scholarly journals Questionnaire Survey on Current Red Blood Cell Transport and Storage in Korea for Reducing Wastage

2022 ◽  
Vol 42 (3) ◽  
pp. 342-351
Author(s):  
Mikyoung Park ◽  
Mina Hur ◽  
Hahah Kim ◽  
Kyungmi Oh ◽  
Hyunmi Kim ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Questionnaire Survey ◽  
Cell Transport ◽  
And Storage

scholarly journals Red‐blood‐cell manufacturing methods and storage solutions differentially induce pulmonary cell activation

Vox Sanguinis ◽  
2020 ◽  
Vol 115 (5) ◽  
pp. 395-404 ◽  
Author(s):  
Mathijs R. Wirtz ◽  
Ruqayyah J. Almizraq ◽  
Nina C. Weber ◽  
Philip J. Norris ◽  
Suchitra Pandey ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Activation ◽  
Cell Manufacturing ◽  
Storage Solutions ◽  
Manufacturing Methods ◽  
And Storage

Red blood cell (RBC) age at collection and storage influences RBC membrane-associated carbohydrates and lectin binding

Transfusion ◽  
2007 ◽  
Vol 47 (6) ◽  
pp. 966-968 ◽  
Author(s):  
Rosemary L. Sparrow ◽  
Margaret F. Veale ◽  
Geraldine Healey ◽  
Katherine A. Payne
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Lectin Binding ◽  
Rbc Membrane ◽  
And Storage

scholarly journals Processing methods and storage duration impact extracellular vesicle counts in red blood cell units

2020 ◽  
Vol 4 (21) ◽  
pp. 5527-5539
Author(s):  
Clementine Gamonet ◽  
Maxime Desmarets ◽  
Guillaume Mourey ◽  
Sabeha Biichle ◽  
Sophie Aupet ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Annexin V ◽  
Analysis Of Covariance ◽  
Active Components ◽  
Storage Duration ◽  
Processing Methods ◽  
Controllable Factors ◽  
Filter Type ◽  
And Storage

Abstract Extracellular vesicles (EVs) are active components of red blood cell (RBC) concentrates and may be associated with beneficial and adverse effects of transfusion. Elucidating controllable factors associated with EV release in RBC products is thus important to better manage the quality and properties of RBC units. Erythrocyte-derived EVs (EEVs) and platelet-derived EVs (PEVs) were counted in 1226 RBC units (administered to 280 patients) using a standardized cytometry-based method. EV size and CD47 and annexin V expression were also measured. The effects of donor characteristics, processing methods, and storage duration on EV counts were analyzed by using standard comparison tests, and analysis of covariance was used to determine factors independently associated with EV counts. PEV as well as EEV counts were higher in whole-blood–filtered RBC units compared with RBC-filtered units; PEV counts were associated with filter type (higher with filters associated with higher residual platelets), and CD47 expression was higher on EEVs in RBC units stored longer. Multivariate analysis showed that EEV counts were strongly associated with filter type (P < .0001), preparation, and storage time (+25.4 EEV/µL per day [P = .01] and +42.4 EEV/µL per day [P < .0001], respectively). The only independent factor associated with PEV counts was the residual platelet count in the unit (+67.1 PEV/µL; P < .0001). Overall, processing methods have an impact on EV counts and characteristics, leading to large variations in EV quantities transfused into patients. RBC unit processing methods might be standardized to control the EV content of RBC units if any impacts on patient outcomes can be confirmed. The IMIB (Impact of Microparticles in Blood) study is ancillary to the French ABLE (Age of Transfused Blood in Critically Ill Adults) trial (ISRCTN44878718).

scholarly journals Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III—Omics

Transfusion ◽  
2018 ◽  
Vol 59 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Angelo D'Alessandro ◽  
Rachel Culp‐Hill ◽  
Julie A. Reisz ◽  
Mikayla Anderson ◽  
Xiaoyun Fu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Storage Time ◽  
Cell Metabolism ◽  
Blood Processing ◽  
Processing And Storage ◽  
And Storage

scholarly journals An Efficient Apparatus for Rapid Deoxygenation of Erythrocyte Concentrates for Alternative Banking Strategies

