scholarly journals Is gentamicin a viable therapeutic option for treating resistant Neisseria gonorrhoeae in New South Wales?

2021 ◽  
Vol 45 ◽  
Author(s):  
Benjamin H Armstrong ◽  
Athena Limnios ◽  
David A Lewis ◽  
Tiffany Hogan ◽  
Ratan Kundu ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Large Scale ◽  
New South ◽  
Therapeutic Option ◽  
New South Wales ◽  
Newborn Health ◽  
Population Level ◽  
Clinical Isolates ◽  
National Guidelines ◽  
South Wales

The key issues with Neisseria gonorrhoeae infections, in Australia and elsewhere, are coincident increases in disease rates and in antimicrobial resistance (AMR), although these factors have not been shown to be correlated. Despite advances in diagnosis, control of this disease remains elusive, and incidence in Australia continues to increase. Of the Australian jurisdictions, New South Wales (NSW) has the highest N. gonorrhoeae notifications, and over the five-year period 2015–2019, notifications in NSW have increased above the national average (by 116% versus 85%, respectively). Gonococcal disease control is reliant on effective antibiotic regimens. However, escalating AMR in N. gonorrhoeae is a global health priority, as the collateral injury of untreated infections has substantive impacts on sexual and newborn health. Currently, our first-line therapy for gonorrhoea is also our last line, with no ideal alternative identified. Despite some limitations, gentamicin is licensed and readily available in Australia, and is proposed for treatment of resistant N. gonorrhoeae in national guidelines; however, supportive published microbiological data are lacking. Analysis of gonococcal resistance patterns within Australia for the period 1991–2019, including 35,000 clinical isolates from NSW, illustrates the establishment and spread of population-level resistance to all contemporaneous therapies. An analysis of gentamicin susceptibility on 2,768 N. gonorrhoeae clinical isolates from NSW, for the period 2015–2020, demonstrates that the median minimum inhibitory concentration (MIC) for gentamicin in NSW has remained low, at 4.0 mg/L, and resistance was not detected in any isolate. There has been no demonstration of MIC drift over time (p = 0.91, Kruskal-Wallis test), nor differences in MIC distributions according to patients’ sex or site of specimen collection. This is the first large-scale evaluation of gentamicin susceptibility in N. gonorrhoeae in Australia. No gentamicin resistance was detected in clinical isolates, 2015–2020, hence this is likely to be an available treatment option for resistant gonococcal infections in NSW.

scholarly journals Broad Spectrum Epidemiological Contribution of Cannabis, Tobacco and Alcohol to the Teratological Profile of Northern New South Wales: Geospatial and Causal Inference Analysis

2020 ◽  
Author(s):  
Albert Stuart Reece ◽  
Gary Kenneth Hulse
Keyword(s):  
Body Wall ◽  
Septal Defect ◽  
New South ◽  
Ductus Arteriosus ◽  
New South Wales ◽  
Prevalence Ratio ◽  
Population Level ◽  
Cannabis Use ◽  
Anal Stenosis ◽  
South Wales

