scholarly journals Alpha-terpineol: evaluation and pharmacological screening as an antidepressant agent

2021 ◽  
Vol 10 (11) ◽  
pp. e191101119571
Author(s):  
Amanda Fonseca Costa Assunção ◽  
Nícolas Davidson Sérvulo Rodrigues ◽  
Andreia Viana da Costa Sampaio ◽  
Karolinny dos Santos Silva ◽  
Laryssa Roque da Silva ◽  
...  
Keyword(s):  
Motor Coordination ◽  
Forced Swimming Test ◽  
Open Field Test ◽  
Tail Suspension Test ◽  
Experimental Tests ◽  
Forced Swimming ◽  
Tail Suspension ◽  
Immobility Time ◽  
Swimming Test ◽  
Antidepressant Action

Objective: To evaluate the possible antidepressant effects of alpha-terpineol in rodents. Material and Methods: Depression levels were analyzed by comparing the total immobility time presented by the animals of the experimental groups in the test session, using the Forced Swimming Test and the Tail Suspension Test. The parameters of locomotion (central, peripheral and total) and motor coordination were evaluated in the Open Field Test and in the Rota Rod Test, respectively. In the second stage, the involvement of the noradrenergic system in the antidepressant action of alpha-terpineol in Forced Swimming Test was investigated. Results and Discussion: After performing the experimental tests, it was observed that the animals that received alpha-terpineol had reduced immobility time in Forced Swimming Test and Tail Suspension Test, compared to the other groups. In the Open Field Test and Rota-rod, the mice showed, respectively, good exploratory activity and motor coordination during the tests. In addition, the study of the Noradrenergic System proved to be a promising mechanism used during its antidepressant action. Conclusion: In view of the results of the experimental tests, alpha-terpineol presented similar responses to those found in other monoterpenes investigated in the literature. Thus, it is shown as a promising antidepressant to be used clinically in humans, with less side effects and low production cost.

Effect of Psoralea corylifolia extract on physically induced depression in mice.

2017 ◽  
Vol 2 (2) ◽  
pp. 199
Author(s):  
Bhawya D. ◽  
K. R. Anilakumar ◽  
Farhath Khanum
Keyword(s):  
Forced Swimming Test ◽  
Dose Range ◽  
Tail Suspension Test ◽  
Cellular Level ◽  
Forced Swimming ◽  
Tail Suspension ◽  
Bioactive Constituents ◽  
Immobility Time ◽  
Swimming Test ◽  
Suspension Test

<p>The mouse forced swimming test (FST) and tail suspension test (TST) are widely used to predict anti-depressant efficacy indicated by immobility time to be reduced by several different classes of anti-depressant drugs. PCE feeding at the dose of 75,150 and 300 mg/kg reduced the immobility duration at 14-days and 21-days, however the decrease was significant in mice treated with PCE for 21-days also, extract had no effect on spontaneous motor activity in mice, indicating that extract had no excitatory or inhibitory action on central nervous system in effective dose range, which eliminated the probability of false-positive results in forced swimming test and tail suspension test. Interestingly, the dose-response effect of PCE on reduction of serum CRF levels was concomitance with that on increase of brain 5-HT contents, as well as on swimming increase, indicating that the serotonergic system and the HPA axis responds with the production of 5-HT and CRF profiles that is characteristic for PCE applied in the mouse FST. Our results demonstrate that the oral administration of PCE possesses an anti-depressant-like activity, as evidenced by behavioural studies. Detailed investigations are needed to fully elucidate the mechanism of action at cellular level for the bioactive constituents present in the extract. </p>

scholarly journals Gunn rats with glial activation in the hippocampus show prolonged immobility time in the forced swimming test and tail suspension test

2018 ◽  
Vol 8 (8) ◽  
pp. e01028 ◽  
Author(s):  
Ryosuke Arauchi ◽  
Sadayuki Hashioka ◽  
Keiko Tsuchie ◽  
Tsuyoshi Miyaoka ◽  
Toshiko Tsumori ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Glial Activation ◽  
Tail Suspension ◽  
Gunn Rats ◽  
Immobility Time ◽  
Swimming Test ◽  
Suspension Test

