scholarly journals Correlation of Urinary Collagen IV: Urinary Albumin Ratio in the Prediction of Preeclampsia

1970 ◽  
Vol 5 (2) ◽  
pp. 59-62
Author(s):  
Asma Ul-Hosna ◽  
Asma Rumanaz Shahid ◽  
AKM Mohiuddin Bhuyan ◽  
Hosna Zari Thamina ◽  
Mohammad Salman ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Serum Lipids ◽  
Collagen Iv ◽  
Urinary Albumin ◽  
Control Group ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Albumin Ratio ◽  
Urinary Creatinine ◽  
Significant Difference

The purpose of this study was to assess the value of MA in the prediction of PE and also to compare urinary collagen IV with MA in this prediction. A total of 200 subjects (age 25±4 years, M±SC), were selected in their early pregnancy (10 to 14 weeks). Blood glucose, serum lipids, serum and urinary creatinine, urinary albumin and urinary collagen IV were measured in these subjects and they were followed up to the term for the possible development of PE, MA was defined by albumin creatinine ratio (ACR) above 32mg/g and high urinary collagen IV was defined by values above the cut-off point 2.54 ng/ml determined by the median value of the controls. The data were analyzed by grouping the subjects who developed PE in later stages of pregnancy (the PE group) and those who did not develop PE in later stages (the control group). Out of 200 subjects 94 were primigravida and 106 were multigravida. From the total subjects 16 developed PE, which shows a prevalence of about 8.4%. The PE group showed a relatively higher value of ACR as compared to control group. 106 subjects had MA out of which 13 developed PE. The sensitivity of ACR in predicting the development of PE was 80%, specificity 49.54%, PPV 12.69% and NPV 96.42%. Regarding urinary collagen IV the PE group showed no significant difference with the value of the control group. 103 subjects had high urinary collagen IV and out of them 11 developed PE. The sensitivity of high urinary collagen IV in prediction PE was found to have no significant difference with ACR in this respect. The data suggest the following conclusions:Early pregnancy levels of microalbuminuria and urinary collagen IV can be used as predictors of PE with high negative value.Urinary collagen IV has no added advantage over MA in this respect. Keywords : MA-Micro DOI: 10.3329/uhj.v5i2.4555 University Heart Journal Vol.5(2) July 2009 pp.59-62

scholarly journals Is there a relationship between sleep apnoea and microalbuminuria?

2021 ◽  
Author(s):  
Melek Cihanbeylerden ◽  
Melike Bağnu Yüceege
Keyword(s):  
Microvascular Complications ◽  
Sleep Apnoea ◽  
Urinary Albumin ◽  
Control Group ◽  
Creatinine Ratio ◽  
Microvascular Damage ◽  
Metabolic Complications ◽  
Albumin Creatinine Ratio ◽  
Obstructive Sleep ◽  
Significant Difference

Abstract Introduction Obstructive sleep apnoea (OSA) is a cause of hypoxia, and the correlation between hypoxia and microvascular complications is well known. Microalbuminuria (MAU) is a marker for endovascular dysfunction and an indicator of cardiovascular events and all-cause mortality in the general population. The aim of this study was to investigate the relationship between microvascular damage and the metabolic complications of OSA based on the presence of MAU. Material and method Urinary albumin/creatinine ratio (ACR) and microalbumin level were examined in patients with an apnoea-hypopnoea index (AHI) greater than 5/h (study group) and in patients with an AHI less than 5/h (control group). The exclusion criteria were other possible causes of MAU (hypertension, nephropathy, coronary artery disease, and severe thyroid dysfunction). Results Of 103 patients enrolled, 80 formed the group with OSA and 23 served as controls. According to the AHI values, the patients were divided into four groups as normal, mild, moderate and severe. There was no significant difference between the four groups in terms of the microalbumin level and urinary albumin/creatinine ratio. Conclusion In this study, no significant relationship was found between MAU and sleep apnoea.

scholarly journals METS-IR, a novel score to evaluate insulin sensitivity, is associated with the urinary albumin–creatinine ratio in Chinese adults: A cross-sectional REACTION study

2021 ◽  
Author(s):  
Wanlu Su ◽  
Jie Wang ◽  
Songyan Yu ◽  
Kang Chen ◽  
Wenhua Yan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Urinary Albumin ◽  
Postprandial Blood Glucose ◽  
Creatinine Ratio ◽  
Discriminative Ability ◽  
Cross Sectional ◽  
Albumin Creatinine Ratio

