scholarly journals A One Pot Synthesis of 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-D] pyrimidin-2, 4-diones (or 2-thioxo-4-ones)

2013 ◽  
Vol 61 (2) ◽  
pp. 167-171 ◽  
Author(s):  
M Mahbubur Rahman ◽  
S Mosaddeq Ahmed ◽  
SMA Hakim Siddiki ◽  
Md Ershad Halim ◽  
Kawsari Akhter ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Barbituric Acid ◽  
Thiobarbituric Acid ◽  
Mass Spectral Data ◽  
Phosphorous Pentoxide ◽  
One Pot ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
One Step

A number of 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-f) have been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-c), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-f have been determined by UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. DOI: http://dx.doi.org/10.3329/dujs.v61i2.17065 Dhaka Univ. J. Sci. 61(2): 167-171, 2013 (July)

scholarly journals Synthesis Of 5, 7-Diaryl-1,5-Dihydro (Or 1, 2, 3, 5-Tetrahydro)- Pyrano[2, 3-D] Pyrimidin-2, 4-Diones (Or 2-Thioxo-4-Ones).

2013 ◽  
Vol 25 (2) ◽  
pp. 124-131
Author(s):  
Mohammad Shahid Ullah ◽  
M Giasuddin Ahmed ◽  
UKR Romman ◽  
Kawsari Akhter ◽  
S Mosaddeq Ahmed ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Barbituric Acid ◽  
Thiobarbituric Acid ◽  
Chemical Society ◽  
Mass Spectral Data ◽  
Phosphorous Pentoxide ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
One Step

Some 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-d] pyrimidin-2, 4- diones (or 2-thioxo-4-ones) (3a-g) has been synthesized in one-step by the cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-d), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-g were determined by their UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. Journal of Bangladesh Chemical Society, Vol. 25(2), 124-131, 2012 DOI: http://dx.doi.org/10.3329/jbcs.v25i2.15064

scholarly journals One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II

2017 ◽  
Vol 52 (2) ◽  
pp. 115-124
Author(s):  
K Akhter ◽  
ME Halim ◽  
SM Ahmed ◽  
PK Sarkar ◽  
F Akter ◽  
...  
Keyword(s):  
Acetic Acid ◽  
13C Nmr ◽  
Glacial Acetic Acid ◽  
Barbituric Acid ◽  
Thiobarbituric Acid ◽  
Mass Spectral Data ◽  
Phosphorous Pentoxide ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
One Step

A number of new 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano [2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-g) have  been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-d), in glacial  acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-g have been determined by UV, IR, 1H NMR, 13C  NMR, mass spectral data and elemental analyses. The compounds 3a-g do not seem to be available in the literature.Bangladesh J. Sci. Ind. Res. 52(2), 115-124, 2017

scholarly journals One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I

2016 ◽  
Vol 51 (2) ◽  
pp. 129-138
Author(s):  
K Akhter ◽  
SM Ahmed ◽  
Md E Halim ◽  
MA Kader ◽  
K Jahan ◽  
...  
Keyword(s):  
Acetic Acid ◽  
13C Nmr ◽  
Glacial Acetic Acid ◽  
Barbituric Acid ◽  
Thiobarbituric Acid ◽  
Mass Spectral Data ◽  
Phosphorous Pentoxide ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
One Step

Some new 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-h) have been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-d), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-h have been determined by UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. The compounds 3a-h do not seem to be available in the literatureBangladesh J. Sci. Ind. Res. 51(2), 129-138, 2016

scholarly journals A one-pot synthesis of 7,11-diaryl-2,4-diazaspiro[5,5]undecane-3-oxo (or thioxo)-1,5,9-triones

1970 ◽  
Vol 24 (2) ◽  
pp. 135-142
Author(s):  
M Giasuddin Ahmed ◽  
Syeda Asghari Ahmed ◽  
UKR Romman ◽  
Kawsari Akhter ◽  
Md Ershad Halim ◽  
...  
Keyword(s):  
Barbituric Acid ◽  
Aqueous Ethanol ◽  
Thiobarbituric Acid ◽  
Chemical Society ◽  
Spiro Compounds ◽  
Mass Spectral Data ◽  
One Pot ◽  
Mass Spectral ◽  
Ethanol Medium ◽  
Elemental Analyses

