A clinical study of the incidence of salivary gland tumors in a tertiary care teaching hospital

Background: The salivary gland system of the upper aero digestive tract plays a critical role in the functions of digestion, respiration, communication, and overall homeostasis. The Salivary gland swellings can be broadly classified into inflammatory, non-inflammatory and neoplastic swellings like calculi, benign tumours such has pleomorphic adenoma, oncocytoma, Warthin's tumour, malignant tumors which include-adenocarcinoma, adenoid cystic carcinoma, undifferentiated carcinoma.Methods: The present cross-sectional study was conducted at the Department of general surgery, Sri Siddhartha Medical College over a period of 2 years from August 2016 to July 2018. All major salivary gland neoplastic swellings confirmed by FNAC were included in this study.Results: In our study 23 patients had major salivary gland tumours out of that 19 patients had parotid and 4 had submandibular major salivary gland tumour. In our study out 23 cases of salivary tumours 19 cases were benign and 4 cases were malignant, out of 19 cases of parotid tumours, 15 (78.94%) cases were seen in superficial lobe and 4 (21.06%) were in deep lobe, out of 23 salivary gland tumours, 19 (82.6%) cases were pleomorphic adenoma 3(13.05%) cases were mucoepidermoid carcinoma and one case (4.35%) was acinic cell carcinoma.Conclusions: Parotid gland was the most common site of origin of both benign and malignant tumours, Pleomorphic adenoma was the most common benign salivary gland tumour and mucoepidermoid carcinoma was the most frequent malignant neoplasm.

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Salivary gland tumours: a hospital-based study on demographic and incidence pattern, histopathological types and treatment strategy

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20205062 ◽

2020 ◽

Vol 6 (12) ◽

pp. 2218

Author(s):

M. K. Mili ◽

Hirak Jyoti Das ◽

Asha Saikia ◽

N. J. Saikia ◽

J. Phookan ◽

...

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

Treatment Strategy ◽

Tertiary Care ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Female Ratio ◽

Salivary Gland Tumours ◽

Gland Tumour

Background: Salivary gland tumours constitute 3-4% of all head and neck cancers (mostly benign). These tumours are epithelial (95%) or mesenchymal in origin. Pleomorphic adenoma is the most common benign salivary gland tumour and mucoepidermoid carcinoma (45%) is the most common malignant salivary gland tumour followed by adenoid cystic carcinoma (30%). The parotid, submandibular and the minor salivary glands of palate are commonly involved and the sublingual gland is rarely affected.Methods: Hospital based cross sectional study was done in a tertiary care centre during a period of 1 year, which included 21 patients (10 men and 11 women). Patients were analysed according to age, gender, food habits, histopathological type and site of the tumour and treatment strategy.Results: All the cases were from upper Assam province sharing a particular demographic pattern between 19-65 years. Peak incidence in males was fourth decade and females was third decade. Male female ratio was 0.9:1. Out of 21 cases, 14 were parotid gland tumours, 6 submandibular gland tumours and 1 minor salivary gland tumour. Most of the tumours were benign (16) and 5 were malignant.Conclusions: Two patients were of age 19 years which is conflicting the normal national incidence. All cases belonged to lower economic strata with decreased intake of beta carotene enriched food items. The most common site is parotid gland and most common tumour is pleomorphic adenoma which is in accordance to other studies. Benign cases were subjected to superficial parotidectomy and malignant cases to total parotidectomy with neck dissection.

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Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

The International Journal of Biological Markers ◽

10.5301/jbm.2012.10373 ◽

2012 ◽

Vol 27 (4) ◽

pp. 381-388 ◽

Cited By ~ 5

Author(s):

Mark R. Darling ◽

Nelly N. Hashem ◽

Irene Zhang ◽

Mohamed Mohamed ◽

Kevin Fung ◽

...

