Diagnosis of Thermal Burn Damage to Respiratory Tract in Children with Severe Burns

Inhalation traumas occur in 10 - 30 of cases among patients with burns with this frequency of unfavorable outcomes of the diseases is 16% higher than in burns of the having the same area of damage. During a 3-year period, 28 children with deep burns of III-IV degree were treated at Burns Department of Republican Scientific Center of Urgent Medical Aid (RSCUMA), Samarkand, Uzbekistan. Performing sanation bronchoscopy, early respiratory supporting, rational anti-bacterial therapy and adequate nutritive supporting are the perspective way of the complex therapy for such type of the patients. Thus thermal damage to respiratory tract in combination with skin burns in children cause high letal outcome that requires to apply more informative method, i.e. of bronchoscopy which makes it possible to diagnose presence of thermal inhalation trauma, to determine prevalence and severity of damage, and to carry out medical manipulations as well.

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GLUCOSAMINYLMURAMYL DIPEPTIDE IN THE THERAPY OF PATIENTS WITH ATOPIC BRONCHIAL ASTHMA AND CLINICAL MANIFESTATIONS OF THE SYNDROME OF SECONDARY IMMUNE DEFICIENCY

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja286 ◽

2017 ◽

Vol 14 (6) ◽

pp. 91-97

Author(s):

O V Skorokhodkina ◽

A V Luntsov

Keyword(s):

Respiratory Tract ◽

Bronchial Asthma ◽

Clinical Manifestations ◽

Atopic Bronchial Asthma ◽

Immune Parameters ◽

Group I ◽

Complex Therapy ◽

Asthma Patients ◽

Group Ii ◽

Tract Infections

Background. Glucosaminylmuramyl dipeptide (likopid) is a selective NOD2 receptor agonist, its ability to activate phagocytes proves its use in infectious manifestations in asthma patients. Its influence on the adaptive immunity, was studied. The aim of the study was to evaluate the effectiveness of likopid in patients with atopic bronchial asthma and recurrent infections of the respiratory tract. Materials and methods. 44 patients with uncontrolled atopic bronchial asthma with recurrent respiratory tract infections were examined. Patients of group I received likopid 10 mg orally once a day during 10 days additionally to the complex therapy. Patients of group II received only complex therapy without likopid. The immune parameters, disease control parameters, frequency of exacerbations and spirography data in patients of two groups before the treatment and after 10 days, 1 and 3 months were assessed. Results. Both I and II group patients (91,6%) showed similar deviations of the immune status parameters in general, a depression of the functional activity of phagocytes was noted in 83,3% of cases. Patients of group I were characterized by the achievement of better asthma control in 1 month of treatment, while the frequency of asthma exacerbations required revision of therapy was lower in patients of group I than in patients of group II (8,3% and 45%, respectively, p

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CLINICAL AND PHARMACOLOGICAL FEATURES OF APPLICATION WITH AN OVERVIEW OF EXTENDING COUNTRIES ON THE MARKET AND MUCOLYTIC DRUGS

Military Medicine ◽

10.51922/2074-5044.2021.3.10 ◽

2021 ◽

pp. 10-15

Author(s):

E.N. Skepian ◽

Keyword(s):

Clinical Practice ◽

Respiratory Tract ◽

Mechanism Of Action ◽

Pathological Process ◽

Infectious Agents ◽

Mucous Secretion ◽

Reflex Action ◽

Complex Therapy ◽

Combined Drugs

One of the pathogenic mechanisms of the development of cough is the formation of viscous sputum difficult to separate. Against the background of a pathological process in the lungs, there is a disruption in the work of muco- ciliary clearance and peristalsis of the bronchi, and in the mucous secretion of the respiratory tract, the ratio of ions dissolved in water and macromolecular compounds is disturbed, which leads to an increase in viscosity, a decrease in the rheological properties of sputum. In connection with this, not only the drainage function of the bronchi is disrupted, but also local immune processes, which also contributes to an increase in the adhesion of infectious agents. In this case, the rational use of expectorant drugs as part of the complex therapy contributes not only to reducing the duration of the disease, but also prevents the formation of chronic diseases of the respiratory system. The article discusses the pathogenetic mechanisms of the onset of cough, the classification of expectorant drugs, which includes various pharmacological classes of drugs, with fundamentally different effects. The mechanism of action, indications, contraindications, as well as clinical and pharmacological features of the use of drugs stimulating expectoration of resorptive, reflex action, mucolytics of synthetic origin, enzyme, mucoregulators, combined drugs available on our market are described, recommendations are given on their use in clinical practice.

