metastasis. Among 36 positive patients, 28 patients (77.86%) were histopathologically diagnosed as adenocarcinoma, 7 patients (19.44%) had squamous cell carcinoma and only one patient (2,7%) had small cell carcinoma. Bone scan findings were compared by either conventional X-ray/CT scan/MRI /pathologically. In present study, the distribution of lesions in bone scan had recorded. Maximum 47.22 % lesions were found in ribs, 27.77% lesions were in lumbar vertebrae, 19.44% in thoracic vertebrae, 19.44% in joints, 16.66% in long bones (femur and humerus), 11.11% in skull bones, 22.22% in pelvic bones, 5.55% in clavicle and 2.77% in scapula. Tc 99m MDP bone scan plays a pivotal role for detection of skeletal metastasis which is very essential to manage Ca lung patient. As bone scintigraphy is very cost effective in govt. nuclear medicine centre in comparison to other imaging modalities, so it can play a major role in detecting skeletal metastasis in ca lung patients in a developing country like Bangladesh.

scholarly journals Radionuclide Lymphoscintigraphy in the Evaluation of Lower Extremity Lymphedema – Single Hospital Experience

2017 ◽  
Vol 18 (1) ◽  
pp. 43-46
Author(s):  
Rahima Parveen ◽  
Shamim MF Begum ◽  
Zeenat Jabin ◽  
Khokon Kumar Nath
Keyword(s):  
Nuclear Medicine ◽  
Retrospective Study ◽  
Lower Extremity ◽  
Lower Extremities ◽  
Normal Flow ◽  
Partial Obstruction ◽  
Secondary Lymphedema ◽  
Hospital Experience ◽  
Radionuclide Lymphoscintigraphy ◽  
Age Range

Objective: To find out the type of pattern of obstruction in patient with lymphedema of lower extremities by Lymphoscintigraphy to evaluate.Method: This retrospective study was carried out at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS) from January 2014 to June 2014. The study included 51 patients. Lymphoscintigraphy performed by Tc-99m nano-colloid and were interpreted by expert of Nuclear Medicine Physician.Result: Lymphoscintigraphy was done total 51patients with clinically diagnosed lymphedema (29 males and 22 females; age range 10–80 years). Seventeen patients (33.3%) revealed normal flow in both limbs, whereas only one patients (1.9%) consistent with primary lymphedema.Thirty-three patients (64.7%) consistent with secondary lymphedema, where thirty patients (58.8%) revealed unilateral partial obstruction and three patient (5.9%) had bilateral partial obstruction.Conclusion: Lymphoscintigraphy is safe and effectiveBangladesh J. Nuclear Med. 18(1): 43-46, January 2015

A Simple Method for the Evaluation of Internal Doses in Nuclear Medicine

1974 ◽  
Vol 13 (02) ◽  
pp. 193-206
Author(s):  
L. Conte ◽  
L. Mombelli ◽  
A. Vanoli
Keyword(s):  
Nuclear Medicine ◽  
Close Agreement ◽  
Whole Body ◽  
Simple Method ◽  
Rapid Estimation ◽  
Absorbed Doses ◽  
The Mean ◽  
The Individual ◽  
Estimation Of Risk

SummaryWe have put forward a method to be used in the field of nuclear medicine, for calculating internally absorbed doses in patients. The simplicity and flexibility of this method allow one to make a rapid estimation of risk both to the individual and to the population. In order to calculate the absorbed doses we based our procedure on the concept of the mean absorbed fraction, taking into account anatomical and functional variability which is highly important in the calculation of internal doses in children. With this aim in mind we prepared tables which take into consideration anatomical differences and which permit the calculation of the mean absorbed doses in the whole body, in the organs accumulating radioactivity, in the gonads and in the marrow; all this for those radionuclides most widely used in nuclear medicine. By comparing our results with dose obtained from the use of M.I.R.D.'s method it can be seen that when the errors inherent in these types of calculation are taken into account, the results of both methods are in close agreement.

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