Abstract Background. Whilst cannabis commercialization is occurring rapidly guided by highly individualistic public narratives, evidence that all congenital anomalies (CA) increase alongside cannabis use in Canada, a link with 21 CA’s in Hawaii, and rising CA’s in Colorado indicate that transgenerational effects can be significant and impact public health. It was therefore important to study Northern New South Wales (NNSW) where cannabis use is high.Methods. Design: Cohort. 2008–2015. Setting: NNSW and Queensland (QLD), Australia. Participants. Whole populations. Exposures. Tobacco, alcohol, cannabis. Source: National Drug Strategy Household Surveys 2010, 2013. Main Outcomes. CA Rates. NNSW-QLD comparisons. Geospatial and causal regression.Results. Cardiovascular, respiratory and gastrointestinal anomalies rose with falling tobacco and alcohol but rising cannabis use rates across Queensland. Maternal age NNSW-QLD was not different (2008–2015: 4,265/22,084 v. 96,473/490,514 > 35 years, Chi.Sq.=1.687, P = 0.194). A higher rate of NNSW cannabis-related than cannabis-unrelated defects occurred (prevalence ratio (PR) = 2.13, 95%C.I. 1.80–2.52, P = 3.24 × 10− 19). CA’s rose more potently with rising cannabis than with rising tobacco or alcohol use. Exomphalos and gastroschisis had the highest NNSW:QLD PR (6.29(2.94–13.48) and 5.85(3.54–9.67)) and attributable fraction in the exposed (84.11%(65.95–92.58%) and 82.91%(71.75–89.66%), P = 2.83 × 10− 8 and P = 5.62 × 10− 15). In multivariable geospatial models cannabis was significantly linked with cardiovascular (atrial septal defect, ventricular septal defect, tetralogy of Fallot, patent ductus arteriosus), genetic (chromosomal defects, Downs syndrome), gastrointestinal (small intestinal atresia), body wall (gastroschisis, diaphragmatic hernia) and other (hypospadias) (AVTPCDSGDH) CA’s. In linear modelling cannabis use was significantly linked with anal stenosis, congenital hydrocephalus and Turner syndrome (ACT) and was significantly linked in borderline significant models (model P < 0.1) with microtia, microphthalmia, and transposition of the great vessels. At robust and mixed effects inverse probability weighted multivariable regression cannabis was related to 18 defects. E-Values in spatial models were generally > 1.3 ranging up to 3.8 × 1030 making uncontrolled confounding unlikely.Conclusions. These results suggest that population level CA’s react more strongly to small rises in cannabis use than tobacco or alcohol; cardiovascular, chromosomal, body wall and gastrointestinal CA’s rise significantly with small increases in cannabis use; that cannabis is a bivariate correlate of AVTPCDSGDH and ACT anomalies, is robust to adjustment for other substances; and is causal.

The breeding behaviour of the endangered regent honeyeater, Xanthomyza phrygia, near Armidale, New South Wales

1998 ◽  
Vol 46 (2) ◽  
pp. 153 ◽  
Author(s):  
Damon L. Oliver
Keyword(s):  
New South ◽  
New South Wales ◽  
Population Level ◽  
Similar Rate ◽  
Nest Construction ◽  
Aggressive Interactions ◽  
Breeding Behaviour ◽  
South Wales ◽  
The Mean ◽  
Breeding Seasons

The regent honeyea ter, Xanthomyza phrygia, is an endangered woodland bird whose range and population size have decreased in the last thirty years. Suggested reasons for this decline include abnormal breeding behaviour, poor reproductive output, and excessive inter- and intra-specific aggression. This study investigated the breeding behaviour and aggressive interactions of regent honeyeaters during the nest construction, incubation, nestling, and fledgling stages in two consecutive breeding seasons in the Bundarra–Barraba region near Armidale, New South Wales. The female was entirely responsible for nest construction and incubation, which is typical of many honeyeaters. Both parents fed the nestlings, and at a similar rate, although only the female brooded chicks on the nest. Both parents fed the fledglings. The mean frequency at which nestlings (23 times per hour) and fledglings (29 times per hour) were fed is the highest published rate of any non-cooperative honeyeater. Breeding males were involved in significantly more aggressive interactions with conspecifics and other nectarivores than were females, although the overall percentage of day-time spent in aggression for both sexes was low (2.5%). It appears that abnormal breeding behaviour, poor reproductive effort, or excessive aggression are not experienced by this species in northern New South Wales, and that other factors are likely to be responsible for its current low population level.

Whole genome sequencing to characterise azithromycin resistant Neisseria gonorrhoeae from New South Wales in 2017

Pathology ◽  
2018 ◽  
Vol 50 ◽  
pp. S51
Author(s):  
C.R.Robert George ◽  
R. Rockett ◽  
David M. Whiley ◽  
Rodney P. Enriquez ◽  
R. Kundu ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
New South ◽  
New South Wales ◽  
Whole Genome ◽  
South Wales

Variation in algal assemblages on wave-exposed rocky shores in New South Wales

1998 ◽  
Vol 49 (3) ◽  
pp. 241 ◽  
Author(s):  
A. J. Underwood ◽  
M. G. Chapman
Keyword(s):  
Large Scale ◽  
New South ◽  
New South Wales ◽  
Temporal Patterns ◽  
Explanatory Models ◽  
Small Scale ◽  
Rocky Shores ◽  
Spatial And Temporal Patterns ◽  
South Wales ◽  
Algal Assemblages