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Contribution of antioxidant systems to regeneration of tracheal epithelium after burn of upper respiratory tract

Russian Pulmonology ◽

10.18093/0869-0189-2008-0-6-80-83 ◽

2008 ◽

pp. 80-83

Author(s):

V. I. Novoselov ◽

E. K. Mubarakshina ◽

V. A. Yanin ◽

S. E. Amelina ◽

E. E. Fesenko

Keyword(s):

Respiratory Tract ◽

Intratracheal Instillation ◽

Goblet Cells ◽

Tracheal Epithelium ◽

Antioxidant Systems ◽

Upper Respiratory Tract ◽

Thermal Burn ◽

Tissue Edema ◽

Upper Respiratory ◽

Epithelium Cells

Study was performed using a rat model of thermal burn of upper respiratory tract (URT). The URT burn in rats was induced by intratracheal instillation of 70 °C water vapor using a micro-vapor generator. In a week after the intervention about 50 % of the ciliated epithelium was destructed. In 2 weeks after the intervention the inflammatory response enhanced and tissue edema increased. In 4 weeks after the intervention partial irregular restoration of tracheal epithelium cells was observed. Both IL-1 and IL-4 expression did not change significantly during restoration of tracheal epithelium, but IL-8 and IL-10 expression increased and was high even 1 month after the burn. Simultaneously, dramatic increase in expression of peroxyredoxine 6, which is the main antioxidant protein in trachea, was observed during regeneration of trachea epithelium. Iimmunohistochemical investigations showed that the increase in peroxyredoxine 6 in trachea during the regeneration of trachea epithelium after the burn could be related to increased peroxyredoxine expression in goblet cells. Therefore, activation of peroxyredoxine 6 synthesis by goblet cells appears to be the key step in activation of epithelium defense systems after thermal burn.

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ACHIEVEMENTS IN THE PROVISION OF SURGICAL CARE TO VICTIMS WITH SEVERE TRAUMATIC BRAIN IN JURY UNDER THE CONDITIONS OF THE REPUBLICAN SCIENTIFIC CENTER FOR EMERGENCY MEDICAL AID , TWENTY YEARS OF EXPERIENCE

10.54185/tbem/vol14_iss4/a11 ◽

2022 ◽

Vol 14 (4) ◽

Author(s):

K.E. Makhkamov ◽

A.B. Salaev ◽

M.K. Makhkamov ◽

D.U. Israilov

Keyword(s):

Surgical Care ◽

Years Of Experience ◽

Scientific Center ◽

Medical Aid ◽

Emergency Medical

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Respiratory tract pathology in patients with severe burns

Human Pathology ◽

10.1016/s0046-8177(06)80033-x ◽

1990 ◽

Vol 21 (12) ◽

pp. 1212-1220 ◽

Cited By ~ 11

Author(s):

Ashfaq H. Toor ◽

Joseph F. Tomashefski ◽

Jerome Kleinerman

Keyword(s):

Respiratory Tract ◽

Severe Burns

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New Ultrastructural Observations on Injury and Regeneration of Cilia in Mammalian Conducting Airway Epithelium

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100099544 ◽

1981 ◽

Vol 39 ◽

pp. 624-625

Author(s):

J.L. Carson ◽

A.M. Collier

Keyword(s):

Respiratory Tract ◽

Airway Epithelium ◽

Defense Mechanisms ◽

Normal Growth ◽

Fetal Lung ◽

Secretory Cells ◽

Airway Epithelial ◽

Ciliated Cells ◽

Conducting Airway ◽

Conducting Airways

The ciliated cells lining the conducting airways of mammals are integral to the defense mechanisms of the respiratory tract, functioning in coordination with secretory cells in the removal of inhaled and cellular debris. The effects of various infectious and toxic agents on the structure and function of airway epithelial cell cilia have been studied in our laboratory, both of which have been shown to affect ciliary ultrastructure.These observations have led to questions about ciliary regeneration as well as the possible induction of ciliogenesis in response to cellular injury. Classical models of ciliogenesis in the conducting airway epithelium of the mammalian respiratory tract have been based primarily on observations of the developing fetal lung. These observations provide a plausible explanation for the embryological generation of ciliary beds lining the conducting airways but do little to account for subsequent differentiation of ciliated cells and ciliogenesis during normal growth and development.

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