Abstract BackgroundThe metabolic score for insulin resistance (METS-IR) is a novel noninsulin-based metabolic index used as a substitution marker of insulin resistance. However, whether METS-IR is associated with the urinary albumin–creatinine ratio (UACR) is not well known. Therefore, we explored the associations between METS-IR and UACR and compared the discriminative ability of METS-IR and its components for elevated UACR. MethodsThis study included 37,290 subjects. METS-IR was calculated as follows: (Ln [2 × fasting blood glucose (FBG) + fasting triglyceride level (TG 0 )] × body mass index (BMI))/[Ln (high-density lipoprotein cholesterol (HDL-C))]. Participants were divided into four groups on the basis of METS-IR: <25%, 25%–49%, 50%–74%, and ≥75%. Logistic regression analyses were conducted to determine the associations between METS-IR vs. its components (FBG, TG 0 , BMI, and HDL-C) with UACR. ResultsParticipants with the highest quartile METS-IR presented a more significant trend towards elevated UACR than towards its components (odds ratio [OR]: 1.260, 95% CI: 1.152–1.378, P < 0.001 in all subjects; OR: 1.321, 95% CI: 1.104–1.579, P = 0.002 in men; OR: 1.201, 95% CI: 1.083–1.330, P < 0.001 in women). There were significant associations between METS-IR and UACR in younger participants (<65 years for women and 55–64 years for men). Increased METS-IR was significantly associated with UACR in men with FBG ≥ 5.6 mmol/L or postprandial blood glucose ≥ 7.8 mmol/L and systolic blood pressure ≥ 120 mmHg or diastolic blood pressure ≥ 80 mmHg. The relationships were significant in women with diabetes and hypertension.ConclusionsIncreased METS-IR was significantly associated with elevated UACR, and its discriminative power for elevated UACR was superior to that of its components. This findings support the clinical significance of METS-IR for evaluating renal function damage.

scholarly journals METS-IR, a Novel Score to Evaluate Insulin Sensitivity, is Associated with the Urinary Albumin–Creatinine Ratio in Chinese Adults: A Cross-sectional REACTION Study

2021 ◽  
Author(s):  
Wanlu Su ◽  
Jie Wang ◽  
Songyan Yu ◽  
Kang Chen ◽  
Wenhua Yan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Chinese Adults ◽  
Albumin Creatinine Ratio

Abstract Background: The metabolic score for insulin resistance (METS-IR) is a novel noninsulin-based metabolic index used as a substitution marker of insulin resistance and for cardiovascular disease evaluation. However, whether METS-IR is associated with the urinary albumin–creatinine ratio (UACR) is not well known. Therefore, we explored the age- and sex-related associations between METS-IR and UACR and compared the discriminative ability of the METS-IR index and its components for elevated UACR. Methods: This study included 37,290 subjects from the REACTION study (Risk Evaluation of cAncers in Chinese diabeTic Individuals: a IONgitudinal study). METS-IR was calculated as follows:(Ln[2×fasting blood glucose{mg/dL}+fasting triglyceride level{mg/dL}]×body mass index)/(Ln [high-density lipoprotein cholesterol{mg/dL}]). Participants were divided into four groups on the basis of METS-IR: <25%, 25%–49%, 50%–74%, and ≥75%. Logistic regression analyses were conducted to determine the associations between METS-IR vs. its components{(fasting blood glucose(FBG), fasting triglyceride level, body mass index, and high-density lipoprotein cholesterol} with UACR. Results: Participants with the highest quartile METS-IR, particularly men,presented a more significant trend towards elevated UACR than towards its components (odds ratio [OR]: 1.260, 95% confidence interval [CI]:1.152–1.378, P<0.001 in all subjects; OR: 1.321, 95% CI: 1.104–1.579, P=0.002 in men; OR: 1.201, 95% CI: 1.083–1.330, P < 0.001 in women). There were significant associations between METS-IR and UACR in younger participants (<65 years for women and 55–64 years for men) and those with an estimated glomerular filtration rate ≥ 90 mL/min/1.73 m2. Increased METS-IR was significantly associated with UACR in men with FBG ≥ 5.6 mmol/L or postprandial blood glucose ≥ 7.8 mmol/L and systolic blood pressure ≥ 120mmHg or diastolic blood pressure ≥ 80 mmHg. The relationships were significant in women with diabetes and hypertension. Conclusions: Increased METS-IR was significantly associated with elevated UACR, and its discriminative power for elevated UACR was superior to that of its components. The findings support the clinical significance of METS-IR for evaluating the cardiometabolic risk and renal function damage among Chinese adults.

scholarly journals Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Reza Shafiee-Nick ◽  
Ahmad Ghorbani ◽  
Farzaneh Vafaee Bagheri ◽  
Hassan Rakhshandeh
Keyword(s):  
Blood Glucose ◽  
Serum Lipids ◽  
Nigella Sativa ◽  
Chronic Administration ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Transferase Activity ◽  
Significant Difference ◽  
Aspartate Amino Transferase

