scholarly journals Regulation of atrial natriuretic peptide (ANP) and its role in blood pressure

2012 ◽  
Vol 1 (7) ◽  
pp. 176-179 ◽  
Author(s):  
Feroz Ahmed ◽  
Nahida Tabassum ◽  
Saima Rasool
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Renin Angiotensin System ◽  
Peptide Hormone ◽  
Decompensated Heart Failure ◽  
Pharmaceutical Journal ◽  
The Body ◽  
Atrial Natriuretic

Atrial natriuretic peptide (ANP) a powerful vasodilator, and a protein (28-amino acid peptide) hormone secreted by heart muscle cells. It is released in response to atrial distention, stretching of the vessel walls, sympathetic stimulation of ?-adrenoceptors, raised sodium concentration, angiotensin-II and endothelin. ANP binds to three cell surface receptors called ANP receptors. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system. It has also been reported to increase the release of free fatty acids from adipose tissue. Regulation of its effects is achieved through gradual degradation of the peptide by the enzyme neutral endopeptidase (NEP). Inhibitors of NEP are currently being developed to treat disorders ranging from hypertension to heart failure. Synthetic analogs of ANP have been investigated as potential therapies for the treatment of decompensated heart failure and other diseases.DOI: http://dx.doi.org/10.3329/icpj.v1i7.10812International Current Pharmaceutical Journal 2012, 1(7): 176-179 

Atrial Natriuretic Peptide: Regulator of Chronic Arterial Blood Pressure

Physiology ◽  
2000 ◽  
Vol 15 (3) ◽  
pp. 143-149 ◽  
Author(s):  
Luis Gabriel Melo ◽  
Stephen C. Pang ◽  
Uwe Ackermann
Keyword(s):  
Blood Pressure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Salt Intake ◽  
Gene Knockout ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Arterial Blood ◽  
Gene Knockout Mouse ◽  
Atrial Natriuretic

Recent findings in atrial natriuretic peptide (ANP) transgenic and gene knockout mouse models uncovered a tonic vasodilatory effect of this hormone that contributes to chronic blood pressure homeostasis. With elevated salt intake, ANP-mediated antagonism of the renin-angiotensin system is essential for blood pressure constancy, suggesting that a deficiency in ANP activity may underlie the etiology of sodium-retaining disorders.

scholarly journals Sibjotang Increases Atrial Natriuretic Peptide Secretion in Beating Rabbit Atria

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Oh Jeong Kwon ◽  
Hyun Cheol Oh ◽  
Yun Jung Lee ◽  
Hye Yoom Kim ◽  
Rui Tan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Body Fluid ◽  
The Body ◽  
Kinase C ◽  
Blood Pressure Homeostasis ◽  
Atrial Natriuretic

Sibjotang (Shizaotang), traditional herbal medicine formula, which was first documented in the Shanghanlun, has long been prescribed for the treatment of impairment of the body fluid homeostasis. The purpose of the present study was to identify the effects of Sibjotang on the secretion of a cardiac hormone, atrial natriuretic peptide (ANP), one of the main hormones involved in the regulation of the body fluid and blood pressure homeostasis. Water extract of Sibjotang increased ANP secretion concomitantly with an increase in atrial dynamics in a concentration-dependent manner. Sibjotang-induced increase in ANP secretion and positive inotropic effect were attenuated by GO6976 and LY333531, selective inhibitors of conventional protein kinase C, but not Rottlerin, an inhibitor of novelPKCδ. Similarly to the effect of Sibjotang, extracts of components of Sibjotang,Euphorbia kansui, andDaphne genkwa, but notEuphorbia pekinensisandZiziphus jujuba, increased ANP secretion and atrial dynamics. Ingredients of Sibjotang, apigenin, rosmarinic acid, and salvianolic acid B decreased ANP secretion and atrial dynamics. These findings suggest that Sibjotang increases ANP secretion and atrial dynamics via activation of conventional protein kinase C signaling. This finding provides experimental evidence for the rationale in the use of Sibjotang in the treatment of impairment of the regulation of body fluid and blood pressure homeostasis.

Attenuated response to atrial natriuretic peptide in rats with myocardial infarction

1989 ◽  
Vol 256 (2) ◽  
pp. H533-H538 ◽  
Author(s):  
M. Kohzuki ◽  
G. P. Hodsman ◽  
C. I. Johnston
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Blood Pressure ◽  
Atrial Natriuretic Peptide ◽  
Diastolic Blood Pressure ◽  
Natriuretic Peptide ◽  
Coronary Artery Ligation ◽  
Left Heart Failure ◽  
Water Excretion ◽  
Atrial Natriuretic

The natriuretic, diuretic, and hypotensive effects of atrial natriuretic peptide (ANP) were examined in rats 4 wk after myocardial infarction induced by left coronary artery ligation. Synthetic rat ANP (fragment 1-28) was infused intravenously in doses of 0.1, 0.3, and 1.0 micrograms.kg-1.min-1 for 30 min. There was a significant decrease in systolic blood pressure in controls and rats with infarction, although only in control rats was there a significant decrease in diastolic blood pressure. Changes in systolic and diastolic blood pressure were attenuated in rats with infarction compared with controls (P less than 0.01). The diuretic and natriuretic effects of ANP were observed in both groups of rats, but the effects were significantly less in rats with infarction (P less than 0.01). The ANP infusion did not induce significant changes in heart rate or hematocrit in controls or rats with infarction. The results indicate that rats with chronic left heart failure are less sensitive to the natriuretic, diuretic, and hypotensive effects of ANP when compared with controls. The attenuated renal response to ANP may contribute to the impaired sodium and water excretion in chronic heart failure, although other mechanisms are involved.

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