Data were collected in New South Wales from replicate sites on five wave-exposed shores separated by hundreds of kilometres at three-monthly intervals for four years, to examine large and small spatial and temporal patterns in low-shore algal assemblages. These data were used to test hypotheses from the models that algal assemblages show large-scale, predictable changes in structure or, alternatively, that variation from time to time is small-scale and differs from shore to shore or site to site on a shore. There was considerable variation at all scales examined — among replicate quadrats within sites, between sites on a shore and among shores. Similarly, assemblages differed from one sampling period to the next and changes in the assemblages over time periods of three months were as great as from year to year. These changes were interactive, with no two sites or shores showing similar temporal patterns. Thus, understanding diversity along a coast-line requires detailed understanding of local processes. Without adequate spatial and temporal replication in sampling designs and without explanatory models, the large and complex variability in intertidal assemblages at different scales cannot be documented and understood.

scholarly journals Azithromycin-resistant Neisseria gonorrhoeae spreading amongst men who have sex with men (MSM) and heterosexuals in New South Wales, Australia, 2017

2018 ◽  
Vol 73 (5) ◽  
pp. 1242-1246 ◽  
Author(s):  
David M Whiley ◽  
Ratan L Kundu ◽  
Amy V Jennison ◽  
Cameron Buckley ◽  
Athena Limnios ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
New South ◽  
New South Wales ◽  
South Wales ◽  
Sex With Men

Large-scale patterns in habitat structure on subtidal rocky reefs in New South Wales

2000 ◽  
Vol 51 (3) ◽  
pp. 255 ◽  
Author(s):  
N. L. Andrew ◽  
A. L. O'Neill
Keyword(s):  
Sea Urchin ◽  
Geographical Information Systems ◽  
Large Scale ◽  
Size Structure ◽  
New South ◽  
New South Wales ◽  
Geographical Information ◽  
South Wales ◽  
Subtidal Rocky Reefs ◽  
A Site

Aerial photography was used to estimate the representation of shallow subtidal habitats in New South Wales. Sixty sites, each between 4 and 5 hectares, were mapped with Geographical Information Systems software using ortho-rectified images digitized from 1:8000-scale photographs and ‘ground truthed’ in the field by divers. Barrens habitat covered an estimated 50% (s.e. = 3.9) of nearshore reefs between Port Stephens and Disaster Bay. Coverage of barrens habitat was greatest in Disaster Bay (68%, s.e. = 6.7) and least south of Disaster Bay (1%, s.e. = 0.3). There were clear differences among localities in the area of reef within the mapped sites; those at Cape Howe, Nadgee, and Turingal were significantly smaller in area than all others. There was no clear latitudinal trend in these differences but there was evidence of sand inundation at a site at Nadgee, where the reef was small. Differences in the densities and size-structure of the sea urchin Centrostephanus rodgersiiat 27 of the mapped sites provide a basis for testing relationships between the demography of this species and the persistence of the barrens habitat. The extensive coverage of the barrens habitat in New South Wales is likely to limit the productivity of the abalone industry. The development of a sea urchin fishery may have large impacts on habitat representation on nearshore reefs.

scholarly journals Automatic Extraction of Mental Health Disorders From Domestic Violence Police Narratives: Text Mining Study (Preprint)

2018 ◽  
Author(s):  
George Karystianis ◽  
Armita Adily ◽  
Peter Schofield ◽  
Lee Knight ◽  
Clara Galdon ◽  
...  
Keyword(s):  
Mental Health ◽  
Domestic Violence ◽  
Text Mining ◽  
Large Scale ◽  
New South ◽  
New South Wales ◽  
Mental Health Disorders ◽  
Free Text ◽  
South Wales ◽  
Health Disorders