Nitric oxide mediates the antidepressant-like effect of modafinil in mouse forced swimming and tail suspension tests

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hossein Omidi-Ardali ◽  
Abolfazl Ghasemi Badi ◽  
Elham Saghaei ◽  
Hossein Amini-Khoei
Keyword(s):  
Nitric Oxide ◽  
Effective Dose ◽  
Animal Studies ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Immobility Time ◽  
Swimming Test ◽  
Underlying Mechanisms

AbstractObjectivesPrevious studies have suggested antidepressant properties for modafinil; however, the underlying mechanisms mediating the antidepressant effect of modafinil have not been well recognized in clinical and animal studies. Nitric oxide (NO) is involved in the pathophysiology of depression. We attempted to investigate the possible role of NO in the antidepressant-like effect of modafinil in mouse forced swimming test (FST) and tail suspension test (TST).MethodsThe antidepressant-like effect of modafinil (25, 50 and 75 mg/kg), alone and in combination with l-arginine, l-arg, (100 mg/kg) and NG-l-arginine methyl ester, l-NAME (5 mg/kg), was evaluated using FST and TST. Following behavioral tests, the hippocampi were dissected out to measure nitrite levels.ResultsFindings suggested that administration of modafinil at doses of 50 and 75 mg/kg significantly reduced immobility time in the FST and TST. Furthermore, administration of l-arg and l-NAME increased and decreased, respectively, the immobility time in the FST and TST. We showed that co-administration of a sub-effective dose of modafinil (25 mg/kg) plus l-NAME potentiated the antidepressant-like effect of the sub-effective dose of modafinil. In addition, co-treatment of an effective dose of modafinil (75 mg/kg) with l-arg attenuated the antidepressant-like effect of the effective dose of modafinil. We showed that the antidepressant-like effect of modafinil is associated with decreased nitrite levels in the hippocampus.ConclusionsOur findings for the first time support that the modulation of NO, partially at least, is involved in the antidepressant-like effect of modafinil in mouse FST and TST.

scholarly journals ANTI-DEPRESSANT EFFECT OF CEFTRIAXONE IN FORCED SWIMMING TEST AND IN TAIL SUSPENSION TEST IN MICE

2016 ◽  
Vol 8 (11) ◽  
pp. 191 ◽  
Author(s):  
Ajoy Borah ◽  
Binita Singha ◽  
Swopna Phukan
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Neuroprotective Effects ◽  
The Central Nervous System ◽  
Swimming Test ◽  
Suspension Test

Objective: Depression is a major psychiatric disorder affecting nearly 350 million people worldwide and imposes a substantial health burden on the society. Ceftriaxone has demonstrated neuroprotective effects in animals. It has also undergone trials as a treatment option for amyotrophic lateral sclerosis. This study was therefore undertaken to evaluate the antidepressant-like effect of ceftriaxone in mice.Methods: Ceftriaxone was administered at three different doses (0.130, 0.195 and 0.260g/kg) to Swiss albino mice of either sex by intra peritoneal (i. p.) route. The period of immobility in control and drug-treated mice were recorded in forced swimming test (FST) and tail suspension test (TST). The antidepressant effect of ceftriaxone indicated by the decrease in duration of immobility was compared to that of fluoxetine (0.020 g/kg, i. p.).Results: Ceftriaxone decreased the duration of immobility in mice. It showed a significant dose-dependent antidepressant effect. The antidepressant effect of 0.260g/kg of ceftriaxone was comparable to that of fluoxetine in the TST but not in the FST.Conclusion: The results of the present study indicate antidepressant activity of Ceftriaxone. The study shows that ceftriaxone has additional action on the central nervous system other than neuroprotection. Ceftriaxone therapy in cases of encephalomeningitis and in various cases of hemorrhages in the brain can, therefore, prevent the development of depression in future

scholarly journals Synthesis and anti-depressant evaluation of novel pyrazolone derivatives

