Relationship between Serum Thyroid-stimulating Hormone Receptor Autoantibodies and Activity and Severity of Thyroid Eye Disease

Purpose: To study the relationship between the levels of serum thyroid-stimulating hormone (TSH)-receptor autoantibodies (TRAbs) and thyroid eye disease (TED) activity and severity scores.Methods: A cross-sectional study was performed. The medical records of 315 patients diagnosed with TED between March 2014 and December 2019 were reviewed. The clinical activity score (CAS) was used to assess TED activity and a modified NOSPECS score was used for severity grading. The serum TRAb level was measured using two assays: a TSHR binding inhibitory immunoglobulin (TBII) assay and thyroid stimulating immunoglobulin (TSI) bioassay.Results: The TBII and TSI assay results were significantly positively correlated with the CAS (R = 0.113 and 0.211, respectively; p < 0.05), modified NOSPECS score (R = 0.173 and 0.316, respectively; p < 0.05), and proptosis (R = 0.136 and 0.167, respectively; p < 0.05). Both assays demonstrated significant differences in the level of TRAb between patients with and without compressive optic neuropathy or corneal epithelial defects.Conclusions: The levels of TRAbs according to both TBII and TSI assays showed significant correlations with clinical signs of corneal involvement, optic neuropathy, and TED activity and severity.

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Association between metabolic syndrome and thyroid stimulating hormone - A cross sectional study

Medpusle International Journal of Medicine ◽

10.26611/1021922 ◽

2019 ◽

Vol 9 (2) ◽

pp. 87-90

Author(s):

Karanam Madhuri ◽

◽

Rishi Kumar Venkatachalam ◽

A Nasreen Begum ◽

Shamsheer Khan P ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Sectional Study ◽

Cross Sectional ◽

Stimulating Hormone

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Evaluation of pituitary function in cases with the diagnosis of pediatric mild traumatic brain injury: Cross-sectional study

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.185509 ◽

2016 ◽

Vol 7 (04) ◽

pp. 537-543 ◽

Cited By ~ 3

Author(s):

Hakan Aylanç ◽

Filiz Tütüncüler ◽

Necdet Süt

Keyword(s):

Head Trauma ◽

Early Period ◽

Serum Cortisol ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Cross Sectional ◽

Pituitary Dysfunction ◽

Duration Time ◽

Basal Cortisol Level ◽

Stimulating Hormone

ABSTRACT Background: This study was to determine whether pituitary dysfunction occurs after head trauma in children or not and which axis is affected more; to define the association of pituitary dysfunction with the severity of head trauma and duration time after the diagnosis of head trauma. Materials and Methods: In this study, 24 children who were diagnosed with head trauma were evaluated regarding pituitary dysfunction. In all cases, after 12 h fasting, serum cortisol, fT3, fT4, thyroid-stimulating hormone, prolactin, insulin-like growth factor-1, serum sodium, urine density, follicle-stimulating hormone, luteinizing hormone, in female cases E2, in male cases, TT levels were determined. Results: Mean age of children was 9.5 ± 3.1 years, 14 children (58.3%) had mild, 9 children (37.5%) had moderate, and 1 children (4.2%) had severe head trauma according to the Glasgow coma scale. Mean duration time after head trauma was 29.4 ± 9.8 months. In all cases, no pathologic condition was determined in the pituitary hormonal axis. In one children (4.2%), low basal cortisol level was found. There were no children with hormonal deficiency in this study. Conclusion: Although pituitary dysfunction after head trauma may develop in the early period, some may present in the late period; therefore, all cases should be followed up at outpatient clinics for a longer period.

