scholarly journals Clinico-Histopathological Consistency in Dermatological Diseases

2021 ◽  
Vol 49 (3) ◽  
pp. 29-34
Author(s):  
Md Mostaque Mahmud ◽  
Md Abdullah Al Mamun ◽  
Samaresh Chandra Hazra ◽  
Rahat Bin Habib ◽  
Md Mostaque Hassan Chowdhury
Keyword(s):  
Connective Tissue ◽  
Skin Biopsy ◽  
Clinical Diagnosis ◽  
Skin Diseases ◽  
Connective Tissue Diseases ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Dermatological Diseases ◽  
Data Collection Sheet ◽  
Histopathological Report

Skin biopsy for histopathology is the most reliable investigation for diagnosis of skin diseases. The main purpose of skin biopsy is to confirm clinical diagnosis but dermatologists usually looking for the concordance with histopathological report. The aim of the study was to observe the consistency of clinical and histopathological diagnosis of skin diseases. An observational study was conducted on 630 patients that undertaken skin biopsy and that was performed at the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University from January 2018 to January 2019. Patients who were advised for biopsy by outpatient and inpatient department and the biopsy was done accordingly was included in the study. Finally the inclusion was confirmed when the histopathological report was available. Demographic information, clinical diagnosis, type of biopsy procedure, types of specimen taken and send for histopathological procedure and the histopathological diagnosis was noted in data collection sheet. Histopathological diagnosis and its correlation with clinical diagnosis was assessed for consistency and it was the main outcome measure of the study. The mean age of patients on whom biopsy was performed was 35.14 ±16.57 years and the age range was 5-82 years. Male patients outnumbered female and the male to female ratio was 1.15: 1. Three types of biopsy were performed among them incisional biopsy was the commonest type (93.5%). In most of the cases collected specimen was skin 94.76%, others type of specimens were mucous membrane 2.6%, nail matrix 1.9% and 0.6% specimen was hair follicle. Among the cases 71.43% was diagnosed clinically. The common clinical diagnosis in which biopsy was done was psoriasis and its types 17.77%, lichen planus and its variants 14.12%, the connective tissue diseases 6.19% and infectious diseases 5.39%.  In 79.52% cases histopathological diagnosis was done and 68.22% diagnosis was consistent with the clinical diagnosis. The maximum clinico-pathological concordance was found in vesiculo-bullous disease 93.33%. Then connective tissue diseases 79.48%, vasculitides 75% and lichenoid diseases 73.56%. Skin biopsy is a conclusive tool to overcome diagnostic dilemmas in dermatological diseases. The clinico-pathological concordance is assumed lower than the expectation of dermatologists but the collective efforts of dermatologists and pathologists can improve the capacity of diagnosis of biopsy samples. Bangladesh Med J. 2020 Sept; 49(3) : 29-34

scholarly journals Experimental models of dermatological diseases

2019 ◽  
Vol 18 (3) ◽  
pp. 203-213
Author(s):  
O. N. Sergeeva ◽  
M. B. Aksenenko ◽  
Yu. F. Fefelova ◽  
E. Yu. Sergeeva ◽  
T. G. Ruksha
Keyword(s):  
Atopic Dermatitis ◽  
Connective Tissue ◽  
Skin Diseases ◽  
Connective Tissue Diseases ◽  
Cell Types ◽  
Skin Lesions ◽  
Experimental Models ◽  
Skin Symptom ◽  
Mechanisms Of Development ◽  
Antigen Presenting

This review presents analysis of experimental models of atopic dermatitis, psoriasis, skin symptoms of autoimmune systemic connective tissue diseases, and blistering skin diseases. Presented in the review are experimental models of atopic dermatitis which reproduce various stages and types of disease that allows the investigation of disease pathogenesis. Atopic dermatitis can develop spontaneously in Nc/Nga mice. There are atopic dermatitis models initiated by monoclonal IgE injection or epicutant sensitization under dermal barrier disfunction imitation. Genetically modified atopic dermatitis models - transgenic and knockout mice – are convenient for investigation of disease stages, cytokines, antigen-presenting cells and T-cells influence. We show that the psoriasis models created by genetic engineering methods are the most convenient for investigation of the role of particular cell types and specific factors in the disease development. Up-regulation of adhesion molecules, cytokines, transcription factors, inflammation mediators in both keratinocytes and immune cells of transgenic mice reveals their influence on psoriasis pathogenesis. There are descriptions of skin symptom models of autoimmune systemic connective tissue diseases and blistering skin disease models with and without genetic modifications. Each model demonstrates some peculiarities of pathogenesis and disease symptoms, whereas combined use of the models will allow to study the mechanisms of development of atopic dermatitis, psoriasis, blistering skin diseases and skin lesions under autoimmune systemic connective tissue diseases, that will contribute to the development of modern effective methods of treatment.

