scholarly journals Role of Autologous Fibrin Glue (AFG) to Reduce Drainage Volume After Modified Radical Mastectomy for Breast Cancer

2021 ◽  
Vol 15 (4) ◽  
pp. 173
Author(s):  
Yohana Azhar ◽  
Ahmad Iffa Maududy ◽  
Nadjwa Zamalek Dalimoenthe

Background: Seroma is arguably the most significant complication that can happen after mastectomy. Although seroma is not a life-threatening complication, this condition can lead to severe morbidities. This situation can cause prolonged hospital stays and delayed adjuvant therapy. In this regard, autologous fibrin glue is a hemostatic agent that can accelerate fibrin formation, stop vascular oozing, and decrease dead space. Therefore, this research was performed to evaluate autologous fibrin glue function in lowering seroma volume after mastectomy and shortening the length of hospital stay.Methods: This randomized control trial research was designed to compare the effect of autologous fibrin glue to a control group that did not receive autologous fibrin glue. Seroma volume was calculated every 24 hours. The drains were then removed after the production of seroma less than 30 mL/24 hours.Results: We recruited 20 patients for each of the two groups who met the inclusion criteria. Age, histopathology type, breast cancer stage, number of lymph nodes, and tumor size did not significantly differ. However, patients in the fibrin glue group had significantly lower cumulative drain production. The median seroma volume in the treatment group was 9.30 mL, while the median in the control group was 20.90 mL (p < 0.05).Conclusions: Autologous fibrin glue significantly decreased seroma formation and length of hospital stay.

2020 ◽  
Author(s):  
Mohammed Faisal ◽  
Sara Salem ◽  
Noha Kamel ◽  
Haidi Abd El Zaher ◽  
Ahmed Abo Bakr ◽  
...  

Abstract Introduction Breast cancer stands out as the second most common cancer in the world with incidence 35.1% of all malignancies among females in Egypt. Fluid build-up after breast surgery is still the most annoying complication which leads to worse outcome. We aimed to evaluate whether autologous fibrin glue might lessen the formation of seroma following modified radical mastectomy. Methods This was a randomized controlled trial designed to configure the effect of autologous fibrin glue given in the study group using the drain in comparison to a control group who received the drain only; seroma volume was calculated every 24 hrs. For all of the cases. The drains were removed when the daily drainage was less than 30 ml for 3 consecutive days. Results We recruited 30 patients to each of the two groups. Age, pathology, breast cancer stage, number of lymph nodes and tumour size did not differ significantly between groups. A comparison of the median days to drain removal showed 8 days reduction in median days to drain removal compared in the intervention group (7 days) than the control (15 days). The patients in the fibrin glue group had a significantly lower cumulative drain output volume (mean ± SD of 505.6 ± 209.3 ml) than those in the control group (1674.1± 1373.8 ml). Additionally, the patients treated with fibrin glue had a significantly shorter postoperative length of stay (8.5 (7–10) days) than the controls (15 (10–23) days. Conclusions Autologous fibrin glue significantly decrease seroma formation post-modified radical mastectomy. Research Registry Unique Identifying Number: researchregistry5372.


2020 ◽  
Author(s):  
Mohammed Faisal ◽  
Sara Salem ◽  
Noha Kamel ◽  
Haidy Abd El- Zaher ◽  
Ahmed Abo Bakr ◽  
...  

Abstract Introduction: Breast cancer stands out as the second most common cancer in the world with incidence 35.1% of all malignancies among females in Egypt. Fluid build-up after breast surgery is still the most annoying complication which leads to worse outcome. We aimed to evaluate whether autologous fibrin glue might lessen the formation of seroma following modified radical mastectomy. Methods: This was a randomized controlled trial designed to configure the effect of autologous fibrin glue given in the study group using the drain in comparison to a control group who received the drain only; seroma volume was calculated every 24 hrs. For all of the cases. The drains were removed when the daily drainage was less than 30 ml for 3 consecutive days. Results: We recruited 30 patients to each of the two groups. Age, pathology, breast cancer stage, number of lymph nodes and tumour size did not differ significantly between groups. A comparison of the median days to drain removal showed 8 days reduction in median days to drain removal compared in the intervention group (7 days) than the control (15 days). The patients in the fibrin glue group had a significantly lower cumulative drain output volume (mean ± SD of 505.6 ± 209.3 ml) than those in the control group (1674.1 ± 1373.8 ml). Additionally, the patients treated with fibrin glue had a significantly shorter postoperative length of stay (8.5 (7–10) days) than the controls (15 (10–23) days. Conclusions: Autologous fibrin glue significantly decrease seroma formation post-modified radical mastectomy. Research Registry Unique Identifying Number: researchregistry5372.