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Salivary Gland Tumour ◽

Immunoperoxidase Staining ◽

Aberrant Expression ◽

Adenoid Cystic ◽

Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

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Histopathological Analysis of Neoplastic and Non Neoplastic Lesions of Salivary Gland – A Retrospective Study in a Tertiary Care Hospital

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/45 ◽

2021 ◽

Vol 8 (05) ◽

pp. 236-240

Author(s):

Sheela K.M ◽

Priya V.S. ◽

Lali K. Rajan ◽

Ashida M. Krishnan

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Histopathological Examination ◽

Tertiary Care ◽

Malignant Neoplasm ◽

Histopathological Analysis ◽

Low Grade ◽

Care Hospital ◽

Neoplastic Lesions

BACKGROUND Salivary gland lesions constitute less than 1 % of tumours and about 4 % of all epithelial neoplasms of head and neck region. These comprise of a wide variety of benign, malignant and non-neoplastic lesions which exhibits a difference in histological behaviour. There are no reliable criteria to differentiate on clinical grounds the benign from malignant ones. So morphological evaluation is necessary. We aim to study the frequency of various salivary gland lesions in sialoadenectomy specimens and categorise them into neoplastic and nonneoplastic lesions. METHODS It is a record based retrospective 5-year study carried out in the Government Medical College, Thiruvananthapuram, Kerala, from January 2014 to December 2018. RESULTS In this study a total of 329 histopathologically proven cases of salivary gland lesions were included. Neoplastic lesions and non-neoplastic lesions constituted 78.42 % and 21.58 % respectively. Pleomorphic adenoma was the most common neoplasm (50.54 %) trailed by Warthin’s tumour (9.73 %). Most common malignant neoplasm encountered in our study was mucoepidermoid carcinoma (9.73 %) among which low grade tumours showed predominance. We observed significantly higher incidence of benign and malignant lesions in the 5 th to 6th decade while non neoplastic lesions were seen more in the 4th to 5th decade. Average age of the patients with salivary gland tumours was 46.12  SD 15.57. Majority of cases of salivary gland lesions in our study were from parotid gland (75.68 %) followed by submandibular gland 24.01 %. CONCLUSIONS Pleomorphic adenoma was the most common benign tumour in our study and mucoepidermoid carcinoma the most common malignant tumour. Neoplastic lesions showed a predominance over non neoplastic lesions. Histopathological examination is the mainstay for diagnosis and clinical management. KEYWORDS Histopathology, Pleomorphic Adenoma, Mucoepidermoid Carcinoma

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Oncocytes in Mucoepidermoid Carcinoma of the Palate: Diagnostic Challenges

Case Reports in Dentistry ◽

10.1155/2017/5741821 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Rammohan Kumar ◽

Srikant Natarajan ◽

K.S. Sneha ◽

Nunna Sai Chitra ◽

Karen Boaz ◽

...

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Salivary Glands ◽

Mucoepidermoid Carcinoma ◽

Good Prognosis ◽

Salivary Gland Tumour ◽

Diagnostic Workup ◽

Low Grade ◽

Minor Salivary Glands ◽

Gland Tumour

The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of the reported cases of OMEC have been histologically of low-grade mucoepidermoid carcinoma with large cystic spaces and good prognosis. In this article, we discuss the differential diagnosis and diagnostic workup of an MEC presenting with oncocytes.

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Salivary gland tumours: a retrospective study at a tertiary care centre in South India

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20211576 ◽

2021 ◽

Vol 7 (5) ◽

pp. 825

Author(s):

Neha Swarnkar ◽

Srinivasan Venkataraman ◽

Prasanna Kumar Saravanam

Keyword(s):