scholarly journals Study of glottic lesions in patients undergoing microlaryngeal surgery

2020 ◽  
Vol 6 (2) ◽  
pp. 277
Author(s):  
Vikrant Mittal ◽  
Manish Munjal ◽  
Rohit Verma ◽  
Parth Chopra ◽  
Hemant Chopra
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Detailed Examination ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Histopathological Correlation ◽  
Male Female Ratio ◽  
Male Preponderance ◽  
Vocal Nodules ◽  
Microlaryngeal Surgery

<p class="abstract"><strong>Background:</strong> Vocal cords are the most common site of laryngeal pathologies. Hoarseness is the sentinel symptom for lesions affecting the glottis. The aim of this study was to categorize various types of lesions affecting the glottis in patients undergoing microlaryngeal surgery. Patients’ demographic profile, gender, occupational factors were studied. Clinical, microlaryngeal and histopathological correlation of the lesions was done.</p><p class="abstract"><strong>Methods:</strong> 50 patients with glottic pathologies undergoing microlaryngeal surgery were included. Patients underwent detailed examination including indirect laryngoscopy, flexible fibreoptic laryngoscopy, followed by microscopic laryngeal examination under general anaesthesia. The lesions were excised using standard microlaryngeal instruments and the specimens were subjected to histopathological examination. The data was analysed.  </p><p class="abstract"><strong>Results:</strong> There was male preponderance (male: female ratio of 1.27:1). Housewives formed the largest group (28%). Commonest pathologies were vocal nodules (34%), vocal polyps (22%) and carcinoma (22%). Microlaryngoscopy was found to be the best means of visualizing the lesions and reaching a clinical diagnosis. In 10 (20%) patients, the final histopathological diagnosis was different from clinical diagnosis.</p><p class="abstract"><strong>Conclusions:</strong> In this study, vocal nodules were the commonest lesions to affect the glottis. Microlaryngoscopy proved to be the best method for examination. Also, there was discrepancy in the clinical and histopathological diagnosis in 20% cases.</p>

scholarly journals Diagnostic significance of immunofluorescent tests in dermatology

2009 ◽  
Vol 62 (11-12) ◽  
pp. 539-546
Author(s):  
Ljiljana Medenica ◽  
Dusan Skiljevic
Keyword(s):  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Leukocytoclastic Vasculitis ◽  
Connective Tissue Diseases ◽  
Diagnostic Significance ◽  
Complement Components ◽  
Autoimmune Bullous Diseases ◽  
Circulating Antibodies ◽  
Bullous Diseases

Introduction. Immunofluorescence (IF) is a laboratory technique introduced to dermatology in 1960s for the purposes of investigating the patophysiology and establishing the diagnosis of skin diseases, particularly autoimmune bullous diseases and connective tissues diseases. There are three basic types of IF techniques: the direct IF (DIF), which is used for the detection of antibodies and complement components fixed in the tissue, the indirect IF (IIF), which is used for the detection of circulating antibodies in patients' serum, and complement-fixed IIF (K-IIF), which is more sensitive in the detection of complement-binding circulating antibodies. Autoimmune bullous diseases. Autoimmune bullous diseases (ABD) can be divided into two groups, depending on the site of blister formation: intraepidermal and subepidermal ABD. The detection of antibodies against the adhesion molecules by DIF techique in both groups of ABD has almost 100% diagnostic accuracy. The titer of circulating antibodies detected and measured by IIF correlates with the activity of pemphigus, but not with the pemphigoid. There are also two modified IIF techniques routinely used, split-skin DIF and IIF, both are most employed in differentiating of subepidermal ABD, since they share many clinical, histopathological and immunopathological features. Connective tissue diseases. DIF test is most useful in diagnosing the connective tissue diseases (CTD), especially lupus erythematosus. Since there are false positive and negative results, DIF findings should be correlated with clinical histological and serological features. Vasculitis. DIF test is used for detection of different immunoreactansts in leukocytoclastic vasculitis and Henoch-Schoenlein purpura. Lichen planus, erythema multiforme. The characteristic pattern of fluorescence in DIF test can be found in most patients with these diseases.