Spiro compounds 7,11-diaryl-2,4-diazaspiro[5,5]undecane-1,3,5,9-tetraones 3a-d were prepared by carrying out reactions between diarylideneacetones, (ArCH=CH)2C=O, 2a-d [Ar= 2-CH3C6H4, 4-CH3C6H4, 4-(CH3)2NC6H4 and 4-HOC6H4 respectively] and  barbituric acid (1a) under refluxing condition in aqueous ethanol medium without using any catalyst. Under similar conditions the corresponding 7,11-diaryl-3-thioxo-2,4-diazaspiro[5,5]undecane-1,5,9-triones 3e-g were synthesized from the reactions of diarylideneacetones 2a, 2d and 2e [Ar= 4-ClC6H4] with 2-thiobarbituric acid (1b). The structures of the spiro compounds were established with the help of their UV, IR, 1H NMR, 13C NMR and mass spectral data and elemental analyses. DOI: http://dx.doi.org/10.3329/jbcs.v24i2.9702 Journal of Bangladesh Chemical Society, Vol. 24(2), 135-142, 2011

scholarly journals Synthesis and Biological Evaluation of Some Novel 1, 3, 5-Trisubstituted Pyrazolines

2010 ◽  
Vol 7 (1) ◽  
pp. 295-298 ◽  
Author(s):  
B. C. Revanasiddappa ◽  
R. Nagendra Rao ◽  
E. V. S. Subrahmanyam ◽  
D. Satyanarayana
Keyword(s):  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Spectral Data ◽  
Glacial Acetic Acid ◽  
Biological Evaluation ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Synthesis And Biological Evaluation

A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR,1H NMR, and Mass spectral data. All the final compounds were evaluated for theirin vitroantimicrobial activity.

scholarly journals A Study on the Synthesis of 5, 7-Diaryl-1,2,3,4-tetrahydro-2, 4-dioxo-5H-pyrano [2,3-d]pyrimidines

1970 ◽  
Vol 41 (3) ◽  
pp. 119-128 ◽  
Author(s):  
MG Ahmed ◽  
UKR Romman ◽  
SM Ahmed ◽  
Khondaker Akhter ◽  
ME Halim ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Spectral Data ◽  
1H Nmr ◽  
13C Nmr ◽  
Glacial Acetic Acid ◽  
Barbituric Acid ◽  
Aqueous Ethanol ◽  
Single Step ◽  
Phosphorous Pentoxide

5,7-Diphenyl-1,2,3,4-tetrahydro-2,4-dioxo-5H-pyrano[2,3-d]pyrimidine (4a) has been synthesized in single-step by the condensation of barbituric acid (1) with benzylideneacetophenone (2a) in glacial acetic acid in the presence of phosphorous pentoxide. Reaction of barbituric acid (1) with arylideneacetophenones (2b-d) which gave the corresponding adducts of 5-(1,3-diaryl-1-oxopropyl) pyrimidine (1H, 3H, 5H)-2,4,6-triones (3a-c) previously in 50 % aqueous ethanol which on further reflux in gl. acetic acid in the presence of phosphorous pentoxide also gave the corresponding pyranopyrimidines 5,7-diaryl-1,2,3,4-tetrahydro-2,4-dioxo-5H-pyrano [2,3- d]pyrimidines (4b-d). The structures of the compounds 4a-d were characterized by their UV, IR, 1H NMR and 13C NMR spectral data. Bangladesh J. Sci. Ind. Res. 41(3-4), 119-128, 2006

scholarly journals Studies on the conversion of ketones of heterocyclic spiro compounds having barbituric acid moieties into oxime derivatives

2013 ◽  
Vol 48 (1) ◽  
pp. 7-12
Author(s):  
MM Rahman ◽  
ME Halim ◽  
SM Ahmed ◽  
K Akhter ◽  
UKR Romman
Keyword(s):  
Spectral Data ◽  
1H Nmr ◽  
13C Nmr ◽  
Barbituric Acid ◽  
Spiro Compounds ◽  
Absolute Alcohol ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
Oxime Derivatives

Five oxime derivatives 7, 11-bis-(4-chlorophenyl)-3-thioxo-2,4-diazaspiro[5,5]undecane-1,5,9-trione-9-oxime (2a), 7,11-bis-(4- methoxyphenyl)-2,4-diazaspiro[5,5]undecane-1,3,5,9-tetraone-9-oxime (2b), 7,11-diphenyl-2,4-diazaspiro[5,5]undecane-1,3,5,9-tetraone- 9-oxime (2c), 7,11-bis-(4-methoxyphenyl)-3-thioxo-2,4-diazaspiro[5,5]undecane-1,5,9-trione-9-oxime (2d), 7,11-diphenyl-3-thioxo-2,4- diazaspiro[5,5]undecane-1,5,9-trione-9-oxime (2e) were synthesized from the corresponding 7,11-diaryl-2,4-diazaspiro[5,5]undecane-3- oxo (or thioxo)-1,5,9-triones (1a-e) with hydroxylaminehydrogenchloride in presence of pyrimidine in absolute alcohol. The structures of the compounds 2a-e were confirmed by their UV, IR, 1H NMR, 13C NMR and mass spectral data and elemental analyses. DOI: http://dx.doi.org/10.3329/bjsir.v48i1.15383 Bangladesh J. Sci. Ind. Res. 48(1), 7-12, 2013