Salivary Gland ◽

Retrospective Study ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

South India ◽

Tertiary Care ◽

Salivary Gland Tumors ◽

Care Centre ◽

Tertiary Care Centre ◽

Salivary Gland Tumours

Background: Salivary gland tumors are morphologically and histologically diverse group of lesions and their frequency varies in several parts of the world. Better understanding of these tumours will help in assessing the behaviour and outcomes of lesions of this region. The aim of this study was to analyse the charactertistics of different tumours occurring in the salivary gland in a tertiary care centre in South India.Methods: A retrospective study was conducted of salivary gland tumors diagnosed from the year 2015 to 2020. Patient age and gender, tumor site and frequency, histopathological diagnosis were evaluated and analysed.Results: A total of 36 salivary gland tumor cases was identified, 30 (87.3%) of which were classified as benign and 6 (12.7%) as malignant. Most tumors occurred in the parotid gland (81.3%). Pleomorphic adenoma was the most common tumor in 23 patients (63.8%), followed by warthins tumour. The tumors occurred more often in women than men.Conclusion: The results of the present study reinforce prevalence of salivary gland tumours. The parotid gland is the most common location and pleomorphic adenoma are the most frequent lesions. The malignant tumors also can occur in these glands and good clinical suspicion is necessary.

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Clinical Presentation and Histological Variation of Pleomorphic Adenoma of Salivary Glands

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v37i2.40563 ◽

2019 ◽

Vol 37 (2) ◽

pp. 72-77

Author(s):

Md Nazmul Hasan Khandker ◽

SM Anwar Sadat ◽

Tarin Rahman ◽

Ismat Ara Haider ◽

Mohiuddin Ahmed

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Clinical Presentation ◽

Maxillofacial Surgery ◽

Mouth Opening ◽

Morphological Characteristics ◽

Salivary Gland Tumour ◽

Frequent Pattern ◽

Gland Tumour

Background: Pleomorphic Adenoma is the most common salivary gland tumour accounts 40-70% of all salivary gland tumour and about 60-80% of the benign tumours and 60- 70% of all parotid tumours. There is no study conducted in Bangladesh to observe the clinical and histological variation of the tumour. This study presents 36 cases of Pleomorphic adenoma collected over 11 months at the different territory hospital of Dhaka city. Design: Observational study (November’ 2011 to September’ 2012) Setting: Department of Oral and Maxillofacial Surgery (Dhaka Dental College and Hospital, Bangabandhu Sheikh Mujib Medical Universityl), Department of ENT and Head- Neck Surgery (Dhaka Medical College and Hospital, Bangabandhu Sheikh Mujib Medical University). Method: The entire patient clinically and cytologically diagnosed as Pleomorphic adenoma were selected. Data were collected in a summarized data sheet. Then histopathological types of them were analyzed from excisional biopsized tissue. Result: There were 36 patients of Pleomorphic adenoma of which 24(66.67%) in Parotid glands, 4(11.11%) in Submandibular glands and 8(22.22%) in minor salivary glands. Among the respondents, female was predominant 20(55.56%) with ages were between 29 years to 65 years old (mean age 44.83 ± 8.32 years) with most patients (44.44%) in 41 to 50 years of life. In histophathological study showed Stromal rich 38.89%, cell rich 36.11% and classic 25%. Cuboidal cells were the most commonly found cellular type followed by plasmacytoid and spindle.Trabeculae and duct like structures were the most frequent pattern by the epithelial cells.Myxoid and Hyalinization were the most frequently found mesenchymal like tissue.Cases presented with symptoms such as swelling (100%), limitation of mouth opening, paesthesia and pain. Conclusion: The knowledge about clinical presentation and the immense variety of cells, architectures and morphological characteristics present in Pleomorphic adenoma of the salivary gland is essential for correct diagnosis and prognosis. The need for improved diagnostic facilities and upgrading of infrastructure was stressed. J Bangladesh Coll Phys Surg 2019; 37(2): 72-77

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Prospective and clinico-pathological study in surgical management of salivary gland tumour in a tertiary care hospital

Medpusle International Journal of Surgery ◽

10.26611/1069315 ◽

2019 ◽

Vol 9 (3) ◽

pp. 188-192

Author(s):

Arul Raj ◽

◽

Ganesan . ◽

Keyword(s):

Salivary Gland ◽

Surgical Management ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Salivary Gland Tumour ◽

Care Hospital ◽

Pathological Study ◽

Gland Tumour

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Congenital pleomorphic adenoma of the nasopharynx