scholarly journals Dermatological Patients at the Outdoor of an Upazila Health Complex

1970 ◽  
Vol 17 (2) ◽  
pp. 93-94
Author(s):  
M Rizaul Kabir ◽  
M Abdul Kuddus Khan ◽  
Ananda Kumar Karmakar
Keyword(s):  
Rural Areas ◽  
Skin Diseases ◽  
Family Welfare ◽  
Venereal Diseases ◽  
Female Ratio ◽  
Dermatological Diseases ◽  
Number Of Patients ◽  
Male Female Ratio ◽  
Male Patients ◽  
Skin Conditions

In outdoor of Adamdighi Upazila Health & Family Welfare Complex of Bogra district, the attendance of patients suffering from skin and venereal diseases were observed. Out of total 1,54,843 patients, 23,820 patients were suffering from various forms of dermatological diseases. The percentage of patients suffering from skin and venereal diseases were 15.34 %. Female patients were 13,667 in number (57.38%) and male patients were 10,153 in number (42.62%). Male, female ratio is 1.35:1. Most of the patients were suffering from dermatological diseases attending outdoor of the said health complex belong to 14 years and above age group (67.53%). It was observed that though previously most of the rural people neglected their skin diseases, but now a day, a good number of patients of the rural areas are conscious about their skin conditions and attend outdoor of health and family welfare complex.   doi: 10.3329/taj.v17i2.3453   TAJ 2004; 17(2): 93-94

scholarly journals Outpatient physiotherapy services in Latvian regional hospitals: Characteristics of receivers, the volume of services and source of funding

2019 ◽  
Vol 68 ◽  
pp. 02004
Author(s):  
Ilze Heize ◽  
Daina Smite
Keyword(s):  
Connective Tissue ◽  
Clinical Diagnosis ◽  
Connective Tissue Diseases ◽  
Perinatal Period ◽  
Electronic Records ◽  
State Budget ◽  
Working Age ◽  
Number Of Visits ◽  
One Year ◽  
Regional Hospitals

Objective: To analyse the outpatient physiotherapy services provided in the regional hospitals of Latvia in 2017 and the profile of their receivers. Methods: In the research, 7 regional hospitals of Latvia participated, in which the analysis of statistical documentation of 2017 was carried out. The following data was collected about the receivers of outpatient physiotherapy services: age, gender, clinical diagnosis and place of residence; about the volume of service provided – the number of visits per patient; about the source of funding (state budget, private resources, insurance). Results:In the regional hospitals of Latvia, outpatient physiotherapy services in 2017 were received by 6957 patients, the most commonly adults of working age with basic clinical diagnosis of the musculoskeletal system and connective tissue diseases, and children up to the age of one year with diagnosis of certain conditions originating in the perinatal period. Among the regional hospitals of Latvia there are significant differences in the volume of outpatient physiotherapy services provided to one patient with a similar clinical diagnosis and age. Latvian regional hospitals still do not have electronic records of all outpatient physiotherapy services, which does not allow to judge about provided services and their receivers, which are financed by patients private resources.

scholarly journals Immunofluorescence in dermatology: A brief review

2021 ◽  
Vol 0 ◽  
pp. 1-9
Author(s):  
Swapna Balakrishnan ◽  
Nobin Babu Kalappurayil
Keyword(s):  
Connective Tissue ◽  
Skin Biopsy ◽  
Connective Tissue Diseases ◽  
Review Article ◽  
Skin Disorders ◽  
The Past ◽  
Biopsy Specimens ◽  
Recent Advances

Immunofluorescence (IF) has been in use for the past five decades, both to investigate the pathophysiology of skin disorders and to help the dermatologists in the diagnosis of various bullous and connective tissue diseases. This review article, deals with different methods, applications, and recent advances in the IF methods used in dermatopathology. Here, we also discuss about the practical aspects of this technique such as handling of skin biopsy specimens and interpretation of direct and indirect IF findings.

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