scholarly journals Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles

2010 ◽  
Vol 60 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Satyajit Dutta
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Ammonium Acetate ◽  
Anthelmintic Activity ◽  
Test Results ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Death Time ◽  
Activity Test

Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazolesA series of 2-substituted-4,5-diphenyl imidazoles1a-jwere synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium acetate and glacial acetic acid. Structures of the synthesized compounds were confirmed on the basis of IR,1H NMR and mass spectral data. Compounds1a-jwere screened for anthelmintic activity. Test results revealed that compounds showed paralysis time of 0.24 to 1.54 min and death time of 0.39 to 4.40 min while the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 min and death time of 2.16 and 2.47 min, respectively, at the same concentration of 1% (m/V). Five compounds, 2-[2-hydroxyphenyl]-4,5-diphenyl imidazole (1b), 2-[3-methoxyphenyl]-4,5-diphenyl imidazole (1c), 2-[2-phenylethenyl]-4,5-diphenyl imidazole (1e), 2-[4-fluorophenyl]-4,5-diphenyl imidazole (1g) and 2-[3-nitrophenyl]-4,5-diphenyl imidazole (1h) showed significant anthelmintic activity compared to the standard drugs.

A Clean, Benign, Energy Efficient One-Pot Multicomponent Synthesis and Bio-evaluation of Novel [1,2,4]Triazolo[1,5-a]quinolines

2021 ◽  
Vol 6 (2) ◽  
pp. 111-115
Author(s):  
H.P. Parekh ◽  
M.H. Chauhan ◽  
N.L. Solanki ◽  
V.H. Shah
Keyword(s):  
Room Temperature ◽  
Cost Effective ◽  
Second Step ◽  
Mass Spectral Data ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Green Catalyst ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
Ft Ir

In present work, a series of novel [1,2,4]triazolo[1,5-a]quinoline derivatives (HP-101-110) have been synthesized using multi-component reaction at room temperature in the presence of ammonium chloride as mild, cost effective green catalyst along with water as eco-friendly green solvent. The synthesis of 1,2,4-triazolo[1,5-a]quinolines (HP-101-110) was achieved by two step process. In first step, diversified Hantzsch pyridine reaction of an appropriate aromatic aldehyde, malononitrile, dimedone and benz hydrazide using ethanol as a solvent gives N-(2-amino-3-cyano-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8- tetrahydro-quinolin-1(4H)-yl)-4-hydroxybenzamide derivatives. In the second step, synthesis of the final product 2-(4-hydroxyphenyl)-8,8-dimethyl-6-oxo-5-phenyl-6,7,8,9-tetrahydro[1,2,4]triazolo[1,5- a]-quinoline-4-carbonitriles was achieved by the intramolecular cyclization of step 1 product.The structure of all the synthesized compounds (HP101-110) has been elucidated by FT-IR, 1H & 13C NMR, mass spectral data and elemental analyses.

scholarly journals Microwave Induced Facile One-Pot Access to Diverse 2-Cyanobenzothiazole-A Key Intermediate for the Synthesis of Firefly Luciferin

2015 ◽  
Vol 44 ◽  
pp. 81-89 ◽  
Author(s):  
Neelam P. Prajapati ◽  
Rajesh H. Vekariya ◽  
Hitesh D. Patel
Keyword(s):  
Microwave Irradiation ◽  
Elemental Analysis ◽  
High Purity ◽  
Mass Spectral Data ◽  
One Pot ◽  
Mass Spectral ◽  
H Nmr ◽  
Solvent Free Conditions ◽  
Firefly Luciferin ◽  
One Step

An eco-friendly one-step preparation of various substituted 2-cyanobenzothiazole by condensation of corresponding substituted ortho-aminothiophenol with ethyl cyanoformate, employing an effective amount of Lawesson’s reagent, under microwave irradiation (MWI) and solvent free conditions is presented. The structures of the compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and mass spectral data. The targeted various substituted 2-cyanobenzothiazole are obtained in good yields and high purity.

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