The Journal of Laryngology & Otology ◽

10.1017/s0022215100098546 ◽

1985 ◽

Vol 99 (12) ◽

pp. 1281-1287 ◽

Cited By ~ 19

Author(s):

Gady Har-El ◽

Howard Y. Zirkin ◽

Ferit Tovi ◽

Jack Sidi

Keyword(s):

Salivary Gland ◽

Head And Neck ◽

Pleomorphic Adenoma ◽

Histological Type ◽

Salivary Gland Tumour ◽

Congenital Tumours ◽

Gland Tumour

AbstractA case of congenital salivary gland tumour occurring in the nasopharynx is reported. Congenital neoplasms of the head and neck (of any histological type) and congenital tumours of the nasopharynx are discussed and the literature is reviewed.

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Oncocytic differentiation in salivary gland tumours

The Journal of Laryngology & Otology ◽

10.1017/s0022215100130749 ◽

1995 ◽

Vol 109 (6) ◽

pp. 569-571 ◽

Cited By ~ 19

Author(s):

Jorge A. Ferreiro ◽

Nickolaos Stylopoulos

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Facial Nerve ◽

Mucoepidermoid Carcinoma ◽

Facial Nerve Paralysis ◽

Major Salivary Gland ◽

Superficial Parotidectomy ◽

Nerve Paralysis ◽

Salivary Gland Tumours ◽

Pleomorphic Adenomas

AbstractAn oncocytic mucoepidermoid carcinoma and an oncocytic pleomorphic adenoma occurred in a 47-year-old male and a 75-year-old female, respectively. Both presented as asymptomatic parotid gland masses without evidence of facial nerve paralysis and were treated by superficial parotidectomy. There has been no evidence of recurrence or metastasis. Oncocytic change is rare in major salivary gland mucoepidermoid carcinoma with only two previously reported cases. Marked oncocytic transformation of pleomorphic adenomas can cause their confusion with oncocytomas. Recognition of oncocytic differentiation in various salivary gland tumours is important to avoid misclassification of these lesions.

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Histopathological spectrum of salivary gland lesions - in a tertiary care centre

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20205658 ◽

2020 ◽

Vol 9 (1) ◽

pp. 97

Author(s):

Gomathi Srinivasan ◽

Francis Asir Joseph J. ◽

Shanmugam Kaliyaperumal ◽

Arunalatha Ponnaiah

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Histopathological Examination ◽

Tertiary Care ◽

Benign Tumors ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Malignant Neoplasms ◽

Morphological Aspect ◽

Chronic Sialadenitis

ABSTRACT Background: Histopathology is the most important means in diagnosis of salivary gland lesions. The objective of this study is, to study occurrence of salivary lesions during a period of one year from January 2019 to December 2019, to study age, sex and site distribution of various salivary gland lesions, to study histo-morphological aspect of these lesions.Methods: Surgically resected salivary gland specimens received at Department of Pathology, Government Stanley Medical College, Chennai were subjected to histopathological examination. Specimens were fixed in 10% neutral buffered formalin, processed, embedded, sections cut and stained with hematoxylin and eosin stain.Results: There were a total of 30 salivary gland specimens. Out of thirty, 25 were neoplastic and 5 were non-neoplastic. Pleomorphic adenoma was the commonest of all benign tumors. Mucoepidermoid carcinoma was the most common malignant tumor. Among the 21 benign tumors, 16 cases of pleomorphic adenoma and a case each of myoepithelioma, benign metastasising pleomorphic adenoma, basal cell adenoma, warthins tumor and schwannoma were found. Among the 4 malignant tumors, 2 cases of mucoepidermoid carcinoma, a case of carcinoma ex pleomorphic adenoma and a case of myoepithelial carcinoma were found. Among the 5 non neoplastic lesions a case each of chronic sialadenitis, Sjogren’s syndrome, inflammatory myofibroblastioc tumor, parotid abscess and lymphoepithelial cyst were found.Conclusions: The diagnosis of salivary gland lesions by histopathological examination is the most important method in diagnosis and differentiating benign and malignant lesions and to predict prognosis by typing, staging and grading of malignant neoplasms.

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