BACKGROUND Vast numbers of domestic violence (DV) incidents are attended by the New South Wales Police Force each year in New South Wales and recorded as both structured quantitative data and unstructured free text in the WebCOPS (Web-based interface for the Computerised Operational Policing System) database regarding the details of the incident, the victim, and person of interest (POI). Although the structured data are used for reporting purposes, the free text remains untapped for DV reporting and surveillance purposes. OBJECTIVE In this paper, we explore whether text mining can automatically identify mental health disorders from this unstructured text. METHODS We used a training set of 200 DV recorded events to design a knowledge-driven approach based on lexical patterns in text suggesting mental health disorders for POIs and victims. RESULTS The precision returned from an evaluation set of 100 DV events was 97.5% and 87.1% for mental health disorders related to POIs and victims, respectively. After applying our approach to a large-scale corpus of almost a half million DV events, we identified 77,995 events (15.83%) that mentioned mental health disorders, with 76.96% (60,032/77,995) of those linked to POIs versus 16.47% (12,852/77,995) for the victims and 6.55% (5111/77,995) for both. Depression was the most common mental health disorder mentioned in both victims (22.30%, 3258) and POIs (18.73%, 8918), followed by alcohol abuse for POIs (12.24%, 5829) and various anxiety disorders (eg, panic disorder, generalized anxiety disorder) for victims (11.43%, 1671). CONCLUSIONS The results suggest that text mining can automatically extract targeted information from police-recorded DV events to support further public health research into the nexus between mental health disorders and DV.

scholarly journals Equine influenza in Australia

2009 ◽  
Vol 30 (4) ◽  
pp. 129
Author(s):  
NR Perkins
Keyword(s):  
Large Scale ◽  
New South ◽  
Animal Health ◽  
New South Wales ◽  
Equine Influenza ◽  
South Wales ◽  
Health Response ◽  
National Response ◽  
Response Capacity ◽  
Major Disruption

A large-scale outbreak of equine influenza (EI) virus in Australia in 2007 resulted in major disruption to horse activities and related industries across the nation and particularly in the two infected states (Queensland and New South Wales). In a major test of animal health response capacity, the outbreak was successfully contained and the EI virus eradicated as a result of a coordinated national response that relied heavily on the cooperation of government and industry stakeholders. Quarantine measures have been strengthened to minimise the risk of future incursions and ensure that Australia remains free of this important and highly contagious disease.

scholarly journals Developmental vulnerability at age five among children who enter and progress through the child protection system in New South Wales, Australia: a cross-sectoral data linkage study

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Kathleen Falster ◽  
Mark Hanly ◽  
Rhiannon Pilkington ◽  
Marilyn Chilvers ◽  
Elizabeth Whittaker ◽  
...  
Keyword(s):  
Early Childhood ◽  
Child Protection ◽  
Data Linkage ◽  
New South ◽  
New South Wales ◽  
Population Level ◽  
Protection System ◽  
Similar Data ◽  
Targeted Interventions ◽  
South Wales

IntroductionA recent independent review of the child protection system in New South Wales (NSW), Australia, highlighted the need for whole-of-government reform to improve outcomes for children at risk of, or experiencing, maltreatment. Population-level evidence on outcomes of children who enter and progress through the child protection system is currently lacking. Objectives and ApproachWe aimed to quantify developmental vulnerability at age five among children who enter and progress through the child protection system during early childhood to demonstrate the value of cross-sectoral data linkage to inform and evaluate policy at a population-level. We used Australian Early Development Census (AEDC) data linked to cross-sectoral population datasets in NSW, including birth registrations, perinatal, and child protectionnotification and out-of-home care (OOHC) placement data. Linked AEDC data, collected in 2009 and 2012, areavailable for 153,670 NSW children. Socio-demographic and perinatal characteristics available in the linked data were used to characterise the population. Results21,179 (13.9%) children had ≥1 ‘screened in’ notification, 4927 (3.2%) had ≥1 substantiated abuse and neglect notification, and 2177 (1.4%) had ≥1 OOHC placement before their fifth birthday. Indicators of disadvantage and adverse birth outcomes were more common among children who progressed to higher levels of the child protection system. The proportion developmentally vulnerable on ≥1 domains of the AEDC increased for children who entered and progressed through the child protection system; from 21% of children with no contact with child protection before age five, to 39% of children with ≥1 ‘screened in’ notification, 50% with ≥1 substantiated notification, and 54% with ≥1 OOHC placement before their fifth birthday. Comparison of findings from other Australian jurisdictions with similar data will be discussed. Conclusion/ImplicationsThis study demonstrates there is scope to improve developmental outcomes through targeted interventions among children who become known to child protection during early childhood in NSW. Moreover, it illustrates that cross-sectoral data linkage can be used to inform and evaluate policy reforms to drive better outcomes for vulnerable children.

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