2017 ◽  
Vol 4 (7) ◽  
pp. 2103 ◽  
Author(s):  
Ahmed Fawzy ◽  
Ahmed Gaber ◽  
Abd Al Monem Farid

Background: Seroma is one of the most common morbidity occurring post modified radical mastectomy (MRM). It can delay post-operative initiation of adjuvant therapy. This study was designed to determine the role of fibrin glue spray in reduction of seroma volume and duration after breast surgeries.Methods: A prospective, randomized, controlled study over forty female patients who underwent (MRM) was done. The study cohort was randomized into control group where only conventional drain placement was used and experimental group where double dose of fibrin glue has been sprayed to the axillary and mammary beds plus conventional drain placement. Data regarding the amount of drained fluid in the first post-operative day, hospital stay, length of drain placement, amount and duration of post-operative seroma, number of excised lymph nodes (L. Ns) and pathological results were recorded.Results: No difference in mean age, number of excised L. Ns and rate of post-operative infection between both groups was detected. There was significant reduction in hospital stay time favouring fibrin glue group (p=0.006). Fibrin glue group had a significant reduction in the length of drain placement (p=0.001). The amount of post-operative serous fluid was reduced and the incidence of occurrence of post-operative seroma was (7/20) 35% in control group compared to (1/20) 5% in fibrin glue group giving significant reduction in incidence and amount.Conclusions: Use of fibrin glue sealant during MRM resulted in noticeable and significant decrease of post-operative rate of seroma formation, its amount and the length of drain placement.


2020 ◽  
Vol 48 (2) ◽  
pp. 49-67
Author(s):  
Ahmad Iffa Maududy ◽  
Kiki Ahmad Rizki ◽  
Raden Yohana ◽  
Nadjwa Jamalek

Background: Seroma is the most significant complication that occurred after mastectomy, happen in 25% until 60% cases. Seroma are not life threatening complications, but can lead to serious morbidity, prolonged hospital stay and delay adjuvant therapy. Autologous Fibrin Glue is a hemostatic agent that can accelerate fibrin thread formation, stop vascular oozing and decrease dead space. This research was performed to evaluate Autologous Fibrin Glue function in lowering seroma volume at 14th days after simple mastectomy. Methods: This research is a clinical trial to compare average seroma volume between advance stage locally breast carcinoma patients group which are given Autologous Fibrin Glue on the surface of surgical wound, 14 days after simple mastectomy (trial group) and control group (without special treatment) with ultrasonography. Result: From 42 patients who met the inclusion criteria, divided into 2 groups, 21 patients were given Autologous Fibrin Glue on the surgical wound surface in a simple mastectomy procedure, 21 patients as a control group. The number of seromas in the treatment group was measured using ultrasound on the 14th day, fewer meaningfully than the control group, the median seroma volume in the treatment group was 9,30 mL and median seroma volume in the control group was 20.90 mL. The P value in the variable number of seroma is smaller than 0.05 (P. < 0.05) which means significant, the number of seromas measured using ultrasonography (USG) on the 14th day, fewer meaningfully in the treatment group. Conclusion: Subjects that was given Autologous Fibrin Glue on the surface of surgical wound after simple mastectomy has a lower volume of seroma compared to control group.


2021 ◽  
Author(s):  
Lucy Bayer-Oglesby ◽  
Andrea Zumbrunn ◽  
Nicole Bachmann ◽  

