Practical approach to extensive cutaneous spread without any underlying malignancy: a rare presentation of Paget’s disease of breast

2020 ◽  
Vol 13 (4) ◽  
pp. e233600
Author(s):  
Kamal Kishore Lakhera ◽  
Sanjeev Patni ◽  
Nidhi Patni ◽  
Rohit Jindal
Keyword(s):  
Abdominal Wall ◽  
Invasive Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Breast Pathology ◽  
Rare Presentation ◽  
Breast Parenchyma ◽  
Areola Complex ◽  
Underlying Malignancy

Paget’s disease of the breast is a rare intraepithelial malignancy involving the nipple–areola complex, often associated with an underlying in-situ or invasive carcinoma in the breast parenchyma. Most of the cases disease is usually limited to nipple–areola or surrounding periareolar skin. We are reporting a case of extensive Paget’s disease, involving entire breast skin and even part of abdominal wall skin without any underlining breast pathology, which is a rare presentation.

Thirty Year Old Female Presented with Nipple Destruction: A Case Report

2019 ◽  
Vol 11 (1) ◽  
pp. 81-83
Author(s):  
Md Mustafizur Rahman ◽  
Nadim Ahmed ◽  
Sami Ahmad ◽  
Shoaeb Imtiaz Alam ◽  
Mohammad Rashedul Hassan ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Paget’S Disease ◽  
Radical Mastectomy ◽  
Paget's Disease ◽  
College Hospital ◽  
Rare Type ◽  
Medical College ◽  
Ductal Cell ◽  
Areola Complex

Paget’s disease of the breast is a rare type of cancer of the nipple–areola complex and that is often associated with an underlying in situ or invasive carcinoma. It is often misdiagnosed as eczema of breast and treatment is delayed. Here we present a case where a 30 year old female presented with itching ulceration and destruction of her left nipple. She was treated initially by local physicians by applying local ointments but as her condition did not improve she was admitted to department of surgery Shaheed Suhrawardy Medical College hospital where she was diagnosed as Paget’s disease with infiltrating ductal cell carcinoma. She underwent modified radical mastectomy with axillary clearance and referred to oncology department for further management. J Shaheed Suhrawardy Med Coll, June 2019, Vol.11(1); 81-83

scholarly journals Practical consensus recommendatons for Paget’s disease in breast cancer

2018 ◽  
Vol 07 (02) ◽  
pp. 083-086 ◽  
Author(s):  
A. Gaurav ◽  
V. Gupta ◽  
R. Koul ◽  
S. Dabas ◽  
R. Sareen ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Treatment Options ◽  
Paget’S Disease ◽  
Practical Experience ◽  
Disease Diagnosis ◽  
Paget's Disease ◽  
Expert Group ◽  
Rare Type ◽  
Areola Complex

AbstractPaget's disease of the breast is a rare type of cancer of the nipple–areola complex and that is often associated with an underlying in situ or invasive carcinoma. Diagnosis and treatment of Paget's disease is controversial. Expert oncologists discuss on the update on the approaches of Paget's disease diagnosis and its treatment options. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.

scholarly journals Paget’s Disease of the Breast in a Patient with Amyopathic Dermatomyositis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Sirin Yasar ◽  
Gunay Gurleyik ◽  
Yesim Sabuncuoglu ◽  
Ali Aktekin ◽  
Bulent Yasar ◽  
...  
Keyword(s):  
Rare Case ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Lymph Node Biopsy ◽  
Amyopathic Dermatomyositis ◽  
Dermatology Department ◽  
Node Biopsy ◽  
Areola Complex ◽  
Underlying Malignancy ◽  
Recurrent Malignancy

Amyopathic dermatomyositis (AD) can be a part of paraneoplastic syndrome of an underlying malignancy. Paget’s disease is a rare form of breast cancer. We present a very rare case of Paget’s disease associated with AD. Paget’s disease has been diagnosed in a patient with AD who is under surveillance of dermatology department. The patient has undergone central lumpectomy with removal of the nipple-areola complex and sentinel lymph node biopsy. Surgical margins after lumpectomy and sentinel node biopsy were negative. The whole breast irradiation was performed after surgery. The patient receives medical treatment for AD of which lesions regressed in 1 year during the follow-up period. This is a very rare case of Paget’s disease diagnosed in a patient with AD. Female patients with dermatomyositis have been absolutely recommended to undergo screening for breast and gynaecological malignancies. AD may be an early finding of primary or recurrent malignancy of the breast.

