scholarly journals Recovery from Leptospira-Related Acute Liver Failure and Acute Kidney Injury ― A Case Report from Bangladesh

2019 ◽  
Vol 9 (2) ◽  
pp. 136-139
Author(s):  
Akmat Ali ◽  
Richmond Ronald Gomes ◽  
Khadiza Begum
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Effective Treatment ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Kidney Injury ◽  
Sudden Onset ◽  
Leptospira Interrogans

Leptospirosis is a zoonosis with protean manifestation caused by the spirochete, Leptospira interrogans. Here we report a 60-year-old male who presented with sudden onset of fever, rigors, myalgia and headache occasionally accompanied by nausea, vomiting and diarrhea. Later during the course of treatment he developed encephalopathy with fulminant hepatic failure and acute kidney injury and was diagnosed as a case of leptospirosis. A timely workup combined with early initiation of antibiotics and hemodialysis led to effective treatment for this patient. J Enam Med Col 2019; 9(2): 136-139

Acute Fulminant Hepatic Failure in a Woman Treated With Phenytoin and Trimethoprim-Sulfamethoxazole

2000 ◽  
Vol 124 (12) ◽  
pp. 1800-1803 ◽  
Author(s):  
Marius J-M. Ilario ◽  
Jose E. Ruiz ◽  
Constantine A. Axiotis
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatic Necrosis ◽  
Rare Occurrence ◽  
Autopsy Findings ◽  
Massive Hepatic Necrosis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.

Acute kidney injury in acute liver failure: a review

2013 ◽  
Vol 7 (8) ◽  
pp. 701-712 ◽  
Author(s):  
Joanna K Moore ◽  
Eleanor Love ◽  
Darren G Craig ◽  
Peter C Hayes ◽  
Kenneth J Simpson
Keyword(s):  
Acute Kidney Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Kidney Injury

Acute Hepatic Failure

2019 ◽  
Author(s):  
Derek J Erstad ◽  
Motaz Qadan
Keyword(s):  
Intensive Care ◽  
Respiratory Distress Syndrome ◽  
Liver Failure ◽  
Respiratory Distress ◽  
Acute Liver Failure ◽  
Fulminant Hepatic Failure ◽  
Cerebral Edema ◽  
Hepatic Failure ◽  
Distress Syndrome ◽  
Diagnosis And Management

Acute liver failure (ALF) is a rare but highly morbid condition that is optimally managed by a multidisciplinary team of surgeons, hepatologists, and intensivists at a tertiary care center that specializes in liver disorders. ALF is caused by four primary mechanisms, including viral infections (most commonly Hepatitis A and B); toxicity from acetaminophen overdose or other substances; postoperative hepatic failure ; and miscellaneous causes such as autoimmune hepatitis, genetic disorders, or idiopathic etiologies. Unlike chronic liver failure in which the body develops compensatory, protective mechanisms, ALF may be associated with severe multisystem organ involvement, including respiratory distress syndrome, renal failure, and cerebral edema. Fulminant hepatic failure represents a rapidly progressive form of ALF that portends worse prognosis. Prompt diagnosis and management of multisystem organ dysfunction in an intensive care setting is paramount to survival. However, a subset of patients will fail to improve with medical management alone. Early identification of these individuals for emergent transplant listing has been shown to improve outcomes. Multiple predictive models for ALF survival have been developed, which are based on weighted evaluation of clinical and laboratory parameters. These models may be used to facilitate treatment, predict prognosis, and guide transplant listing. In this chapter, we provide an in-depth review these concepts, focusing on the classification, epidemiology, diagnosis, and management of ALF. This review contains 5 tables and 69 references. Key Words: acute liver failure, acute respiratory distress syndrome, coagulopathy, cerebral edema, fulminant hepatic failure, hepatic necrosis, liver transplantation, metabolic disarray, multidisciplinary intensive care, prognostication

Acute kidney injury following acute liver failure: potential role of systemic cadmium mobilization?

2012 ◽  
Vol 38 (3) ◽  
pp. 467-473 ◽  
Author(s):  
Perrine Hoet ◽  
Vincent Haufroid ◽  
Gladys Deumer ◽  
Xavier Dumont ◽  
Dominique Lison ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Potential Role ◽  
Kidney Injury

T1956 Incidence of Elevated Creatine Kinase and Acute Kidney Injury in Acute Liver Failure

2010 ◽  
Vol 138 (5) ◽  
pp. S-836
Author(s):  
Shannan R. Tujios ◽  
Linda S. Hynan ◽  
Miguel A. Vazquez ◽  
Corron M. Sanders ◽  
William M. Lee
Keyword(s):  
Acute Kidney Injury ◽  
Creatine Kinase ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Kidney Injury ◽  
Elevated Creatine Kinase

scholarly journals Hemostasis in patients with acute kidney injury secondary to acute liver failure

2013 ◽  
Vol 84 (1) ◽  
pp. 158-163 ◽  
Author(s):  
Banwari Agarwal ◽  
Alex Gatt ◽  
Anne Riddell ◽  
Gavin Wright ◽  
Pratima Chowdary ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Kidney Injury
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