AbstractBackgroundSocial factors are recognized determinants of morbidity and mortality and also have an impact on use of medical services. Low education level and lack of social and financial resources have been associated with prolonged hospital stays while for migration factors evidence is inconclusive. The objective of this study was i) to assess the associations of social factors with length of hospital stays for chronic conditions, ii) to investigate the role of comorbidity and discharge destination in mediating these associations and iii) to identify the main drivers of length of stays.MethodsThis analysis made use of nationwide inpatient data from Swiss hospital discharge statistics that was linked on the individual level with Swiss census data. The study sample included n=141,307 records of n=92,623 inpatients aged 25 to 84 years, hospitalized between 2010 and 2016 for acute care in Switzerland with a main diagnosis of one of 15 selected chronic conditions, including cancers and cardiovascular, respiratory and musculoskeletal diseases. Cross-classified multilevel models were used to assess the impact of social factors on length of hospital stay and for mediation analysis in the retrospective inpatient cohort.FindingsThe strongest determinants of length of stay were medical factors, namely main diagnosis (up to seven days difference), comorbidities (up to 10 days) and treatment-related factors (two to three days). Also, social factors were associated with duration of hospital stays. Taking into account demographic factors, main diagnosis and clustering on patient and hospital level, patients with upper secondary and compulsory education stayed longer in hospital compared to those with tertiary education (β 0.24 days, 95% CI 0.14-0.33; β 0.37, 95% CI 0.27-0.47, respectively). However, these effects were almost fully mediated by burden of comorbidity. The effect of living alone on length of stay (β 0.60 days, 95% CI 0.50-0.70) was partially mediated by both burden of comorbidities (33%) and discharge destination (30.4%). (Semi-) private insurance was associated with prolonged stays, but an inverse effect was observed for colon and breast cancer. Allophone patients, first generation migrants and non-EU/EFTA-nationals had also prolonged hospital stays (β 0.34, 95% CI 0.13-0.55; β 0.16, 95% CI 0.05-0.27; β 0.22, 95% CI 0.02, 0.42, resp.).ConclusionsHospital stays could be a window of opportunity to discern patients with low health literacy who need additional instructions and support to better cope with everyday life after discharge, reducing the risks of future hospital stays. However, inpatient care in Switzerland seems to take into account rather obvious individual needs such as interpreter services or rehabilitation due to lack of language skills or lack of immediate support at home, respectively, but not necessarily more hidden needs of patients with low health literacy and less resources to assert their interests within the health system. Our findings underpin the importance of health policies promoting shared decision making and patient-centred care tailored to the differential needs of social and cultural groups.


2012 ◽  
Vol 15 (2) ◽  
pp. 84 ◽  
Author(s):  
Canturk Cakalagaoglu ◽  
Cengiz Koksal ◽  
Ayse Baysal ◽  
Gokhan Alici ◽  
Birol Ozkan ◽  
...  

<p><b>Aim:</b> The goal was to determine the effectiveness of the posterior pericardiotomy technique in preventing the development of early and late pericardial effusions (PEs) and to determine the role of anxiety level for the detection of late pericardial tamponade (PT).</p><p><b>Materials and Methods:</b> We divided 100 patients randomly into 2 groups, the posterior pericardiotomy group (n = 50) and the control group (n = 50). All patients undergoing coronary artery bypass grafting surgery (CABG), valvular heart surgery, or combined valvular and CABG surgeries were included. The posterior pericardiotomy technique was performed in the first group of 50 patients. Evaluations completed preoperatively, postoperatively on day 1, before discharge, and on postoperative days 5 and 30 included electrocardiographic study, chest radiography, echocardiographic study, and evaluation of the patient's anxiety level. Postoperative causes of morbidity and durations of intensive care unit and hospital stays were recorded.</p><p><b>Results:</b> The 2 groups were not significantly different with respect to demographic and operative data (<i>P</i> > .05). Echocardiography evaluations revealed no significant differences between the groups preoperatively; however, before discharge the control group had a significantly higher number of patients with moderate, large, and very large PEs compared with the pericardiotomy group (<i>P</i> < .01). There were 6 cases of late PT in the control group, whereas there were none in the pericardiotomy group (<i>P</i> < .05). Before discharge and on postoperative day 15, the patients in the pericardiotomy group showed significant improvement in anxiety levels (<i>P</i> = .03 and .004, respectively). No differences in postoperative complications were observed between the 2 groups.</p><p><b>Conclusion:</b> Pericardiotomy is a simple, safe, and effective method for reducing the incidence of PE and late PT after cardiac surgery. It also has the potential to provide a better quality of life.</p>


2019 ◽  
Vol 2 (2) ◽  
pp. 24-31
Author(s):  
Gulraj Singh ◽  
Mulawan Umar ◽  
Nur Qodir

Abstract Introduction: Modified radical mastectomy (MRM) is a breast cancer treatment option that is still operable. One of the postoperative complications that can be found is the formation of seroma. High negative suction drain is done to treat seroma after surgery but it can contribute to increase the length of stay in hospital. Methods: This study was a clinical randomized control trial (cRCT) conducted on 30 breast cancer patients in June - July 2019 at Moehammad Hoesin Hospital in Palembang. This study divided the two sample groups, each group consisting of 15 patients. One group was given half negative pressure on suction drain (experimental group) and the other used full negative pressure on suction drain (control group). Results: There was a significant difference (p <0.005) between the full and half negative pressure groups where there were more seroma events in the full vacuum group in 9 (60%) cases and half vacuum in 2 (30%) but there were no significant differences in long period of stay (p> 0.005). Conclusion: Half negative pressure is more effective in treating seroma than full negative pressure.


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