scholarly journals Paget’s disease of the breast: a case series

2020 ◽  
Vol 7 (8) ◽  
pp. 2706
Author(s):  
Solomon N. Elenwo ◽  
Rollings S. Jamabo
Keyword(s):  
Invasive Carcinoma ◽  
Paget’S Disease ◽  
Case Series ◽  
Radical Mastectomy ◽  
Paget's Disease ◽  
Histological Findings ◽  
Modified Radical Mastectomy ◽  
Modes Of Presentation ◽  
Simple Mastectomy

Paget’s disease of the nipple is a rare disease with a rather bizarre presentation which makes the diagnosis easily missed. Three cases are presented here with different modes of presentation and histological findings. A biopsy provided the definitive diagnosis in the three patients and the treatments offered was based on the histological findings - modified radical mastectomy and simple mastectomy for invasive carcinoma and carcinoma in-situ respectively.

scholarly journals Paget’s disease of breast with an unusual presentation of involvement of overlying skin of breast: a case report

2020 ◽  
Vol 7 (12) ◽  
pp. 4231
Author(s):  
Pravin Kumar ◽  
Arpita Jindal ◽  
Bhushan Bhalgat ◽  
Phanindra Kumar Swain ◽  
Raj Govind Sharma
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Rare Type ◽  
Areola Complex ◽  
Mammary Paget’S Disease ◽  
Surrounding Skin

Paget’s disease of breast is also known as Paget’s disease of the nipple & mammary Paget’s disease, involving the skin of nipple & areola. It is rare type of cancer with tumors inside the same breast which may be either ductal carcinoma in-situ or invasive breast cancer. We report a case with Paget’s disease of breast which is not only involving the nipple-areola complex but also involving surrounding skin of breast.

scholarly journals An Unusual Case of Mammary Paget’s Disease Diagnosed Using Dynamic Contrast-Enhanced MRI

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Eleonora Gaspari ◽  
Aurora Ricci ◽  
Valeria Liberto ◽  
Angela Lia Scarano ◽  
Maria Fornari ◽  
...  
Keyword(s):  
Unusual Case ◽  
Ductal Carcinoma ◽  
Paget’S Disease ◽  
Skin Lesions ◽  
Paget's Disease ◽  
Mri Findings ◽  
Rare Presentation ◽  
Nipple Areola Complex ◽  
Areola Complex ◽  
Mammary Paget’S Disease

Mammary Paget’s disease is a rare presentation of breast cancer. At clinical examination, it is characterized by skin lesions of the nipple-areola complex, almost always a sign of malignancy. In fact, it is often associated with an underlying mammary ductal carcinoma in situ (DCIS) or invasive carcinoma. An underlying carcinoma is also common in women with negative mammography and ultrasound (US); in these cases, magnetic resonance imaging (MRI) is a diagnostic tool useful in the detection of occult cancer. We described an unusual case of mammary Paget’s disease with underlying DCIS, in a patient without nipple-areola complex alterations and/or palpable lump. On suspicion of Paget’s disease, the patient underwent MRI examination that proved useful for an accurate diagnosis. Biopsy confirmed dynamic MRI findings.

Differentiating Pagetoid Bowen's disease from Paget's disease on the nipple‐areola complex: Two unique, challenging cases

2021 ◽  
Author(s):  
Leire Barrutia ◽  
Gerardo Martínez‐García ◽  
Alba Santamarina‐Albertos ◽  
Esther Leticia Garabito Solovera ◽  
Víctor Volo ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Bowen’S Disease ◽  
Bowen's Disease ◽  
Nipple Areola Complex ◽  
Areola Complex

Not All Cases of Mammary Paget’s Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!

2021 ◽  
pp. 106689692110029
Author(s):  
Kerschen Anja ◽  
Dano Hélène ◽  
Van Eeckhout Pascal ◽  
Marot Liliane ◽  
Van Bockstal Mieke
Keyword(s):  
Present Report ◽  
Paget’S Disease ◽  
Growth Factor Receptor ◽  
Punch Biopsy ◽  
Paget's Disease ◽  
Cytokeratin 7 ◽  
In Situ Carcinoma ◽  
Epidermal Growth ◽  
Mammary Paget’S Disease

Mammary Paget’s disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resulted in an initial misdiagnosis and, subsequently, a delay in the patient's follow-up. Additional immunohistochemistry for GATA binding protein 3 (GATA3) and human epidermal growth factor receptor 2 (HER2), as well as a second opinion of a breast pathologist, resulted in the diagnosis of mammary Paget's disease. The aim of this article is to raise awareness among pathologists and prevent them from misdiagnosing CK7-negative Paget disease of the breast.

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