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Lello Zolla ◽  
Angelo D'Alessandro
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Small Scale ◽  
Prolonged Storage ◽  
Case Scenario ◽  
Electron Microscopic ◽  
Production Chain ◽  
Erythrocyte Concentrates ◽  
Blood Cell Morphology ◽  
And Storage

Erythrocyte concentrates (ECs) stored for transfusion purposes still represent a lifesaving solution in a wide series of clinically occurring circumstances, especially for traumatized and perioperative patients. However, concerns still arise and persist as to whether current criteria for collection and storage of ECs might actually represent the best case scenario or there might rather be still room for improvement. In particular, the prolonged storage of EC has been associated with the accumulation of a wide series of storage lesions, either reversible (metabolism) or irreversible (protein and morphology). Independent laboratories have contributed to propose alternative strategies, among which is the introduction of oxygen removal treatments to ECs. Convincing biochemical and preliminary clinical evidences have been produced about the benefits derived from the introduction of this practice. We, hereby, propose a rapid, efficient, and time-effective strategy for blood deoxygenation which might fit in current EC production chain. The proposed strategy resulted in the complete deoxygenation of red blood cell hemoglobin (pO2<0.0021 mmHg). A preliminary small-scale study about the application of the present method resulted in reduced hemolysis, decreased vesiculation, and limited alterations to the red blood cell morphology, as gleaned from flow cytometry and scanning electron microscopic analyses. Further in-depth and larger-scale investigations are encouraged.

scholarly journals Extracellular Vesicles from Red Blood Cell Products Induce a Strong Pro-Inflammatory Host Response, Dependent on Both Numbers and Storage Duration

2015 ◽  
Vol 43 (4) ◽  
pp. 302-305 ◽  
Author(s):  
Marleen Straat ◽  
Anita N. Böing ◽  
Anita Tuip-De Boer ◽  
Rienk Nieuwland ◽  
Nicole P. Juffermans
Keyword(s):  
Blood Cell ◽  
Extracellular Vesicles ◽  
Red Blood Cell ◽  
Host Response ◽  
Storage Duration ◽  
And Storage

scholarly journals Proteomics of Stored Red Blood Cell Membrane and Storage-Induced Microvesicles Reveals the Association of Flotillin-2 With Band 3 Complexes

2018 ◽  
Vol 9 ◽  
Author(s):  
Michel Prudent ◽  
Julien Delobel ◽  
Aurélie Hübner ◽  
Corinne Benay ◽  
Niels Lion ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Band 3 ◽  
Red Blood Cell Membrane ◽  
And Storage

Implementation of an intraoperative blood transport and storage initiative and its effect on reducing red blood cell and plasma waste

Transfusion ◽  
2013 ◽  
Vol 54 (3) ◽  
pp. 701-707 ◽  
Author(s):  
Michael J. Brown ◽  
Lisa M. Button ◽  
Karafa S. Badjie ◽  
Jean M. Guyer ◽  
Sarah R. Dhanorker ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Cell And Plasma ◽  
Blood Transport ◽  
And Storage

scholarly journals Red blood cell transport velocity in microchannels indicates the growth of abnormal subpopulation under oxidative stress

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Nadezhda Besedina ◽  
Elisaveta Skverchinskaya ◽  
Alexander Ivanov ◽  
Stanislav Shmackov ◽  
Igor Mindukshev ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Transport ◽  
Transport Velocity

The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis

Blood ◽  
2005 ◽  
Vol 106 (13) ◽  
pp. 4034-4042 ◽  
Author(s):  
Richard van Wijk ◽  
Wouter W. van Solinge
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Current Knowledge ◽  
High Energy ◽  
Structural Features ◽  
High Energy Phosphates ◽  
Cellular Survival ◽  
Vital Functions ◽  
Erythrocyte Enzyme ◽  
And Storage

The red blood cell depends solely on the anaerobic conversion of glucose by the Embden-Meyerhof pathway for the generation and storage of high-energy phosphates, which is necessary for the maintenance of a number of vital functions. Many red blood cell enzymopathies have been described that disturb the erythrocyte's integrity, shorten its cellular survival, and result in hemolytic anemia. By far the majority of these enzymopathies are hereditary in nature. In this review, we summarize the current knowledge regarding the genetic, biochemical, and structural features of clinically relevant red blood cell enzymopathies involved in the Embden-Meyerhof pathway and the Rapoport-Luebering shunt.

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