The effects of a polyherbal compound, containing six plants (Allium sativum, Cinnamomum zeylanicum, Nigella sativa, Punica granatum, Salvia officinalis and Teucrium polium) were tested on biochemical parameters in streptozotocin-induced diabetic rats. Streptozotocin caused an approximately 3-fold increase in fasting blood sugar level after 2 days. The diabetic control rats showed further increase in blood glucose after 30 days (384 ± 25 mg/dl in day 30 versus 280 ± 12 mg/dl in day 2,P<0.001). Administration of the compound blocked the increase of blood glucose (272 ± 7 and 269 ± 48 mg/dl at day 2 and day 30, respectively). Also, there was significant difference in the level of triglyceride (60 ± 9 versus 158 ± 37 mg/dl,P<0.01), total cholesterol (55 ± 2 versus 97 ± 11 mg/dl, P < 0.01) and aspartate amino transferase activity (75 ± 12 versus 129 ± 18 U/L,P<0.05) between treated rats and diabetic control group. In conclusion, the MSEC inhibited the progression of hyperglycemia and decreased serum lipids and hepatic enzyme activity in diabetic rats. Therefore, it has the potential to be used as a natural product for the management of diabetes.

scholarly journals Effect of Heroin on Liver and Kidney Functions

2020 ◽  
pp. 204-215
Author(s):  
Aalaa Desoky Ahmad Abohamar ◽  
Wesam Abd El Salam Ghareeb ◽  
Gihan Farouk Attia ◽  
El Sayed Abd El Hamied Gad
Keyword(s):  
Severity Index ◽  
Addiction Severity Index ◽  
Control Group ◽  
Creatinine Ratio ◽  
Significant Elevation ◽  
Heroin Addicts ◽  
Heroin Use ◽  
Albumin Creatinine Ratio ◽  
Renal Functions ◽  
Significant Difference

Background and Aim: Drug use disorders are serious health issues with a significant burden for individuals affected and their families. There are also significant costs to society including lost productivity, security challenges and crime. Heroin has the highest dependence, tolerance and withdrawal score. The aim of this study is to assess the effect of heroin on liver and renal functions. Materials and Methods: This comparative case - control study was carried out on 60 males aged from 15 to 45 years old at the Department of Neuropsychiatry and the Center of Psychiatry, Neurology and Neurosurgery, Tanta University, Egypt from March 2019 through April 2020. Patients group: 30 patients with heroin use disorders diagnosed according to DSM-5 criteria with history of smoking. Control group: thirty smoker persons were taken as a control group matching with patients group. All participants were subjected to: History taking, physical examination and investigations including liver and renal function tests, urine drug screening and psychometry by the addiction severity index scale. Results: Heroin addicts had significant elevation in liver enzyme (Aspartate and Alanine transaminase) and alkaline phosphatase (p<0.001). There was no significant difference between heroin group and control regarding Albumin/Globulin ratio, Prothrombin Time, International Normalized Ratio and bilirubin level. Heroin addicts had significant elevation in blood urea, serum creatinine and Albumin/Creatinine ratio (P <0.001). There was significant decrease in Estimated Glomerular Filtration Rate in heroin group in comparison to control group (p<0.001). Positive correlation with statistical significance between (dose of heroin in grams, duration of use of heroin and severity index of addiction) and (liver functions and renal functions) in patient group. Conclusion: In heroin addicts, there was significant elevation in liver enzymes, ALP, Albumin/creatinine ratio, Urea and Creatinine and significant decrease in eGFR. The higher the dose of heroin use, the more the impairment of liver and renal functions. The longer the duration of heroin use,the more the deterioration of liver and renal functions. The more the severity index of addiction, the more the impairment of liver and renal functions.

Safety evaluation of an antimalarial herbal product from Andrographis paniculata (AS201-01) in healthy volunteers

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aty Widyawaruyanti ◽  
Arijanto Jonosewojo ◽  
Hilkatul Ilmi ◽  
Lidya Tumewu ◽  
Ario Imandiri ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Healthy Volunteers ◽  
Day Treatment ◽  
Phase 1 ◽  
Andrographis Paniculata ◽  
Control Group ◽  
Healthy Human ◽  
Double Blind ◽  
Random Blood Glucose ◽  
Significant Difference

Abstract Objectives Andrographis paniculata tablets (AS201-01) have previously been shown to have potent bioactivity as an antimalarial and to produce no unwanted side effects in animal models. Here, we present the phase 1 clinical trial conducted to evaluate the safety of AS201-01 tablets in healthy volunteers. Methods The study was a randomized, double-blind controlled cross-over, a placebo-controlled design consisting of a 4-day treatment of AS201-01 tablets. A total of 30 healthy human volunteers (16 males and 14 females) were divided into two groups, and each group was given 4 tablets, twice daily for 4 days. Group 1 received AS201-01, while group 2 received placebo tablets. Volunteers were given a physical examination before the treatment. The effects of AS201-01 on random blood glucose, biochemical, and hematological as well as urine profiles were investigated. Results There were no changes in observed parameters as a result of AS201-01 being administered. Statistical analysis showed no significant difference (p>0.05) between the test and control group regarding hematology profile, biochemical profile, and random blood glucose. Increased appetite and better sleep, which categorized as grade 1 adverse event was reported after treatment with AS201-01 tablet Conclusions The outcome supports our previous observation that the AS201-01 tablet, given twice a day for 4 days, is safe and nontoxic.

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