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Course of upper eyelid retraction in thyroid eye disease

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-313578 ◽

2019 ◽

Vol 104 (2) ◽

pp. 254-259

Author(s):

Dong Cheol Lee ◽

Stephanie M Young ◽

Yoon-Duck Kim ◽

Kyung In Woo

Keyword(s):

Positive Family History ◽

Thyroid Stimulating Hormone ◽

Thyroid Eye Disease ◽

Eye Disease ◽

Clinical Activity ◽

Eyelid Retraction ◽

Tertiary Institution ◽

Upper Eyelid ◽

Upper Eyelid Retraction ◽

History Of

AimsTo evaluate the natural course of upper eyelid retraction (UER) in patients with thyroid eye disease (TED) and factors affecting its course.MethodsRetrospective non-interventional cohort study in a single tertiary institution from March 2006 to March 2015 on patients with TED with (1) unilateral or bilateral UER within 6 months from initial presentation, and (2) no prior interventions nor surgical treatment for their UER. Main outcomes and measures were mean margin reflex distance 1 (MRD1) and factors associated with UER improvement.ResultsThere were a total of 61 patients and 81 eyes (41 unilateral and 20 bilateral UER). Mean age was 42.3±15.1 years. Mean MRD1 decreased from 6.1 mm at presentation to 4.8 mm at 12 months, and 4.4 mm at 24 months. The proportion of eyes with normalisation of lid height increased from 0% at presentation to 22.2% at 6 months, 37.0% at 12 months and 49.4% at 24 months. Mean time to normalisation of MRD1 was 18.0±12.4 months. A positive family history of TED was found to be associated with a 6.2 times lower likelihood of normalisation. Change in exophthalmometry, clinical activity score and thyroid-stimulating immunoglobulin were significantly correlated to change in MRD1 (p<0.05). There was no correlation between change in MRD1 and thyroid-stimulating hormone receptor antibodies.ConclusionAn improved knowledge of the natural history of UER in TED will allow us to better decide and evaluate the optimal management for such patients.

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Influence of Perinatal Factors on Thyroid Stimulating Hormone Level in Cord Blood : A Cross Sectional Study

Egyptian Journal of Pediatrics ◽

10.12816/0049373 ◽

2016 ◽

Vol 33 (1-2) ◽

pp. 15-26

Author(s):

Nashwa M. Samra ◽

Mohamed E. Al Ghwass ◽

Heba A. Abdel Ghany

Keyword(s):

Cord Blood ◽

Hormone Level ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Sectional Study ◽

Perinatal Factors ◽

Cross Sectional ◽

Stimulating Hormone

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EFFECT OF PREANALYTICAL VARIABLES ON SERUM THYROID STIMULATING HORMONE ANALYSIS BY CHEMILUMINESCENCE METHOD

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71isuppl-1.6202 ◽

2021 ◽

Vol 71 (Suppl-1) ◽

pp. S102-05

Author(s):

Ambreen Rehman ◽

Naveed Asif ◽

Saima Shakeel Malik ◽

Waqas Sheikh ◽

Quratulain . ◽

...

Keyword(s):

Venous Blood ◽

Armed Forces ◽

Epidemiological Studies ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

P Value ◽

Cross Sectional ◽

Specimen Handling ◽

Tsh Levels ◽

Stimulating Hormone

Objective: To identify effect of pre-analytical variables on serum thyroid stimulating hormone. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology (AFIP) Rawalpindi, Department of Chemical Pathology & Endocrinology, from Mar 2018 to Aug 2018. Methodology: Hundred subjects with ages ranging from 18 to 34 years, irrespective of gender, were randomly selected for this study. Five milliliters venous blood sample was collected from each subject in a serum separator and divided into two aliquots. First aliquot was centrifuged and analyzed immediately for TSH, while second aliquot was stored for 24 hours and was then analyzed. TSH was measured by third generation assay usingchemiluminescence technique on ADVIA Centaur® XP. Serum TSH levels were also analyzed twice daily; in the morning (0800 to 0900 hours) and afternoon (1400 to 1600 hours). Data was analyzed using SPSS version 24. Frequency and percentages were calculated for qualitative variables like gender and pre-analytical variables. Test of significance Mann-Whitney U-test was applied and p-value <0.05 was taken as significant. Results: Mean age of subjects was 23 ± 3.4 years. Change in circadian rhythm was observed in 17 (28%) males and 14 (36%) females. Statistically significant association was found between morning and evening TSH levels, while no change was observed in TSH level by early and late centrifugation of samples. Conclusion: TSH levels vary significantly between blood samples collected at different timings of the day from the same person. TSH is resistant to degradation, immunologically stable, and reasonably insensitive to potential problems associated with routine specimen handling, when measured by immunoassay technique. Therefore, it is helpful in large epidemiological studies and small size laboratory, which require long transportation time and storage.

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