2016 ◽  
Vol 11 (2) ◽  
pp. 558 ◽  
Author(s):  
Vijay Kumar Merugumolu ◽  
Revanasiddappa Bistuvalli Chandrashekara
Keyword(s):  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Physical Parameters ◽  
Tail Suspension ◽  
Substituted Anilines ◽  
Standard Drug ◽  
Pyrazolone Derivatives ◽  
Swimming Test ◽  
Suspension Test

<p class="Abstract">Diazotization of substituted anilines with NaNO<sub>2</sub> and concentrated hydro-chloric acid at 0ºC gave the diazonium chlorides. Coupling of substituted aryl diazonium chlorides with ethyl acetoacetate in methanol gave ethyl-2-aryl-hydrazono-3-oxobutyrates (2a-h). Reaction of (2a-h) with naphthoic carbohydrazide (3) gave the title compounds pyrazolone derivatives (4a-h). The newly synthesized compounds were screened for their in vivo anti-depressant activity by tail suspension test and forced swimming test. Some of the tested compounds 4f, 4g showed very good activity when compared to the standard drug imipramine. The newly synthesized compounds were characterized by physical parameters and the structures were elucidated by spectral data.</p><p><strong>Video Clips</strong></p><p><a href="https://www.youtube.com/v/TZtb2a5u4CU">Forced swimming test</a>: 12 min 19 sec</p><p><a href="https://www.youtube.com/v/92mFRfBJgBw">Tail suspension test</a>: 8 min 5 sec</p><p> </p>

Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in mice

Neuroreport ◽  
2000 ◽  
Vol 11 (17) ◽  
pp. 3699-3702 ◽  
Author(s):  
Gisele de Lourdes da Silva ◽  
Andreza S. Matteussi ◽  
Adair Roberto S. dos Santos ◽  
João Batista Calixto ◽  
Ana Lúcia S. Rodrigues
Keyword(s):  
Nitric Oxide ◽  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Tail Suspension ◽  
Swimming Test ◽  
Suspension Test

scholarly journals AN EXPERIMENTAL STUDY EVALUATING THE INFLUENCE OF BISPHOSPHONATES ON DEPRESSION PATTERNS IN SWISS ALBINO MICE AND WISTER RATS

2017 ◽  
Vol 9 (8) ◽  
pp. 187
Author(s):  
S. S. Torgal ◽  
Amitha N
Keyword(s):  
Adult Male ◽  
Forced Swimming Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Control Group ◽  
Tail Suspension ◽  
Swiss Albino Mice ◽  
Swimming Test ◽  
Suspension Test

Objective: Bisphosphonates are used for treating osteoporosis. Few studies have reported their effect on alterations in comorbid behaviour such as depression. Therefore, present study was performed to investigate the effects of bisphosphonate drugs on depression in adult male Wister rats and Swiss albino mice.Methods: The study was conducted on adult male Wister rats and Swiss albino mice, 36 of each type, equally divided into six groups. One group was classified as control group and the rest were treated as test groups. Initial photoperiod of 12 h was provided for acclimatization, prior to the start of the experiment. Drug administration was not performed in control group. Forced swimming test and tail suspension test were performed to investigate the antidepressant activity. Locomotor activity was performed to evaluate the action of drugs on the nervous system. Effects of the test drugs were compared with a standard drug—amitriptyline. Results were statistically evaluated by one-way analysis of variance followed by Bonferroni’s multiple comparison test. P≤0.05 was considered significant.Results: In forced swimming test, duration of immobility was significantly reduced in the standard and test drugs when compared to control group; however, it was not significant in all the four test groups as compared to that of amitriptyline-administered group (p>0.05). In tail suspension test, significant decrease (p<0.01) in the duration of immobility was observed with administration of drugs when compared to control group. Results of test groups were not found to be significant as compared to amitriptyline-treated group (p>0.05). Mean values of amitriptyline-, alendronate-, risedronate-, ibandronate-and etidronate-treated groups failed to show significant difference (p>0.05) when compared to control group suggesting homogeneity among the groups.Conclusion: Bisphosphonates appeared to have an antidepressant activity. More extensive research is required to substantiate and elucidate the role of bisphosphonates in behavioural disorders such as depression.

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